CSF3 promotes colorectal cancer progression by activating p65/NF-κB signaling pathway and inducing an immunosuppressive microenvironment by Junfeng Xu, Na Li, Hui Xie, Changwei Duan, Xingchen Liao, Ruoran Li, Heng Zhang, Yuanming Pan, Xianzong Ma, Shuwen Du, Jianqiu Sheng, Xin Wang, Lang Yang, Peng Jin

“…Background: Colony-stimulating factor 3 (CSF3) is a cytokine that promotes inflammation by stimulating the maturation, proliferation, and trafficking of myeloid progenitor cells. However, the functional importance of CSF3 in colorectal cancer (CRC) remains unclear. …”
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SMAD3 orchestrates RNF167 and STAMBPL1-mediated Sestrin2 ubiquitination to drive gastric cancer progression by Ning Zhang, Na Zhao, Hainan Zhang, Le Yao, Hongtao Si

“…In vitro models of SMAD3 overexpression and knockdown were utilized to assess the functional consequences on GC cell proliferation, migration, invasion, and apoptosis. …”
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CDCA genes as prognostic and therapeutic targets in Colon adenocarcinoma by Zongquan Zhao, Xinwei Feng, Bo Chen, Yihong Wu, Xiaohong Wang, Zhenyuan Tang, Min Huang, Xiaohua Guo

“…Abstract Objectives The study investigates the role of Cell Division Cycle Associated (CDCA) genes in colorectal cancer (COAD) by analyzing their differential expression, epigenetic alterations, prognostic significance, and functional associations. Methodology This study employed a detailed in silico and in vitro experiments-based methodology. …”
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The potential biomarker value of soluble CD36 in the treatment of diabetic kidney disease: evidence from GLP-1 and insulin interventions by Wenxuan Li, Yangang Wang

“…The renoprotective effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) may involve modulation of sCD36. This study aimed to evaluate the impact of GLP-1RA and insulin treatment on sCD36 levels and their association with renal function in DKD patients.MethodsThis single-center, prospective observational cohort study enrolled 191 patients with type 2 diabetes and early-stage DKD, who were stratified into three groups based on treatment regimen: control group (n = 63), insulin group (n = 71), and GLP-1RA group (n = 57). …”
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Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache by Costantini Antonio, Tiberi Massimo, Zarletti Gianpaolo, Pala Maria Immacolata, Trevi Erika

“…Considering the role of thiamine in brain function, in energetic metabolism, and in pain modulation, we treated a patient affected by cluster headache with oral high-dose thiamine. …”
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ELMO2 is an essential regulator of carotid artery development by Athira Suresh, Kai Kruse, Hendrik Arf, Rodrigo Diéguez-Hurtado, Ralf H. Adams

“…In vitro experiments further confirm that ELMO2 regulates vascular smooth muscle cell adhesion, spreading and contractility through Rac1 activation and modulation of actin dynamics. Our findings provide new insights into the biological function of ELMO2 with relevant implications for understanding VMOS pathogenesis and raise the possibility of vessel-targeted diagnostic and treatment strategies.…”
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ASEP of MIMO System with MMSE-OSIC Detection over Weibull-Gamma Fading Channel Subject to AWGGN by Keerti Tiwari, Davinder S. Saini, Sunil V. Bhooshan

“…Consequently, generalized Q-function is used to model noise. The average symbol error probability (ASEP) of MIMO system is computed for 16-quadrature amplitude modulation (16-QAM) using MMSE-OSIC detection in WG fading perturbed by AWGGN. …”
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Peroxisome proliferator‐activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut by Mathurin Fumery, Silvia Speca, Audrey Langlois, Anne‐Marie Davila, Caroline Dubuquoy, Marta Grauso, Anthony Martin Mena, Martin Figeac, Daniel Metzger, Christel Rousseaux, Jean‐Frederic Colombel, Laurent Dubuquoy, Pierre Desreumaux, Benjamin Bertin

“…While the intestine is essential for carbohydrate digestion and absorption, the role of PPARγ in enterocyte metabolic functions has been poorly investigated. This study aims at characterizing PPARγ target genes involved in intestinal metabolic functions. …”
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SNRPB/CCNB1 axis promotes hepatocellular carcinoma progression and cisplatin resistance through enhancing lipid metabolism reprogramming by Xin Jin, Xigan He, Runze Huang, Qinyu Liu, Lei Wang, Xuanci Bai, Yibin Wu, Yixiu Wang, Ziting Jiang, Yi Shi, Gautam Sethi, Lu Wang, Weiping Zhu

“…This study explores the function of Small Nuclear Ribonucleoprotein Polypeptides B and B1 (SNRPB) in HCC, unveiling critical pathways that affect the progression of the disease. …”
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Dental and oral health assessments in the German National Cohort (NAKO) by Stefanie Samietz, Katrin Borof, Katrin Hertrampf, Ghazal Aarabi, Antonio Ciardo, Hannah Finke, Daniel Hagenfeld, Jan Kühnisch, Maurice Rütters, Sebastian-Edgar Baumeister, Stefan Lars Reckelkamm, Ti-Sun Kim, Thomas Kocher, Wolfgang Ahrens, Hermann Brenner, Carina Emmel, Beate Fischer, Amand Führer, Karin Halina Greiser, Jasmin Grischke, Kathrin Günther, Volker Harth, Stefanie Jaskulski, André Karch, Thomas Keil, Yvonne Kemmling, Alexander Kluttig, Lilian Krist, Oliver Kuss, Michael Leitzmann, Claudia Meinke-Franze, Karin B. Michels, Nadia Obi, Anette Peters, Nicole Pischon, Tobias Pischon, Sabine Schipf, Börge Schmidt, Henning Teismann, Stefan Rupf, Birte Holtfreter

“…This extended program was carried out in a subgroup of 20,828 participants, including collection of detailed information on the dental and prosthetic status as well as on periodontal, cariological and functional aspects. To ensure reliability and reproducibility, study nurses were trained and calibrated by dental experts. …”
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Hesperetin attenuates ischemia/reperfusion-induced acute kidney injury by regulating ferroptosis in mice by Xiaoyu Xie, Chen Guan, Ningxin Zhang, Chenyu Li, Zengying Liu, Chengyu Yang, Liting Wang, Yan Xu

“…Molecular docking revealed that hesperetin binds to Src, and immunohistochemistry confirmed that hesperetin downregulates Src phosphorylation in renal tubular epithelial cells.Conclusion Hesperetin exerts renoprotective effects against I/R-induced AKI by improving renal function and inhibiting ferroptosis. Its therapeutic potential may be attributed to modulation of the Src, making it a promising candidate for AKI treatment.…”
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Evaluation of Albizia lebbeck and Curcuma longa Extracts on Gastrointestinal Motility, Safety, and Hematological Parameters: A Sub-Chronic Toxicity and Pharmacological Study by Bushirat Fagbohun, Hassan Adewuyi, Maryam Musa, Ojochenemi Unuata, Ochonung Ogar, Agor Achi, Usman Mohammed, Jaiyeola Olukayode

“…Safety was evaluated through sub-chronic toxicity studies, including liver and kidney function tests and hematology parameters.Results: Albizia lebbeck and Curcuma longa extracts significantly enhanced gastrointestinal motility and antioxidant activity (p<0.05), improved liver function (ALT: -15.4 %, AST: -12.5 %), and kidney function (creatinine: -10.3 %, urea: -9.5 %). …”
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Optimizing AlexNet for accurate tree species classification via multi-branch architecture and mixed-domain attention by Jianjianxian Liu, Tao Xing, Xiangyu Wang

“…The model integrates a multi-branch convolutional module, a mixeddomain attention module, and a joint loss function to improve feature extraction and class separation. …”
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The Sensory Input from the External Cuneate Nucleus and Central Cervical Nucleus to the Cerebellum Refines Forelimb Movements by Chidubem Eneanya, George M. Smith

“…Together, this information provides evidence that the requirement of ascending sensory information is important in forelimb function.…”
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On the Shaker Simulation of Wind-Induced Non-Gaussian Random Vibration by Fei Xu, Chuanri Li, Tongmin Jiang

“…A new synthesis method is used to model the non-Gaussian signal as a Gaussian signal multiplied by an amplitude modulation function (AMF). A case study is presented to show that the synthesized non-Gaussian signal has the same power spectral density (PSD), probability density function (PDF), and loading cycle distribution (LCD) as the field data. …”
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CLINICAL LABORATORY INDICATORS OF PREGNANT WITH ANTIPHOSPHOLIPID SYNDROME IN COMPLEX THERAPY WITH USING INTRAVENOUS IMMUNOGLOBULIN by V. I. Linnikov

“…It is noted that immune-modulating effect is probably related to its positive impact on the function of T-regulatory lymphocytes.…”
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Peripheral gene dysregulation in Negr1-deficient mice: insights into possible links with affective behavior by Abdulkadir Yusif Maigoro, Jangrae Kim, Seoyeon Cho, Ara Yoo, Soojin Lee

“…This work enhances our understanding of NEGR1’s function in peripheral tissues and its possible involvement in peripheral-central immune crosstalk relevant to psychiatric disorders.…”
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A look at the concept of “sexual dysfunction” through psychotropic drugs: a review by İrem ARABACI, Birgül OZKAN, Görkem KARAKAŞ UĞURLU

“…Many different drugs used in psychiatric treatments can cause changes in sexual function. Especially antipsychotics, antidepressants, anxiolytics and mood-modulating drugs that are effective on the central nervous system affect sexual function with different mechanisms. …”
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DIVERSITY SIGNAL PROCESSING OVER WEIBULL FADING CHANNELS by V. P. Tuzlukov

“…Moreover, using the well-known moment-generating function approach, the outage and the average symbol error probability for several coherent, non-coherent, binary, and multilevel modulation schemes, are studied. …”
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An Enhanced DCO-OFDM Scheme for Dimming Control in Visible Light Communication Systems by Yang Yang, Zhimin Zeng, Julian Cheng, Caili Guo

“…By introducing a piecewise function with adaptive slopes according to the required optical power, the proposed eDCO-OFDM scheme has the potential to effectively eliminate the clipping noise. …”
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