Alternative Splicing of <i>PheNAC23</i> from Moso Bamboo Impacts Flowering Regulation and Drought Tolerance in Transgenic <i>Arabidopsis</i> by Lihua Xie, Xiangyu Li, Pengqiang Yao, Zhanchao Cheng, Miaomiao Cai, Chunyang Liu, Zhe Wang, Jian Gao

“…NAC (NAM, ATAF, and CUC) transcription factors are essential in regulating plant stress response and senescence, with their functions being modulated by alternative splicing. …”
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Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast. by Mingzi M Zhang, Mingzi M Zhang, Pei-Yun Jenny Wu, Felice D Kelly, Paul Nurse, Howard C Hang

“…We propose that control of palmitoyltransferase activity levels provides a fundamental mechanism for modulating palmitoylomes and cellular functions.…”
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Real-time congestion control using cascaded LSTM deep neural networks for deregulated power markets by G. Madhu Mohan, T. Anil Kumar, A. Srujana, Yasser Fouad, Alexey Mikhaylov, Nora Baranyai, Kitmo, Ch. Rami Reddy

“…The independent system operator (ISO) is responsible for implementing appropriate measures to mitigate congestion and ensure the proper functioning of the power market. This study utilized generation rescheduling (GR) to address congestion in spot or day-ahead power markets. …”
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Large language model agent for nuclear reactor operation assistance by Yoon Pyo Lee, Joowon Cha, Yonggyun Yu, Seung Geun Kim

“…We developed an AI agent architecture that integrated documentation, functions, and other modules. Two experiments were conducted to demonstrate the usefulness and potential of the proposed system. …”
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Unraveling the interplay of CD8 + T cells and microRNA signaling in cancer: implications for immune dysfunction and therapeutic approaches by Arefeh Zabeti Touchaei, Sogand Vahidi

“…Additionally, we explore how extracellular vesicles and cytokines modulate CD8 + T-cell function through complex interactions with miRNAs. …”
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CTRP3 attenuates myocardial lipotoxicity via suppression of lipid accumulation, inflammation, apoptosis, and mitochondrial oxidative stress by Qingpeng Wang, Jiangyang Chi, Chen Wang, Yanhong Yuan, Rui Tian, Yun Yang, Xinzhong Chen

“…C1q/tumor necrosis factor-related protein-3 (CTRP3), a novel adipocytokine with pleiotropic metabolic regulatory properties, has recently been implicated in lipid homeostasis modulation. Nevertheless, its cardioprotective potential against myocardial lipotoxicity remains poorly understood.ObjectiveA comprehensive approach combining in vivo high-fat diet (HFD) murine models and in vitro palmitic acid-induced cardiomyocyte injury systems was employed.Methodsthis study used animal and cellular experiments to verify the function of CTRP3.ResultsHFD feeding induced significant lipid droplet deposition in cardiomyocytes, concomitant with enhanced inflammatory responses, elevated apoptotic activity, and exacerbated oxidative stress, ultimately leading to cardiac dysfunction. …”
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Role of human herpesvirus homologs of infected cell protein 27 (ICP27) in the biogenesis, processing, and maturation of mRNAs by Abel A. Soto-Machuca, Gerardo E. Ortiz, Javier Carbone-Schellman, Ignacio A. Pastén-Ferrada, Angello Retamal-Díaz, Alexis M. Kalergis, Pablo A. González

“…Notably, some of these proteins have functional RNA-binding domains consisting of arginine-glycine-glycine (RGG) amino acid (aa) sequences that, when methylated, regulate their nucleic acid-binding capacities and can influence the export of mRNAs lacking introns from the nucleus into the cytoplasm. …”
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Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia by Yanrong Yang, Hua Chen, Qibing Liu, Yang Niu, Chunyang Mao, Rui Wang

“…Cerebrovascular endothelial cells exhibit remarkable heterogeneity, serving dual roles as both architectural components of the blood–brain barrier (BBB) and functional regulators of NVC. Furthermore, pericytes residing abluminal on capillary endothelia demonstrate critical involvement in hemodynamic modulation through contractile regulation of microvascular tone, while concurrently maintaining BBB integrity through dynamic paracrine signaling. …”
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First principles design of multifunctional spintronic devices based on super narrow borophene nanoribbons by En-Fei Xing, Zi-Han Niu, Guang-Ping Zhang, Chuan-Kui Wang, Gang Chen, Yang Song

“…Based on these findings, a χ-type borophene nanojunction is proposed, and its spintronic transport properties are investigated using the non-equilibrium Green’s function method combined with density functional theory. …”
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Genetically engineered MSC-derived hybrid cellular vesicles for ROS-scavenging and mitochondrial homeostasis in hepatic ischemia-reperfusion injury by Pu Shen, Kaijun Huang, Xuanlin Zhang, Guiyuan Yin, Meiting Qin, Hua Ma, Zhijin Fan, Yuhui Liao

“…This therapeutic cascade facilitated mitochondrial structural and functional restoration via multiple pathways: Resveratrol specifically activated PINK1-mediated mitophagy, as confirmed by increased LC3 and beclin-1 expression, thereby promoting selective clearance of depolarized mitochondria. …”
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Phase II trial of intravenous human dental pulp stem cell therapy for Huntington’s disease: a randomized, double-blind, placebo-controlled study by Joyce Macedo Sanches Fernandes, Eduardo Pagani, Cristiane Valverde Wenceslau, Leandro Hideki Ynoue, Luciana Ferrara, Irina Kerkis

“…Secondary outcomes included UHDRS Total Functional Capacity (TFC), Total Chorea Score (TCS), Functional Checklist (FC), and magnetic resonance imaging (MRI) based white matter quantification. …”
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The Efficacy and Brain Network Mechanism of Acupuncture for Knee Osteoarthritis: A Study Protocol for Randomized Controlled Neuroimaging Trial by Sun YY, Wang ML, Zhao RH, Hao MY, Song S, Zhou Y, Zhang N

“…The primary efficacy indicator will be the change in NRS score after four weeks of treatment, with secondary outcomes including WOMAC, STAI, and safety assessments. fMRI observations will employ independent component analysis, brain network construction, and functional connectivity, complemented by Pearson correlation analysis to explore the relationship between brain responses and clinical improvements.Conclusion: This study will initially uncover how acupuncture intervention for chronic KOA pain centrally regulates and exerts therapeutic effects through the modulation of abnormal brain network functional connectivity patterns, with a demonstrated long-term effect.Ethics and Dissemination: This study has been approved by the ethics committee of Shandong University of Traditional Chinese Medicine Affiliated Hospital ((2024) Lunshen No. (028) - KY).Clinical Trial Registration: This study has been approved by registered in the Chinese Clinical Trial Registry (ChiCTR2400083695).Keywords: acupuncture, knee osteoarthritis, neuroimaging, RCT, protocol…”
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Evidence from NHANES 2011–2014: a correlation between the weight-adjusted-waist index and cognitive abilities in the United States by Chan Zhao, Xintian Xu, Chunyan Hao

“…BackgroundObesity exerts a significant detrimental impact on cognitive function. The weight-adjusted waist index (WWI) serves as a more precise indicator of visceral obesity that is independent of weight, in contrast to body mass index (BMI). …”
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The Role of Mitochondria in Diabetic Kidney Disease and Potential Therapeutic Targets by Masanobu Takasu, Seiji Kishi, Hajime Nagasu, Kengo Kidokoro, Craig R. Brooks, Naoki Kashihara

“…Strategies targeting mitochondrial function, such as AMP-activated protein kinase (AMPK) activation and modulation of nitric oxide (NO) availability, are promising for suppressing diabetic nephropathy. …”
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Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli by Martina Rudgalvyte, Zehan Hu, Dieter Kressler, Jörn Dengjel, Dominique A Glauser

“…Cell-specific manipulations indicate that CMK-1 acts in AFD and ASER thermo-sensory neurons, while TAX-6 functions in FLP thermo-sensory neurons and downstream interneurons. …”
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A hybrid YOLO-UNet3D framework for automated protein particle annotation in Cryo-ET images by Ziyang Liu, Chunhong Yuan, Zixin Zhang, Xiang Zhou, Xiangyu Li, Zhen Tian, Yuting Pei, Zuowen Jiang, Zhikui Tian

“…Abstract Accurate localization and identification of protein complexes in cryo-electron tomography (cryo-ET) volumes are essential for understanding cellular functions and disease mechanisms. However, automated annotation of these macromolecular assemblies remains challenging due to low signal-to-noise ratios, missing wedge artifacts, heterogeneous backgrounds, and structural diversity. …”
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AKTMD: Attention-KAN-Based Neural Networks for Transportation Mode Detection by Rui Li, Xueyi Song, Yunmei Wu, Xubo Yu, Hua Huang

“…By introducing learnable B-spline functions, KAN can express more abundant feature information with fewer parameters which strengthens the non-linearities modeling and interpretability. …”
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Effects of Resveratrol on the Kidney in Rats with Streptozotocin Induced Diabetic Nephropathy by Duygu Tozcu, Çiğdem Özer, Aydan Babül, Sevim Ercan, Ergin Dileköz, Gülnur Take Kaplanoğlu, Güleser Göktaş

“…Conclusion: RSV may protect against diabetic nephropathy by modulating key pathways involved in renal degeneration and vascular function and may have potential as a therapeutic agent for slowing disease progression.…”
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Identification of metabolism-related key genes as potential biomarkers for pathogenesis of immune thrombocytopenia by Xiangmei Xu, Jiamin Zhang, Hongyun Xing, Liying Han, Xiaoming Li, Pengqiang Wu, Jirui Tang, Li Jing, Jie Luo, Jing Luo, Lin Liu

“…The hub genes were screened based on the degree function in the coytoscape sofware. The key ITP-related genes were subjected to functional enrichment analysis. …”
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CNPY3’s regulation of tumor microenvironment and its impact on colon cancer aggressiveness by Xucan Gao, Biaohuan Zhou, Xiudong Feng, Zhouxin Ji, Qiang Li, Huining Liu

“…This study aims to investigate the function of CNPY3 in CC and its potential as a therapeutic target. …”
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