Detection method of small size defects on pipeline weld surface based on improved YOLOv7. by Xiangqian Xu, Wenting Hou, Xing Li

“…Finally, the loss function CIoU of YOLOv7 is optimized to EIoU loss function to accelerate the convergence speed of the model. …”
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Genomic engineering in Rhizobium etli: implementation and evaluation of systems based on dCas9 by Oussama Bellahsen, Rafael Díaz-Méndez, David Romero

“…CRISPR-Cas9 is a powerful tool for gene editing and regulation, facilitating the analysis of gene function. In this study, we developed a robust CRISPR interference (CRISPRi) system to precisely modulate gene expression in the bacterium Rhizobium etli, the nitrogen-fixing symbiont of the common bean. …”
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Dual asparagine-depriving nanoparticles against solid tumors by Yubo Shen, Huifang Wang, Daoxia Guo, Jiantao Liu, Jinli Sun, Nan Chen, Haiyun Song, Xiaoyuan Ji

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Pengembangan Permainan Edukasi Berbasis Augmented Reality untuk Pembelajaran Senyawa Hidrokarbon bagi Siswa Sekolah Menengan Atas (SMA) by Carlista Naba, Muhammad Aminul Akbar, Ahmad Afif Supianto

“…This study will be done with Iterative Rapid Prototyping design cycle. The study’s functionality result will be tested with Black Box Testing and tested on students with Game Experience Questionnaire (GEQ) module to asses the student’s experience. …”
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Investigation of the role of GEM in systemic lupus erythematosus through multi-omics joint analysis by Ruofei Chen, Xiao Zhang, Yifang Shang, Huaixuan Zhang, Xiaolei Li, Hanren Dai, Zongwen Shuai

“…However, the precise molecular mechanisms through which GEM modulates fibroblast functions in the context of SLE are yet to be fully elucidated. …”
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Brief transcranial focused ultrasound stimulation causes lasting modifications to the synaptic circuitry of the hippocampus by William W. Watts, Benjamin Clennell, James K. Jiang, Konoha Izaki-Lee, Abhishek Binodh, Robyn Cuthell, Deniz Tonyali, Jon Crompton, Rosie Taaffe, Alanoud Alqahtani, Anna Andrieu, Igino Rafael Besinga, Kate Heesom, Tom G.J. Steward, Kwangwook Cho, Bruce W. Drinkwater, Elek Molnár, Daniel J. Whitcomb

“…However, how so-called ‘offline’ effects impact the dynamic function of neural circuits is largely unknown. Objectives: To determine the persistent effects of ultrasound stimulation on hippocampal circuit function. …”
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Genetically Programmed Single‐Component Protein Hydrogel for Spinal Cord Injury Repair by Yi Wei, Xiaolin Zhou, Zhenhua Li, Qing Liu, Han Ding, Yunlong Zhou, Ruo‐feng Yin, Lifei Zheng

“…Additionally, the hydrogel shows efficacy in alleviating inflammation and promotes neuronal regeneration at the injury site, leading to significant functional recovery in a rat model with compression injury spinal cord cavity. …”
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Regulatory T Cells Boost Efficacy of Post-Infarction Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cell Transplants by Aline Derisio de Lima, Hernán Gonzalez-King Garibotti, Qing-Dong Wang, Cecilia Graneli, Tania Incitti, Valérie Bellamy, Maria Eduarda Anastácio Borges Corrêa, Myriam Assal, Makoto Miyara, Jean-Sébastien Silvestre, Karin Jennbacken, Philippe Menasché

“…Treg therapy with CPC transplantation enhances cardiac functional and structural outcomes in mice. Though it does not directly avert graft rejection, it primarily affects NKG2D+ cytotoxic cells, indicating systemic immune modulation and remote heart repair benefits.…”
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Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents. by Gabriel Bricard, Manjunatha M Venkataswamy, Karl O A Yu, Jin S Im, Rachel M Ndonye, Amy R Howell, Natacha Veerapen, Petr A Illarionov, Gurdyal S Besra, Qian Li, Young-Tae Chang, Steven A Porcelli

“…They are conserved between mice and humans and exert various immunoregulatory functions through their rapid secretion of a variety of cytokines and secondary activation of dendritic cells, B cells and NK cells. …”
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Resveratrol and p53: How are they involved in CRC plasticity and apoptosis? by Aranka Brockmueller, Constanze Buhrmann, Amir Reza Moravejolahkami, Mehdi Shakibaei

“…Background: Colorectal cancer (CRC), which is mainly caused by epigenetic and lifestyle factors, is very often associated with functional plasticity during its development. In addition, the malignant plasticity of CRC cells underscores one of their survival abilities to functionally adapt to specific stresses, including inflammation, that occur during carcinogenesis. …”
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Comparative transcriptome analysis reveals key long noncoding RNAs for cadmium tolerance in Tibetan hull-less barley by Md Rafat Al Foysal, Md Rafat Al Foysal, Cheng-Wei Qiu, Feibo Wu

“…Additionally, 12 lncRNAs forming 18 lncRNA-mRNA pairs were identified as key regulators of Cd tolerance. The functional roles of these lncRNA-mRNA interactions suggest that they modulate proteins such as DJ-1, EDR, PHT, and ABC transporters, which may contribute to the Cd tolerance observed in genotype X178. …”
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Application of Nerve Stimulation: Current Status and Future Directions by Hee Young Kim, Younbyoung Chae

“…Neuromodulation is frequently used to modulate neuronal activity and influence brain function [...]…”
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Protective Effects of Tormentic Acid on Unilateral Ureteral Obstruction-Induced Renal Injury, Inflammation, and Fibrosis: A Comprehensive Approach to Reducing Oxidative Stress, Apo... by Ah Young Yang, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyun Hee Kwon, Jaechan Leem, Eon-Ju Jeon

“…Chronic kidney disease (CKD) progresses through mechanisms involving inflammation, fibrosis, and oxidative stress, leading to the gradual structural and functional deterioration of the kidneys. Tormentic acid (TA), a triterpenoid compound with known anti-inflammatory and antioxidant properties, shows significant potential in counteracting these pathological processes. …”
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The Contribution of Endogenous Modulatory Systems to TMS- and tDCS-Induced Analgesia: Evidence from PET Studies by Marcos F. DosSantos, Aleli T. Oliveira, Natália R. Ferreira, Antônio C. P. Carvalho, Paulo Henrique Rosado de Castro

“…Recent scientific evidence coming from neuroimaging research, particularly functional magnetic resonance (fMRI) and positron emission tomography (PET) studies, indicates that chronic pain is associated with structural and functional changes in several brain structures that integrate antinociceptive pathways and endogenous modulatory systems. …”
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Prognosis of cholangiocarcinoma patients based on multiple patterns of programmed cell death, integrated analysis of the immune microenvironment and drug sensitivity by Yupeng Xu, Yupeng Xu, Jian Sun, Xin Yan, Zhenliao Mao, Yiming Chen

“…Functional analyses indicated enrichment in immune-related processes. …”
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Whole Genome Analysis of <i>Pediococcus acidilactici</i> XJ-24 and Its Role in Preventing <i>Listeria monocytogenes</i> ATCC^® 19115^TM Infection in C57BL/6 Mic... by Weizhong Hu, Shuxin Zhou, Amel Ibrahim, Guannan Li, Sameh Awad, José Ramos-Vivas, Jianquan Kan, Muying Du

“…This study investigates the genomic characteristics and functional potential of <i>Pediococcus acidilactici</i> XJ-24 (XJ-24) in the prevention of <i>Listeria monocytogenes</i> (LM) infection in mice. …”
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Trehalose: Neuroprotective Effects and Mechanisms—An Updated Review by Borislav Sevriev, Simeonka Dimitrova, Gabriela Kehayova, Stela Dragomanova

“…Trehalose’s impact on neuronal cell survival and function was also examined. As a result, we identified that trehalose’s neuroprotection includes autophagy modulation as well as its capability to stabilize proteins and inhibit the formation of misfolded ones. …”
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Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease by Dawei Gong, Xiaojie Gong, Lili Wang, Xinjuan Yu, Quanjiang Dong

“…Species diversity plays an important role in maintaining the stability of the intestinal ecosystem as well as normal ecological function. A reduction in microbial diversity corresponds to a decrease in the stability of the ecosystem and can impair ecological function. …”
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Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies by Jianlin Shen, Yue Lai, Yanjiao Wu, Xuan Lin, Cheng Zhang, Huan Liu

“…Ubiquitination, a multifaceted post-translational modification, regulates protein function, degradation, and gene expression. The pivotal role of ubiquitination in the pathogenesis and progression of cancer, including colorectal, breast, and liver cancer, is well-established. …”
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Gandouling ameliorates Wilson’s disease-associated liver fibrosis in mice with associated faecal microbiome and metabolome remodeling by Lulu Tang, Wei Dong, Danqing Liu, Chenling Zhao, Jie Chen, Yuya Wen, Jingyu Zeng, Ting Dong, Wenming Yang, Wenming Yang

“…Furthermore, a medium dosage of GDL treatment significantly rebalance microbiota composition and function and modulated lipid and lipid-like molecule levels.DiscussionModulating intestinal homeostasis is a promising approach for treating liver fibrosis in patients with WD. …”
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