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6261
Parsing social context in auditory forebrain of male zebra finches.
Published 2025-01-01“…Impediments to long-term single unit recordings in awake-behaving animals include tradeoffs between weight, functional flexibility, expense, and fabrication difficulty in microdrive devices. …”
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6262
A salt-tolerant growth-promoting phyllosphere microbial combination from mangrove plants and its mechanism for promoting salt tolerance in rice
Published 2024-12-01“…However, the characteristics of microbial communities in the phyllosphere of mangrove species with and without salt glands and the differences between them remain unknown, and the exploration and the agricultural utilization of functional microbial resources from the leaves of mangrove plants are insufficient. …”
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6263
Unraveling the role of GPCR signaling in metabolic reprogramming and immune microenvironment of lung adenocarcinoma: a multi-omics study with experimental validation
Published 2025-06-01“…Further, adrenomedullin inhibited CD8+ T cells proliferation, induced exhaustion, and impaired cytotoxic function. Finally, drug sensitivity and cell viability analysis showed LUAD patients with high levels of ADM exhibited sensitivity to the treatment of Staurosporine and Dasatinib.ConclusionsIn summary, this study reveals the pivotal role of GPCR signaling particularly mediated by ADM in orchestrating metabolic reprogramming and immune modulation in LUAD. …”
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6264
Investigating the prevalence of CRISPR-Cas system and their association with antibiotic resistance genes and virulence factors in Enterococcus faecalis and Enterococcus faecium str...
Published 2025-06-01“…Conservation analyses of CRISPR1-Cas csn1 and CRISPR3-Cas csn1 genes revealed conserved regions potentially linked to functional activity. Furthermore, CRISPR-Cas repeat-spacer array were correlated with specific antimicrobial resistance phenotypes and genotypes, as well as with virulence factors. …”
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6265
Identification of natural compounds as potential inhibitors of Interleukin-23: virtual screening, ADMET, drug-likeness, and dynamic simulation
Published 2025-04-01“…Several well-characterized phytochemicals, including sulforaphane, resveratrol, and curcumin, have demonstrated efficacy in inhibiting the production and function of Th17 cells, which are regulated by IL-23. …”
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6266
The role of melatonin in the regulation of the immune system and reproductive health: mechanisms and prospects for clinical application
Published 2025-04-01“…It plays a critical role in maintaining immune homeostasis by reducing oxidative stress, modulating cytokine production, and enhancing immune cell function, thereby offering protection against infections and inflammatory disorders. …”
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6267
A Novel Approach to Approximating Generalized Pointing Errors Modeled by Beckmann Distribution in FSO Communication Systems
Published 2025-01-01“…These unified formulations are applicable to intensity modulation with direct detection and heterodyne detection methods, and are expressed using the generalized Meijer's-G function. …”
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6268
Discovery of genes that positively affect biomass and stress associated traits in poplar
Published 2024-10-01“…Such dominant forward genetics approaches can aid in biotechnological manipulation of woody biomass traits and help unravel the functions and mechanisms of individual genes, gene families, and regulatory modules.…”
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6269
An updated non-intrusive, multi-scale, and flexible coupling interface in WRF 4.6.0
Published 2025-02-01“…The present paper details the development and the functionalities of the coupling interface we implemented in WRF. …”
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6270
The Interplay between Reproductive Social Stimuli and Adult Olfactory Bulb Neurogenesis
Published 2014-01-01“…We will point out that newborn interneurons in the accessory olfactory bulb (AOB) represent a privileged cellular target for social stimuli that elicit reproductive behaviors and that such cues modulate adult neurogenesis at two different levels increasing both proliferation of neuronal progenitors in the germinative regions and integration of newborn neurons into functional circuits. …”
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6271
P05 | ENTERIC NERVOUS SYSTEM NEUROPLASTICITY IN COLON OF ANIMAL MODELS OF OBESITY
Published 2025-08-01“…Using different markers through immunohistochemical and immunochemical techniques, the morphological and functional modulations of the heterogeneous neuronal population of the gut wall were evaluated and the histological damage, neurodegeneration, and pro-inflammatory cytokines expression were detected on the colon. …”
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6272
REENGINEERING OF OPEN SOFTWARE SYSTEM OF 3D MODELING BRL-CAD
Published 2019-09-01“…The purpose of the work is to perform reengineering (evolutionary improvement while maintaining the positive qualities that are confirmed by the operation) of an open-source three-dimensional software system with inheritance of full functionality and principles of operation. BRL-CAD is a specialized open source cross-platform system that is a powerful 3D computer aided design system for bulk body modeling. …”
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6273
Development of an automated quality control and assay performance management system for biochemical genetics laboratory
Published 2025-09-01“…Results: This QC program has modules for different assay platforms. The program's functions include automated collection and assay data analysis, Levey-Jennings charts with integrated data from multiple instruments, graphical data visualization, instrument data centralization, assay monitoring, and a QC audit trail. …”
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6274
EDUCATIONAL TRAINING SIMULATOR FOR MONITORING READING TECHNIQUE AND SPEED BASED ON SPEECH-TO-TEXT (STT) METHODS
Published 2024-10-01“…The architecture of the proposed system consists of the following modules: preparation module, which ensures the correct functioning of the system regardless of the existing speech disorders; the speech-to-text converter directly converts the voice of the child reading the text on the gadget screen into text; The text comparison module is responsible for comparing the text read aloud with the text obtained as a result of conversion. …”
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6275
Integrated Analysis of Ferroptosis- and Cellular Senescence-Related Biomarkers in Atherosclerosis Based on Machine Learning and Single-Cell Sequencing Data
Published 2025-07-01“…Enrichment and immune infiltration analyses were used to investigate the biological functions and immune features of subtype-specific differentially expressed genes. …”
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6276
Integrated mRNA and miRNA Omics Analyses Reveal Transcriptional Regulation of the Tolerance Traits by <i>Aquatica leii</i> in Response to High Temperature
Published 2025-03-01“…This indicates that starting at 28 °C, <i>A. leii</i> needs to maintain normal cellular physiological functions by regulating ligand–receptor binding and signal transduction. …”
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6277
Simulation of Vertical Movements of Seawater in Stratified Reservoirs
Published 2023-07-01“…This is open-source software that provides not only the redefinition of empirical dependences (as algebraic functions), but also the connection of external simulating modules to display dependences algorithmically.Discussion and Conclusion. …”
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6278
Power Distribution in Transmissions of Forestry and Transport Wheeled Vehicles
Published 2025-08-01“…It has been shown that kinematic and force analysis makes it possible to evaluate the influence of mechanical forces and movements on the functioning of the device. The points on the main links of the mechanism have been identified to ensure the reliability and efficiency of the design. …”
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6279
Integrative machine learning and bioinformatics analysis to identify cellular senescence-related genes and potential therapeutic targets in ulcerative colitis and colorectal cancer
Published 2025-07-01“…In addition, immune cell infiltration, protein–protein interaction (PPI) networks, and drug enrichment analyses—including molecular docking—were performed to further elucidate the biological functions and therapeutic potentials of the identified genes.ResultsOur analysis revealed significant transcriptomic alterations in UC and CRC tissues, with the turquoise module demonstrating the strongest association with disease traits. …”
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6280
3D IntelliGenes: AI/ML application using multi-omics data for biomarker discovery and disease prediction with multi-dimensional visualization
Published 2025-08-01“…Results The overall functionality of 3D IntelliGenes is divided into two modules, data clustering and feature plotting. …”
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