Thrombospondin-1 induces CD8+ T cell exhaustion and immune suppression within the tumor microenvironment of ovarian cancer by Haiyan Liang, Suwei Zhang

“…Methods We analyzed THBS1 expression and its clinical significance using publicly available datasets (TCGA-OV, GSE14407) and tissue microarrays containing OC and adjacent normal tissues. In vitro functional studies were conducted using OC cell lines (SKOV3, A2780) and co-cultures with macrophages. …”
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Genome-wide identification and analysis of potassium ion transporter HAK/KUP/KT family in rapeseed (Brassica napus L.) by ZHU Le, ZHAO Xinze, JIANG Lixi

“…This study provides a reference for further revealing the functional mechanism of HAK/KUP/KT gene family in B. napus.…”
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Units mechanization for improving mountain slope areas by Soldatova I.E., Gulueva L.R.

“…Methods of evaluation of functional indicators. Ministry of Agriculture and Food of Russia”. …”
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Cytochrome P450 CYP76F14 Mediates the Conversion of Its Substrate Linalool in Table Grape Berries by Zhizhong Song, Jinjin Zhang, Matthew Shi, Dong Li, Xiaohua Liu

“…While the cytochrome P450 enzyme CYP76F14 is implicated in aroma biosynthesis, its functional role in grape berries remains uncharacterized. …”
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Cigarette smoke induced airway inflammation is independent of NF-κB signalling. by Joseph M D Rastrick, Christopher S Stevenson, Suffwan Eltom, Megan Grace, Meirion Davies, Iain Kilty, Steven M Evans, Manolis Pasparakis, Matthew C Catley, Toby Lawrence, Ian M Adcock, Maria G Belvisi, Mark A Birrell

“…<h4>Results</h4>We showed in an airway inflammation model known to be NF-κB-dependent that the NF-κB pathway activity assays and modulators were functional in the mouse lung. Then, using the same methods, we demonstrated that the NF-κB pathway appears not to play an important role in the inflammation observed after exposure to CS. …”
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Temporal–Spatial Acupuncture Effects on Poststroke Sensorimotor Cortex via Yanglingquan (GB34) by Ruoyi Liu, Yue Wang, Myadagbadam Boldbayar, Yuanyuan Li, Chen Chen, Xin Yu, Tianjiao Xu, Muzhao Zhang, Yihuai Zou, Hua Zhang

“…To explore motor cortex pathology and acupuncture’s immediate spatiotemporal effects on poststroke motor pathway impairment, 63 patients and 42 healthy subjects underwent three functional magnetic resonance imaging (fMRI) scans: resting-state, passive finger movement, and acupuncture at Yanglingquan points. …”
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Death receptor (DR4) haplotypes are associated with increased susceptibility of gallbladder carcinoma in north Indian population. by Rajani Rai, Kiran L Sharma, Surbhi Sharma, Sanjeev Misra, Ashok Kumar, Balraj Mittal

“…Hence, the present study aimed to investigate the association of functional SNPs of DR4 (rs20575, rs20576 and rs6557634), FAS (rs2234767) and FASL (rs763110) with gallbladder cancer (GBC) risk.…”
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Product family modeling technology for customized cosmetic packaging design based on basic-element theory by Tao Chen, Ding-Bang Luh, Jinguang Wang

“…Results: By examining the mapping relationships between the demand domain, functional domain, technology domain, and structure domain, four interrelated models have been developed, including the demand model, functional model, technology model, and structure model. …”
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A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF... by Madhushika Ratnayake, Maria Tselepi, Robert Bloxham, Frank Plöger, Louise N Reynard, John Loughlin

“…The growth differentiation factor 5 gene GDF5 was one of the first reported OA susceptibility signals that showed consistent association to OA, with the transcript single nucleotide polymorphism (SNP) rs143383 demonstrating association in Asians and Europeans. The functional effect of the signal is reduced expression of the gene. …”
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Optimized Fermentation Conditions of Pulses Increase Scavenging Capacity and Markers of Anti-Diabetic Properties by Andrea Jimena Valdés-Alvarado, Erick Damián Castañeda-Reyes, Elvira Gonzalez de Mejia

“…These results suggest that fermentation with Lp299v enhances the nutritional and functional quality of pulses, producing bioactive ingredients with antioxidant and antidiabetic potential. …”
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Comprehensive in silico analysis to decipher the role of long non-coding RNAs in bread wheat during fusarium head blight and leaf rust interactions by Jyothsna S, Alagu Manickavelu

“…Thisstudy unveils a potential functional divergence within lncRNAs and serves as a fine resource that can be harnessed to elucidate the interplay of miRNA-lncRNA-mRNA networks governing wheat–fungal interactions.…”
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The Potential Role of Probiotics in the Management of Childhood Autism Spectrum Disorders by J. William Critchfield, Saskia van Hemert, Michael Ash, Linda Mulder, Paul Ashwood

“…Probiotics can influence microbiota composition and intestinal barrier function and alter mucosal immune responses. The administration of probiotic bacteria to address changes in the microbiota might, therefore, be a useful novel therapeutic tool with which to restore normal gut microbiota, reduce inflammation, restore epithelial barrier function, and potentially ameliorate behavioural symptoms associated with some children with ASD. …”
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Effector Pt31812 from Puccinia triticina acts as avirulence factor for Lr42-mediated resistance in wheat by Jianyuan Li, Jianyuan Li, Jiali Li, Jie Wei, Jie Wei, Lin Li, Yue Qi, Yue Qi, Yue Zhang, Yue Zhang, Wenxiang Yang, Qian-Hua Shen

“…Here, we identify the Pt31812 effector and characterize its function in pathogenesis and immune-related activity in plants. …”
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High-entropy assisted capacitive energy storage in relaxor ferroelectrics by chemical short-range order by Tongxin Wei, Jinzhu Zou, Xuefan Zhou, Miao Song, Yan Zhang, Cewen Nan, Yuanhua Lin, Dou Zhang

“…Although high entropy relaxor ferroelectric exhibited enormous potential in functional materials, the chemical short-range order, which is a common phenomenon in high entropy alloys to modulate performances, have been paid less attention here. …”
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The influence of gut microbiota on the gut-brain-kidney axis and its implications for chronic kidney disease by Jue Zhu, Yutong Fu, Yutong Fu, Chinasa Valerie Olovo, Chinasa Valerie Olovo, Jianguo Xu, Qian Wu, Wei Wei, Ke Jiang, Ke Jiang, Xueming Zheng, Xueming Zheng

“…The gut-brain-kidney axis represents a dynamic interplay among the gut microbiota, renal function, and neurological processes, emerging as a critical factor in chronic kidney disease (CKD) pathophysiology. …”
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Industrial Design of High Voltage Flexible DC Converter Valve by Li QIAO, Jian XIE, Yunpeng LI, Chunyi GUO

“…Based on analyzing the design of the sub-module, valve module and valve tower of a ±320 kV flexible DC converter valve, a reasonable design method is proposed from the aspects of function, structure, modeling, man-machine, assembly, cost, coating and so on. …”
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Medium-scale flexible integrated circuits based on 2D semiconductors by Yalin Peng, Chenyang Cui, Lu Li, Yuchen Wang, Qinqin Wang, Jinpeng Tian, Zhiheng Huang, Biying Huang, Yangkun Zhang, Xiuzhen Li, Jian Tang, Yanbang Chu, Wei Yang, Dongxia Shi, Luojun Du, Na Li, Guangyu Zhang

“…Despite notable progress, so far the showcased 2D flexible ICs have been constrained to basic logic gates and ring oscillators with a maximum integration scale of a few thin film transistors (TFTs), creating a significant disparity in terms of circuit scale and functionality. Here, we demonstrate medium-scale flexible ICs integrating both combinational and sequential elements based on 2D molybdenum disulfide (MoS2). …”
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Critical Analysis of Cytoplasmic Progression of Inflammatory Signaling Suggests Potential Pharmacologic Targets for Wound Healing and Fibrotic Disorders by Michael L. Samulevich, Liam E. Carman, Brian J. Aneskievich

“…Their balanced function is integral to successful wound healing, given their significant control over the expression of inflammation-, fibrosis-, and matrix remodeling-associated genes. …”
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Alternative introduction of milk formulas based on goat milk: discoveries and prospects by N. A. Geppe, M. D. Velikoretskaya, S. I. Shatalina, M. B. Aksenova, A. A. Venerin, A. V. Polyanskaya, S. N. Chebysheva

“…A number of studies have shown that human milk oligosaccharides effectively stimulate the growth of bifidobacteria and shape the composition of the intestinal microbiota, reducing the risk of infections, as well as modulating immune cell function and providing nutrients for the development of the child. …”
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Identification of CaVβ1 Isoforms Required for Neuromuscular Junction Formation and Maintenance by Amélie Vergnol, Aly Bourguiba, Stephanie Bauché, Massiré Traoré, Maxime Gelin, Christel Gentil, Sonia Pezet, Lucile Saillard, Pierre Meunier, Mégane Lemaitre, Julianne Perronnet, Frederic Tores, Candice Gautier, Zoheir Guesmia, Eric Allemand, Eric Batsché, France Pietri-Rouxel, Sestina Falcone

“…While primarily known for regulating VGCC function, CaVβ proteins also have channel-independent roles, including gene expression modulation. …”
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