Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk betwee... by Karen L G Farizatto, Uzoma S Ikonne, Michael F Almeida, Merari F R Ferrari, Ben A Bahr

“…Unexpectedly, the proteasomal augmentation was significantly pronounced in Aβ42-compromised slices, while absent in lactacystin-treated tissue, resulting in >2-fold improvement for nearly complete recovery of proteasome function by the CatB-enhancing compound. The PADK treatment also reduced Aβ42-mediated tau phosphorylation and synaptic marker declines, corresponding with the positive modulation of both proteasome activity and the lysosomal CatB enzyme. …”
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Impact of Poly(Lactic Acid) and Graphene Oxide Nanocomposite on Cellular Viability and Proliferation by Karina Torres Pomini, Júlia Carolina Ferreira, Laira Mireli Dias da Silva, Paulo Gabriel Friedrich Totti, Monique Gonçalves Alves, Eliana de Souza Bastos Mazuqueli Pereira, Marcelo Melo Soares, Durvanei Augusto Maria, Rose Eli Grassi Rici

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Aerobic exercise alleviates cognitive impairment in T2DM mice through gut microbiota by Shuping Ruan, Juan Liu, Xiaoqing Yuan, Xinhua Ye, Qing Zhang

“…Additionally, transplantation of intestinal microbiota from exercised mice improved cognitive function in T2DM mice. Aerobic exercise may mitigate cognitive impairment in T2DM mice by modulating the gut microbiota. …”
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FAULT DIAGNOSIS OF ROLLING BEARING BASED ON LEARNING SAMPLE SELECTION VIA CORRELATION ENERGY FLUCTUATION EVALUATION AND DEEP BELIEF NEURAL NETWORK (MT) by QIN Bo, LUO QuanYi, FENG WeiWei, ZHANG Peng, ZHAO ZhenHua, LI ZiXian, WANG Zhuo

“…First, aiming at the time-varying modulation characteristics of the rolling bearing vibration signal, a finite number of intrinsic mode function components were decomposed using variational mode decomposition, which represents different components of the original signal. …”
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Radiosensitizing effects of Withaferin A in gastric cancer cells via autophagy Inhibition and mitochondrial disruption by Ping Lu, Juan Xue, Xuemeng JI

“…Withaferin A (WA), a bioactive compound from Withania somnifera, has anticancer effects and can modulate cellular processes like autophagy and mitochondrial function. …”
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KAN-ResNet-Enhanced Radio Frequency Fingerprint Identification with Zero-Forcing Equalization by Hongbo Chen, Ruohua Zhou, Qingsheng Yuan, Ziye Guo, Wei Fu

“…The module combines the B-spline basis function and the traditional activation function Sigmoid Linear Unit (SiLU) to realize the nonlinear mapping of the complex function, which enhance the classification ability of the network for RFF features. …”
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Nitric oxide in exercise physiology: past and present perspectives by Breanna J. Mueller, Michael D. Roberts, Christopher B. Mobley, Robert L. Judd, Andreas N. Kavazis

“…This review focuses on the modulation of skeletal muscle function, mitochondrial adaptation and function, redox state by NO, and the effect of nitrate supplementation on exercise performance. …”
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A dendritic hexamer acceptor enables 19.4% efficiency with exceptional stability in organic solar cells by Tao Jia, Tao Lin, Yang Yang, Lunbi Wu, Huimin Cai, Zesheng Zhang, Kangfeng Lin, Yulong Hai, Yongmin Luo, Ruijie Ma, Yao Li, Top Archie Dela Peña, Sha Liu, Jie Zhang, Chunchen Liu, Junwu Chen, Jiaying Wu, Shengjian Liu, Fei Huang

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Induced zero-phase synchronization as a potential neural code for optimized visuomotor integration by Kirstin-Friederike Heise, Geneviève Albouy, Nina Dolfen, Ronald Peeters, Dante Mantini, Stephan P. Swinnen

“…Methods: Participants received transcranial alternating current stimulation over bilateral motor cortices (M1) while performing a visually-guided force adjustment task during functional magnetic resonance imaging. Results: Inter-hemispheric zero-phase entrainment resulted in effector-specific modulation of performance precision and effector-generic minimization of force signal complexity paralleled by BOLD activation changes in bilateral caudate and increased functional connectivity between the right M1 and contralateral putamen, inferior parietal, and medial temporal regions. …”
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Amphoteric coplanar conjugated molecules enabling efficient and stable perovskite/silicon tandem solar cells by Dan Yang, Bita Fahadi, Xiao Jia, Shiqi Rong, Qingshun Dong, Wenming Tian, Xiao Jiang, Zhe Yan, Shaojuan Bao, Jilei Wang, Minyong Du, Ke Tao, Xu Zhang, Kai Wang, Jing Ma, Shengzhong Liu

“…The inductive effects among the functional groups within the ACCM allow it to exist in various ionic forms. …”
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Space Imaging of Six-Wave Mixing in a Rydberg Dressing Atomic Ensemble by Junling Che, Jintao Bai, Yanpeng Zhang

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MiR-147b-3p promotes osteogenesis by targeting NDUFA4 and PI3K/AKT pathway by Yuanyuan Guo, Kai Shen, Zhijie Li, Changchun Niu, Yang Luo

“…Therefore, further investigation is warranted to elucidate the function and underlying mechanism of miR-147b-3p in osteogenic differentiation. …”
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Bactericidal Properties of Modular Protective Materials by V. V. Zavyalov, N. V. Zavyalova, V. I. Kholstov, V. A. Kovtun, V. K. Gorelenkov, G. A. Frolov, I. V. Lyagin, N. A. Stepanov, E. N. Efremenko, A. G. Frolov

“…The bactericidal properties depended on the chosen method of fibrous material functionalization. Due to the principle of modular construction of materials with desired properties, it turned out to be possible to use organometallic composites with complexes of metal nanoparticles introduced into them. …”
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A precise Bicoid gradient is nonessential during cycles 11-13 for precise patterning in the Drosophila blastoderm. by Elena M Lucchetta, Meghan E Vincent, Rustem F Ismagilov

“…Recent work has emphasized the stability of the Bicoid gradient as a function of egg length and the role of nuclear dynamics in maintaining the Bicoid gradient. …”
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AMPA GluA1-flip targeted oligonucleotide therapy reduces neonatal seizures and hyperexcitability. by Nicole M Lykens, David J Coughlin, Jyoti M Reddi, Gordon J Lutz, Melanie K Tallent

“…Due to the critical nature of AMPA-Rs in normal brain function, typical AMPA-R antagonists have deleterious effects on cognition and motor function, highlighting the need for more precise modulators. …”
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Lipoxin A4 analogue, BML-111, reduces platelet activation and protects from thrombosis by Shatha AlOmar, Joanne L Mitchell, Eman AlZahrani

“…Hence, we sought to study the role of FPR2/ALX ligand and lipoxin A4 lipid analogue, BML-111, in the modulation of platelet function and thrombus formation. …”
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Integrating necroptosis into pan-cancer immunotherapy: a new era of personalized treatment by Yan Gao, Sheng Chen, Lei Li

“…Functional experiments demonstrated that HMGB1 knockdown significantly suppressed tumor proliferation and malignancy, reinforcing the therapeutic potential of targeting necroptosis. …”
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Adverse Effects of Nicotine on Human Sperm Nuclear Proteins by Amir Masoud Firouzabadi, Ralf Henkel, Maryam Tofighi Niaki, Farzaneh Fesahat

“…However, only a few studies have highlighted the direct effects of nicotine on sperm function. Nicotine, as a chemical compound found in tobacco, has been shown to modulate different aspects of spermatogenesis and sperm functions. …”

Thermal behavior of the Klein Gordon oscillator in a dynamical noncommutative space by Ilyas Haouam

“…These properties are determined via the partition function, which is derived using the Euler–Maclaurin formula. …”
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Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures. by Aubrey Converse, Madeline J Perry, Shweta S Dipali, Jose V V Isola, Emmett B Kelly, Joseph M Varberg, Mary B Zelinski, Michael B Stout, Michele T Pritchard, Francesca E Duncan

“…These findings implicate MNGCs in modulation of the ovarian immune landscape during aging given their high penetrance and unique molecular signature that supports degradative and immune functions.…”
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