DNA damage induces down-regulation of Prp19 via impairing Prp19 stability in hepatocellular carcinoma cells. by Jie Yin, Yi-An Zhang, Tao-Tao Liu, Ji-Min Zhu, Xi-Zhong Shen

“…Prp19 overexpression in cells with functional p53 leads to decreased apoptosis and increases cell survival after DNA damage. …”
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Influence of pyridinic nitrogen on tautomeric shifts and charge transport in single molecule keto enol equilibria by G. R. Berdiyorov

“…These findings can be valuable in the development of functional molecular devices based on the keto-enol isomerization phenomenon.…”
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Understanding Mycobacterium tuberculosis through its genomic diversity and evolution. by Mollie I Sweeney, Carson E Carranza, David M Tobin

“…This review examines mechanistic findings that have emerged from pairing whole genome sequencing data and evolutionary analysis with functional dissection of specific bacterial variants. …”
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Microbiota-derived extracellular vesicles: current knowledge, gaps, and challenges in precision nutrition by Elvira Marquez-Paradas, Elvira Marquez-Paradas, Maria Torrecillas-Lopez, Maria Torrecillas-Lopez, Luna Barrera-Chamorro, Luna Barrera-Chamorro, Jose L. del Rio-Vazquez, Teresa Gonzalez-de la Rosa, Teresa Gonzalez-de la Rosa, Sergio Montserrat-de la Paz, Sergio Montserrat-de la Paz

“…The gut microbiota has co-evolved with its host, profoundly shaping the development and functioning of the immune system. This co-evolution has led to a dynamic relationship where microbial metabolites and molecular signals influence immune maturation, tolerance, and defense mechanisms, highlighting its essential role in maintaining host health. …”
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p85β acts as a transcription cofactor and cooperates with BCLAF1 in the nucleus by Panpan Wang, Victor CY Mak, Ling Rao, Qiuqiu Wu, Yuan Zhou, Rakesh Sharma, S. Chul Kwon, Lydia WT Cheung

“…Collectively, this study provides functional evidence and mechanistic basis to support a role of nuclear p85β in modulating gene transcription.…”
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Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. by Charles R Farber, Brian J Bennett, Luz Orozco, Wei Zou, Ana Lira, Emrah Kostem, Hyun Min Kang, Nicholas Furlotte, Ani Berberyan, Anatole Ghazalpour, Jaijam Suwanwela, Thomas A Drake, Eleazar Eskin, Q Tian Wang, Steven L Teitelbaum, Aldons J Lusis

“…This list was reduced to 26 functional candidates by identifying those genes that were regulated by local eQTL in bone or harbored potentially functional non-synonymous (NS) SNPs. …”
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Quality of life of gastric cancer patients after radical surgery depending on the status of the duodenal passage by O. M. Asipovich, I. B. Uvarov, V. A. Porkhanov

“…QOL was assessed using the EORTC QLQ-C30 questionnaire with the QLQ-STO22 module for GC patients.Results. Changes in QOL in patients 3 months after TGE were expressed in a statistically significant decrease in scores of all functional scales (QL, PF, RF, EF, CF and SF), and an increase in the scores ​​of symptom scales (FA, NV, PA, DY, SL, AL, CO, DI, FI), to the same extent for both groups. …”
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An essential role for katanin p80 and microtubule severing in male gamete production. by Liza O'Donnell, Danielle Rhodes, Stephanie J Smith, D Jo Merriner, Brett J Clark, Claire Borg, Belinda Whittle, Anne E O'Connor, Lee B Smith, Francis J McNally, David M de Kretser, Chris C Goodnow, Chris J Ormandy, Duangporn Jamsai, Moira K O'Bryan

“…The in vivo function of katanin p80 in mammals is unknown. Here we show that katanin p80 is essential for male fertility. …”
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Background-Supported Global Feature Response Image Classification Network by JIANG Wentao, LI Weida, ZHANG Shengchong

“…Firstly, based on WRN (wide residual networks) residual networks, a new background-supported activation function BS (background-supported) is proposed, which introduces a background support mechanism through the BS activation function, so that the network can focus on the background information smoothly while focusing on the foreground information of the target. …”
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Corticotropin-Releasing Factor and the Brain-Gut Motor Response to Stress by Yvette Taché, Vicente Martinez, Mulugeta Million, Jean Rivier

“…The characterization of corticotropin-releasing factor (CRF) and CRF receptors, and the development of specific CRF receptor antagonists selective for the receptor subtypes have paved the way to the understanding of the biochemical coding of stress-related alterations of gut motor function. Reports have consistently established that central administration of CRF acts in the brain to inhibit gastric emptying while stimulating colonic motor function through modulation of the vagal and sacral parasympathetic outflow in rodents. …”
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Proton and Metal Dication Affinities of Tetracyclic Imidazo[4,5-<i>b</i>]Pyridine-Based Molecules: Insights from Mass Spectrometry and DFT Analysis by Lucija Vrban, Ingrid Ana Martinac, Marijana Hranjec, Marijana Pocrnić, Nives Galić, Renata Kobetić, Robert Vianello

“…Employing a dual approach of electrospray ionization mass spectrometry (ESI-MS) and density functional theory (DFT) calculations, we characterized the formation, stability, and structural features of metal–ligand complexes. …”
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Impact of seasonal changes on root-associated microbial communities among phreatophytes of three basins in desert ecosystem by Yulin Zhang, Yulin Zhang, Yulin Zhang, Yulin Zhang, Yi Du, Yi Du, Yi Du, Yi Du, Zhaobin Mu, Zhaobin Mu, Zhaobin Mu, Zhaobin Mu, Waqar Islam, Waqar Islam, Waqar Islam, Fanjiang Zeng, Fanjiang Zeng, Fanjiang Zeng, Fanjiang Zeng, Fanjiang Zeng, Norela C. T. Gonzalez, Zhihao Zhang, Zhihao Zhang, Zhihao Zhang

“…This study underscores seasonal root-associated microbiome variations and their important roles in desert ecosystem functions.…”
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The Paradox Role of Regulatory T Cells in Ischemic Stroke by Xiaomeng Xu, Min Li, Yongjun Jiang

“…We would like to introduce the basic concepts of Tregs and then discuss their paradox function in ischemic stroke. On one side, Tregs could protect brain against ischemic injury via modulating the inflammation process. …”
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NEW WAVEGUIDE METHOD FOR DIELECTRIC PARAMETER MEASUREMENT by Andrey D. Grigoriev

“…By means of the vector network analyzer the waveguide section reflection factor is measured. Objective function is de-termined as difference between calculated and measured module and phase of the reflection factor. …”
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Ultrafast longitudinal and transverse dielectric response of collective polar modes in liquids by Matthias Runge, Michael Woerner, Thomas Elsaesser

“…Longitudinal polaron oscillations modulate both the longitudinal and transverse dielectric function with a frequency set by the partial electron concentration generated in the separate excitation steps. …”
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Haptoglobin is required to prevent oxidative stress and muscle atrophy. by Enrico Bertaggia, Gaia Scabia, Stefania Dalise, Francesca Lo Verso, Ferruccio Santini, Paolo Vitti, Carmelo Chisari, Marco Sandri, Margherita Maffei

“…<h4>Background</h4>Oxidative stress (OS) plays a major role on tissue function. Several catabolic or stress conditions exacerbate OS, inducing organ deterioration. …”
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PSAT1 regulates hair follicle growth and stem cell behavior in cashmere goats by Xiao-yu Han, Jia-ning Liu, Nan-xiang Sun, Yin-xian Zhang, Hao-bing Bai, Wei-guo Song, Xiao Hu, Hao Liang, Xiong Miao, Yun-mei He, Dong-jun Liu, Xu-dong Guo

“…Notably, key signaling pathways essential for hair follicle growth and development, such as Wnt/β-catenin, MAPK, and TGF-β, were significantly affected by PSAT1 modulation. Conclusions This study highlights PSAT1 as a critical regulator of SHFSC function in cashmere goats, affecting both cellular survival and regenerative capacity. …”
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Multifaceted effects of soluble human CD6 in experimental cancer models by Inês T Simões, Fernando Aranda, Sergi Casadó-Llombart, María Velasco-de Andrés, Cristina Català, Pilar Álvarez, Marta Consuegra-Fernández, Marc Orta-Mascaró, Ramón Merino, Jesús Merino, José Alberola-Ila, Gloria González-Aseguinolaza, Esther Carreras, Vanesa Martínez, Francisco Lozano

“…Characterization of sCD6-induced changes was performed by ex vivo flow cytometry and functional analyses of mouse lymphoid organ cells. The in vivo relevance of those changes was explored by challenging mice with subcutaneous or metastatic tumors induced by syngeneic cancer cells of different lineage origins.Results Through a combination of in vitro and in vivo studies, we show that circulating sCD6 expression induces defective regulatory T cell (Treg) generation and function, decreased CD166/ALCAM-mediated tumor cell proliferation/migration and impaired galectin-induced T-cell apoptosis, supporting the fact that sCD6 modulates antitumor lymphocyte effector function and tumorigenesis. …”
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Seismic fault identification method based on CBAM-TransUNet by Xin WANG, Wei ZHANG, Tongjun CHEN, Ao ZHANG, Dang ZHAO

“…Firstly, the CBAM-Block attention module is integrated into the TransUNet network, and the module is added into the CNN tomography encoder part and the 3-layer jump connection part connecting the tomography encoder and the tomography decoder, respectively, to enhance the recognition ability of the seismic tomography image from two dimensions, namely, the channel and the space; secondly, the loss function optimised jointly by the Dice loss function and the cross-entropy loss function is selected to make the segmentation of the tomography image more accurate. function and cross-entropy loss function to make the fault image segmentation more accurate, and the DICE and IOU values obtained by the CBAM-TransUNet fault identification network on the synthetic seismic dataset are increased to 0.84 and 0.75, respectively, and the experimental results show that the continuity of the fault identification is stronger, which is obviously superior to other classical segmentation methods; finally, the constructed model is used to interpret the faults on the real seismic dataset of the F3 block of the North Sea, off the coast of the Netherlands. …”
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Automated experimental complex on the platform of modern ASCME by Omorov Turatbek, Asiev Abai, Osmonova Rima, Takyrbashev Beishenaly, Imanakunova Zgenishkul, Suerkulov Manas

“…The complex includes a physical model of the distribution network and the main functional elements of modern automated control and accounting systems for electricity (ASCAE), such as a data concentrator, a computer server, single-phase and three-phase electricity meters and a telecommunications module for transmitting and receiving data. …”
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