MicroRNA-based promotion of human neuronal differentiation and subtype specification. by Laura Stappert, Lodovica Borghese, Beate Roese-Koerner, Sandra Weinhold, Philipp Koch, Stefanie Terstegge, Markus Uhrberg, Peter Wernet, Oliver Brüstle

“…Here, we use a population of long-term self-renewing neuroepithelial-like stem cells (lt-NES cells) derived from human embryonic stem cells to study the expression and function of microRNAs at early stages of human neural stem cell differentiation and neuronal lineage decision. …”
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Emerging Role of Ubiquitin Proteasome System and Autophagy in Pediatric Demyelinating Leukodystrophies and Therapeutic Opportunity by Dar-Shong Lin, Che-Sheng Ho

“…Maintaining proteostasis, which is critical for normal cellular function, relies fundamentally on the ubiquitin–proteasome system (UPS) and autophagy for the degradation of misfolded and damaged proteins. …”
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An Overview on Mitochondrial-Based Therapies in Sepsis-Related Myocardial Dysfunction: Mitochondrial Transplantation as a Promising Approach by Behnaz Mokhtari, Rana Yavari, Reza Badalzadeh, Ata Mahmoodpoor

“…Given that the heart is a mitochondria-rich organ and the normal function of mitochondria is essential for successful modulation of septic response, the contribution of mitochondrial damage in sepsis-related myocardial dysfunction has attracted the attention of many scientists. …”
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Mechanisms and roles of hydroxychloroquine in pregnancy in rheumatic diseases by Lingjun Kong, Qian Wang, Yanan He, Wen Zhang

“…Results: HCQ mainly modulates autoimmune response through inhibition of lysosomal function, toll-like receptor (TLR) signalling, nicotinamide adenine dinucleotide phosphate-mediated oxidative stress and autophagy. …”
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Microbial effects of cold-pressed Sacha inchi oil supplementation in rats. by Tepparit Samrit, Supawadee Osotprasit, Athit Chaiwichien, Phawiya Suksomboon, Supanan Chansap, Thitikul Suthisintong, Narin Changklungmoa, Pornanan Kueakhai

“…The results of this study suggest that SI supplementation modulates the gut microbiota, thereby enhancing gut health and metabolic function.…”
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Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions. by Eike Steinmann, Francois Penin, Stephanie Kallis, Arvind H Patel, Ralf Bartenschlager, Thomas Pietschmann

“…Although much has been learned about the function of individual viral proteins, the role of the HCV p7 protein in virus replication is not known. …”
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Programming of mice circadian photic responses by postnatal light environment. by Elisabeth Brooks, Dhruval Patel, Maria Mercè Canal

“…Firstly, we used electroretinography, pupillometry and histology protocols to show that gross retinal function and morphology in the adult are largely independent of postnatal light experiences that modulate circadian photosensitivity. …”
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Neurostimulation device for ameliorating salivary dysfunction: A novel neuromodulatory perspective by Rajkumar Krishnan, Nagarathinam Anbu Elangovan, Ramya Ramadoss

“…Neurostimulation offers a targeted and personalised approach to treatment, allowing for precise modulation of salivary gland function based on individual patient needs. …”
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Wind Power Plant Expert System Diagnostic Knowledge Base Creation by Radosław Duer, Stanisław Duer, Konrad Zajkowski, Marek Woźniak, Dariusz Bernatowicz, Jacek Paś, Marek Stawowy, Atif Iqbal, Marta Harničárová

“…The article presents the creation of an expert knowledge base on wind farm equipment that is the basis for the functioning of an intelligent expert system. For this purpose, a functional and diagnostic model of wind farm equipment was presented and described. …”
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The role of imprinted gene ZmFIE1 during maize kernel development by Jing Yang, Shengnan Liu, Zhen Lin, Ning Song, Xiaomei Dong, Jinsheng Lai, Weibin Song, Zhijia Yang, Jian Chen, Qiujie Liu

“…In this study, we applied a reverse genetics approach to investigate the role of ZmFIE1, the homolog of the PRC2 complex component Extra sex combs (Esc), in maize development. The functional loss of ZmFIE1 significantly reduces embryo size in the early stage but has a relatively small impact on mature kernels. …”
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Energy metabolism disorders in migraine: triggers, pathways, and therapeutic repurposing by Wen-xiu Sun, Ting-yan Chen, Mao-mei Song, Ying-jie Gao, Sui-yi Xu, Sui-yi Xu

“…Many migraine triggers, such as stress, sleep deprivation, fatigue, strenuous exercise, and fasting, are potentially linked to disturbances in brain energy metabolism, mitochondrial function, and oxidative stress. Alongside efforts to avoid modifiable factors, prophylactic migraine treatments that target brain energy metabolism have garnered increasing attention. …”
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Impact of myokines on chronic liver diseases: exploring the effects of metabolic dysfunction-associated steatotic liver disease (MASLD) on skeletal muscle. A narrative review by Francisco Aguirre, Mayalen Valero-Breton, Daniel Cabrera, Luis Peñailillo, María Carolina Otero, Claudia Fredes, Claudio Cabello-Verrugio

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition characterized by altered liver function due to fatty accumulation, which can lead to liver inflammation and, in advanced stages, liver carcinoma. …”
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Effect of alkali activated potassium persulfate solution immersion on wettability and pore structure of coking coal by Jun DAI, Yuzhen ZHANG, Juan YANG, Leisi XU, Jianping WEI

“…By combination with the fitting results of FT-IR spectra for coal samples before and after AAP immersion experiment, the relative content changes of various functional groups on the surface of coal samples were obtained. …”
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Exosomal miR-93-3p targets EIF4EBP1 to regulate macrophage polarization and accelerate wound healing post-anal fistula surgery by Wei Zhang, Wenzhe Feng, Junhong Chen, Ruoxi Cao, Xi Chen

“…Potential miRNA target genes were predicted using TargetScan before Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. …”
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Components of Mineralocorticoid Receptor System in Human DRG Neurons Co-Expressing Pain-Signaling Molecules: Implications for Nociception by Shaaban A. Mousa, Xueqi Hong, Elsayed Y. Metwally, Sascha Tafelski, Jan David Wandrey, Jörg Piontek, Sascha Treskatsch, Michael Schäfer, Mohammed Shaqura

“…The mineralocorticoid receptor (MR), traditionally associated with renal function, has also been identified in various extrarenal tissues, including the heart, brain, and dorsal root ganglion (DRG) neurons in rodents. …”
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Effect of Bacillus paralicheniformis Q13 on Alleviating Hyperuricemia Induced by Potassium Oxonate in Mice by SUO Linglan, LI Yue, JIANG Bin, LENG Yue, REN Dayong

“…Conclusion: B. paralicheniformis Q13 significantly inhibited the elevation of uric acid and enhanced renal function. Moreover, it significantly down-regulated xanthine oxidase activity, mitigated renal, hepatic and colonic injury induced by potassium oxonate in mice, abated renal inflammation, boosted hepatic antioxidant function, and modulated the homeostasis of gut microbiota, ultimately alleviating HUA. …”
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Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia by Soo Yeon Jang, Kyung Mook Choi

“…SIRT1 and AMPK, two key energy sensors, are involved in mitochondrial biogenesis through regulation of PGC‐1α. Modulation of PGC‐1α levels in skeletal muscle may help protect against sarcopenia by preserving muscle integrity, enhancing muscle function, improving insulin sensitivity and reducing inflammation and oxidative stress. …”
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Biomarker Evolution in Pediatric SMA: Insights from CSF pNF-H Dynamics and SMN2 Copy Number During Nusinersen Therapy by Mihaela Badina, Gabriel Cristian Bejan, Andrada Mirea, Corina Sporea, Madalina Cristina Leanca, Georgiana Nicolae, Ioana Elena Cioca, Maria Veronica Morcov, Angelo Pellegrini, Elena-Nicoleta Bordea

“…Patients were stratified by SMN2 gene copy number, which modulates disease severity and response to therapy. pNF-H levels inversely correlated with SMN2 copy number, with higher levels indicating more severe neurodegeneration. pNF-H levels also correlated with motor function, with higher baseline levels linked to lower scores. …”
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LncRNA GABARAPL2 promotes non‑union long bone fractures by suppressing bone mesenchymal stromal cell osteogenesis by Hurong Du, Wenlong Zhang, Zeyuan Liu, Wei Liu

“…Conclusion These findings establish that lnc_GABARAPL2 may as a regulator of fracture healing and a promising predictive biomarker for non-union and targeting miR-302a-3p to modulate bone marrow mesenchymal stem cell functions, providing new insights for the development of RNA-based therapeutic strategies for impaired bone repair.…”
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Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…Immunoprecipitation coupled with mass spectrometry (IP-MS), bioinformatics analysis and ubiquitination assays, were employed to identify the molecular targets responsible for SEL-induced degradation of XPO1. shRNA-mediated knockdown assays and small molecule inhibitors of USP7 were utilized to disrupt the function of USP7. The role of USP7 in modulating SEL sensitivity was analyzed in MM cell lines, primary CD138+ cells, and xenograft mouse models. …”
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