PrPC Glycoprotein Is Indispensable for Maintenance of Skeletal Muscle Homeostasis During Aging by Wenduo Liu, Thi Thu Trang Kieu, Zilin Wang, Hyun‐Jaung Sim, Seohyeong Lee, Jeong‐Chae Lee, Yoonjung Park, Sang Hyun Kim, Sung‐Ho Kook

“…Conclusions Our findings demonstrate that PrPC is indispensable for maintaining skeletal muscle homeostasis during ageing by modulating the functional integrity of mitochondria, ER and SCs.…”
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Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases by Suryakant Niture, Minghui Lin, Qi Qi, John T. Moore, Keith E. Levine, Reshan A. Fernando, Deepak Kumar

“…Cd is also involved in the development and progression of fatty liver diseases and hepatocellular carcinoma. Cd affects liver function via modulation of cell survival/proliferation, differentiation, and apoptosis. …”
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A Digital Mental Health Solution to Improve Social, Emotional, and Learning Skills for Youth: Protocol for an Efficacy and Usability Study by Kayla V Taylor, Laurent Garchitorena, Carolina Scaramutti-Gladfelter, Mykayla Wyrick, Katherine B Grill, Azizi A Seixas

“…Following this, in phase 2, school administrators and teachers undergo intensive training sessions on Neolth’s functionalities and intervention processes as well as understand barriers and facilitators of implementing a digital mental health program at their respective schools. …”
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Les quais nos 1, 12 et 13 du port romain de Saint-Lupien à Rezé/Ratiatum (Loire-Atlantique) by Xavier Favreau, Nicolas Ménez

“…This tiering of monumental port terraces, which developed, operated and was modified, only functioned for about a century. Initiated in the first half of the 3rd c. …”
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Bioinformatics analysis identifies BST1 as a potential therapeutic target linked to neutrophil extracellular traps in patients with acute liver failure by Mengyu Tao, Jiwei Fu, Xiaoping Wu

“…Twenty-seven expression modules were obtained by WGCNA, among which the ME pink and ME cyan module had the highest correlation with ACLF. …”
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Cognitive Training Mobile Apps for Older Adults With Cognitive Impairment: App Store Search and Quality Evaluation by Leyi Wu, Jiajuan Pan, Chuwen Dou, An Gu, An Huang, Hong Tao, Xiaoyan Wang, Chen Zhang, Lina Wang

“…Global quality scores based on the MARS dimensions ranged from 2.38 to 4.13, with a mean (SD) of 3.57 (0.43) across 24 apps, indicating generally acceptable quality. The functionality dimension received the highest score, while engagement scored the lowest. …”
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THE PLACE OF PROFESSIONAL EDUCATION SYSTEM IN FORMATION OF GRADUATES’ COMPETITIVENESS by G. F. Shafranov-Kutsev, G. Z. Efimova

“…Consequently, there is the demand for the development of individual educational  programmes and modules, freedom of access for students to new resources and technologies, change of functions and competencies of pedagogical workers.The conclusion is drawn that the assessment of own competitiveness acts as the defining factor of the relation to the chosen field of occupation. …”
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ANALYSIS OF THE PROFESSIONAL COMPETENCES OF POSTAL OPERATORS by Kaitanovska Olha

“…A comparative analysis of the content of the modules according to the qualifications of each class was carried out. …”
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Digital Mental Health Interventions for the Prevention and Treatment of Social Anxiety Disorder in Children, Adolescents, and Young Adults: Systematic Review and Meta-Analysis of R... by Noemi Walder, Alessja Frey, Thomas Berger, Stefanie Julia Schmidt

“… BackgroundSocial anxiety disorder (SAD) substantially affects young individuals’ social and academic functioning, emphasizing the need for accessible and effective treatments such as digital mental health interventions (DMHIs). …”
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Postbiotic <i>Lactiplantibacillus plantarum</i> CECT 9161 Influences the Canine Oral Metagenome and Reduces Plaque Biofilm Formation by Adrián Florit-Ruiz, Laura Rago, Antonia Rojas, Bellahanum Guzelkhanova, Adrià Pont-Beltran, Araceli Lamelas, María Carmen Solaz-Fuster, Juan F. Martinez-Blanch, María Enrique López, Guillermo García-Lainez, Bob T. Rosier, Richard Day, Teresa Rubio, Rhiannon Batchelor, Sophie L. Nixon

“…Periodontal diseases are highly prevalent in dogs and intricately interconnected with the composition and functional attributes of the oral microbiota. The demand for non-invasive interventions to support oral health presents an opportunity for functional ingredients. …”
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Krüppel-like factor 5 remodels lipid metabolism in exercised skeletal muscle by Konstantin Schneider-Heieck, Joaquín Pérez-Schindler, Jonas Blatter, Laura M. de Smalen, Wandrille Duchemin, Stefan A. Steurer, Bettina Karrer-Cardel, Danilo Ritz, Christoph Handschin

“…Surprisingly, gain- and loss-of-function studies in muscle in vivo revealed seemingly opposite functions of Klf5 in the response to an acute exercise bout and chronic training, modulating lipid oxidation and synthesis, respectively. …”
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Efficacy and safety of stem cells in the treatment of glaucoma: systematic review and meta-analysis based on animal experiments by Danning Wu, Yanjing Liu, Xia Zhang, Ruixuan Zhang, Shaopeng Wang, Hui Lu, Tao Yue

“…Accordingly, this systematic review and meta-analysis evaluated the therapeutic efficacy and safety of stem cell transplantation in experimental glaucoma models, with a focus on functional outcomes (IOP modulation), structural preservation (RGC survival, and nerve fiber layer integrity), and neuroprotective efficacy.MethodsA systematic literature retrieval from multiple online databases (e.g., PubMed, Web of Science, Embase, Cochrane Library, Scopus, CNKI, WFSD, VIP, and CBM) was conducted through 3 January 2025, to identify relevant animal experimental studies. …”
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Integrating network pharmacology and experimental validation to reveal the anti-growth mechanism of panaxadiol against glioblastoma via calcium signaling by Guobin Qiu, Zhiyong Wu, Dunhui Yang, Luqiu Zhou

“…Furthermore, we conducted experiments in vitro and in vivo experiments, which encompassed CCK-8, colony formation, flow cytometry apoptosis, intracellular calcium ion measurement, and xenograft tumor experiments utilizing nude mice, to validate the function of Panaxadiol in suppressing the growth of GBM via the modulation of calcium ion levels. …”
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Molecular insights into the rescue mechanism of an HERG activator against severe LQT2 mutations by Amit Kumawat, Elisa Tavazzani, Giovanni Lentini, Alessandro Trancuccio, Deni Kukavica, Amanda Oldani, Marco Denegri, Silvia G. Priori, Carlo Camilloni

“…Conclusions Our results support the development of HERG activators like ICA-105574 as promising pharmacological molecules against some severe LQT2 mutations and suggest that molecular dynamics simulations can be used to test the ability of molecules to modulate HERG function in silico, paving the way for the rational design of new HERG activators.…”
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Effects of Home-Based Rehabilitation for Patients With Advanced Lung Cancer Undergoing Platinum-Based Chemotherapy: A Randomized Controlled Trial by Mi Jin Hong, Yung Jin Lee, Jong Bum Park, Sin Yung Woo, Seungcheol Lee, Hokwan Ko, Ji Woong Son

“…Outcome evaluations included the 6-minute walk test, spirometry to measure lung function (specifically assessing forced expiratory volume in 1 second [FEV1] and forced vital capacity, hand grip strength, and QOL assessments using the Short Form 36-Item Health Survey and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Lung Cancer Module 29. …”
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Immunomodulation by extracorporeal ozone-based bactericide system in porcine Pseudomonas aeruginosa septic shock by Henrik Rundgren, Johan Sjöholm, Sanja Juric, Pellina Janson, Joline Kolerud, Robert Wallin, Paul Skorup, Miklos Lipcsey, Mattias Günther

“…Extracorporeal ozone blood treatment modulated the immune response in P. aeruginosa septic shock, which decreased mostly proinflammatory cytokines and was associated with indications of decreased vascular permeability and improved lung function and warrants further investigation for potential use in clinical settings.…”
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Lysophosphatidylethanolamine improves diastolic dysfunction by alleviating mitochondrial injury in the aging heart by Guiwen Xu, Wei Xiao, Pengqi Sun, Yuanjun Sun, Xinyu Yang, Xiaomeng Yin, Yang Liu

“…Echocardiography was used to assess cardiac diastolic function in adult and aging mice treated with lysophosphatidylethanolamine (LPE) or saline. …”
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Mechanisms of beneficial effects of DPP-4 inhibitors as a promising perspective for the prevention/treatment of the disruption of cardio-cerebrovascular homeostasis by Katarina Tomović Pavlović, Marko Anderluh, Andrija Šmelcerović

“…These include improvements in endothelial function, reduction of oxidative stress and inflammatory responses, modulation of lipid and glucose metabolism, and regulation of blood pressure. …”
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Benign regulation of short-chain fatty acids: the underlying mechanism of the beneficial effects of manual acupuncture on cognitive ability and the intestinal mucosal barrier in AP... by Ning Ding, Xin Hao, Yue Zhang, Yanxiang Zhang, Zhigang Li

“…SCFAs/FFAR3/NF-κB may be important targets through which MA benignly regulates intestinal mucosal barrier function.…”
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Attention Mechanism and Weighted Trend Loss for Wind Speed Correction by Liu Xu, Yang Hao, Liang Xiaoyun, Chen Jing, Li Qiaoping, Li Ruqing, Chen Min

“…A new weighted trend-based mean squared error loss function is developed to optimize the correction process. …”
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