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Role and mechanisms of exercise therapy in enhancing drug treatment for glioma: a review
Published 2025-04-01“…Exercise not only improves patients’ physical function and cognitive abilities but may also enhance the efficacy of conventional drug treatments by modulating the immune system, suppressing inflammatory responses, and improving blood-brain barrier permeability. …”
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6363
Regulatory effects of Poria cocos polysaccharides on gut microbiota and metabolites: evaluation of prebiotic potential
Published 2025-04-01“…Abstract Dietary polysaccharides have long been recognized for their capacity to modulate gut microbiota composition and metabolic activities, making them promising resources for functional food development. …”
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6364
How Do Cyclodextrins and Dextrans Affect the Gut Microbiome? Review of Prebiotic Activity
Published 2024-11-01“…The modulation of the gut microbiome through dietary components has garnered significant attention for its potential health benefits. …”
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6365
436 Elucidating the role of the rete ovarii in fertility and progesterone signaling
Published 2025-04-01“…We expect this work to reveal that progesterone signaling in the RO is important for regulating ovarian functions and to show that the RO is a critical modulator of female fertility and reproductive function.…”
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6366
An in vitro model for cardiac organoid production: The combined role of geometrical confinement and substrate stiffness
Published 2025-04-01“…Moreover, modulation of environmental mechanical cues showed a significant effect on organoid cardiac features. …”
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6367
ZNF385B as a potential prognostic and immunotherapy biomarker in ovarian cancer: insights from pan-cancer analysis
Published 2025-08-01“…Separately, ZNF385B expression shows a significant correlation with immune cell infiltration in multiple tumor types, implying a potential role in tumor immune modulation and cancer prognosis. These findings provide novel insights into the biological functions of ZNF385B and highlight its potential as a prognostic and immunological biomarker in ovarian and other cancers.…”
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6368
2-O-β-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: inv...
Published 2024-01-01“…The present study provided the evidence that AA-2βG could improve indices of cognition and neuroinflammmation via modulating gut dybiosis and preventing leaky gut. As a potential functional food ingredient, AA-2βG may be applied to attenuate neuroinflammation associated with Western-style diets.…”
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6369
Identification of the xyloglucan endotransglycosylase/hydrolase genes and the role of PagXTH12 in drought resistance in poplar
Published 2024-01-01“…In a population of 549 Populus individuals, functional SNPs in XTH12's coding region did not affect its conserved ExDxE catalytic site, highlighting its irreplaceable function. …”
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6370
The insular cortex-nucleus tractus solitarius glutamatergic pathway involved in acute stress-induced gastric mucosal damage in rats
Published 2025-05-01“…In this study, we examined the expression of neuronal c-Fos, PSD95 and SYN-1 protein expression in IC during RWIS by immunofluorescence and western blot techniques, as well as assessed IC blood oxygenation level dependant (BOLD) through functional MRI. Chemical genetics techniques specifically modulate the activity of IC glutamatergic neurons and IC-nucleus tractus solitary (NTS) glutamatergic pathway to elucidate their contributions to RWIS-induced gastric mucosal damage. …”
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6371
Monopotassium maleate salt stabilizes SnO2 colloid solution for efficient perovskite solar cells
Published 2025-03-01“…Herein, we report a SnO2 modification strategy by using monopotassium maleate (MPM) salt to functionalize the SnO2 nanocrystals. It is demonstrated that MPM can effectively inhibit the agglomeration of SnO2 nanocrystals, thereby improving the conductivity and electron mobility of SnO2 and passivating the defects at the buried SnO2/perovskite interface. …”
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6372
Exercise: a non-drug strategy of NK cell activation
Published 2024-11-01“…Moreover, the interaction between exercise and other components of the immune system, such as cytokines and chemokines, could further modulate the functionality of NK cells. The above research is of crucial significance for achieving a deeper understanding of the intricate connection between exercise and NK cell function, as well as the development of effective health promotion strategies. …”
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6373
Impact of Lifestyle Intervention on HDL-Induced eNOS Activation and Cholesterol Efflux Capacity in Obese Adolescent
Published 2016-01-01“…A correlation between change in eNOS-Ser1177 phosphorylation or RCT and change in endothelial function was noted. Conclusion. A structured lifestyle intervention program improves antiatherosclerotic HDL functions, thereby positively influencing endothelial function.…”
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6374
Towards Explainable Anomaly Detection in Safety-critical Systems: Employing FRAM and SpecTRM in International Space Station Telemetry
Published 2024-10-01“…The methodology is verified and validated through its application to the thermal control system within the ISS's Japanese Experimental Module (JEM), illustrating its capacity to augment diagnostic capabilities and assist flight controllers and specialists in preserving the ISS's functional integrity. …”
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6375
Gut Microbiome and Carotid Artery Intima-Media Thickness: A Narrative Review of the Current Scenario
Published 2024-11-01“…The aim of this narrative review is to investigate the connection between the GM and carotid IMT, encompassing mechanisms like the microbiome impact on metabolite production, and systemic inflammation, and its effects on endothelial function. The literature analysis revealed that the GM appears to exert an influence on carotid IMT development, likely through mechanisms involving metabolites’ production, systemic inflammation, and endothelial function modulation. …”
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6376
Piezo1 activation protects against sepsis-induced myocardial dysfunction in a pilot study
Published 2025-05-01“…A SIMD model was established in mice via intraperitoneal lipopolysaccharide (LPS) injection. Cardiac function, histology, Piezo1 protein expression, and cardiac troponin T (cTnT) were assessed. …”
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6377
Ketogenic therapy for schizophrenia: evidence, mechanisms, and clinical perspectives
Published 2025-06-01“…Mechanistically, ketone bodies enhance mitochondrial function, modulate neurotransmitter systems (GABA, glutamate, dopamine), and reduce inflammation and oxidative stress. …”
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6378
Transcranial vibration stimulation at 40 Hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flow
Published 2025-03-01“…Functional magnetic resonance imaging (fMRI) were performed before and after 5 mins TVS to explore the changes in ALFF and fALFF and the coupling of global brain activity with cerebrospinal fluid flow (CSF), which is related to the glymphatic clearance. …”
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The Role of Astrocytes in the Molecular Pathophysiology of Schizophrenia: Between Neurodevelopment and Neurodegeneration
Published 2025-04-01“…Finally, astrocytes are emerging as potential pharmacological targets for antipsychotics such as clozapine, which may modulate their function by regulating glutamate clearance, redox balance, and synaptic remodeling.…”
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The association of vitamin deficiency with depression risk in late-life depression: a review
Published 2025-04-01“…Specific vitamins, including B-complex vitamins (B1, B6, B9, B12), vitamin D, and antioxidants (C, E), demonstrate therapeutic potential through mechanisms ranging from neurotransmitter regulation to mitochondrial function enhancement. For instance, vitamin D modulates serotonin synthesis and calcium signaling, while B vitamins mitigate homocysteine-mediated neurotoxicity and support energy metabolism. …”
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