Hydrophobic Carbon Dots Prevent α‐Synucleinopathy and Suppress Neuroinflammation to Treat Parkinson's Disease by Lihua Li, Yao Lu, Xiangling Ye, Chi Zhang, Jialin Liu, Zhongmin Yang, Jianhua Hao

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Araçá-Boi Extract and Gallic Acid Reduce Cell Viability and Modify the Expression of Tumor Suppressor Genes and Genes Involved in Epigenetic Processes in Ovarian Cancer by Felipe Tecchio Borsoi, Henrique Silvano Arruda, Amanda Cristina Andrade, Mônica Pezenatto dos Santos, Isabelle Nogueira da Silva, Leonardo Augusto Marson, Ana Sofia Martelli Chaib Saliba, Severino Matias de Alencar, Murilo Vieira Geraldo, Iramaia Angélica Neri Numa, Glaucia Maria Pastore

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Resolution of Sterile Inflammation: Role for Vitamin C by Bassem M. Mohammed, Bernard J. Fisher, Quoc K. Huynh, Dayanjan S. Wijesinghe, Charles E. Chalfant, Donald F. Brophy, Alpha A. Fowler III, Ramesh Natarajan

“…VitC sufficiency favorably modulates macrophage function. In vivo or in vitro VitC supplementation restores macrophage phenotype and function leading to timely resolution of inflammation.…”
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Technology Research of Railway Lines and Signal Equipment Three-dimensional Modeling Based on Creator by ZHANG Yan, WANG Zhi-wei

“…For train-control equipment simulation and function verification, a set of railway lines and signal equipment three-dimensional modeling method was elaborated with virtual-reality simulation technology, and the method was realized with the software of Creator. …”
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Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications by Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang

“…Abstract HDAC6 is integral to the regulation of primary cilia, which are specialized structures that serve as crucial signaling hubs for cellular communication and environmental response. These ciliary functions are essential for maintaining cellular homeostasis and orchestrating developmental processes. …”
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Statins regulate kinase signaling by causing changes in phosphorylation, rather than through changes in gene expression or direct inhibition: evidence in colorectal cancer by Francisco Alejandro Lagunas-Rangel, Francisco Alejandro Lagunas-Rangel, Jörgen Jonsson, Ludmila Jackevica, Robert Fredriksson, Maija Dambrova, Maija Dambrova, Helgi B. Schiöth, Helgi B. Schiöth

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Cognition in males and females with autism: similarities and differences. by Meng-Chuan Lai, Michael V Lombardo, Amber N V Ruigrok, Bhismadev Chakrabarti, Sally J Wheelwright, Bonnie Auyeung, Carrie Allison, MRC AIMS Consortium, Simon Baron-Cohen

“…In this study we investigate four key cognitive domains (mentalizing and emotion perception, executive function, perceptual attention to detail, and motor function) in ASC, to test for similarities and differences between males and females with and without ASC (n = 128 adults; n = 32 per group). …”
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Triplicator phase-only hologram and its use as a snapshot optical convolver and correlator by Gao Shang, Sánchez-López María del Mar, García-Martínez Pascuala, Moreno Ignacio

“…This modified hologram generates three equally-energetic orders with the highest diffraction efficiency, yielding a direct version and an inverted complex conjugate version of the target pattern in the ±1st orders, respectively, and a delta function in the DC zero order. When combined with another phase-only function, the resulting hologram yields convolution and correlation terms in the ±1st orders, respectively, while the target function encoded in the added phase appears in the zero order. …”
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Modeling visual working memory using recurrent on-center off-surround neural network with distance dependent inhibition by Rakesh Sengupta

“…A novel cross-talk function modulates feature specificity based on feedback depth, capturing the uncertainty in representations before full localization reaches lower visual areas.…”
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Histamine H3 receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide im... by Sentaro Kaita, Yoshikazu Morishita, Kenta Kobayashi, Hiroshi Nomura

“…Abstract The histaminergic system plays a key role in modulating learning and memory, wakefulness, and energy balance. …”
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Peptide Multifunctionalization via Modular Construction of Trans‐AB2C Porphyrin on Resin by Yue Wu, Yuen‐Ting Wong, Yik‐Hoi Yeung, Pak‐Lun Lam, Ho‐Fai Chau, Wing‐Sze Tam, Qian Zhang, William C. S. Tai, Ka‐Leung Wong

“…The products from this approach, which inherit both functionalities from the porphyrins and the modules employed for constructing porphyrins, show potential in biomedical and biomaterial applications. …”
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P16 | A 3D IN VITRO MODEL TO STUDY CAF PLASTICITY AND TUMOR-STROMA INTERACTIONS IN OVARIAN CANCER

“…Among its components, cancer-associated fibroblasts (CAF) are key players in remodeling the extracellular matrix, promoting tumor invasion, and modulating immune responses. In this context we developed a robust 3D in vitro model of ovarian cancer, integrating cancer cells and stromal components to recreate key structural and functional aspects of the human TME. …”
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Perisynaptic GABA Receptors: The Overzealous Protector by Andrew N. Clarkson

“…Indeed, recent evidence suggests that local inhibitory and excitatory currents are altered after stroke and modulation of these networks to enhance excitability during the repair phase can facilitate functional recovery after stroke. …”
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Nance-Horan-syndrome-like 1b controls mesodermal cell migration by regulating protrusion and actin dynamics during zebrafish gastrulation by Sophie Escot, Yara Hassanein, Amélie Elouin, Jorge Torres-Paz, Lucille Mellottee, Amandine Ignace, Nicolas B. David

“…We here analysed its function in vivo, during zebrafish gastrulation, when nhsl1b is expressed in migrating mesodermal cells. …”
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Targeting NLRC5 in cardiomyocytes protects postinfarction cardiac injury by enhancing autophagy flux through the CAVIN1/CAV1 axis by Lingfeng Gu, Sibo Wang, Liuhua Zhou, Wenjing Wang, Yulin Bao, Ye He, Tongtong Yang, Jiateng Sun, Qiqi Jiang, Tiankai Shan, Chong Du, Zemu Wang, Hao Wang, Liping Xie, Aihua Gu, Yang Zhao, Yong Ji, Qiming Wang, Liansheng Wang

“…Silencing NLRC5 in cardiomyocytes impairs cardiac repair and functional recovery, while its overexpression enhances these processes. …”
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Integrated metabolomics and metagenomics reveal plant-microbe interactions driving aroma differentiation in flue-cured tobacco leaves by Yifan Jia, Yifan Jia, Jianwei Wang, Xiaojie Lin, Xiaojie Lin, Taibo Liang, Huaxin Dai, Baojian Wu, Mengmeng Yang, Yanling Zhang, Ruifang Li, Ruifang Li

“…These findings reveal conserved microbial functional traits (e.g., metabolic pathway modulation) that may drive plant phenotypic differentiation beyond tobacco, offering insights into microbiome-mediated crop quality improvement. …”
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Voltage-Gated Ion Channels in Neuropathic Pain Signaling by Ricardo Felix, Alejandra Corzo-Lopez, Alejandro Sandoval

“…Therefore, targeting specific K_V channel subtypes to restore their function is also a promising therapeutic strategy for alleviating neuropathic pain symptoms. …”
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METTL16 Contributes to Coronary Heart Disease by Inducing TET2 m6A Modification by Ruan R, Zhang Y

“…Knockdown of METTL16 suppressed VSMC proliferation and elevated cell apoptosis. METTL16 directly modulated the m6A enrichment on TET2 mRNA, and overexpression of TET2 could reverse the inhibitory effects of siMETTL16 on VSMC proliferation.Conclusion: METTL16 affects the cardiac damage and function during CHD via epigenetically modulating the m6A modification of TET2.Keywords: coronary heart disease, epigenetic regulation, N6-methyladenosine, METTL16…”
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From Microcirculation to Aging-Related Diseases: A Focus on Endothelial SIRT1 by Martin Law, Pei-Chun Wang, Zhong-Yan Zhou, Yu Wang

“…The present review summarizes recent findings on the regulation of microvascular function by SIRT1, the underlying mechanisms, and various approaches to modulate SIRT1 activity in microcirculation. …”
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Bioactive Peptides in Greek Goat Colostrum: Relevance to Human Metabolism by Maria Louiza Petre, Anna Nefeli Kontouli Pertesi, Olympia Eirini Boulioglou, Eleana Sarantidi, Artemis G. Korovesi, Athina Kozei, Angeliki I. Katsafadou, George T. Tsangaris, Antonia Trichopoulou, Athanasios K. Anagnostopoulos

“…This primary source of nourishment during the first days of infant life is rich in functional components conductive to the enhancement of neonate immunity and growth. …”
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