Blockade of CLEVER-1 restrains immune evasion and enhances anti-PD-1 immunotherapy in gastric cancer by Tianwei Xu, Jing Qin, Xiaolei Zhang, Zihao Zhang, Xinxin Guo, Yifan Cao, Yichao Gu, Kuan Yu, Leihao Wang, Zhenbin Shen

“…Transcriptomic and phenotypic analyses revealed that CLEVER-1+TAMs display a dynamic immunophenotype and critically suppress T-cell function, fostering an immunosuppressive microenvironment. …”
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Effects and mechanisms of acupuncture for PIGD-subtype Parkinson’s disease via integration of fMRI and gut microbiota-metabolomics analysis: protocol for a prospective randomized c... by Jili Sheng, Jili Sheng, Yingqi Xu, Tao Liu, Jianfang Zhu, Caiyun Mu, Lihao Zhai, Shanhu Xu, Hanyi Wang, Xiangzhi Liu, Tao Liu, Xiaoqing Jin

“…We will also analyze the modulation of gut microbiota and serum metabolome to explore the underlying neural mechanisms. …”
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НЕКОТОРЫЕ ПАРАМЕТРЫ АТЕРОГЕНЕЗА У БОЛЬНЫХ АНЕМИЯМИ by В. Г. Желобов, А. В. Туев, Л. А. Некрутенко

“…Influence hypoxia on parameters of the metabolic module (lipide a spectrum, lipide peroxidase, antioxidizing activity of blood) and vasodilatum function endothelium is investigated at various pathogenetic variants of an anemia. …”
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Microbiome-derived bile acids as endogenous regenerative mediators in liver repair by Surya Nath Pandey, Kavita Goyal, Mohit Rana, Soumya V. Menon, Subhashree Ray, Haider Ali, Popat S. Kumbhar, John Disouza, Sachin Kumar Singh, Gaurav Gupta, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan

“…The liver's extraordinary capacity for self-repair is often compromised by chronic injury, fibrosis, or extensive resection, creating an urgent need for innovative regenerative therapies to restore liver function. Emerging evidence suggests that microbiome-derived bile acid metabolites are potent endogenous mediators of hepatic regeneration. …”
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Chinese herbal medicine for the treatment of children with cerebral palsy: a meta-analysis of randomized controlled trials with core herbs exploration by Ying-Yu Huang, Ya-Yun Cheng, Hsing-Yu Chen, Hsing-Yu Chen, Ren-Huei Fu, Yi-Jung Chang, Tsung-Hsien Yang, Tsung-Hsien Yang

“…IntroductionChinese herbal medicine (CHM) taken orally is frequently utilized to enhance functional ability and independence in cerebral palsy (CP); nonetheless, there is a lack of current evidence regarding the efficacy of oral CHM in treating CP. …”
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Simulation Study on the Spatiotemporal Difference of Complex Neurodynamics between P3a and P3b by Xin Wei, Xiaoli Ni, Junye Liu, Haiyang Lang, Rui Zhao, Tian Dai, Wei Qin, Wei Jia, Peng Fang

“…The integration of event-related potential (ERP) and functional magnetic resonance imaging (fMRI) helps to obtain and study neural networks with high temporal and spatial resolution. …”
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MTMR6 downregulation contributes to cisplatin resistance in oral squamous cell carcinoma by Kah Young Lee, Su Young Oh, Heon-Jin Lee, Tae-Geon Kwon, Jin-Wook Kim, Chang-Geol Shin, Su-Hyung Hong, So-Young Choi

“…Results MTMR6 expression was markedly reduced in cisplatin-resistant UM-Cis cells compared to UMSCC1 cells. Functional analyses revealed that modulating MTMR6 activity alters cisplatin resistance. …”
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Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway by Aiqing Yu, Yujun Zhang, Saifeng Zhong, Zhizhen Yang, Mingming Xie

“…Both microRNAs are recognized regulators of genes critical to hair follicle function, including Cyclin D1, c-MET, and LEF1, which collectively activate the Wnt/β-catenin signaling pathway and thereby enhance the functional differentiation of hDPCs. …”
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Decoding a novel non-enzymatic protein acetylation mechanism in sperm that is essential for fertilizing potential by María Iniesta-Cuerda, Jan Nevoral, Dario Krapf, Julián Garde, Ana Josefa Soler-Valls, Marc Yeste

“…Abstract Background Protein acetylation has emerged as essential for sperm function, attracting considerable attention recently. …”
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Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. by Gordan Lauc, Jennifer E Huffman, Maja Pučić, Lina Zgaga, Barbara Adamczyk, Ana Mužinić, Mislav Novokmet, Ozren Polašek, Olga Gornik, Jasminka Krištić, Toma Keser, Veronique Vitart, Blanca Scheijen, Hae-Won Uh, Mariam Molokhia, Alan Leslie Patrick, Paul McKeigue, Ivana Kolčić, Ivan Krešimir Lukić, Olivia Swann, Frank N van Leeuwen, L Renee Ruhaak, Jeanine J Houwing-Duistermaat, P Eline Slagboom, Marian Beekman, Anton J M de Craen, André M Deelder, Qiang Zeng, Wei Wang, Nicholas D Hastie, Ulf Gyllensten, James F Wilson, Manfred Wuhrer, Alan F Wright, Pauline M Rudd, Caroline Hayward, Yurii Aulchenko, Harry Campbell, Igor Rudan

“…Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we quantitated N-linked IgG glycans using two approaches. …”
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Long-term exposure to high-altitude hypoxic environments reduces blood pressure by inhibiting the renin-angiotensin system in rats by Delong Duo, Junbo Zhu, Mengyue Wang, Xuejun Wang, Ning Qu, Xiangyang Li, Xiangyang Li

“…Blood pressure was measured via non-invasive tail-cuff method, cardiac function via echocardiography, and right heart pressures via catheterization. …”
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Genome-wide identification and expression analysis of the WRKY transcription factors related to sesquiterpenes biosynthesis in Atractylodes lancea by Hua Liang, Weiwei Liu, Zhiqiang Zhao, Yaqian Li, Liangping Zha, Liangping Zha, Liangping Zha

“…These results suggest that AlWRKY20 and AlWRKY37 likely function as regulators of sesquiterpene biosynthesis, positively regulating cis-β-farnesene and α-curcumene production through AlTPS gene modulation.DiscussionThis study lays the groundwork for further exploration of the molecular mechanisms and functional validation of WRKY transcription factors in A. lancea.…”
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Band gap engineering and electronic structure of Cu2Ni(Sn,Ge,Si)Se4 kesterites: A DFT perspective on new earth-abundant semiconductors for high-performance photovoltaics by Iskandar Raufov, Dilshod Nematov, Saidjaafar Murodzoda, Anushervon Ashurov, Sakhidod Sattorzoda

“…This work presents a systematic first-principles investigation of the electronic structure and bandgap modulation in Cu2Ni(Sn,Ge,Si)Se4 kesterites using density functional theory (DFT). …”
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LIN28B promotes the progression of endometrial cancer through upregulating MYC and correlates with immune microenvironment by Yuchao Diao, Xiangkun Li, Chang Wang, Jinwen Jiao, Dongmei Gao, Weifang Mao, Xinping Yu, Hongjuan Yang

“…Survival outcomes associated with LIN28B were analyzed using the Kaplan-Meier methodology. Functional validation was conducted in HEC-1A, HEC-1B, and KLE cell lines through siRNA-mediated LIN28B knockdown. …”
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Identifying Priority Areas for Planning Urban Green Infrastructure: A Fuzzy Artificial Intelligence-Based Framework by Leonardo Massato Nicacio Nomura, Adriano Bressane, Vitoria Valente Monteiro, Inara Vilas Boas de Oliveira, Graziele Ruas, Rogério Galante Negri, Alexandre Marco da Silva

“…The system’s modular structure, use of triangular membership functions, and incorporation of the gamma operator allow for adaptable prioritization across different planning horizons. …”
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Nuclear Receptor Cofactors in PPARγ-Mediated Adipogenesis and Adipocyte Energy Metabolism by Emily Powell, Peter Kuhn, Wei Xu

“…Transcriptional cofactors are integral to the proper function and regulation of nuclear receptors. Members of the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors are involved in the regulation of lipid and carbohydrate metabolism. …”
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Probiotics and muscle health: the impact of Lactobacillus on sarcopenia through the gut-muscle axis by Jingjun Zhu, Fei Peng, Huixin Yang, Jing Luo, Li Zhang, Xiaolong Chen, Huazhi Liao, Hao Lei, Shuai Liu, Tingqian Yang, Tingqian Yang, Guanghua Luo, Guodong Chen, Heng Zhao

“…In addition, we also discuss the possible mechanisms by which Lactobacillus affect muscle function, such as alleviating inflammatory states, clearing excessive reactive oxygen species (ROS), improving skeletal muscle metabolism, enhancing intestinal barrier function and modulating the gut microbiota and its metabolites. …”
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UP3: Unsupervised Predictive Path Planner for Mobile Robots in Unknown Environment by Jianing Luo, Jiwei Zhu, Ruopeng Cui, Gaoxiong Lu, Wei Li

“…Herein, the approach through simulation and real‐world experiments is tested to verify the function of each module. In the results, it is indicated that UP3 performs well on dense and maze scenarios and has good generalization.…”
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Exploring the prognostic role and expression patterns of FAM3A family genes in kidney renal clear cell carcinoma by Shoaib Muhammad, Pengyu Yan, Huifang Wang, Ahmad Mahmood, Syed Shah Zaman Haider Naqvi, Muhammad Zaeem, Chun Liu

“…This study investigated the expression, diagnostic potential, and functional significance of FAM3 family genes in KIRC. …”
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Comprehensive characterization of high-risk coding and non-coding single nucleotide polymorphisms of human CXCR4 gene. by Bonoshree Sarkar, Muhammad Safiul Alam Mondal, Taibur Rahman, Md Ismail Hosen, Atiqur Rahman

“…The functional impact of wild-type and mutated CXCR4 variants was evaluated through molecular docking with its natural ligand CXCR4-modulator 1, using the PyRx tool. …”
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