Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. by Pingzhao Hu, Sarath Chandra Janga, Mohan Babu, J Javier Díaz-Mejía, Gareth Butland, Wenhong Yang, Oxana Pogoutse, Xinghua Guo, Sadhna Phanse, Peter Wong, Shamanta Chandran, Constantine Christopoulos, Anaies Nazarians-Armavil, Negin Karimi Nasseri, Gabriel Musso, Mehrab Ali, Nazila Nazemof, Veronika Eroukova, Ashkan Golshani, Alberto Paccanaro, Jack F Greenblatt, Gabriel Moreno-Hagelsieb, Andrew Emili

“…To elucidate the orphans' biological roles, we performed an extensive proteomic survey using affinity-tagged E. coli strains and generated comprehensive genomic context inferences to derive a high-confidence compendium for virtually the entire proteome consisting of 5,993 putative physical interactions and 74,776 putative functional associations, most of which are novel. Clustering of the respective probabilistic networks revealed putative orphan membership in discrete multiprotein complexes and functional modules together with annotated gene products, whereas a machine-learning strategy based on network integration implicated the orphans in specific biological processes. …”
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THE RESULTS OF THE STUDY OF INTENTIONAL ELECTROMAGNETIC INTERFERENCE ON DISRUPTION OF THE FUNCTIONING OF UNMANNED VECHICLES by Aleksandr N. Shemonaev, Konstantin A. Epifantsev, Leonid N. Kessarinskiy, Mikhail Y. Ponchakov

“…In the course of the study, sources of radio frequency interference were developed for experimental observation of reversible and irreversible failures in the functioning of individual electronic components and entire units of an unmanned vehicle. …”
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Proteomic characterization and bioinformatic insights into MUC18 function in gastric cancer by Sung-Jin Kim, Su-Min Lee, Yun-Jeong Seo, Jae-Young Kim

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Methodology for ensuring the functional stability of aircraft integrated modular avionics complex by Г. А. Калашник, М. А. Калашник-Рибалко

“… The article presents the methodology of ensuring the functional stability of aircraft avionics complexes under the influence of failure and destabilizing factors. …”
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Bioinformatics prediction of function of T-cell exhaustion related genes in ischemic stroke by Yajun Gao, Ruyu Bai, Bo Gao, Ma Li

“…By weighted gene co-expression network analysis (WGCNA) and machine learning algorithms, we identified five key genes: CD163, LAMP2, PICALM, RGS2 and PIN1. Functional enrichment analysis revealed that these genes were involved in immune response and cellular processes, which were closely related to the level of immune cell infiltration. …”
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A functional portrait of Med7 and the mediator complex in Candida albicans. by Faiza Tebbji, Yaolin Chen, Julien Richard Albert, Kearney T W Gunsalus, Carol A Kumamoto, André Nantel, Adnane Sellam, Malcolm Whiteway

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Mercapto-functionalized scaffold improves perovskite buried interfaces for tandem photovoltaics by Jianan Wang, Shuaifeng Hu, He Zhu, Sanwan Liu, Zhongyong Zhang, Rui Chen, Junke Wang, Chenyang Shi, Jiaqi Zhang, Wentao Liu, Xia Lei, Bin Liu, Yongyan Pan, Fumeng Ren, Hasan Raza, Qisen Zhou, Sibo Li, Longbin Qiu, Guanhaojie Zheng, Xiaojun Qin, Zhiguo Zhao, Shuang Yang, Neng Li, Jingbai Li, Atsushi Wakamiya, Zonghao Liu, Henry J. Snaith, Wei Chen

“…Here, we devise a mercapto-functionalized mesoporous silica layer as a superstructure at the buried interface to modulate the crystallisation, eliminate nanovoids, passivate defects, and suppress the oxidation of Sn(II) in the tin–lead perovskite films, contributing substantially to reduce charge carrier losses and improve stability in positive-intrinsic-negative structured devices. …”
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The functional extracellular vesicles target tumor microenvironment for gastrointestinal malignancies therapy by Dongqi Li, Xiangyu Chu, Yudong Ning, Yinmo Yang, Chen Wang, Xiaodong Tian, Yanlian Yang

“…This review explores the latest strategies for the production and functionalization of EVs, along with advances in utilizing EVs for targeted therapy of the TME in GI tumor treatment.…”
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Binary program taint analysis optimization method based on function summary by Pan YANG, Fei KANG, Hui SHU, Yuyao HUANG, Xiaoshao LYU

“…Taint analysis is a popular software analysis method, which has been widely used in the field of information security.Most of the existing binary program dynamic taint analysis frameworks use instruction-level instrumentation analysis methods, which usually generate huge performance overhead and reduce the program execution efficiency by several times or even dozens of times.This limits taint analysis technology’s wide usage in complex malicious samples and commercial software analysis.An optimization method of taint analysis based on function summary was proposed, to improve the efficiency of taint analysis, reduce the performance loss caused by instruction-level instrumentation analysis, and make taint analysis to be more widely used in software analysis.The taint analysis method based on function summary used function taint propagation rules instead of instruction taint propagation rules to reduce the number of data stream propagation analysis and effectively improve the efficiency of taint analysis.For function summary, the definition of function summary was proposed.And the summary generation algorithms of different function structures were studied.Inside the function, a path-sensitive analysis method was designed for acyclic structures.For cyclic structures, a finite iteration method was designed.Moreover, the two analysis methods were combined to solve the function summary generation of mixed structure functions.Based on this research, a general taint analysis framework called FSTaint was designed and implemented, consisting of a function summary generation module, a data flow recording module, and a taint analysis module.The efficiency of FSTaint was evaluated in the analysis of real APT malicious samples, where the taint analysis efficiency of FSTaint was found to be 7.75 times that of libdft, and the analysis efficiency was higher.In terms of accuracy, FSTaint has more accurate and complete propagation rules than libdft.…”
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DSS1 is required for proper Integrator–PP2A function by Congling Xu, Qian-Xing Zhou, Hai Zheng, Aixia Song, Wen-Ying Zhao, Ting-Ting Xu, Yan Xiong, Yi-Jie Zhang, Zixuan Huang, Yanhui Xu, Jingdong Cheng, Fei Xavier Chen

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The Adverse Effects of Thyrotropin Absence on Pancreatic β Cell Function in Mice by Yu Yang, Yu Chen, Jie Chen, Danyu Zhang, Jianhua Wang, Xiaodong Mao, Xiao Wei, Xingjia Li, Xianghua Ma, Chao Liu, Kun Wang

“…Thyrotropin (TSH) is a modulator of glucose metabolism by binding to its receptor on pancreatic cells. …”
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Low-threshold dual-polarization electro-optic nonlinear activation functions by Tao Jin, Jian Lin, Pengjun Wang, Qiang Fu, Yuhan Sun, Yi Zou, Shixun Dai, Weiwei Chen, Jun Li, Tingge Dai, Jianyi Yang

“…When a fixed proportion of the input optical signal is transformed into the electrical signal and the remaining input optical signal is modulated by using the thermo-optic effect, the rectified linear unit activation function with a low-threshold power of 0.2 mW for transverse-electric polarization and the Gaussian activation function with a low-threshold power of 0.1 mW for transverse-magnetic polarization can be measured separately. …”
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Expanding the Functions of KHSRP Protein: Insights into DNA G‐Quadruplex Binding by Pasquale Russomanno, Pasquale Zizza, Linda Cerofolini, Federica D'Aria, Sara Iachettini, Serena Di Vito, Annamaria Biroccio, Jussara Amato, Marco Fragai, Bruno Pagano

“…G‐quadruplexes (G4s) are noncanonical nucleic acid structures involved in essential cellular activities, including gene expression, and are recognized as potential therapeutic targets in cancer. The biological functions of G4s are mediated by proteins making their formation highly dynamic within cells. …”
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Regulation of CXCR4 function by S1P1 through heteromerization by Hyun-Tae Kim, Jae-Yeon Jeong, Won-Ki Huh

“…Conclusions This study identifies CXCR4-S1P1 heteromers and demonstrates a unidirectional modulation of CXCR4 by S1P1. S1P1 affects CXCR4 function by disrupting its G protein pre-association and oligomerization. …”
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METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic value by Xinyu Zhang, Yuan Chen, Min Li, Min Li, Xiaomeng Zhou, Qingcui Song, Qingcui Song

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New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain by Jordan D. Gregory, Tenzin Kunkhyen, Sean C. Sweat, Jane S. Huang, Taryn R. Brechbill, Claire E. J. Cheetham

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Phototherapy and optogenetic stimulation improve cognitive function in sleep-deprived mice by Na Li, Xuechun Li, Zhongdi Jiang, Xiafei Shi, Huancheng Wu, Yi Liu, Huijuan Yin, Hongli Chen

“…In this study, we used phototherapy combined with optogenetic technology to investigate the effect of noninvasive phototherapy on cognitive functions in sleep-deprived mice. Our results suggest that phototherapy might improve cognitive functions in sleep-deprived mice by modulating the hippocampus. …”
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Bridging regional neurovascular unit heterogeneity and cognitive function: a review by Amalia Tsintzou, Roseline Poirier, Rania Harati, Almira Kustubayeva, Clemence Disdier, Rifat Hamoudi, Aloïse Mabondzo

“…The structural and functional differences of the endothelial cells, glial cells, and neurons of different brain structures are pinpointed. …”
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On Fixed Point Results in Neutrosophic Metric Spaces Using Auxiliary Functions by Anwar Bataihah, Ayman. A Hazaymeh

“…These contractions generalize classical contractive conditions by incorporating a function L that bounds the interaction between displacement terms and a control function φ that modulates the contraction intensity. …”
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Laminin-derived peptide drives the cardiomyogenic potential and cardiac cells functionality by Simona Casarella, Federica Ferla, Dalila Di Francesco, Dalila Di Francesco, Veronica Pagani, Carolina Di Varsavia, Irene Regano, Francesca Boccafoschi

“…The role of a small bioactive peptide (KKGSYNNIVVHV) derived from laminin in cardiac differentiation and functionality has been demonstrated. Briefly, results showed how the presence of laminin-derived peptide enhanced the differentiation of mesenchymal stem cells into cardiomyocytes-like phenotype, by modulating not only the cytoskeletal apparatus but also enhancing the cardiac and adhesion markers. …”
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