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6381
The role of platelets in inflammation and immunity
Published 2018-09-01“…In recent decades, significant progress has been made in understanding the mechanisms of platelet function and platelet hemostasis correction. Platelets are considered as the most important participants of both normal, and pathological thrombotic process characteristic of the most different diseases and states. …”
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6382
Evaluate the Probability of Failure in Rainfall-Induced Landslides Using a Fuzzy Point Estimate Method
Published 2019-01-01“…Therefore, a probabilistic approach, which uses the probability distribution function to explain the randomness of parameters, is proposed for quantifying the uncertainty. …”
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6383
Research Progress of Sea Cucumber Polysaccharides on the Structure, Health Efficacy and Mechanism
Published 2025-04-01“…Sea cucumber polysaccharides (SCPs) are characterized by their unique structural configurations and broad-spectrum bioactivities, which are manifested through their regulatory functions or interactions with microbial communities upon entering the organism. …”
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6384
Effects of intermittent theta burst stimulation on the inflammatory response and cerebral blood flow in promoting neurovascular repair after ischemic stroke
Published 2025-06-01“…Abstract Secondary injuries from ischemia‒reperfusion in stroke, such as edema and hemorrhagic transformation, can significantly impact brain function. This study investigated the effects of intermittent theta burst stimulation (iTBS) on neurological function and cerebral blood flow in a mouse model of ischemia‒reperfusion injury. …”
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6385
Mesenchymal Stromal Cell Secretome and Its Key Bioactive Metabolites Induce Long‐Term Neuroprotection After Traumatic Brain Injury in Mice
Published 2025-08-01“…In vivo, SYNT conferred similar long‐term functional benefits as CM, improving sensorimotor function up to 6 months and memory preservation at 4 months compared to saline‐treated animals, though only CM reduced contusion volume at 5 months. …”
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6386
Targets of Neutrophil Influx and Weaponry: Therapeutic Opportunities for Chronic Obstructive Airway Disease
Published 2017-01-01“…In addition, neutrophil function can be modulated using selective PI3Kδ inhibitors. …”
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6387
Exercise preconditioning alleviates photothrombotic ischemic stroke in mice by orchestrating neutrophils
Published 2025-07-01“…Notably, exercise preconditioning (EP) has the potential to modulate neutrophil function, thereby contributing to the amelioration of IS. …”
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6388
Multi-omic analyses reveal PTPN6’s impact on tumor immunity across various cancers
Published 2025-04-01“…We observed correlations between PTPN6 and immune genes/cell infiltration in these cancers, suggesting a potential role in modulating the tumor immune microenvironment. Single-cell analysis revealed that PTPN6 is predominantly localized in macrophages, B cells, and dendritic cells within the tumor microenvironment, implying its involvement in regulating immune cell function. …”
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6389
Microbial fermentation of soybeans: synergistic enhancement of bioactivity and sensory properties
Published 2025-08-01“…Microbial fermentation plays a crucial role in enhancing the functional and sensory qualities of soybean-based products. …”
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6390
M2 macrophage-derived exosomes suppress tumor intrinsic immunogenicity to confer immunotherapy resistance
Published 2023-12-01“…T-cell-based immune checkpoint blockade therapy (ICB) can be undermined by local immunosuppressive M2-like tumor-associated macrophages (TAMs). However, modulating macrophages has proved difficult as the molecular and functional features of M2-TAMs on tumor growth are still uncertain. …”
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6391
Research on the Low-voltage Distribution and Data Acquisition System ofAutonomous-rail Rapid Tram
Published 2020-01-01“…Finally, the function of data diagnostic information and remote monitoring was described. …”
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6392
Insights into the protein domains of C-VI TRIM subfamily in viral infection
Published 2025-05-01“…Additionally, we explore the post-translational modifications (PTMs) of Class VI TRIM proteins including their functional differences in modulating viral infection. …”
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6393
Antiretroviral-Related Adipocyte Dysfunction and Lipodystrophy in HIV-Infected Patients: Alteration of the PPARγ-Dependent Pathways
Published 2009-01-01“…Adverse effects of PIs and NRTIs have also been reported in macrophages, a cell type that coexists with, and modulates, adipocyte function in fat tissue. In HIV-infected patients under ART, a decreased expression of PPARγ and of PPARγ-related genes was observed in adipose tissue, these anomalies being more severe in patients with ART-induced lipoatrophy. …”
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6394
High-dimensional anticounterfeiting nanodiamonds authenticated with deep metric learning
Published 2024-12-01“…Abstract Physical unclonable function labels have emerged as a promising candidate for achieving unbreakable anticounterfeiting. …”
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6395
Mining of Candidate Genes and Developing Molecular Markers Associated with Pokkah Boeng Resistance in Sugarcane (<i>Saccharum</i> spp.)
Published 2024-12-01“…Utilizing weighted gene co-expression network analysis (WGCNA), we identified gene modules closely related to disease phenotypes. We annotated their functions with bioinformatics tools, particularly focusing on genes enriched in the plant immune response’s MAPK signaling pathway and ABC transporter synthesis pathways. …”
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6396
GMMA-based vaccine candidates against invasive nontyphoidal salmonellosis elicit bactericidal antibodies against a panel of epidemiologically relevant Salmonellae
Published 2025-06-01“…We characterized the O-antigen of the panel of isolates and demonstrated the sera functionality in both animal species against all isolates, providing evidence of the potential broad coverage of both GMMA-based formulations, which are currently undergoing testing in Phase I/II clinical trials.…”
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6397
Wideband Circularly-Polarized Hexagonal SIW Cavity-Backed Slot Antenna With Enhanced Bandwidth and Compact Design
Published 2025-01-01“…These results highlight the antenna’s suitability for modern wireless systems requiring wideband CP functionality, including satellite communications, 5G modules, and compact embedded devices.…”
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6398
A single cysteine residue in vimentin regulates long non-coding RNA XIST to suppress epithelial–mesenchymal transition and stemness in breast cancer
Published 2025-07-01“…A single cysteine at position 328 in vimentin plays a crucial role in assembly, organisation, and stability of IFs. However, its exact function during epithelial–mesenchymal transition (EMT) and cancer progression has not been investigated. …”
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6399
Hampered AMPK-ULK1 cascade in Alzheimer’s disease (AD) instigates mitochondria dysfunctions and AD-related alterations which are alleviated by metformin
Published 2025-06-01“…This study investigated the AMPK-ULK1 pathway activation state in AD and the impact of its modulation on mitochondria structure and function as well as on AD-related alterations. …”
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6400
Therapeutic Potential of Nutritional Aryl Hydrocarbon Receptor Ligands in Gut-Related Inflammation and Diseases
Published 2024-12-01“…Nutritional AhR ligands play a significant role in modulating intestinal immunity and the function of mucosal immune cells, thereby exerting clinical effects on colitis and innate immunity. …”
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