ACOUSTIC-ELECTRONIC CHEMICAL SENSORS ON THE BASIS OF MODIFIED NANOTUBES ARRAYS: ADSORPTIVE PROPERTIES OF CNT ARRAYS by A. S. Chashynski, V. V. Barkaline

“…The possibility of their non-covalent functional modification is proved. Chemical sensitivity of such systems and ways of its selectivity rising are discussed.…”
Get full text

New perspectives of renoprotection in patients with Type 2 diabetes mellitus and arterial hypertension by A. S. Ametov, T. Yu. Demidova, S. A. Kosykh

“…Therapeutic effects of a new, super-selective beta blocker with NO-modulating activity, nebivolol (nebilet), on renal functional status in hypertensive patients with Type 2 diabetes mellitus were investigated. …”
Get full text

Non-volatile electric-field control of room-temperature ferromagnetism in Fe3GaTe2 heterostructures by Chuanyang Cai, Yao Wen, Lei Yin, Ruiqing Cheng, Hao Wang, Xiaoqiang Feng, Liang Liu, Chao Jiang, Jun He

“…This phenomenon originates from the competition between interlayer/intralayer magnetic exchange coupling driven by the electric field (density functional theory calculations), supporting non-volatile switching of the magnetization state, which is suitable for high-precision neural network computing. …”
Get full text

The Speaker Identification Model for Air-Ground Communication Based on a Parallel Branch Architecture by Weijun Pan, Shenhao Chen, Yidi Wang, Sheng Chen, Xuan Wang

“…The CET model incorporates three key components: the Chrono Block module, the speaker embedding extraction module, and the optimized loss function module. …”
Get full text

Regulation of HuR by DNA Damage Response Kinases by Hyeon Ho Kim, Kotb Abdelmohsen, Myriam Gorospe

“…The RNA-binding protein HuR robustly influences gene expression following DNA damage. HuR function is controlled in two principal ways: (1) by mobilizing HuR from the nucleus to the cytoplasm, where it modulates the stability and translation of target mRNAs and (2) by altering its association with target mRNAs. …”
Get full text

P66 | FROM INNERVATION TO STEROIDOGENIC DEFECT: IMPLICATIONS OF CGRP IN THE PATHOPHYSIOLOGY OF POLYCYSTIC OVARY SYNDROME

“…Although its pathogenesis remains unclear, recent studies suggest a potential role for neuropeptides in modulating ovarian function2. This study aims to investigate the presence of calcitonin gene related peptide (CGRP), a 37-amino-acid neuropeptide involved in vasodilation, nociceptive signaling, and modulation of the inflammatory response3, within the ovary and follicular fluid of women with PCOS. …”
Get full text

1-methylnicotinamide attenuated inflammation and regulated flora in Necrotizing enterocolitis. by Lian Hou, Junbao Du, Jinxin Li, Qing Luo, Quan Kang

“…In addition, 1-MNA improved intestinal barrier function and modulated intestinal flora in NEC rats.…”
Get full text

YOLOv8-DBW: An Improved YOLOv8-Based Algorithm for Maize Leaf Diseases and Pests Detection by Xiang Gan, Shukun Cao, Jin Wang, Yu Wang, Xu Hou

“…At the same time, the Wise-IoU loss function was combined to optimize the training process, which improved the convergence speed and regression accuracy of the loss function. …”
Get full text

Pharmacological potential of endocannabinoid and endocannabinoid-like compounds in protecting intestinal structure and metabolism under high-fat conditions by Francesco Vari, Francesco Vari, Ilaria Serra, Ilaria Serra, Marzia Friuli, Viviana Cavallo, Nicola Gammaldi, Daniele Vergara, Michel Salzet, Anna M. Giudetti

“…Recent evidence suggests that endocannabinoids and endocannabinoid-like compounds, such as oleoylethanolamide have a protective effect on the function and structure of the intestine. These endocannabinoid pathways modulating compounds can act on receptors in the intestinal epithelium, improving the intestinal barrier and counteracting inflammation, facilitating a more favorable environment for intestinal health. …”
Get full text

Role of EP4 factor in paediatric type 1 diabetes mellitus: a comprehensive review focusing on the honeymoon period by Forough Taheri, Nekoo Panahi, Aida Vahidi, Mojgan Asadi, Mahsa M. Amoli, Naieme Goharifar

“…Recent research has suggested a potential link between a specific allele of the prostaglandin receptor EP4 (PTGER4) and the modulation of remission in individuals with T1DM. This review aims to provide an overview of current scientific findings on the biological functions and role of the EP4 receptor in T1DM, with a particular focus on its involvement in the PCR phase. …”
Get full text

Sparse Attention-Based Residual Joint Network for Aspect-Category-Based Sentiment Analysis by Jooan Kim, Hyunyoung Kil

“…Recent studies on sparse attention transformation functions have demonstrated their effectiveness over the conventional softmax function. …”
Get full text

Mechanism of circRNA_4083 Circularization and Its Role in Regulating Cell Viability by Wenhao Li, Ting Yang, Haojie Wang, Hao Bai, Guobin Chang, Lingling Qiu

“…This study elucidated the biogenesis, functional significance, and regulatory network of circRNA_4083, a novel exon-derived circRNA originating from exons 22 and 23 of the <i>MSH3</i> gene in chicken. …”
Get full text

Miniaturized scalable arrayed CRISPR screening in primary cells enables discovery at the single donor resolution by Miti A. Patel, Brittany P. Boribong, Hugo Sinha, Bin Xiao, Keqiang Xie, Philippe Q. N. Vo, Andrew B. Chin, Ayoub Ellouzi, Samuel R. Little, Steve Shih, Hao Wu, William J. Muller, Alison Hirukawa

“…To showcase its utility in functional genomics, we applied the platform to an arrayed CRISPR-Cas9 screen in chronically stimulated human CD4⁺ T cells, identifying novel regulators of exhaustion, including epigenetic and transcriptional modulators. …”
Get full text

JAGGED controls Arabidopsis petal growth and shape by interacting with a divergent polarity field. by Susanna Sauret-Güeto, Katharina Schiessl, Andrew Bangham, Robert Sablowski, Enrico Coen

“…A flowering plant generates many different organs such as leaves, petals, and stamens, each with a particular function and shape. These types of organ are thought to represent variations on a common underlying developmental program. …”
Get full text

Probiotic supplementation prevents stress-impaired spatial learning and enhances the effects of environmental enrichment by Cassandra M. Flynn, Lara M. Blackburn, Qi Yuan

“…Probiotics can improve cognitive functions, including learning and memory, by modulating the gut microbiota, reducing inflammation, and producing neuroactive substances. …”
Get full text

The STING-activating nanofactory relieves T cell exhaustion in Mn-based tumor immunotherapy by regulating mitochondrial dysfunction by Nana Chen, Yushan Yang, Limin Fan, Yanni Cai, Weimin Yin, Zichen Yang, Yuge Zhao, Shiyu Chen, Hui Zhi, Liangyi Xue, Xiaoyou Zhang, Lulu An, Yongyong Li, Tianbin Ren

“…Mitochondrial dysfunction is a key factor contributing to T cell exhaustion. Modulating mitochondrial function during manganese-based immunotherapy offers a promising strategy to reverse T cell exhaustion. …”
Get full text

Suppression of Spry1 reduces HIF1α-dependent glycolysis and impairs angiogenesis in BRAF-mutant cutaneous melanoma by Barbara Montico, Giorgio Giurato, Roberto Guerrieri, Francesca Colizzi, Annamaria Salvati, Giovanni Nassa, Jessica Lamberti, Domenico Memoli, Patrizia Sabatelli, Marina Comelli, Arianna Bellazzo, Albina Fejza, Lucrezia Camicia, Lorena Baboci, Michele Dal Bo, Alessia Covre, Tuula A. Nyman, Alessandro Weisz, Agostino Steffan, Michele Maio, Luca Sigalotti, Maurizio Mongiat, Eva Andreuzzi, Elisabetta Fratta

“…Accordingly, Ingenuity Pathway Analysis identified “HIF1α Signaling” as the most significant molecular and cellular function affected by Spry1 silencing, whereas the glycolytic function was significantly impaired in Spry1 depleted BRAFV600-mutant CM cells. …”
Get full text

ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways by Jiaxuan Xu, Xiaoqing Dong, Yue Peng, Jie Yan, Peipei Xu, Feiyu Li, Suwen Zhang, Lanxin Chen, Xingjun Meng, Kangning Wang, Mengying Xing, Wenyang Li, David C. S. Huang, Quan Zhao, Bing Chen

“…However, the recognition signature of H3K36me2 and its functional role in MM remain largely unknown. Here, the zinc‐finger MYND‐type‐containing 8 (ZMYND8) is identified as a potential reader of the H3K36me2 mark that suppresses MM progression. …”
Get full text

The impact of citicoline on brain mitochondrial dysfunction induced in rats after head irradiation by Nahed Abdel-Aziz, Fatma Rabia Algeda, Shereen M. Shedid

“…We concluded that citicoline could attenuate the harmful effects of γ-radiation on the brain by modulating mitochondrial function, neurotransmission, and calcium & iron homeostasis, thus suppressing the mitochondrial-mediated apoptosis pathway. …”
Get full text

CREATION OF COLLABORATIVE DEVELOPMENT ENVIRONMENT IN THE SYSTEM OF DISTANCE LEARNING by Julia Malieieva, Viktor Kosenko, Olga Malyeyeva, Dmitrij Svetlichnyj

“…At the same time, the following tasks are solved: a review and comparison of existing systems of distance learning; analysis of the functional and features of the Sphere Engine platform; development of the integration algorithm of the service with the system Moodle. …”
Get full text