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6541
Bioactive compounds in fermented foods: a systematic narrative review
Published 2025-07-01“…The reported effects were grouped under the following categories: cardiovascular health, lipid metabolism, glucose regulation, immune modulation, neuroprotection, liver function, and other health outcomes. …”
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6542
Prosopagnosia and the role of face-sensitive areas in race perception
Published 2025-02-01“…These results refine our understanding of the functional roles of these key cortical regions and offer novel insights into the neural mechanisms underlying the perception of face race and prosopagnosia.…”
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6543
Integrated pan-cancer analysis and experimental verification of the roles of ZBED3 in kidney renal clear cell carcinoma
Published 2024-11-01“…Abstract The present study investigated the Zinc finger BED-type containing 3 (ZBED3) mRNA expression levels, diagnostic and prognostic values, co-expressed and differentially expressed genes, immune infiltration, and functional enrichment analysis in patients with kidney renal clear cell carcinoma (KIRC) using various public databases such as The Cancer Genome Atlas, Genotype-Tissue Expression Project, LinkedOmics, Gene Set Enrichment Analysis databases, and the Xiantao academic tool. …”
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6544
Fine‐Tuning Porous Structure of Zirconium‐Based Metal–Organic Frameworks for Efficient Separation and Purification of Astaxanthin by Defect Engineering
Published 2024-12-01“…This work broadens the preparation methods for thermosensitive active substances and provided new research ideas for the controlled adsorption of functional food factors.…”
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6545
Neuromodulation: clinical advances and future perspectives
Published 2025-01-01“…Neurological diseases, especially brain functional disorders, have become major threats to human health. …”
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6546
Dynamic Adjacency Matrix Learning and Multi-Order Random Walk Aggregation for Alzheimer’s Disease Diagnosis From Resting-State fMRI
Published 2025-01-01“…Alzheimer’s disease (AD) is a progressive, irreversible neurodegenerative disorder, and early diagnosis is critical for timely intervention and slowing down the course of the disease. Functional magnetic resonance imaging (fMRI), a non-invasive neuroimaging technique, can be used to detect functional brain activity. …”
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6547
Circular RNA Circ_0002762 promotes cell migration and invasion in cervical squamous cell carcinoma via activating RelA/nuclear factor kappa B (Nf-kB) signalling pathway
Published 2025-12-01“…The expression of circ_0002762 was predicted to be high in CSCC tissues in GEO dataset, but the functional role and underlying regulatory mechanism of circ_0002762 in CSCC was unclear. …”
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6548
Evaluation of the efficacy of icariin against heat stress-induced spermatogenic dysfunction in the testes of dogs
Published 2025-07-01“…Furthermore, molecular docking analysis confirmed a strong binding affinity between icariin and 17βHSD, mediated by hydrogen bonding and hydrophobic interactions.ConclusionThese findings suggest that icariin may alleviate testicular heat stress by modulating testosterone synthesis, enhancing ATPase function, restoring blood–testis barrier integrity, and inhibiting apoptosis. …”
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6549
Sociability genetically separable from social hierarchy in amniotes
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6550
LMO2 confers value as a potential immunotherapy marker in pan-cancer analysis and inhibits progression of Clear Cell Renal Cell Carcinoma
Published 2025-07-01“…Conclusions: Our findings establish substantial evidence for LMO2 as both a potential therapeutic candidate in cancer immunotherapy and a significant prognostic modulator in ccRCC pathogenesis. The mechanistic characterization of LMO2′s tumor-suppressive functions warrants heightened translational consideration in both clinical management strategies and molecular etiology research.…”
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6551
Action and therapeutic targets of folliculin interacting protein 1: a novel signaling mechanism in redox regulation
Published 2025-03-01“…Rapid activation of adenosine monophosphate-activated protein kinase (AMPK) induces phosphorylation of mitochondrial-associated proteins, a process by which phosphate groups are added to regulate mitochondrial function, thereby modulating mitochondrial energy metabolism, triggering an acute metabolic response, and sustaining metabolic adaptation through transcriptional regulation. …”
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6552
Exploring the eco-evolutionary role of plasmids and defense systems in ‘Fervidacidithiobacillus caldus’ extreme acidophile
Published 2025-08-01“…Plasmids are major drivers of microbial evolution, enabling horizontal gene transfer (HGT) and facilitating adaptation through the dissemination of relevant functional genes and traits. However, little is known about plasmid diversity and function in extremophiles. …”
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6553
Adipokinetic Hormones and Their Receptor Regulate the Locomotor Behavior in <i>Tribolium castaneum</i>
Published 2025-04-01“…The central nervous system plays a pivotal role in modulating physiological behaviors, particularly movement, with neuropeptides serving as key modulators of these processes. …”
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6554
Evaluation of Dietary Bioactive Agents Against Aflatoxin B1 and Ochratoxin A-Induced Duodenal Toxicity in Rats
Published 2025-05-01“…For this purpose, this study evaluates the protective effects of fermented whey (FW) and pumpkin (P), as functional ingredients in bread, on duodenum tissue against sub-chronic toxicity induced by AFB1 and OTA. …”
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6555
Spinal cord injury repair: Mechanisms, applications, and prospects of hydrogel therapies
Published 2025-06-01“…Spinal cord injury (SCI) is a severe condition of the central nervous system that leads to significant functional impairments and imposes heavy socioeconomic burdens. …”
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6556
Three distinct gamma oscillatory networks within cortical columns in macaque monkeys’ area V1
Published 2024-12-01“…Other features, like the different patterns of input and output connections of neurons located in separate layers and systematic differences in feature tuning, hint at a more segregated and possibly flexible functional organization of neurons within a column.MethodsTo distinguish between these views of columnar processing, we conducted laminar recordings in macaques’ area V1 while they performed a demanding attention task. …”
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6557
Haptoglobin and sickle cell polymorphisms and risk of active trachoma in Gambian children.
Published 2010-06-01“…In vitro studies of the causative organism, Chlamydia trachomatis, demonstrate that iron availability regulates its growth, suggesting that host genes involved in regulating iron status and/or availability may modulate the risk of trachoma. The objective was to investigate whether haptoglobin (Hp) haplotypes constructed from the functional polymorphism (Hp1/Hp2) plus the functional promoter SNPs -61A-C (rs5471) and -101C-G (rs5470), or sickle cell trait (HbAS, rs334) were associated with risk of active trachoma when stratified by age and sex, in rural Gambian children.…”
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6558
Identifying key genetic variants in Alzheimer’s disease progression using Graph Convolutional Networks (GCN) and biological impact analysis
Published 2025-07-01“…Our dual-pathway architecture combines: (1) linear SNP feature processing for individual genetic variants and (2) non-linear GCN analysis of functional gene networks, fused through an optimized integration module. …”
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6559
Dual Inhibition of BMP and WNT Signals Promotes Pancreatic Differentiation from Human Pluripotent Stem Cells
Published 2019-01-01“…Understanding how signaling pathways regulate pancreatic lineage and searching for combinations of signal modulators to promote pancreatic differentiation will definitely facilitate the robust generation of functional beta cells for curing hyperglycemia. …”
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6560
A novel current‐source management integrated circuit applied to high‐voltage integrated gate commutated thyristor gate driver
Published 2025-06-01“…The customised requirements of IGCT gate driver chips under various operating conditions are explored regarding functional module division, power sequencing, and chip parameter specifications. …”
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