Electroacupuncture improves sleep deprivation-induced cognitive impairment by suppressing hippocampal inflammatory response in mice by Guoyan Li, Jingbo Liu, Kejing Zhang

“…Electroacupuncture has therapeutic potential in mitigating SD-induced cognitive dysfunction by modulating hippocampal inflammation, which offers a promising non-pharmacological approach for preserving cognitive function in sleep-deprived individuals.…”
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Inspiratory muscle training improves heart rate variability and respiratory muscle strength in obese young adults. by Piangkwan Sa-Nguanmoo, Sainatee Pratanaphon, Arisa Parameyong, Jitapa Chawawisuttikool, Krekwit Shinlapawittayatorn, Nipon Chattipakorn, Siriporn C Chattipakorn

“…This study determined the effect of inspiratory muscle training (IMT), a non-pharmacological treatment on pulmonary function, inspiratory muscle strength and autonomic modulation measured by heart rate variability in obese young adults. …”
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Ameliorating potential of Auricularia auricula-judae polysaccharides in mitigating hypercaloric diet-induced behavioral disorders through gut microbiota regulation by Yujie Fei, Jingwen Zhang, Sijia Yuan, Ye Liu, Xiaoru Wang, Xiaoru Wang, Meng Wang, Meng Wang, Haoan Zhao, Qian Liu, Qian Liu, Qian Liu

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Post-stroke butyrate treatment shows sex-dependent microglial responses but does not improve outcomes in a mouse model of endothelin-1 sensory motor stroke by Ashley de Witte, Juliana Montoya Sanchez, Emerson Daniele, Jingan Chen, Yibang Fan, Pranav Khatri, Daniela Lozano Casasbuenas, Angel Zhang, Kathryn G. Todd, Maryam Faiz, Matthew Churchward

“…Previous studies have demonstrated that SCCA supplementation can improve functional recovery, with one recent study suggesting this occurs via modulation of microglial responses. …”
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Upregulation of MicroRNA-125b Leads to the Resistance to Inflammatory Injury in Endothelial Progenitor Cells by Ke Yang, Xing Liu, Wanwen Lin, Yuanyuan Zhang, Chaoquan Peng

“…This study sought to dissect the role of miR-125b in modulating the function of endothelial progenitor cells (EPCs) in the inflammatory environment of ischemic hearts. …”
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Macrophages in chronic infections: regulation and remodeling by Hongle Cui, Min Wang, Sitan Jiao, Sirui Tian, Hui Liu, Bo Luo

“…It examines how pathogens modulate macrophage functional expression through metabolic reprogramming to sustain chronic infection. …”
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Research progress on immunometabolism and gut microbiota in cryptococcal meningitis: mechanisms and therapeutic implications by Sha Wen, Sha Wen, Sha Wen, Sha Wen, Mu Liu, Mu Liu, Mu Liu, Chengyu Pan, Chengyu Pan, Chengyu Pan, Linhai Zhang, Linhai Zhang, Linhai Zhang, Rong Yan, Rong Yan, Rong Yan, Zucai Xu, Zucai Xu, Zucai Xu

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Small interval interpolation fitting bootstrapping method based on residue number system by LI Huixian, WANG Fulei, SHEN Chun, LIU Shiyuan, PANG Liaojun

“…Lagrange interpolation polynomial is used to interpolate and fit the sine function among different intervals. The comparison function is implemented by the compound implementation of low-degree polynomials, and an interval judgment algorithm is proposed to identify the interval of the ciphertext. …”
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The Study of Roadside Visual Perception in Internet of Vehicles Based on Improved YOLOv5 and CombineSORT by LI Xiaohui, YANG Jie, XIA Qin

“…To improve the convergence and reduce the complexity of the model, an advanced loss function of super-efficient IOU (SEIOU) and network pruning are applied. …”
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Social Networks Link Prediction Based on Incremental Learning by Jian SHU, Zhichen CHEN

“…The computed node pair contribution is passed through a sigmoid function to determine the probability of a link forming.Results and Discussions Experiments are conducted to evaluate the prediction performance of IL−SNLP on three real-world social networks with varying sizes and sparsity levels: Super User, Math Overflow, and Ask Ubuntu. …”
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Lamins regulate cancer cell plasticity and chemosensitivity by Guofang Chen, Tingyi Wei, Tingyi Wei, Ao Huang, Junwei Shen, Furong Ju, Shichao Huang, Haisen Li, Haisen Li

“…The deficiency of all lamin subtypes impaired the stemness and cell cycle transition of cancer cell. Lamin knockdown modulated genomic damage and repair pathways, inhibited mitochondrial function, and triggered cellular senescence. …”
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Exploring Novel Therapeutic Targets in Breast Cancer via Comprehensive Omics Profiling and Experimental Verification by Shengjun Chai, Jiayong Cui, Yinuo Sun, Xiaowu Wang, Chunmei Cai

“…Strikingly, functional assays of the less-reported genes DNASE2 and ATOH8 demonstrated their involvement in breast cancer pathogenesis through modulating proliferation, migration, and invasion of cancer cells. …”
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Modification of Faba Bean Protein Gels Using Thermal Treatment and Calcium Sulphate by Andreas Hopf, Deepa Agarwal, Daniel J. Skylas, Peter Valtchev, Chris Whiteway, Roman Buckow, Fariba Dehghani

“…These findings demonstrate the potential of thermal treatment and salt coagulants to modulate the gelation properties of pulse protein concentrates, offering sustainable strategies for developing plant‐based edible gels with enhanced functionality.…”
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Metformin improves age-related visual cortex dysfunction in mice by reducing noise correlation in the primary visual cortex by Xiaoming Liu, Xiaoming Liu, Yifeng Zhou, Yifeng Zhou, Jiachen Liu, Guangwei Xu, Guangwei Xu

“…Elevated noise correlations between neurons are associated with impaired visual discrimination in aging; however, less is known about therapeutic interventions that could preserve visual cortical function during aging. In this study, we investigated the effects of metformin treatment on age-related changes in visual processing and neuronal correlations in V1.MethodsWe conducted in vivo electrophysiological recordings to investigate whether 3 weeks of acute gavage with metformin improves visual processing in 12-month-old mice compared to 8-week-old mice by modulating neural noise in the V1, and used western blot analysis to investigate the molecular mechanism of the effect of metformin.ResultsIn vivo electrophysiological recordings revealed that aging led to V1 neuronal hyperactivity, accompanied by reduced orientation selectivity, a decreased signal-to-noise ratio, and increased response variability. …”
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YAP enhances mitochondrial OXPHOS in tumor-infiltrating Treg through upregulating Lars2 on stiff matrix by Hui Li, Yuan Yao, Yang Qu, Yihan Xu, Peng Jin, Yuhan Zhang, Liling Niu, Jingchao Bai, Meinan Yan, Youhui Wang

“…RNA-seq, quantitative PCR, flow cytometry, lentivirus infection and mitochondrial function assay were employed to uncover the mechanism of YAP modulating mitochondrial function in TI-Tregs. …”
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Optimization of an Intelligent Music-Playing System Based on Network Communication by Liaoyan Zhang

“…From the actual requirements of the system, the functional and performance goals of the system are proposed to address these deficiencies, and then the functional structure, general architecture, and database model of the system are designed, and how to interact with the server side and the client side is investigated. …”
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Pleiotropic effects of PPAR-α – from benchside to bedside by I. V. Shirinsky, V. S. Shirinsky

“…In contrast with lymphocytes, activated myeloid cells do not proliferate well but still have increased glycolysis which is necessary for their effector function. It is stressed that modulation of immune cells metabolism via PPARα gives new opportunities to modulate intensity and duration of immune responses in chronic diseases. …”
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Iridoids derived from Valeriana jatamansi Jones alleviates neuroinflammation and blood spinal cord barrier permeability after spinal cord injury by activating the Nrf2/HO-1 signali... by Yongzhi He, Yongzhi He, Yongzhi He, Jiachun Lu, Rizhao Pang, Lijuan Ding, Yunyun Wang, Hua Xiao, Chao Cheng, Yushan Luo, Xiaoming Hu, Wenchun Wang

“…However, the specific effects of IRFV on neuroinflammation and BSCB integrity remain unexplored.Methods and ResultsThis study aims to elucidate the functional significance and molecular mechanisms by which IRFV modulates neuroinflammation and preserves BSCB function following SCI. …”
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Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects by Mohamad Bakkar, Sara Khalil, Komal Bhayekar, Narva Deshwar Kushwaha, Amirreza Samarbakhsh, Sadaf Dorandish, Holly Edwards, Q. Ping Dou, Yubin Ge, Navnath S. Gavande

“…Particular attention is given to the role of USP inhibitors in enhancing cancer immunotherapy, e.g., modulation of the tumor microenvironment, effect on regulatory T cell function, and influence on immune checkpoint pathways. …”
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Identification and validation of poor prognosis immunoevasive subtype of esophageal cancer with tumor-infiltrating SAMD3 + NK cell abundance by Xu Huang, Runze You, Fangyi Liu, Zitao Jian, Guanyou Zhou, Hao Yin, Mengyuan Wu, Tiantao Sun, Zhiyun Duan, Wenyi Xu, Shaoyuan Zhang, Xinyu Yang, Heng Jiao, Shuyi Yang, Qingle Wang, Jun Yin, Han Tang, Miao Lin, Lijie Tan

“…While natural killer (NK) cells are central to antitumor immunity, their functional states in EC are poorly characterized. Methods We integrated bulk RNA-seq (TCGA/GEO) and single-cell data to construct an NK cell-derived prognostic signature (NK score) via LASSO-Cox regression. …”
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