Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment by Shokoufeh Karimi, Mats Hellström, Oscar Badillo-Godinez, Jenni Niemi, Liam Helfridsson, Mohanraj Ramachandran, Hitesh Bhagavanbhai Mangukiya, Sven Nelander

“…Furthermore, we identified OX40 (Tnfrsf4) as a modulator of immunoregulatory DC-c function and found that its antitumor effect depended on lymphocyte trafficking and the DC transcription factor Batf3. …”
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Epithelial Membrane Protein 1 is a Potential Prognostic Biomarker for Ovarian Cancer by Yongjin Xie, Zhen Huang, Zhiwei Chen, Yingying Lin

“…Genes that were co-expressed with EMP1 were identified using LinkedOmics and the Link-Interpreter module was used to analyse pathway enrichment and the possible functions of co-expressed genes. …”
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Calcineurin homologous protein isoform 2 supports tumor survival via the sodium hydrogen exchanger isoform 1 in non-small cell lung cancer by Wayne Taylor Cottle, Clarice Hayley Wallert, Kristine Kay Anderson, Michelle Fang Tran, Clare Loraine Bakker, Mark Anthony Wallert, Joseph John Provost

“…We show that calcineurin B homologous protein 2 is upregulated during oncogenesis in many adeno and squamous carcinomas. To understand the functional role of calcineurin B homologous protein 2 upregulation, we evaluated the effect of Na + /H + exchanger isoform 1 and calcineurin B homologous protein 2 depletion on cellular function during cancer progression in situ. …”
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Brain-derived neurotrophic factor and cytokines as predictors of cognitive impairment in adolescent and young adult cancer patients receiving chemotherapy: a longitudinal study by Julia Trudeau, Ding Quan Ng, Michael Sayer, Chia Jie Tan, Yu Ke, Raymond J. Chan, Alexandre Chan

“…Methods Newly diagnosed AYAC (15–39 years old) and age-matched NC completed the Functional Assessment of Cancer Therapy-Cognitive Function questionnaire (FACT‐Cog), the Cambridge Neuropsychological Test Automated Battery (CANTAB), and blood draws every 3–6 months up to 12 months (AYAC) or 6 months (NC) from baseline. …”
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Effects of <i>Lactobacillus plantarum</i>-Fermented Feed on Growth and Intestinal Health in <i>Haliotis discus hannai</i> by Ling Ke, Chenyu Huang, Song Peng, Mengshi Zhao, Fengqiang Lin, Zhaolong Li

“…Notably, it enhanced contents of cis-9-palmitoleic acid, α-linolenic acid (ALA), and functional amino acids (GABA, L-histidine, and L-asparagine), indicating that fermentation optimized ω-3 fatty acid accumulation and amino acid profiles through the modulation of fatty acid metabolic pathways, thereby improving feed biofunctionality and stress-resistant potential. …”
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Necator americanus infection: a possible cause of altered dendritic cell differentiation and eosinophil profile in chronically infected individuals. by Ricardo T Fujiwara, Guilherme G L Cançado, Paula A Freitas, Helton C Santiago, Cristiano Lara Massara, Omar Dos Santos Carvalho, Rodrigo Corrêa-Oliveira, Stefan M Geiger, Jeffrey Bethony

“…<h4>Conclusion</h4>Chronic N. americanus infection alters the host's innate immune response, resulting in a possible modulation of the maturation process of DCs, a functional change that may diminish their ability for antigen presentation and thus contribute to the ablation of the parasite-specific T cell proliferative response. …”
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Strain Engineering of Anisotropic Electronic, Transport, and Photoelectric Properties in Monolayer Sn₂Se₂P₄ by Haowen Xu, Yuehua Xu

“…In this study, we demonstrate that the Sn₂Se₂P₄ monolayer exhibits intrinsic anisotropic electronic characteristics with the strain-synergistic modulation of carrier transport and optoelectronic properties, as revealed by various levels of density functional theory calculations combined with the non-equilibrium Green’s function method. …”
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MicroRNA: a clinician's view of the state of the problem. Part 2. MicroRNA as a biomarker by O. Iu. Mironova, M. V. Berdysheva, E. M. Elfimova

“…In response to the impact of various factors, the structure and function of several types of cells changes, contributing to the occurrence and progression of cardiovascular diseases. …”
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Molecular characterization of Neospora caninum major antigens NcSAG1 and NcSRS2 by Soledad Echeverría, Federico Carrión, Martín Soñora, Andrés Cabrera, Carlos Robello

“…This comprehensive analysis bridges sequence divergence, structural conservation and biological function, providing a robust framework for investigating SRS proteins’ roles in pathogenesis and immunity. …”
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Identification of Exosome-Associated Biomarkers in Diabetic Foot Ulcers: A Bioinformatics Analysis and Experimental Validation by Tianbo Li, Lei Gao, Jiangning Wang

“…Gene set enrichment analysis (GSEA) implicated IL-17 signaling, proteasome function, and microbial infection pathways. A GeneMANIA network highlighted RNA processing and vesicle trafficking. …”
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Oxygen determines the requirement for cobalamin but not riboflavin in the growth of Propionibacterium freudenreichii by Ruoxi Zhang, Yuandong Sha, Bhawani Chamlagain, Minnamari Edelmann, Kirsi Savijoki, Vieno Piironen, Paulina Deptula, Pekka Varmanen

“…Abstract Vitamin B12 (cobalamin, hereafter B12) is essential for human health, particularly for neural function and DNA synthesis. It is synthesized exclusively by bacteria and archaea, with animal-derived foods serving as the primary sources for humans. …”
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Crosstalk between renin and arachidonic acid (and its metabolites) by Undurti N. Das, Ahmet Hacimüftüoglu, Erol Akpinar, Mustafa Gul, A. M. Abd El-Aty

“…Renin suppression reduces serum aldosterone levels and lowers blood pressure in addition to preserving renal function. However, exactly how renin synthesis and action are regulated and how renin suppression preserves renal function are not clear. …”
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Carbon subsurface traffic jam as driver for methane oxidation activity and selectivity on palladium surfaces by Ulrike Küst, Rosemary Jones, Julia Prumbs, Alessandro Namar, Mattia Scardamaglia, Andrey Shavorskiy, Jan Knudsen

“…Here, we report on an operando approach to establish surface/subsurface/function correlations. Using temperature modulations we oscillate carbon deposition and segregation over a Pd catalyst. …”
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USP53 Drives Ethanol-Induced Myocardial Injury by Promoting K63 Deubiquitination-Dependent RIPK1 Activation at K377 by Jichen Pan, Xiaolin Liu, Xiao Li, Shanshan Wang, Yuliang Zhao, Chong Yuan, Dongdong Liu, Liyan Wang, Meng Zhang, Fengming Liu, Mei Zhang, Shen Dai

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CD73+CD8+ T cells define a subset with anti-tumor potential in DLBCL patients by Lingyu Zhang, Rui Cheng, Zongbing Fan, Yunxiao Liu, Jie Huang, Jiabing Peng

“…IntroductionCD73, a recently discovered immune checkpoint, catalyzes the conversion of AMP to adenosine, thereby suppressing anti-tumor immune responses.CD8+ T cells play a critical role in the immune response against cancer, yet their functionality can be modulated by various factors within the tumor microenvironment. …”
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Bi‐allelic pathogenic variants in NDUFC2 cause early‐onset Leigh syndrome and stalled biogenesis of complex I by Ahmad Alahmad, Alessia Nasca, Juliana Heidler, Kyle Thompson, Monika Oláhová, Andrea Legati, Eleonora Lamantea, Jana Meisterknecht, Manuela Spagnolo, Langping He, Seham Alameer, Fahad Hakami, Abeer Almehdar, Anna Ardissone, Charlotte L Alston, Robert McFarland, Ilka Wittig, Daniele Ghezzi, Robert W Taylor

“…Here, we describe three affected children from two unrelated families who presented with Leigh syndrome due to homozygous variants (c.346_*7del and c.173A>T p.His58Leu) in NDUFC2, encoding a complex I subunit. Biochemical and functional investigation of subjects’ fibroblasts confirmed a severe defect in complex I activity, subunit expression and assembly. …”
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Atomic‐Level Strain Sensing and Piezoresistance Effect in a 1D Single‐Atom Chain by Zhi Qu, Wenqi Zhang, Shuideng Wang, Donglei Chen, Yiqing Yao, Mingxing Cheng, Lixin Dong

“…It is considered that this strong piezoresistivity is due to the impact of interatomic distance on electron scattering and transport mechanisms. The density functional theory simulations of electron transport reveal that variations in interatomic distance significantly influence the relaxation time of electron scattering and the effective electron mass, thereby modulating the characteristics of electron transport. …”
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Developing a disease-specific accessible transcriptional signature as a biomarker for ataxia with oculomotor apraxia type 2 by Kathie J. Ngo, Darice Y. Wong, Alden Y. Huang, Hane Lee, Stanley F. Nelson, Brent L. Fogel

“…Abstract Background Genetic ataxias are clinically heterogenous neurodegenerative conditions often involving rare or private mutations and it is often difficult to assign pathogenicity to rare gene variants solely based on DNA sequencing. An effective functional assay from an easy-to-obtain biospecimen would aid this assessment and be of high clinical value. …”
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DTC-m6Am: A Framework for Recognizing N6,2′-O-dimethyladenosine Sites in Unbalanced Classification Patterns Based on DenseNet and Attention Mechanisms by Hui Huang, Fenglin Zhou, Jianhua Jia, Huachun Zhang

“…Background: m6Am is a specific RNA modification that plays an important role in regulating mRNA stability, translational efficiency, and cellular stress response. m6Am’s precise identification is essential to gain insight into its functional mechanisms at transcriptional and post-transcriptional levels. …”
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Enhancing Photonic Spin Hall Effect in the Surface Plasmon Resonance Structure Covered by the Graphene–MoS2 Heterostructure by Qingkai Wang, Xing Jiang, Xi Wang, Xiaoyu Dai, Yuanjiang Xiang

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