The reprogramming factor KLF4 in normal and malignant blood cells by H. Daniel Lacorazza

“…The landmark 2006 publication identified KLF4 as one of the factors involved in reprogramming differentiated cells into pluripotent stem cells, sparking increased interest in KLF4 research a decade after its discovery, particularly in the fields of stem cell research, epithelial cell biology, endothelial cell function, and tumorigenesis. Over the years, KLF4 has emerged as a key transcription factor in modulating innate and adaptive immunity, especially in macrophage differentiation and function. …”
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Identification and validation of the common pathogenesis and hub biomarkers in Papillary thyroid carcinoma complicated by rheumatoid arthritis. by Yingming Liu, Xiangjun Kong, Qianshu Sun, Tianxing Cui, Shengnan Xu, Chao Ding

“…Following the discovery of shared differentially expressed genes (DEGs) between these two conditions, three separate analyses were conducted. These included functional annotation, the establishment of a protein‒protein interaction (PPI) network and module, and the identification of hub genes via coexpression analysis. …”
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The Irish potato famine pathogen Phytophthora infestans translocates the CRN8 kinase into host plant cells. by Mireille van Damme, Tolga O Bozkurt, Cahid Cakir, Sebastian Schornack, Jan Sklenar, Alexandra M E Jones, Sophien Kamoun

“…We demonstrated that CRN8 is a functional RD kinase and that its auto-phosphorylation is dependent on an intact catalytic site. …”
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The effect of plant mucilaginous gel polysaccharides on oxidative tolerance and fermentation of dietetic yoghurts by Tulay Ozcan, Lutfiye Yilmaz-Ersan, Raziye Asli Keser

“…To evaluate the bio-functional activity of yoghurt, analyses of probiotic bacterial growth, the total phenolic compounds and copper-reducing antioxidant capacity were carried out. …”
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The role of lycopene in alleviating soybean meal-induced intestinal injury in an early-weaned piglet model by Shugui Zheng, Mingbo Li, Xinhong Luan, Chuan Tong, Jiguang Li, Zhiying Zhang

“…Furthermore, lycopene modulated gut microbiota by promoting the growth of beneficial bacteria, particularly Lactobacillus, while reducing the abundance of harmful bacteria.ConclusionThese findings demonstrated that lycopene supplementation in SBM-based diets significantly enhanced antioxidant capacity, decreased apoptosis in small intestinal cells, improved intestinal barrier function and morphology, and optimized gut microbiota composition. …”
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A splice site mutation in laminin-α2 results in a severe muscular dystrophy and growth abnormalities in zebrafish. by Vandana A Gupta, Genri Kawahara, Jennifer A Myers, Aye T Chen, Thomas E Hall, M Chiara Manzini, Peter D Currie, Yi Zhou, Leonard I Zon, Louis M Kunkel, Alan H Beggs

“…This laminin-α2 deficient mutant fish represents a novel disease model to develop therapies for modulating splicing defects in congenital muscular dystrophies and to restore the muscle function in human patients with CMD.…”
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IL-7 in autoimmune diseases: mechanisms and therapeutic potential by Ziyuan Zeng, Hanxiao Mao, Qirong Lei, Yuanmin He

“…For T1D, IL-7 affects the function of immune cells that attack pancreatic β cells. …”
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Activation of pro-resolving pathways mediate the therapeutic effects of thymosin beta-4 during Pseudomonas aeruginosa-induced keratitis by Yuxin Wang, Loveleen Banga, Abdul Shukkur Ebrahim, Thomas W. Carion, Gabriel Sosne, Elizabeth A. Berger

“…Our recent work elucidating the therapeutic mechanisms of adjunctive thymosin beta-4 (Tβ4) in resolving inflammation and infection in bacterial keratitis revealed modulation of effector cell function and enhanced bacterial killing. …”
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Bile acid signaling in skeletal muscle homeostasis: from molecular mechanisms to clinical applications by Feng Jia, Xiangliang Liu, Yahui Liu

“…The intricate relationship between bile acid metabolism and skeletal muscle function has emerged as a crucial area of research in metabolic health. …”
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Matrix Metalloproteinase-9 (MMP-9) induced disruption of intestinal epithelial tight junction barrier is mediated by NF-κB activation. by Rana Al-Sadi, Jessica Engers, Mohammad Haque, Steven King, Deemah Al-Omari, Thomas Y Ma

“…However, the intracellular mechanisms that mediate the MMP-9 modulation of intestinal barrier function remain unclear.…”
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Therapeutic strategies, consequences and prospects of glucagon-like peptide-1 agonists by N.M. Bobok

“…Studies show that these drugs affect not only carbohydrate metabolism but also the cardiovascular system and kidney function. However, their prolonged and unreasonable use may be accompanied by undesirable effects. …”
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Transcriptomic and proteomic profiling identifies feline fibrosarcoma as clinically amenable model for aggressive sarcoma subtypes by Mikiyo Weber, Daniel Fuchs, Amiskwia Pöschel, Erin Beebe, Zuzana Garajova, Armin Jarosch, Laura Kunz, Witold Wolski, Lennart Opitz, Franco Guscetti, Mirja C. Nolff, Enni Markkanen

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Molecular Characterization and Feeding-Associated Expression Dynamics of the Period Gene Family in Channel Catfish (<i>Ictalurus punctatus</i>) by Hongyan Liu, Shiyong Zhang, Xiaohui Chen, Minghua Wang, Liqiang Zhong, Yongqiang Duan, Bingjie Xie, Luyu Tang, Yi Cheng

“…This study provides insights into the evolutionary divergence and functional roles of the period gene family in channel catfish, showing how feeding schedules modulate circadian gene expression in the brain and liver. …”
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Unraveling key transposable elements in pathogen-induced bovine mastitis through comparative in vivo and in vitro transcriptomic analysis by Songyan An, Siyuan Mi, Siqian Chen, Yongjie Tang, Yue Xing, Yi Jing, Ying Yu

“…Transposable elements (TEs), occupying a notable proportion of livestock genomes, primarily function as regulatory elements modulating gene expression. …”
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Effects of processing parameters on the reversible phase transition of germanium telluride by Haoran Ma, Shaorui Yang, Yi Liu, Yaguang Ye, Le Liu, Lei Liu, Wei Xiong, Leimin Deng, Tianting Chen

“…The tunable and reversible manufacturing function of stealth metamaterials is of great practical significance to adapt to complex electromagnetic environment. …”
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TEEMLEAP—A New Testbed for Exploring Machine Learning in Atmospheric Prediction for Research and Education by J. Wilhelm, J. Quinting, M. Burba, S. Hollborn, U. Ehret, I. Pena Sánchez, S. Lerch, J. Meyer, B. Verfürth, P. Knippertz

“…This document outlines the testbed's setup, demonstrates its functionality with a pilot experiment, and discusses examples of potential applications. …”
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Supervised Learning of Depth Estimation From Imperfect Rectified Stereo Laparoscopic Images of Liver Surface by Chongan Zhang, Ziyi Jin, Xiaoyue Liu, Yuelong Liang, Xiao Liang, Peng Wang, Xiujun Cai, Xuesong Ye

“…This method uses structured light reconstruction for depth estimation. which includes deformable convolution modules, vertical disparity correction weights, and edge-enhanced loss functions. …”
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A brain-inspired memory transformation based differentiable neural computer for reasoning-based question answering by Yao Liang, Yao Liang, Yuwei Wang, Yuwei Wang, Hongjian Fang, Hongjian Fang, Feifei Zhao, Yi Zeng, Yi Zeng, Yi Zeng, Yi Zeng, Yi Zeng

“…Reasoning and question answering, as fundamental cognitive functions in humans, remain significant hurdles for artificial intelligence. …”
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Prefrontal serotonin depletion delays reversal learning and increases theta synchronization of the infralimbic-prelimbic-orbitofrontal prefrontal cortex circuit by Yoana Estrada-Reyes, Yoana Estrada-Reyes, José Miguel Cervantes-Alfaro, Miguel Ángel López-Vázquez, María Esther Olvera-Cortés

“…However, the mechanisms by which serotonin modulates the prefrontal cortex functions during reversal learning remain unclear. …”
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USP15 Drives NSCLC Progression and Chemoresistance, Potentially via Regulation of the U2‐Type Spliceosomal Complex by Chien‐Chih Chiu, Sheng‐Kai Hsu, Wangta Liu, I‐Ling Lin, Wenhua Qiu, Ching‐Hung Hsieh, Chon‐Kit Chou

“…This study aimed to investigate the biological function and mechanistic relevance of USP15 in NSCLC. …”
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