Overcoming Immune Barriers in Allogeneic CAR-NK Therapy: From Multiplex Gene Editing to AI-Driven Precision Design by Hyunyoung Kim

“…In addition, we discuss functional enhancements such as IL-15 pathway activation, KIR modulation, and transcriptional reprogramming (e.g., FOXO1 knockout) to improve persistence and antitumor activity. …”
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Neural dynamics of semantic control underlying generative storytelling by Clara Rastelli, Antonino Greco, Chiara Finocchiaro, Gabriele Penazzi, Christoph Braun, Nicola De Pisapia

“…Moreover, we found specific spatial frequency patterns underlying the modulation of semantic control during story generation, while functional coupling in default, salience, and control networks differentiated creative stories with their controls. …”
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Nanomedicine's shining armor: understanding and leveraging the metal-phenolic networks by Zhengming Tang, Zhijie Huang, Yisheng Huang, Mingshu Huang, Hongyu Liu, JianZhong Du, Bo Jia

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Extracellular Vesicles: Recent Advances and Perspectives by Enrico Ragni

“…Furthermore, the natural biocompatibility, ability to cross biological barriers, and capacity for functional cargo delivery of EVs position them as therapeutic tools and drug-delivery vehicles. …”
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TRANSLATION STRATEGIES IN ENGLISH-UKRAINIAN RENDERING OF DUAL-NUMBER QUANTIFI by Oleksandr O. Lytvynov

“….; 2) to determine their semantic and functional characteristics and direct translation equivalents; 3) to identify their semantic roles and syntactic functions in the source text; 4) to specify the types of grammatical shifts and methods of their rendering into Ukrainian; 5) to identify and analyze the translation strategies applied by the translator to reach equivalence and adequacy of translation. …”
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Anti‐PF4 antibody inhibit proliferation of lung cancer cells without TP53 mutation by inducing apoptosis and cell cycle arrest by Mengjia Qian, Zhihui Min, Yanxia Zhan, Lili Ji, Bijun Zhu, Miaomiao Zhang, Qi Shen, Pengcheng Xu, Hao Chen, Yunfeng Cheng

“…Platelet factor 4 (PF4), a platelet‐specific protein, plays an important role in platelet function. Emerging evidence suggests that regulation of PF4 can modulate platelet function to impact the progression of lung cancer. …”
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Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation by Peijun Tian, Yunfei Hou, Zheng Wang, Jiaona Jiang, Xin Qian, Zhihao Qu, Jianxin Zhao, Gang Wang, Wei Chen

“…Gut microbiome is indispensable for maintaining normal brain function. Specifically, gut microbiota plays a causal role in sleep deprivation (SD)-induced cognitive impairment. …”
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Interaction between gut-heart axis in sepsis-induced cardiomyopathy by Zi-Kang Zhou, Mu-Ming Yu, Song-Tao Shou, Yan-Fen Chai, Yan-Cun Liu

“…Conversely, therapeutic interventions for SIC and the resultant cardiac alterations can reciprocally modulate gut microbial composition and function. To systematically elucidate this complex bidirectional relationship during SIC, this review delineates two key aspects: the 'forward gut-heart axis', defined as influences originating from the gut microbiota and its metabolites directed towards the cardiovascular system, and the 'reverse gut-heart axis', encompassing the reciprocal effects of cardiovascular drugs and cardiac factors on the gut microbiota. …”
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Identification of Novel Gene Signature Predicting Lymph Node Metastasis in Papillary Thyroid Cancer via Bioinformatics Analysis and in vitro Validation by Li H, Sun D, Jin K, Wang X

“…Those six hub genes were all more highly expressed in PTC tumors and played potential biological functions on the development of PTC in in vitro experiments, which had potential values as diagnostic and therapeutic targets.Keywords: papillary thyroid cancer, lymph node metastasis, bioinformatics analysis, WGCNA…”
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The Impact of Parental Support on Adherence to Therapist-Assisted Internet-Delivered Acceptance and Commitment Therapy in Primary Care for Adolescents With Anxiety: Naturalistic 12... by Anna Larsson, Sandra Weineland, Linnea Nissling, Josefine L Lilja

“…Nevertheless, no differences in overall functioning measured by the Children’s Global Assessment Scale were found. …”
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Beyond glycemic control: the neuroprotective potential of tirzepatide by Milen Hristov, Gurjeet Cheema, Heba Ali, Pavlina Andreeva-Gateva

“…Recent preclinical studies suggest that tirzepatide may help prevent neurodegeneration, reduce inflammation in the brain, and improve cognitive function. Its effects are attributed to the modulation of insulin signaling, suppression of inflammatory molecules, and promotion of neurotrophic factors that support brain health. …”
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USP14/S100A11 axis promote colorectal cancer progression by inhibiting cell senescence by Yong Huang, Xiaolei Tang, Hao Xie, Zhaoying Wu, Lei Jin, Lei Zhang, Xidong Lin, Hailang Zhou, Junwei Zou

“…Abstract The aberrant expression of S100A11 has been identified in various malignancies but its functional roles and underlying mechanisms in colorectal cancer (CRC) have not been fully elucidated. …”
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Skin microbiota and diabetic foot ulcers by Jiaqi Lou, Ziyi Xiang, Xiaoyu Zhu, Jiliang Li, Guoying Jin, Shengyong Cui, Neng Huang, Xin Le, Youfen Fan, Qionghui Sun

“…The abundance of pathogenic bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa increases, forming biofilms, destroying the skin barrier function, aggravating infection, and leading to poor wound healing. …”
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Effects of antimicrobial peptides (AMPs) on egg quality, immunity, antioxidant capacity, and intestinal microbiota in late-laying hens by Yuanli Cai, Yucong Zhang, Okasha Hamada, Peng Sun, Zhigang Song

“…Furthermore, AMPs enhanced immune function, evidenced by the modulation of key immune factors. …”
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Nature’s magic: how natural products work hand in hand with mitochondria to treat stroke by Lin Cheng, Shangbin Lv, Chengkai Wei, Sucheng Li, Hao Liu, Yong Chen, Zhaoliang Luo, Hongyan Cui

“…However, current pharmacological treatments for stroke are challenged by issues such as drug resistance and side effects, necessitating the exploration of new therapeutic strategies.ObjectiveThis review aims to summarize the regulatory effects of natural compounds targeting mitochondria on neuronal mitochondrial function and metabolism, providing new perspectives for stroke treatment.Main findingsNumerous in vitro and in vivo studies have shown that natural products such as berberine, ginsenosides, and baicalein protect neuronal mitochondrial function and reduce stroke-induced damage through multiple mechanisms. …”
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Age and estrogen-associated reductions in hypoxic ventilatory response and chemosensitivity in female rats by Jessica M. L. Grittner, Rebecca Barok, Edgar Juarez Lopez, Misha Shah, Brendan J. Dougherty

“…Respiratory function is modulated by circulating steroid hormones. …”
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AhR regulation of amyloid beta-induced inflammation in astrocyte cells by Emmanuel Ojo, Temitope Adu, Raheem F. H. AI Aameri, Shelley A. Tischkau, Shelley A. Tischkau

“…Aryl hydrocarbon receptor (AhR), a transcription factor engaged in regulation of immune function, may be involved in the pathogenesis of AD, through modulation of neuroinflammation. …”
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A TRPV1 agonist from the transcriptome profiling of Dipsastraea rotumana inhibits neuroinflammation in vivo through the NF-κB and MAPK pathways by Hanbin Chen, Nan Xu, Hiotong Kam, Chen Zhao, Qian Chen, Guangyi Fan, Shirley Weng In Siu, Clarence Tsun Ting Wong, Jian-Wen Qiu, Alex Kwok-Kuen Cheung, Ariane Teixeira, Gandhi Rádis‑Baptista, Pak Kin Wong, Shang Li, Guiyi Gong, Simon Ming-Yuen Lee

“…Transient receptor potential cation channel subfamily V member 1 (TRPV1), widely expressed in microglia, influences their function by regulating the production of these immune-modulating molecules. …”
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Relumino mode may provide video terminal assistance for the amblyopic patients by Jiayun Yu, Yiting Sun, Hongjing Sun, Xirenayi Zhuoruo, Jiangxiong Cai, Xiuming Jin

“…We recruited 38 participants with anisometropic amblyopia, all literate and cognitively capable. The Modulation Transfer Function (MTF) of the normal and Relumino modes was measured to evaluate the relationship between spatial frequency variations and visual effects. …”
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CPNE5 overexpression inhibits cardiomyocytes apoptosis by promoting the degradation of FAS receptor by Tingting Zhao, Yangjinming Bai, Yudong Fei, Zhixing Wei, Pengcheng Yao, Qianji Che, Yichao Zhang, Ji Yan, Kaiyan Chen, Zhengyang Wu, Junhao Qiu, Yuepeng Wang, Wei Li, Qian Wang, Yigang Li

“…Summary: CPNE5, a member of the Copine family, is characterized by its membrane-binding properties and functions as a regulatory modulator of intracellular signaling through the spatial redistribution of interacting protein partners. …”
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