Corynebacterium glutamicum for Microbial Production of Chitin Oligosaccharides Using Modular Engineering by Chen Deng, Ruijie Xin, Xingjian Li, Liqiang Fan, Yongjun Qiu, Liming Zhao

“…Furthermore, we fortified the uridine 5′‐diphospho‐N‐acetylglucosamine (UDP‐GlcNAc) synthesis module, vital for CHOS and other functional sugar synthesis, and developed a system for regenerating uridine triphosphate (UTP) precursors. …”
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Evaluation of additional points in the 24-2C visual field test in pre-perimetric glaucoma by Gökhan Çelik, Tuncay Karaçocuk, Furkan Çiftci

“…The relationship between structural and functional parameters was statistically evaluated. Results: The PPG group showed significantly lower RNFL and mGCC thickness values than the healthy group. …”
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Effects of Maternal Stress on the Development of the Somatotropic Axis During the Larval and Juvenile Stages in Zebrafish (<i>Danio rerio</i>) by Maira da Silva Rodrigues, Vinícius Prazeres Barbosa Toledo, Rafael Henrique Nóbrega

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Pyroptosis drives tumor progression and immune evasion in Hepatocellular Carcinoma: a single-cell and spatial transcriptomic study by Siyu Tao, Yunhao Yang

“…However, the limited sample size calls for further validation using larger datasets and multi-omics approaches, such as proteomics and metabolomics, to fully elucidate its functional role in HCC pathogenesis.…”
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Regulatory T Cell in Stroke: A New Paradigm for Immune Regulation by Sheng Chen, Haijian Wu, Damon Klebe, Yuan Hong, Jianmin Zhang, Jiping Tang

“…In this review, we summarized evidence of FoxP3+CD25+CD4+ Tregs as potentially important immunomodulators in stroke pathogenesis and highlight further investigations for possible immunotherapeutic strategies by modulating the quantity and/or functional effects of FoxP3+CD25+CD4+ Tregs in stroke patients.…”
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Left ventricular segmentation method based on optimized UNet and improved CBAM: ESV and EDV tracking study. by Kerang Cao, Miao Zhao, Minghui Geng, Shuai Zheng, Hoekyung Jung

“…This paper introduces an optimized nested UNet model for automated left ventricular segmentation in cardiac function assessment. We utilize the EchoNet-Dynamic dataset, which contains both video data and expert annotations. …”
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Effect of polysaccharide fractions from Fortunella margarita on the fecal microbiota of mice and SCFA production in vitro by Peilin Chen, Suzhen Lei, Mingyao Tong, Qing Chang, Baodong Zheng, Yi Zhang, Hongliang Zeng

“…Polysaccharide fractions could modulate metabolic function of the fecal microbiota, altering the levels of SCFAs. …”
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A Novel Network for Choroidal Segmentation Based on Enhanced Boundary Information by Wenbo Huang, Chaofan Qu, Yang Yan

“…The boundary enhancement module effectively improves the accuracy of choroidal segmentation, while the custom loss function optimizes network performance, increasing both stability and generalization capabilities. …”
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Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis. by David Mellis, Katherine A Staines, Silvia Peluso, Ioanna Ch Georgiou, Natalie Dora, Malgorzata Kubiak, Rob Van't Hof, Michela Grillo, Colin Farquharson, Elaine Kinsella, Anna Thornburn, Stuart H Ralston, Donald M Salter, Natalia A Riobo-Del Galdo, Robert E Hill, Mark Ditzel

“…To investigate a possible role of UBR5 in regulation of the musculoskeletal system through modulation of mammalian HH signaling, we created a mouse model for specific loss of Ubr5 function in limb bud mesenchyme. …”
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Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice. by Shuqiu Zheng, Erin B D Clabough, Sovan Sarkar, Marie Futter, David C Rubinsztein, Scott O Zeitlin

“…Previous investigations into the role of the polyglutamine stretch (polyQ) in htt function have suggested that its length may modulate a normal htt function involved in regulating energy homeostasis. …”
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Immunology &amp; Immune System by Gehlert S, 2, Jacko D

“…Myotube formation, extracellular matrix production and angiogenesis nally contribute to the restoration of the skeletal muscle functional environment. Here, we give a short overview of the major cytokines, modulators and interacting cells that contribute to and coordinate immune responses to promote muscle regeneration. …”
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Computer Simulation of Noise Effects of the Neighborhood of Stimulus Threshold for a Mathematical Model of Homeostatic Regulation of Sleep-Wake Cycles by Wuyin Jin, Qian Lin, An Wang, Chunni Wang

“…The noise effects on a homeostatic regulation of sleep-wake cycles’ neuronal mathematical model determined by the hypocretin/orexin and the local glutamate interneurons spatiotemporal behaviors are studied within the neighborhood of stimulus threshold in this work; the neuronal noise added to the stimulus, the conductance, and the activation variable of the modulation function are investigated, respectively, based on a circadian input skewed in sine function. …”
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The new perspective on understanding the mechanisms of cardiovascular diseases development by Ulyana Khovantseva, Diana Kiseleva, Vadim Cherednichenko, Deyyara Chakal, Denis Breshenkov, Yuliya Markina, Rustam Ziganshin, Eduard Charchyan, Alexander Markin

“…However, scientists have suggested that the main causes of the development of CVD might be functional disorders and phenotypic modulation of smooth muscle cells (SMCs) that make up the vascular wall. …”
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Natural Toolbox–Chemical Engineering Aspect and High‐Value Applications of Janus Cellulose Nanomaterials by Yu Zhao, Shengjie Wang, Zongchen Wei, Shiming Qiu, Guofu Zhou, Jr‐Hau He, Xuezhu Xu

“…This article aims to address the current lack of fundamental mechanistic understanding in Janus cellulose by investigating the intrinsic relationship between structural design and functional performance. Specifically, it begins by elucidating the construction principles of Janus cellulose nanomaterials, with a particular focus on how their asymmetric architectures impart anisotropic physicochemical properties, such as interfacial tension modulation, directional interactions, and selective transport. …”
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Characteristics of B-lymphocyte subpopulations in renal transplant recipients by S. V. Zybleva, S. L. Zyblev

“…The presence of multiple subsets of B-cells with specific regulatory functions capable of modulating inflammatory responses havebeen detected. …”
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An optoelectrochemical synapse based on a single-component n-type mixed conductor by Yazhou Wang, Wentao Shan, Hanrui Li, Yizhou Zhong, Shofarul Wustoni, Johana Uribe, Tianrui Chang, Valentina E. Musteata, Tania Cecilia Hidalgo Castillo, Wan Yue, Haifeng Ling, Nazek El‐Atab, Sahika Inal

“…The conjugated polymer channel, consisting of a fluorinated bisistain-lactone-bithiazole acceptor, has a current modulated in response to both electrical and optical stimuli, emulating the multimodal function of the visual nervous system. …”
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A cryo-shocked M2 macrophages based treatment strategy promoting repair of spinal cord injury via immunomodulation and axonal regeneration effects by Ermei Lu, Kecheng Zhou, Jiansen Miao, Yanlin Zhu, Jiyao Tang, Siting Du, Yanzhen Feng, Linyuan Jiang, Tianyao Jiang, Ting Huang, Ping Li, Xinjun Miao, Qi Han, Jian Xiao

“…The LNT M2-based dual-functional scaffold significantly enhances motor function, reduces neuroinflammation, and accelerates axonal regeneration by modulating the inflammatory microenvironment and preventing the formation of glial and fibrotic scars. …”
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Dietary fiber enhances milk yield in plateau dairy cows via activation of the rumen microbiota-mammary gland axis by Bin Li, Bin Li, Dongxu Wen, Ziwei Zhou, Ziwei Zhou, Quji Suolang, Wangmu Siwang, Lamu Kangji, Tuoxian Tang, Zhenjiang Liu, Yachun Wang, Yachun Wang

“…Milk yield in high-altitude regions such as the Qinghai-Tibet Plateau is low due to hypoxic stress and impaired mammary gland function. This study aims to determine whether a fiber-supplemented diet could increase milk yield in plateau dairy cows through modulating rumen microbiota and downstream metabolic signaling. …”
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Regionally Specific Regulation of Sensorimotor Network Connectivity Following Tactile Improvement by Stefanie Heba, Melanie Lenz, Tobias Kalisch, Oliver Höffken, Lauren M. Schweizer, Benjamin Glaubitz, Nicolaas A. J. Puts, Martin Tegenthoff, Hubert R. Dinse, Tobias Schmidt-Wilcke

“…Correlations between inherent, task-free low-frequency fluctuations in the blood oxygenation level-dependent (BOLD) signals of the brain provide a potent tool to delineate its functional architecture in terms of intrinsic functional connectivity (iFC). …”
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Effect of Rendering Virtual Vibrotactile Motion on the Perceived Lateral Force by Changhyeon Park, Seokmin Hong, Jaeyoung Park

“…Overall, this study suggests that rendering virtual vibrotactile motion at the fingertip during swiping motion can create the sensation of additive lateral force and that the perceived intensity can be controlled by modulating the vibrotactile signal intensity and the signal envelope functions.…”
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