Cardiac fibroblast-mediated ECM remodeling regulates maturation in an in vitro 3D engineered cardiac tissue by Yongjun Jang, Myeongjin Kang, Yong Guk Kang, Dongtak Lee, Hyo Gi Jung, Dae Sung Yoon, Jongseong Kim, Yongdoo Park

“…In this study, we investigated the functional and structural maturation of engineered cardiac tissue by modulating fibroblast activity within a three-dimensional (3D) in vitro model. …”
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Decoding cortical chronotopy—Comparing the influence of different cortical organizational schemes by Falko Mecklenbrauck, Jorge Sepulcre, Jana Fehring, Ricarda I. Schubotz

“…Based on this data, we extracted six organizational schemes: (1) the structural Rich Club (RC) architecture, shown to synchronize the connectome; (2) the structural Diverse Club architecture, as an alternative to the RC based on the network's module structure; (3) the functional uni-to-multimodal gradient, reflected in a wide range of structural and functional features; and (4) the spatial posterior/lateral-to-anterior/medial gradient, established for hierarchical levels of cognitive control. …”
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Dietary inclusion of cyanobacteria Arthrospira (Spirulina platensis) spp. decreases the aggravating effect of hemin from red meat in a rat colorectal carcinogenesis model by Luis Manuel Sarmiento-Machado, Simone Oliveira Amadeu, Nelci Antunes de Moura, Luciana Azevedo, Luis Fernando Barbisan

“…(AP) is a cyanobacteria employed as a functional food with the potential to reduce malnutrition in developing countries. …”
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Sports Medicine in Transition by Ticinesi A, 2, Tana C, Nouvenne A, Meschi T, 2

“…KEY WORDS: Microbiota, Sarcopenia, Mobility Limitations, Aging, Inflammation, Muscle Mass, Muscle Function…”
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PDE3B and HBB are key prognostic biomarkers driving cell proliferation and regulating immune microenvironment in breast cancer by Bolong Yin, Xiangrong Luo, Xuebo Yan, Hui Shen, Jianping Jiang

“…This study explores the prognostic and functional roles of PDE3B and HBB in breast cancer, focusing on their contributions to proliferation and immune microenvironment modulation. …”
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Heat-killed Lactobacillus paracasei JY56 can relieve ovalbumin-induced food allergy via regulating immuno-inflammatory responses and gut microbiota by Miao Zheng, Ming Ma, Ruxue Fang, Yilin Sun, Xinyan Yang, Chaoxin Man, Qianyu Zhao, Yujun Jiang

“…Moreover, jejunal histological analysis and intestinal barrier function related gene expression measurement were performed to verify the intestinal barrier repair of HK-L. paracasei JY56. …”
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Auts2 enhances neurogenesis and promotes expansion of the cerebral cortex by Cédric Boucherie, Maisa Alkailani, Yves Jossin, Nuria Ruiz-Reig, Asma Mahdi, Arwa Aldaalis, Mohamed Aittaleb, Fadel Tissir

“…Introduction: The AUTS2 gene is associated with various neurodevelopmental and psychiatric disorders and has been suggested to play a role in acquiring human-specific traits. Functional analyses of Auts2 knockout mice have focused on postmitotic neurons, and the reported phenotypes do not faithfully recapitulate the whole spectrum of AUTS2-related human diseases. …”
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Enhancing the effects of nusinersen with cybernic treatment using Hybrid Assistive Limb (HAL) in spinal muscular atrophy: a real-world case series and exploratory cohort analysis by Takashi Nakajima, Toshio Saito, Akihiro Hashiguchi, Taiki Nakabayashi, Kazuki Kodera, Kota Utsumi, Takeshi Kanayama, Haruka Urabe, Satoru Kinoshita

“…Functional improvement indicators included the Hammersmith Functional Motor Scale-Expanded (HFMSE) and Revised Upper Limb Module (RULM) scores, and the 2-minute walk test (2MWT), measured 15 months post-nusinersen initiation. …”
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Multi-omics-based construction of a palmitoylation-driven prognostic model reveals tumor immune phenotypes in osteosarcoma by Jingyu Chen, Feihu Chen, Haiping Zhang, Yuanlong Hu, Xingyu Zhou, Xijia Weng, Guofeng Bao, Xiaomin Ding

“…However, its prognostic value and functional role in OS remain unclear. Methods Transcriptomic and clinical data from the TARGET and GEO cohorts were used to identify palmitoylation-related prognostic genes. …”
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Development and testing of range of motion driven motor unit recruitment device for knee rehabilitation: A randomized controlled trial by Manoj Kumar Sharma, Sarika Chaudhary, Shweta Shenoy

“…Such advancements would not only improve muscle strengthening outcomes but also enhance participant adherence through more effective cortical and peripheral neuromuscular engagement. • Development of neuromuscular electrical stimulation (NMES) device to replicate natural neuromuscular activation patterns through bio-inspired stimulation protocols. • Engineered to mitigate existing limitations of conventional NMES systems, optimizing therapeutic applications for neuromuscular re-education and functional recovery. • Integrates muscle synergy principles, enabling synchronized synergistic, agonist and antagonist activation for enhanced cortical and peripheral neuromuscular engagement and optimize functional rehabilitation outcomes. • Advances rehabilitation strategies by combining dual focus on muscular reconditioning and neural adaptation for holistic recovery. • Demonstrates potential to amplify strength gains while fostering neuroplasticity, supporting long-term functional recovery in neuromuscular rehabilitation.…”
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Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-Analysis by Michael Vincent DiCaro, Brianna Yee, KaChon Lei, Kavita Batra, Buddhadeb Dawn

“…The anti-inflammatory and immune modulating properties of mesenchymal stem cells (MSCs) may prove useful in inducing functional cardiac regeneration following acute MI. …”
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Automatic Grading for Complex Multifile Programs by Tiantian Wang, Djoko Budi Santoso, Kechao Wang, Xiaohong Su

“…Next, standardization process is performed for problematic code removal, unused function removal, and function sequence ordering based on function call. …”
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Dissociated Steroids by Matthew C. Catley

“…Compounds that can dissociate the transactivation function of GCs from the transrepression function may, therefore, have an improved therapeutic index. …”
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A mixed methods pilot feasibility study of the unified protocol group psychotherapy for early bipolar disorder by Magnus Johan Engen, Siv Hege Lyngstad, Erlend Eikenæs, Jon Vøllestad, Margrethe Collier Høegh, Trine Vik Lagerberg, Trine Vik Lagerberg, Sofie Ragnhild Aminoff

“…Quantitative findings indicated significant improvements in affective lability, overall functioning, and well-being. Qualitative findings highlighted participants’ appreciation for the structured format and peer support from the group, which facilitated exploration of emotional experiences and skills practice. …”
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The power of small signaling peptides in crop and horticultural plants by Chao Ji, Hui Li, Zilin Zhang, Shuaiying Peng, Jianping Liu, Yong Zhou, Youxin Yang, Huibin Han

“…The physiological functions of small signaling peptides are implicated in a multitude of developmental processes and adaptive responses, including but not limited to, shoot and root morphogenesis, organ abscission, nodulation, Casparian strip formation, pollen development, taproot growth, and various abiotic stress responses such as aluminum, cadmium, drought, cold, and salinity. …”
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Anti-Chemical Properties of Modular Protective Material by V. V. Zavyalov, N. V. Zavyalova, V. I. Kholstov, V. A. Kovtun, V. K. Gorelenkov, G. A. Frolov, I. V. Lyagin, N. A. Stepanov, E. N. Efremenko

“…The catalytic characteristics of fibrous materials functionalized by enzyme-polyelectrolyte complexes carrying out hydrolysis of organophosphorus compounds and mycotoxins have been studied.…”
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Taurine alleviated paraquat-induced oxidative stress and gut-liver axis damage in weaned piglets by regulating the Nrf2/Keap1 and TLR4/NF-κB signaling pathways by Chen Chen, Min Qi, Weilong Zhang, Fanxing Chen, Zhihong Sun, Weizhong Sun, Wenjie Tang, Zhenguo Yang, Xuan Zhao, Zhiru Tang

“…In particular, we evaluated the coordinated regulation of gut-liver axis function mediated by Tau through the Nrf2/Keap1 (antioxidant) and TLR4/NF-κB (immune modulation) signaling pathways. …”
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Tunable phenotypic variability through an autoregulatory alternative sigma factor circuit by Christian P Schwall, Torkel E Loman, Bruno M C Martins, Sandra Cortijo, Casandra Villava, Vassili Kusmartsev, Toby Livesey, Teresa Saez, James C W Locke

“…This variability can be functional, for example by allowing a fraction of stress prepared cells to survive an otherwise lethal stress. …”
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Characterization of TLR9 responsiveness in cell subsets derived from in vitro pDC differentiation of hematopoietic stem and progenitor cells by Sabina Sánchez Hernández, Tobias Wang Bjerg, Ian Helstrup Nielsen, Anders Laustsen, Hai Q Tang, Lars Henning Pedersen, Lars Henning Pedersen, Lars Henning Pedersen, Eynav Klechevsky, Martin R. Jakobsen, Rasmus O. Bak

“…In conclusion, we phenotypically and functionally characterize different cell subsets and modulate their relative frequencies by manipulating TF expression during pDC differentiation. …”
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Gustatory receptors interact with the serotonin pathway to regulate silkmoth stereotyped courtship behavior by Zhongjie Zhang, Xiaojing Liu, Mengdan Chen, Chenxin Sun, Dalin Zhu, Jialong Lei, Qingyun He, Qi Yan, Shuanglin Dong, Anjiang Tan

“…Loss of GR27-31 function results in significant time retardation of courtship by impairing the ability of male silkmoths to seek female silkmoths. …”
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