Herbal extract fermented with inherent microbiota improves intestinal health by exerting antioxidant and anti-inflammatory effects in vitro and in vivo by Mara Heckmann, Nadiia Sadova, Georg Sandner, Cathrina Neuhauser, Bernhard Blank-Landeshammer, Bettina Schwarzinger, Alice König, Meizhen Liang, Michael Spitzer, Julian Weghuber, Verena Stadlbauer

“…Abstract Background Maintaining intestinal health is crucial for the overall well-being and productivity of livestock, as it impacts nutrient absorption, immune function, and disease resistance. Oxidative stress and inflammation are key threats to intestinal integrity. …”
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SKIL Promotes Pancreatic Cancer Metastasis by Inhibiting TSPYL2 to Activate the TGF‐β Pathway by Chenxi Wang, Weiwei Song, Yixuan Zhang, Hongming Deng, Zixiang Zhou, Jing Zhu, Xiaobing Wang

“…SKIL, known to promote cancer progression, is implicated in cell proliferation, epithelial–mesenchymal transition (EMT), and metastasis, but its specific function in pancreatic cancer remains unclear. Methods We investigated the effects of SKIL on the proliferation, apoptosis, and metastasis of pancreatic cancer cells. …”
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Mesenchymal Stem Cell–Sourced Exosomes as Potentially Novel Remedies for Severe Dry Eye Disease by Carl Randall Harrell, Valentin Djonov, Ana Volarevic, Aleksandar Arsenijevic, Vladislav Volarevic

“…Severe dry eye disease (DED) is an inflammatory condition characterized by a lack of sufficient moisture or lubrication on the surface of the eye, significantly impacting the quality of life and visual function. Since detrimental immune response is crucially responsible for the development and aggravation of DED, therapeutic agents which modulate phenotype and function of eye-infiltrated inflammatory immune cells could be used for the treatment of severe DED. …”
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DNA–Protein Binding is Dominated by Short Anchoring Elements by Hong Chen, Yongping Xu, Hao Ge, Xiao‐Dong Su

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Surface enzyme-polymerization endows Janus hydrogel tough adhesion and regenerative repair in penetrating orocutaneous fistulas by Ye Ju, Chunyue Ma, Ling Ding, Mingyue Shi, Xia Wang, Dongbei Wu, Qing Wu, Xingjun Qin, Qigang Wang

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Individualized transcranial temporal interference stimulation (tTIS) for cognitive impairments and negative symptoms in patients with schizophrenia: a study protocol for a randomiz... by Shuzhe Wang, Junhao Chen, Linxuan Wang, Jingxuan Liu, Lijun Wang, Wenjie Sun, Shen Li, Jie Li

“…We hypothesize that participants receiving active tTIS will demonstrate significantly greater improvements in cognitive function and negative symptoms compared to those receiving sham stimulation. …”
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Toward measurements of absolute membrane potential in Bacillus subtilis using fluorescence lifetime by Debjit Roy, Xavier Michalet, Evan W. Miller, Kiran Bharadwaj, Shimon Weiss

“…Membrane potential (MP) changes can provide a simple readout of bacterial functional and metabolic state or stress levels. While several optical methods exist for measuring fast changes in MP in excitable cells, there is a dearth of such methods for absolute and precise measurements of steady-state MPs in bacterial cells. …”
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Host immune response mediates changes in cagA copy number and virulence potential of Helicobacter pylori by Sungil Jang, Lori M. Hansen, Hanfu Su, Jay V. Solnick, Jeong-Heon Cha

“…PMSS1 recovered from Rag1−/− mice, lacking functional T or B cells, retained more cagA copies. …”
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Impact of intragastric administration of donkey milk on mouse immunity utilizing gut microbiomics and plasma metabolomics by Jianwen Wang, Jianwen Wang, Wanlu Ren, Zhiwen Sun, Shibo Liu, Zixiang Han, Yongfa Wang, Yaqi Zeng, Yaqi Zeng, Jun Meng, Jun Meng, Xinkui Yao, Xinkui Yao

“…This study systematically investigated the effects of donkey milk supplementation on murine immune function and gut microbiome dynamics, thereby providing mechanistic insights to support its clinical development in functional food applications.MethodsFollowing daily intragastric administration of 10 mL/kg of body weight of donkey milk (DM) or distilled water (DW) to the mice for 28 consecutive days, liver tissues were harvested for immunological profiling, with concurrent collection of blood samples for plasma metabolomic analysis and fecal specimens for gut microbiome characterization. …”
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Clinical Outcomes and Optical Bench Analysis of a Novel Enhanced Monofocal Intraocular Lens by Giovanni Romualdi, Matilde Buzzi, Pier Giuseppe Ruggeri, Federico Tommasi, Alessio Giorgetti, Stefano Cavalieri, Rita Mencucci

“…Optical quality was also analyzed in terms of higher-order aberrations (HOAs), modulation transfer function (MTF), objective scatter index (OSI), Strehl ratio, effective lens position (ELP), and halo analysis. …”
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Diets shape thermal responses in Chinese giant salamanders by altering liver metabolism by Runliang Zhai, Runliang Zhai, Chunlin Zhao, Liming Chang, Liming Chang, Jiongyu Liu, Tian Zhao, Jianping Jiang, Jianping Jiang, Wei Zhu, Wei Zhu

“…While both temperature and diet shape microbiota composition, functional shifts occur only in response to temperature, indicating that the microbiota is not a major link between diet and liver metabolism. …”
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Phospholipase C Beta 2 as a Key Regulator of Tumor Progression and Epithelial-Mesenchymal Transition via PI3K/AKT Signaling in Renal Cell Carcinoma by Shijin Wang, Deqian Xie, Hongzhe Yue, Guandu Li, Bowen Jiang, Yaru Gao, Zunwen Zheng, Xu Zheng, Guangzhen Wu

“…This enzyme plays a vital role in managing key cellular functions such as growth, differentiation, migration, and survival. …”
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Membrane charge primes the necroptotic kinase RIPK3 for amyloid assembly by Fátima C. Escobedo-González, Andrea Gelardo, Alexandra Reimers, Paula Polonio, Miguel Mompeán, Gustavo A. Titaux-Delgado

“…Abstract Receptor-interacting protein kinase 3 (RIPK3) drives necroptosis by assembling into functional amyloid fibrils. Here we show that lipids modulate RIPK3 amyloidogenesis by stabilizing an aggregation-prone intermediate. …”
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Life Pattern-Based Human Attribute Estimation Using Only GPS Data by Kazuyuki Shoji, Haru Terashima, Naoki Tamura, Shin Katayama, Kenta Urano, Takuro Yonezawa, Nobuo Kawaguchi

“…However, existing methods analyze sequences of individual-derived stay labels, such as home or workplace, which do not accurately reflect actual area functions and can fail to distinguish individuals based on differences in workplaces. …”
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LSN-GTDA: Learning Symmetrical Network via Global Thermal Diffusion Analysis for Pedestrian Trajectory Prediction in Unmanned Aerial Vehicle Scenarios by Ling Mei, Mingyu Fu, Bingjie Wang, Lvxiang Jia, Mingyu Yu, Yu Zhang, Lijun Zhang

“…This framework symmetrically distributes the semantic segmentation and trajectory prediction modules, enhancing the overall functionality of the network. …”
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Dynamic Network Drivers of Seizure Generation, Propagation and Termination in Human Neocortical Epilepsy. by Ankit N Khambhati, Kathryn A Davis, Brian S Oommen, Stephanie H Chen, Timothy H Lucas, Brian Litt, Danielle S Bassett

“…The epileptic network is characterized by pathologic, seizure-generating 'foci' embedded in a web of structural and functional connections. Clinically, seizure foci are considered optimal targets for surgery. …”
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Deciphering the methylation landscape of long noncoding RNAs in hepatocellular carcinoma: a focus on LINC00942 by Zhaoqi Shi, Xiaolong Liu, Duguang Li, Jing Yang, Haonan Chen, Hui Lin, Xiaoxiao Fan

“…Conclusions A substantial quantity of lncRNAs is transcriptionally modulated by methylation in HCC. The demethylation of LINC00942 within its promoter region facilitates the upregulation of LINC00942 expression, thereby contributing to its function as an oncogene in HCC.…”
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Integration of Transcriptomic Analysis, Network Pharmacology, and Experimental Validation Demonstrates Enhanced Muscle-Protective Effects of Ethanol Extract of Jakyak-Gamcho-Tang by Aeyung Kim, Minh Nhat Tran, A Yeong Lee, Heerim Yeo, Su-Jin Baek, No Soo Kim, Seongwon Cha, Sang-Min Park

“…Functional assays demonstrated that under oxidative stress conditions, JGT-E preserved mitochondrial content more effectively, reduced reactive oxygen species levels, and enhanced both myoblast viability and myotube integrity. …”
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Integrative Identification of Chloroplast Metabolism-Related RETICULATA-RELATED Genes in Soybean by Qianli Dong, Lu Niu, Xiyu Gong, Qianlong Xing, Jie Liang, Jun Lang, Tianya Wang, Xiangdong Yang

“…RETICULATA-RELATED (RER), known to regulate chloroplast function and plastid metabolism in Arabidopsis, plays an essential role in leaf development. …”
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Effect of Raspberry (<i>Rubus indeaus</i> L.) Juice Fermented by <i>Limosilactobacillus fermentum</i> FUA033 on the Human Gut Microbiota Cultured In Vitro: A Multi-Omics Approach by Ziyan Hua, Yunfan Lv, Han Zhang, Tianyi Mao, Ruyu Xv, Mingxuan Pan, Yadong Hu, Shu Liu, Yaowei Fang

“…The modulation of the gut microbiota through dietary interventions has emerged as a promising approach, leading to significant interest in the development of functional foods that provide health benefits. …”
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