Identifying nexilin as a central gene in neutrophil-driven abdominal aortic aneurysm pathogenesis by Bohan Yang, Yiyan Xu, Fengfei Yan, Cheng Peng, Ye Song, Song Han, Haiyang Wang

“…Methods We utilized weighted gene co-expression network analysis (WGCNA) and differential gene expression analysis to compare AAA and healthy abdominal aortic tissues. Functional enrichment analysis and a protein–protein interaction (PPI) network were constructed to understand gene functions. …”
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A novel fertility-sparing nanocomposite for endometriosis treatment via oxidative stress and inflammation alleviation by Wenwen Liu, Jie Shen, Jiaqi You, Tao Wang, Pusheng Yang, Yaxin Miao, Xiaotong Peng, Yimin Yu, Chengyu Liu, Ang Li, Jing Sun

“…Current therapeutic strategies primarily focus on lesion removal and pain alleviation, often at the cost of compromising ovarian function and natural conception. Herein, we engineered a nanocomposite with polydopamine and dydrogesterone for precise and gentle endometriosis treatment while protecting ovarian function and fertility. …”
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Role of Redox-Induced Protein Modifications in Spermatozoa in Health and Disease by Chika Onochie, Keturah Evi, Cristian O’Flaherty

“…This review explores the role of redox-induced protein modifications in sperm function, focusing on thiol oxidation, S-nitrosylation, sulfhydration, glutathionylation, CoAlation, and protein carbonylation. …”
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Non-coding RNA-mediated regulation of seed endosperm development by Xinqi Wei, Xinqi Wei, Huanhuan Wang, Kaifeng Zheng, Shengcheng Han, Fanfan Zhang, Fanfan Zhang

“…Despite growing evidence of their roles, functional characterization of ncRNAs in endosperm biology remains limited, with many regulatory mechanisms unresolved. …”
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RS4 Type Resistant Starch Improves Type 2 Diabetes Mellitus in Mice by Interacting With Lactobacillus johnsonii by Tao Xu, Yongheng Zhong, Shengyang Ji, Hang Xiao, Jun Li, Kaimian Li, Peiwu Li, Baiyi Lu

“…ABSTRACT RS4‐type resistant starches have been applied in food industry as thickeners or studied as functional foods for a long time. However, the influence and mechanism of RS4 on Type 2 diabetes mellitus (T2DM) have not been elucidated. …”
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The Pathophysiological Role of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm by Dou Shi, Mo Zhang, Yuhan Zhang, Yang Shi, Xing Liu, Xianxian Wu, Zhiwei Yang

“…In this review, we systematically summarize the current understanding of VSMC biology, including their developmental origins, structural characteristics, and functional roles in aortic wall homeostasis, along with the regulatory networks governing the VSMC phenotype and functional maintenance. …”
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Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy by Francesco Di Matteo, Fabrizia Pipicelli, Christina Kyrousi, Isabella Tovecci, Eduardo Penna, Marianna Crispino, Angela Chambery, Rosita Russo, Ane Cristina Ayo‐Martin, Martina Giordano, Anke Hoffmann, Emilio Ciusani, Laura Canafoglia, Magdalena Götz, Rossella Di Giaimo, Silvia Cappello

“…In embryonic mouse brain, we find that functional CSTB influences progenitors’ proliferation and modulates neuronal distribution by attracting interneurons to the site of secretion via cell‐non‐autonomous mechanisms. …”
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Enhancing Soil Phosphorus Availability in Intercropping Systems: Roles of Plant Growth Regulators by Chunhua Gao, Weilin Kong, Fengtao Zhao, Feiyan Ju, Ping Liu, Zongxin Li, Kaichang Liu, Haijun Zhao

“…Foliar applications were administered at the V7 stage (seventh leaf) of intercropped corn plants to assess how foliar-applied PGRs (T1/T2) modulated the soil phosphorus availability, microbial communities, and functional genes in maize intercropping systems. …”
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Optimisation of Ultrasound-Assisted Extraction Conditions Using Response Surface Methodology and Identification of Thymoquinone from Black Cumin (Nigella sativa L.) Seed Extract§ by Nita Kaushik, Aradhita Barmanray

“…Additionally, Fourier transform infrared (FTIR) spectroscopy confirmed the presence of thymoquinone and several functional groups, including amines, alkanes, acids, esters, alkyls and alkenes. …”
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Synthetic and natural organic photochromic systems for optic application by V. A. Barachevsky

“…It was shown that synthetic photochromic systems are characterized by more wide functional possibilities as compared with the natural systems based on bacteriorhodopsine for application in the optical devices. …”
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Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system: current status and future perspective by Song-Po Liu, Yun-Fei Li, Dan Zhang, Chun-Yang Li, Xiao-Fang Dai, Dong-Feng Lan, Ji Cai, He Zhou, Tao Song, Yan-Yu Zhao, Zhi-Xu He, Jun Tan, Ji-Dong Zhang

“…Modern pharmacological research and clinical practice have proved that Epimedium and its active components have a wide range of pharmacological effects, especially in improving sexual function, hormone regulation, anti-osteoporosis, immune function regulation, anti-oxidation, and anti-tumor activity. …”
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Genetic and biochemical characterizations of Zika virus NS2A protein by Xianwen Zhang, Xuping Xie, Jing Zou, Hongjie Xia, Chao Shan, Xinwen Chen, Pei-Yong Shi

“…Functional analysis has defined distinct NS2A residues essential for viral RNA synthesis or virion assembly. …”
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Targeting gut microbiota as a therapeutic approach for neurodegenerative diseases by Tobiloba S. Olajide, Omamuyovwi M. Ijomone

“…Recent advancements, including germ‐free animal models, fecal microbiota transplantation (FMT), and diverse probiotic strains, have revealed the underlying mechanisms linking gut health to brain function. Notably, several Lactobacillus and Bifidobacterium species have been shown to exert neuroprotective effects via the upregulation of neurotrophic factors such as brain‐derived neurotrophic factor and enhancing mitochondrial function through reducing the impacts of oxidative stress. …”
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The INT6 cancer gene and MEK signaling pathways converge during zebrafish development. by Michal Grzmil, Danny Whiting, John Maule, Corina Anastasaki, James F Amatruda, Robert N Kelsh, Chris J Norbury, E Elizabeth Patton

“…INT6 expression is altered in human cancers, but the precise role of disrupted INT6 in tumorigenesis remains unclear, and an animal model to study Int-6 physiological function has been lacking.<h4>Principal findings</h4>Here, we create an in vivo model of Int6 function in zebrafish, and through genetic and chemical-genetic approaches implicate Int6 as a tissue-specific modulator of MEK-ERK signaling. …”
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Prediction of Spontaneous Protein Deamidation from Sequence-Derived Secondary Structure and Intrinsic Disorder. by J Ramiro Lorenzo, Leonardo G Alonso, Ignacio E Sánchez

“…Asparagine residues in proteins undergo spontaneous deamidation, a post-translational modification that may act as a molecular clock for the regulation of protein function and turnover. Asparagine deamidation is modulated by protein local sequence, secondary structure and hydrogen bonding. …”
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Advancements in the investigation of gut microbiota-based strategies for stroke prevention and treatment by Min Wang, Yan Liu, Li Zhong, Fang Wu, Jinjin Wang

“…The MGBA plays a crucial role in modulating immune function, neurotransmitter levels, and metabolic byproducts, which may intensify neuroinflammation and impair cerebral health. …”
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Bone Marrow Niche Aging: Are Adipocytes Detrimental Cells in the Bone Marrow? by Urban Švajger, Patrik Milić, Primož J. Rožman

“…By summarizing current insights into the aging BM niche and the central role of BMAds, this review highlights mechanisms that could be targeted to rejuvenate hematopoiesis and improve immune function in the elderly.…”
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Modeling the Frequency–Amplitude Characteristics of a Tunable SAW Oscillator by Ionut Nicolae, Cristian Viespe

“…The resonant frequency of an SAW oscillator can be modulated by varying the signal amplitude, due to non-linear acoustic interactions within the chemoselective layer. …”
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Epigenetic mechanisms in stem cell therapies for achilles tendinopathy by Zheyang Yuan, Zheyu Yao, Xufeng Mao, Xiang Gao, Sengyi Wu, Haijiao Mao

“…The influence of epigenetic modifications on stem cell proliferation, differentiation, and immune regulatory function in the treatment of AT was also explored. …”
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Pelota: A double-edged sword in virus infection. by Xue Li, Xueping Zhou, Fangfang Li

“…Beyond its canonical role in maintaining translational fidelity via No-Go Decay and Non-Stop Decay pathways, Pelota exhibits a dual function during viral infection-serving either as a restriction factor or as a susceptibility element depending on the virus species and their hosts. …”
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