Targeting membrane contact sites to mediate lipid dynamics: innovative cancer therapies by Jie Wang, Meifeng Wang, Xueni Zeng, Yanhan Li, Lingzhi Lei, Changan Chen, Xi Lin, Peiyuan Fang, Yuxuan Guo, Xianjie Jiang, Yian Wang, Lihong Chen, Jun Long

“…This proximity enables a synergistic regulation of cellular homeostasis and functions. The formation and maintenance of these contact sites are governed by specific proteins that bring organelle membranes into close apposition, thereby enabling functional crosstalk between cellular compartments. …”
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NEURO-IMMUNE MECHANISM OF EPILEPSY AS A KEY TO PATHOGENETIC TREATMENT OF THE DISEASE by L. V. Lipatova

“…Recent studies have proven the functioning of neuro-endocrine and immune systems as a united integrative functional system. …”
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Effect of m⁶A Recognition Protein YTHDC1 on Skeletal Muscle Growth by Huijun Huang, Geyan Lu, Liyao Xiao, Baohua Tan, Yuming Yang, Linjun Hong, Zicong Li, Gengyuan Cai, Ting Gu

“…The N⁶-methyladenosine ed(m⁶A) modification is a conserved and most prevalent RNA modification, whose function is dependent on m⁶A writers, erasers, and m⁶A readers, such as the YTH protein family. …”
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Exploring intracellular anti-mycobacterium activity of lactoferricin-loaded niosomes: proteomics insights into Immunomodulation by Sirikwan Sangboonruang, Natthawat Semakul, Worrapan Poomanee, Thasang Thavanapong, Sittiruk Roytrakul, Sawanya Charoenlappanit, Siriwan Thaisakun, Jiaranai Khantipongse, Nathiprada Netirat, Apiwadee Tongsong, Usanee Wattananandkul, Sorasak Intorasoot, Ponrut Phunpae, Khajornsak Tragoolpua

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Coordinating oncogenesis and immune evasion: KPNA2, GOLM1, and TK1 as novel CAR T-cell targets in lung adenocarcinoma by Wangrui Liu, Hui Zou, Lei Guo, Zhonghua Zhou, Yahui Xie, Huaqi Guo, Gang Wei, Kai Zhang, Hui Yin, Shiyin Wei, Jiachang Chi

“…Their membrane expression (notable in the case of PD-L1) and functional roles in immune modulation, make them reasonable targets of CAR T-cell immunotherapy. …”
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A multicenter cross-sectional study on quality of life and influencing factors in patients with 10 kinds of chronic diseases by Chenyao Li, Ying Chen, Wu Li, Haifeng Ding, Qiongling Liu, Chuanzhi Xu, Chonghua Wan

“…A Multicenter Large Sample Cross-sectional Study with nine hospitals. 1953 patients with 10 kinds of chronic diseases were investigated by a general situation questionnaire, and the QLICD-GM including three domains of physical function (PHD), psychological function (PSD) and social function (SOD). …”
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Aging-declined RNA exportation impairs hematopoietic stem cells by inducing R-loop by Ruiqing Chen, Qiongye Dong, Lihong Zhou, Hanqing He, Yingxue Du, Qianwen Sun, Toshio Suda, Tao Cheng, Jianwei Wang

“…Targeted induction of R-Loop impairs the function of HSCs. Mechanistically, RNA exportation is compromised in aged HSCs due to a decline in Alyref, the primary constituent of the TREX (transcription-export complex). …”
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IscR-tmRNA regulatory axis plays a key role in multiple stress response and pathogenicity in Aeromonas veronii by Xiang Ma, Yuan Tong, Pingwei Gao, Lingmin Sun, Hong Li, Yanqiong Tang, Juanjuan Li, Xue Chi, Zhu Liu

“…Transfer-messenger RNA (tmRNA), which plays an important role in pathogenicity due to its major function in the trans-translation system for ribosome rescue, has been proved as a stress response molecule. …”
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Surface-Related Multiple Suppression Based on Field-Parameter-Guided Semi-Supervised Learning for Marine Data by Jiao Qi, Siyuan Cao, Zhiyong Wang, Yankai Xu, Qiqi Zhang

“…The FPSSL framework comprises a supervised network module (SNM) and an unsupervised network module (USNM). …”
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Design of a Multifunctional Distribution Room State Monitoring Sensor by Min ZHANG, Jian FANG, Hongbin WANG, Linhuan LUO, Fangzhou HAO, Fan YANG, Xiang LIN

“…Performance testing results show that the designed KIS-GTH5A multi-functional sensor has a detection accuracy of ±3%FS for gas, ±0.5 ℃for temperature and±3%RH for humidity. …”
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The Bioactivity of Byproducts from the Blackberry (<i>Rubus fruticosus</i>) Juice Industry by Maria Dolores Rivero-Pérez, Gisela Gerardi, Mónica Cavia-Saiz, Miriam Ortega-Heras, Pilar Muñiz

“…Blackberry byproducts, namely skin and seeds, are rich in phenolic compounds, especially the skin, which is rich in anthocyanins and presents an antioxidant capacity that makes it potentially usable as a functional ingredient. All the fermented samples present in vitro genoprotective activity and a modulation effect on the intestinal microbiota, promoting the growth of <i>Bifidobacterium</i> and <i>Lactobacillus</i> and reducing the abundance of the Clostridia XIVa cluster and <i>Faecalibacterium prausnitzii</i>. …”
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IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population. by Ashish Dhyani, Gianpaolo Tibolla, Andrea Baragetti, Katia Garlaschelli, Fabio Pellegatta, Liliana Grigore, Giuseppe Danilo Norata, Alberico Luigi Catapano

“…Inducible degrader of the low density lipoprotein receptor (IDOL), is an E3 ubiquitin ligase that negatively modulates low density lipoprotein receptor (LDL-R) expression. …”
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Effects of fluconazole and amphotericin B in the control of cryptococcal pneumonia in vivo by Zhao Yu, Zhihao Liu, Jiaojiao Qian, Yuanyuan Qian

“…Results demonstrated marked improvements in pulmonary function within the observation group, with significantly higher FEV1, FVC, and FEV1/FVC values than those in the control group (P < 0.05). …”
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Roxadustat improves diabetic myocardial injury by upregulating HIF-1α/UCP2 against oxidative stress by Tingting Fang, Congcong Ma, Bingyun Yang, Meiyu Zhao, Luning Sun, Ningning Zheng

“…Methods We established diabetic myocardial injury mice and high glucose-induced rat cardiomyocyte models, administered FG-4592 pretreatment to clarify the protective effects and related mechanisms of FG-4592 on diabetic myocardial injury by detecting changes in oxidative stress, mitochondrial function, and related pathways. Results FG-4592 demonstrated cardioprotective effects in diabetic mice by regulating mitochondrial structure and function, as well as maintaining oxidative stress balance in the myocardium. …”
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LOX-induced tubulointerstitial fibrosis via the TGF-β/LOX/Snail axis in diabetic mice by Yicheng Lu, Heyangzi Li, Mohan Chen, Yicheng Lin, Xiaoming Zhang

“…Besides, we further assessed kidney fibrosis and renal function. Results LOX expression was elevated in kidneys of diabetic mice. …”
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The Arabidopsis bZIP11 transcription factor links low-energy signalling to auxin-mediated control of primary root growth. by Christoph Weiste, Lorenzo Pedrotti, Jebasingh Selvanayagam, Prathibha Muralidhara, Christian Fröschel, Ondřej Novák, Karin Ljung, Johannes Hanson, Wolfgang Dröge-Laser

“…Whereas transgenic gain-of-function approaches of these bZIPs interfere with the activity of the root apical meristem and result in root growth repression, root growth of loss-of-function plants show a pronounced insensitivity to low-energy conditions. …”
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Environmental enrichment in middle age rats improves spatial and object memory discrimination deficits by Magdalena Miranda, Maria Carla Navas, Maria Belen Zanoni Saad, Dinka Piromalli Girado, Noelia Weisstaub, Pedro Bekinschtein

“…Although a bulk of studies have examined the contribution of EE for preventing age related memory decline in diverse cognitive domains, there is limited knowledge of how this intervention could specifically impact on BPS function in middle-aged animals. Here we evaluate the effects of EE as modulator of BPS, and its ability to revert the deficits caused by normal aging at early stages. …”
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Mitochondrial respiration and ROS emission during β-oxidation in the heart: An experimental-computational study. by Sonia Cortassa, Steven J Sollott, Miguel A Aon

“…Also, for the first time, we show that an integrated two compartment mitochondrial model of β-oxidation of long-chain fatty acids and main energy-redox processes is able to simulate the relationship between VO2 and H2O2 emission as a function of lipid concentration. Model and experimental results indicate that PCoA oxidation and its concentration-dependent uncoupling effect, together with a partial lipid-dependent decrease in the rate of superoxide generation, modulate H2O2 emission as a function of VO2. …”
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C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1. by Zhiyong Shao, Yi Zhang, Qi Ye, Jenifer Neeta Saldanha, Jo Anne Powell-Coffman

“…Prior studies have established that strong loss-of-function mutations in the egl-9 gene protect the nematode C. elegans from P. aeruginosa PAO1 fast killing. …”
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Allegro data-recording system based on MySQL database by Liu Tao, Fu Shenzhen, Zhang Zhu, Zhou Dong

“…The realization of data acquisition module of the system has a strong reference value for the communication between Allegro software and other languages, and the function expansion of web page.…”
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