DUSP1 Gene Polymorphisms Are Associated with Obesity-Related Metabolic Complications among Severely Obese Patients and Impact on Gene Methylation and Expression by F. Guénard, L. Bouchard, A. Tchernof, Y. Deshaies, F. S. Hould, S. Lebel, P. Marceau, L. Pérusse, M. C. Vohl

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An electroactive microfluidic platform integrated with AM-pDEP focusing and side-counter design for selective cell sorting and single-cell quantification by Zuyuan Tian, Mohamed Shaheen, Tianxiang Jiang, Shaoxi Wang, Xihua Wang, Jie Chen

“…Recent advances in label-free microfluidic techniques have attempted to overcome these limitations but often suffer from reduced reliability and throughput when integrating multiple functions. Here, we demonstrate an electroactive microfluidic platform that integrates functions of selective concentration, particle focusing, and single-cell level quantification without introducing additional complex physical microstructures. …”
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RNA-Seq analysis reveals the long noncoding RNAs associated with immunity in wild Myotis myotis bats by Sebastien Riquier, Samuel Carthy, Graham M. Hughes, Frederic Touzalin, Wilfried Haerty, Zixia Huang, Emma C. Teeling

“…This initial exploration lays the groundwork for future experimental validations of lncRNA functions, offering promising insights into their role in bat immunity.…”
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Intelligent collaborative management and control platform for continuous mining equipment in open-pit mines by Zhiyong LEI, Xiaolong MA, Shujun ZHAO, Shiming ZHANG, Bin YAN

“…The platform delivers multiple functionalities, including comprehensive multi-machine synchronous monitoring, online fault self-diagnosis, and early warning systems, alongside improved multi-machine cooperative control efficiency. …”
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The ‘Pleasure&Pregnancy’ web-based interactive educational programme versus expectant management in the treatment of unexplained subfertility: protocol for a randomised controlled... by Eline A F Dancet, Thomas M D’Hooghe, Felicia Dreischor, Ellen T M Laan, Cornelius B Lambalk, Sjoerd Repping, Inge M Custers

“…Secondary outcomes include time-to-pregnancy, live birth rate, costs, sexual functioning and personal and relational well-being. …”
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Research Progress in the Treatment of Post-Stroke Aphasia with Theta Burst Stimulation Based on Different Stimulation Targets in the Cerebral Cortex by FANG Qun, DAI Yanhong, WANG Hong, CHEN Zhuoming, GOU Lei

“…Theta burst stimulation (TBS), as a novel non-invasive brain stimulation technique, has potential clinical significance for the recovery of speech function in patients with post-stroke aphasia (PSA) by modulating the excitability of the cerebral cortex. …”
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Adenylate kinase 1 overexpression increases locomotor activity in medaka fish. by Michiyo Maruyama, Yuko Furukawa, Masato Kinoshita, Atsushi Mukaiyama, Shuji Akiyama, Takashi Yoshimura

“…Maintenance of the energy balance is indispensable for cell survival and function. Adenylate kinase (Ak) is a ubiquitous enzyme highly conserved among many organisms. …”
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Plasmalogen deficiency and neuropathology in Alzheimer's disease: Causation or coincidence? by Vijitha Senanayake, Dayan B. Goodenowe

“…Role of lipids, particularly phospholipids, in the optimal function of the nervous system, impact of the aberrations of phospholipid metabolism on β‐amyloid deposition and cholinergic neuronal function, epidemiological evidence on the association of phospholipids with AD, and preliminary data on the possible modulation of risk factors of AD by phospholipids are examined. …”
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Hsa_circ_0005571 promotes the proliferation and invasion of colorectal cancer cells by Haipeng Ge, Jiaxuan Zhang, Ran Tao, Li Ding, Song Jiang, Jiale Shen, Longjun Bian, Jun Qin

“…Bioinformatic predictions and experimental evidence indicated that hsa_circ_0005571 may function as a sponge for miR-520f-3p, which was found to be downregulated in CRC cells. …”
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Beyond what was said: Neural computations underlying pragmatic reasoning in referential communication by Shanshan Zhen, Mario Martinez-Saito, Rongjun Yu

“…Importantly, individual differences in higher-order reasoning were correlated with stronger activation in IFG and AI and positively modulated the vmPFC functional connectivity with AI. …”
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Identification of replicative aging and inflammatory aging signatures via whole-genome CRISPRi screens by Lingling Wu, Xiang Zhu, Yanxia Liu, Dehua Zhao, Betty Chentzu Yu, Zheng Wei, Xueqiu Lin, Lei S. Qi

“…Conclusions The signatures verified through comprehensive functional genomics and genetic analyses may provide new targets for modulating the aging process and enhancing the quality of cell therapy products.…”
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All‐in‐one perovskite memristor with tunable photoresponsivity by Guan‐Hua Dun, Yuan‐Yuan Li, Hai‐Nan Zhang, Fan Wu, Xi‐Chao Tan, Ken Qin, Yi‐Chu He, Ze‐Shu Wang, Yu‐Hao Wang, Tian Lu, Shi‐Wei Tian, Dan Xie, Jia‐Li Peng, Xiang‐Shun Geng, Xiao‐Tong Zhao, Jia‐He Zhang, Yu‐Han Zhao, Xiaoyu Wu, Ning‐Qin Deng, Zheng‐Qiang Zhu, Yan Li, Xian‐Zhu Liu, Xing Wu, Weida Hu, Peng Zhou, Yang Chai, Mario Lanza, He Tian, Yi Yang, Tian‐Ling Ren

“…Abstract Photoelectric memristors have shown great potential for future machine visions, via integrating sensing, memory, and computing (namely “all‐in‐one”) functions in a single device. However, their hard‐to‐tune photoresponse behavior necessitates extra function modules for signal encoding and modality conversion, impeding such integration. …”
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Role of GnRH Neurons and Their Neuronal Afferents as Key Integrators between Food Intake Regulatory Signals and the Control of Reproduction by Juan Roa

“…Reproductive function is regulated by a plethora of signals that integrate physiological and environmental information. …”
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Processing of orthogonal frequency-compensated signals transmitted via communication channels with fading by V. P. Tuzlukov

“…Thus, the classical methods for determining the generating function of moments can be directly used to determine the exact mathematical representation of the probability of error receiving signals for various types of modulation and diversity of signals.…”
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Non-Targeted Metabolomics Analysis Reveals Metabolite Profiles Change During Whey Fermentation with <i>Kluyveromyces marxianus</i> by Yansong Gao, Lei Gao, You Kang, Ge Yang, Zijian Zhao, Yujuan Zhao, Shengyu Li

“…<b>Background:</b> Whey fermentation could produce bioactive substances with immunomodulatory effects, metabolic syndrome modulation, and antioxidant properties, thereby imparting functional characteristics to products and facilitating the development of novel foods with health-promoting potential. …”
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Comparative reactivity of hypohalous acids with proteins: Chemistry, biological effects and consequences by Els A. Hartsema, Helen Hemmling, Clare L. Hawkins

“…This review describes the reactivity of HOX with proteins, including the mechanisms involved in the modification of specific amino acid residues, and how this contributes to structural and functional changes. We describe potential pathways by which modification of proteins by HOX contribute to disease and outline some strategies to modulate this type of damage therapeutically.…”
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Impact of estrogen on morphology and programmed cell death in the meibomian glands of rats by Vinícius da Silva Varandas, Caio Brenno Abreu, Márcio Penha Morterá Rodrigues, Christina Maeda Taliya, Artur Marin Varandas, Adroaldo de Alencar Costa Filho

“…Conclusion: Estrogen likely modulates lacrimal gland function and tear film stability. …”
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Exploiting Interlimb Arm and Leg Connections for Walking Rehabilitation: A Training Intervention in Stroke by Taryn Klarner, Trevor S. Barss, Yao Sun, Chelsea Kaupp, Pamela M. Loadman, E. Paul Zehr

“…Nineteen chronic stroke (>six months) participants were recruited and performed 30 minutes of A&L cycling training three times a week for five weeks. Changes in walking function were assessed with (1) clinical tests; (2) strength during isometric contractions; and (3) treadmill walking performance and cutaneous reflex modulation. …”
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Comprehensive genetic dissection of the hemocyte immune response in the malaria mosquito Anopheles gambiae. by Fabrizio Lombardo, Yasmeen Ghani, Fotis C Kafatos, George K Christophides

“…The development of robust functional cell-based assays paves the way for genome-wide functional screens to study the mosquito immune response to infections with human pathogens.…”
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Biomolecular phase separation in tumorigenesis: from aberrant condensates to therapeutic vulnerabilities by Lan Hu, Zikun Huang, Zhaoyong Liu, Ying Zhang

“…Abstract Biomolecular phase separation has emerged as a fundamental mechanism governing intracellular spatial organization and functional compartmentalization, and is increasingly recognized as a critical factor in tumor initiation and progression. …”
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