Lipid droplet accumulation in microglia and their potential roles by Yunxia Li, Qi Zhao, Yan Wang, Wenyi Du, Riyun Yang, Jian Wu, Yi Li

“…This review aims to investigate the processes involved in LD formation and degradation, the factors that modulate them, focusing particularly on the function of LDAM and their implications for CNS disorders. …”
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Deep nested U-structure network with frequency attention for building semantic segmentation by Khaled Moghalles, Zaid Al-Huda, Dalal AL-Alimi, Yeong Hyeon Gu, Mugahed A. Al-antari

“…We have introduced a novel approach to address these issues: an end-to-end residual U-structure embedded within a U-Net, enhanced by a frequency attention module and a hybrid loss function. The novel residual U-structure is introduced to replace the encode-decode blocks of traditional U-Nets, and the hybrid loss function is utilized to guide segmentation for more complete and accurate segmentation masks. …”
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Assessment of Two Online Interventions for Veterans With Chronic Pain: Protocol for a Randomized Controlled Efficacy Trial by Erin D Reilly, Hannah L Grigorian, Alicia A Heapy, Bella Etingen, Megan M Kelly, Noah R Wolkowicz, Caitlin M Girouard, Timothy P Hogan, Katarina Bernice, Timothy Bickmore

“…Both interventions will include 7 modules delivered over 7 weeks, with each module lasting approximately 15 minutes. …”
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HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition by Guochun Liu, Binyi Zhao, Qinglong Chen, Xiang Li, Xuejiao Zhu, Maowei Duan, Mengdie Zhang, Zhuohan Liu, Xuan Wen, Jia Guo, Man Zheng, Ruiyu Wang, Minghao Luo

“…This study compared the therapeutic effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on vascular endothelial function in early-stage AS mice, specifically investigating PCSK9 modulation and the TRX/TXNIP/NLRP3/GSDMD-N pathway. …”
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Schwann Cells and Their Exosomes: Research Progress and Prospect in Spinal Cord Injury by Xin Wang, Wei Yan, Lin Zhu, Lingzhi Wei, Haobo Cao, Fanni Yang, Yibao Zhang

“…Schwann cells (SCs) transplantation for SCI has been well demonstrated in preclinical studies, showing that it can achieve therapeutic goals by improving autonomic function, reducing neuropathic pain, and enhancing limb function through mechanisms such as alleviating inflammation, modulating immunity, and reducing dense scar formation. …”
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Metabolomics and Microbiomics Perspectives Reveal the Regulatory Pathways of Monaphilone B Derived From Red Yeast Rice on Alcoholic Liver Injury in Mice by Li Wu, Zihua Liang, Ziyi Yang, Hao Wang, Li Ni, Weiling Guo, Xucong Lv

“…The results showed that MB effectively ameliorated alcohol‐induced liver lipid metabolism (decreasing serum total cholesterol [TC], triglyceride [TG], low‐density lipoprotein cholesterol [LDL‐C], and increasing high‐density lipoprotein cholesterol [HDL‐C]), oxidative stress (decreasing hepatic maleic dialdehyde [MDA] level, increasing catalase [CAT], superoxide dismutase [SOD], alcohol dehydrogenase [ADH] and glutathione [GSH] hepatic activities), and inflammatory response (decreasing hepatic lipopolysaccharide [LPS], tumor necrosis factor‐α [TNF‐α], Interferon‐γ [IFN‐γ] and interleukin 6 [IL‐6]), repaired liver function (reducing serum alanine aminotransferase [ALT], aspartate aminotransferase [AST], and liver lactate dehydrogenase [LDH] activity). 16S amplicon sequencing showed that MB administration effectively modulated intestinal flora and its metabolism, which were highly correlated with the improvement of liver function and intestinal barrier function. …”
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IL-33/ST2 signalling promotes tumor growth by regulating polarization of alternatively activated macrophages by Liping Liu, Haoge Luo, Yingdong Xie, Ying Wang, Shiying Ren, Haiyang Sun, Dong Li

“…Objective: Suppression of tumorigenicity 2 (ST2), the receptor for interleukin (IL)-33, has a critical role in tumor growth, angiogenesis, metastasis, and immune modulation. The IL-33/ST2 pathway is known to influence the polarization and function of macrophages, which is integral to modulating the tumor microenvironment. …”
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Generative adversarial networks with texture recovery and physical constraints for remote sensing image dehazing by Yanfei Jia, Wenshuo Yu, Liquan Zhao

“…Introducing a physical constraint loss function to improve the loss function of the original generative adversarial network allows for better preservation of the physical characteristics of remote sensing images. …”
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The correlation between MTHFD2 and the tumor microenvironment in head and neck squamous cell carcinoma by SHI Zhenxiang, WU Sa, CAI Weisong, MING Xiaoping, CHEN Xiong

“…Log-rank test was used to compare the overall survival (OS) of patients with high and low expression of MTHFD2, and the KEGG and GO signaling pathway function enrichment of MTHFD2 and related gene functions was performed. …”
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New roles for autophagy and spermidine in T cells by D. J. Puleston, A. K. Simon

“…These results suggest the autophagy pathway as a desirable target to improve aged immunity and modulate T cell function.…”
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Metabolic pathway activation and immune microenvironment features in non-small cell lung cancer: insights from single-cell transcriptomics by Yanru Liu, Yanru Liu, Yanru Liu, Hanmin Liu, Hanmin Liu, Ying Xiong, Ying Xiong

“…Wet lab experiments validated the role of KRT6B in NSCLC, demonstrating that KRT6B expression is elevated and it stimulates the proliferation of cancer cells.DiscussionThese observations not only enhance our understanding of metabolic reprogramming and its biological functions in NSCLC but also provide new perspectives for early detection, prognostic evaluation, and targeted therapy. …”
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The MinDag app for symptom monitoring and feedback to patients and clinicians during the initial treatment of bipolar disorder – a feasibility study by Margrethe Collier Høegh, Stine Holmstul Glastad, Siv Hege Lyngstad, Magnus Johan Engen, Sofie Ragnhild Aminoff, Ingrid Melle, Thomas Bjella, Trine Vik Lagerberg

“…Methods The MinDag app includes six content modules covering mood, sleep, functioning/activities, substance use, emotional reactivity, and psychotic symptoms. …”
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DESIGNING A SUSTAINABLE SOCIAL PROTECTION SYSTEM IN UKRAINE: A COMPREHENSIVE EVALUATION by Анжела Ігнатюк, Мартіна Раштіцова, Наталія Приказюк, Антоніна Шолойко, Наталія Ткаленко, Наталія Версаль

“…This tool consists of four modules: policy, program design, program implementation, and system assessment guidelines. …”
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Multifunctional PN optoelectronic synapse and its smart integration towards augmented artificial visual system by Qinghong Lin, Yangbin Zhu, Xin Hu, Jiayu Sun, Zhen Wang, Kejia You, Xuan Guo, Yue Wang, Deli Li, Liangxu Lin, Yi Zhao, Guangyu Wang, Yang Liu, Fushan Li, Wei Huang

“…Abstract Mimicking and extending biological sensory memory processing functions and systems—that play significant roles in enhancing interconnections of the human-physical world—are highly preferable for the Internet of Things. …”
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Edaravone dexborneol provides neuroprotective benefits by suppressing ferroptosis in experimental intracerebral hemorrhage by Han Li, Xiang Li, Mingzhi Li, Wenxin Li, Jinghui Wei, Yuming Huang, Haiqing Yan, Juntang Lin, Ping Zhang

“…However, it remains unclear whether EDB can ameliorate ICH through the modulation of ferroptosis. This study aimed to evaluate the function and mechanism of EDB in treatment of ICH. …”
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Targeting cellular senescence in kidney diseases and aging: A focus on mesenchymal stem cells and their paracrine factors by Seyyedeh Mina Hejazian, Seyyed Sina Hejazian, Seyyedeh Mina Mostafavi, Seyed Mahdi Hosseiniyan, Soheila Montazersaheb, Mohammadreza Ardalan, Sepideh Zununi Vahed, Abolfazl Barzegari

“…The MSC-derived secretome compromises significant therapeutic benefits in kidney diseases by facilitating tissue repair via anti-inflammatory, anti-fibrosis, anti-apoptotic, and pro-angiogenesis effects, thereby improving kidney function and mitigating disease progression. Moreover, by promoting the clearance of senescent cells or modulating their secretory profiles, MSCs could potentially reverse some age-related declines in kidney function. …”
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Research on Parallel Task Scheduling Algorithm of SaaS Platform Based on Dynamic Adaptive Particle Swarm Optimization in Cloud Service Environment by Jian Zhu, Qian Li, Shi Ying, Zhihua Zheng

“…After the service management module provides diversified application service support according to the scheduling requirements, the core service module determines the SaaS platform parallel scheduling objective function, and uses dynamic adaptive particle swarm optimization to solve the objective function to obtain the SaaS platform parallel task scheduling results. …”
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The Role and Mechanism of Deubiquitinase USP7 in Tumor-Associated Inflammation by Luhong Wang, Yong Zhang, Tao Yu, Huijian Wu

“…Deubiquitinating enzymes are a class of proteases that remove ubiquitin tags from proteins, thereby controlling protein stability and function. Tumor inflammation arises from interactions between tumor cells and their microenvironment, which trigger an inflammatory response. …”
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Enhancing catalytic durability in alkaline oxygen evolution reaction through squaric acid anion intercalation by Ruoyao Fan, Shanshan Lu, Fuli Wang, Yusheng Zhang, Mirabbos Hojamberdiev, Yongming Chai, Bin Dong, Bin Zhang

“…Abstract The corrosive acidic interfacial microenvironment caused by rapid multi-step deprotonation of alkaline oxygen evolution reaction in industrial high current water electrolysis is one of the key problems limiting its stability. Some functional anions derived from electrocatalysis exhibit special functionalities in modulating the interface microenvironment, but this matter has not received adequate attention in academic discussions. …”
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Unveiling the Polypharmacological Potency of FDA-Approved Rebamipide for Alzheimer’s Disease by Israa J. Hakeem, Hadil Alahdal, Hanadi M. Baeissa, Tahani Bakhsh, Misbahuddin Rafeeq, Alaa Hamed Habib, Mohammed Matoog Karami, Maryam A. AL-Ghamdi, Ghadeer Abdullah, Abeer Al Tuwaijri

“…Pharmacokinetic predictions, interaction fingerprinting, WaterMap analysis, density functional theory (DFT) calculations, and 100 ns MD simulations were performed for each protein–ligand complex to evaluate its multitarget potential. …”
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