Investigating the effects of global gene knockout of MrgF on motor performance and pain sensitivity in mice by Xuejiao Chen, Yan Chen, Runzhe Shu, Shunyuan Lu, Ming-Min Gu, Chunling Shen, Zhugang Wang, Xiaofang Cui

“…Abstract Mas-related G protein-coupled receptors (Mrgs) are a subset of GPCRs linked to pain modulation. MrgF was identified as an orphan Mrg whose function and ligand remain unclear. …”
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The Novel Action of miR-193b-3p/CDK1 Signaling in HCC Proliferation and Migration: A Study Based on Bioinformatic Analysis and Experimental Investigation by Xue Pang, Wei Wan, Xingxing Wu, Yu Shen

“…Kaplan–Meier survival analysis revealed that 10 hub genes were linked with a poorer prognosis in HCC patients. Functional assays showed that CDK1 knockdown repressed HCC cell proliferation and migration. …”
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Evaluation of the effects of DBS in the caudal Zona incerta on brain activity during a working memory task in patients with essential tremor by Johanna Philipson, Amar Awad, Lena Lindström, Patric Blomstedt, Marjan Jahanshahi, Johan Eriksson

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Methods of creating a multimedia online gallery by Є.М. Грабовський

“…The working hypothesis of the study was the statement that the structure of sections of a multimedia online gallery can be determined on the basis of the necessary functionality of the gallery. To test the working hypothesis of the study, such scientific tasks were achieved to achieve goals as algorithmization of the choice of the structure of a multimedia online gallery, coordination of the basic set of functions, classification of functions and sections by clustering. …”
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Socio-health factors, ability to perform instrumental and basic activities of daily living, and use of assistive mobility devices during the COVID-19 pandemic: Interrelationships a... by Vicente Martín Moreno, María Inmaculada Martínez Sanz, Irene Sánchez González, Miguel Recuero Vázquez, Sara Guerra Maroto, Miriam Fernández Gallardo, Amanda Martín Fernández, Julia Herranz Hernando, María Palma Benítez Calderón, Elena Pérez Rico, Laura Calderón Jiménez, Elena Sánchez Rodríguez, Helena Alonso Samperiz, Irene León Saiz, Juana Marcos Guerra

“…<h4>Introduction</h4>Functional dependence for the performance of basic activities of daily living (ADLs) is one of the main causes of institutionalization. …”
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Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors by Mengyue Zhu, Jieqiao Peng, Mi Wang, Shan Lin, Huiying Zhang, Yu Zhou, Xinyue Dai, Huiying Zhao, Yan-qin Yu, Li Shen, Xiao-Ming Li, Jiadong Chen

“…Abstract Understanding the anatomical connection and behaviors of transcriptomic neuron subtypes is critical to delineating cell type-specific functions in the brain. Here we integrated single-nucleus transcriptomic sequencing, in vivo circuit mapping, optogenetic and chemogenetic approaches to dissect the molecular identity and function of heterogeneous GABAergic neuron populations in the zona incerta (ZI) in mice, a region involved in modulating various behaviors. …”
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Integrated transcriptomics and metabolomics analysis of flower petals color transition in different phenotype of Lonicera macranthoides by Jiayuan Zhu, Meiling Qu, Juan Zeng, Jiawei He, Jingyu Zhang, Simin Zhou, Qiaozhen Tong, Qiaozhen Tong, Qiaozhen Tong, Qiaozhen Tong, Xiangdan Liu, Xiangdan Liu, Xiangdan Liu, Xiangdan Liu, Xiangdan Liu, Ribao Zhou, Ribao Zhou, Ribao Zhou, Ribao Zhou, Ribao Zhou

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NAD+ Metabolism-Mediated SURF4-STING Axis Enhances T-Cell Anti-Tumor Effects in the Ovarian Cancer Microenvironment by Jiacheng Shen, Fangfang Xu, Tingwei Liu, Yingjun Ye, Shaohua Xu

“…Previous studies have indicated that metabolic competition among microenvironmental cells regulates the function of immune cells. Recent research has shown that NAD+ metabolism plays a significant role in modulating immune cell activity, and increasing NAD+ levels is a promising therapeutic strategy to enhance the effector functions of immune cells. …”
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Antiviral and Immune Enhancement Effect of <i>Platycodon grandiflorus</i> in Viral Diseases: A Potential Broad-Spectrum Antiviral Drug by Pei Gao, Xinshan Li, Jianlei Ding, Bosen Peng, Muhammad Munir, Fei Liu, Limin Chao, Chengfei Li, Li Wang, Jinyou Ma, Gaiping Zhang

“…It also reduces inflammation through NF-κB, PI3K/AKT, MAPK, and other signalling pathways, enhancing T cell and macrophage function and increasing host immunity. PG exhibits diverse pharmacological effects with promising clinical applications for antiviral and immune modulation. …”
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Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation in Drosophila olfactory receptor neurons by Masaya Muramoto, Nozomi Hanawa, Misako Okumura, Takahiro Chihara, Masayuki Miura, Natsuki Shinoda

“…The nervous system undergoes functional modification independent of cell turnover. …”
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HEALTH TECHNOLOGIES FOR INCREASING ADAPTIVE CAPABILITIESOF PREGNANT WOMEN by T. S. Krivonogova, O. M. Gerget, A. A. Ber, Ya. S. Pekker

“…The usage of complex of breathing exercises combined with aqua-gymnastics, modulating antioxidant activity in the organism, can be a crucial factor in improving the functional reserves when there are any complications in pregnancy. …”
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Antiarrhythmic medication classification based on pathogenetic cardiac arrhythmia mechanisms by T. N. Lipnitsky, V. A. Kozlovsky

“…The authors propose to divide all antiarrhythmic medications into four groups: ion channel function modulators, cardiac receptor modulators, ion pump function modulators, and membrane protectors. …”
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Bioactive metallic nanoparticles for synergistic cancer immunotherapy by Lulu Wang, Demin Lin, Muqing Li, Yu Jiang, Yanfang Yang, Hongliang Wang, Hongqian Chu, Jun Ye, Yuling Liu

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Miniature Modular Reconfigurable Underwater Robot Based on Synthetic Jet by Dehong Wang, Fanheng Zhang, Shijing Zhang, Daqing Liu, Jing Li, Weishan Chen, Jie Deng, Yingxiang Liu

“…Then, various configurations of the multi‐module robot system are established with corresponding motion schemes, and the experiments with replaceable intermediate modules are further conducted to verify the transportation and image‐capturing functions. …”
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The Gr64 cluster of gustatory receptors promotes survival and proteostasis of epithelial cells in Drosophila. by Michael E Baumgartner, Alex Mastrogiannopoulos, Iwo Kucinski, Paul F Langton, Eugenia Piddini

“…Here, we discover an unexpected nonneuronal function of Gr64 receptors and show that they promote proteostasis in epithelial cells affected by proteotoxic stress. …”
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Gut microbiota-mitochondrial crosstalk in obesity: novel mechanistic insights and therapeutic strategies with traditional Chinese medicine by Lingmiao Wen, Kun Yang, Jiexin Wang, Hang Zhou, Weijun Ding

“…Recent research emphasizes the bidirectional communication between gut microbiota and mitochondrial function in obesity development. Gut microbiota regulates energy metabolism through metabolites that impact mitochondrial processes, such as oxidative phosphorylation, biogenesis, and autophagy. …”
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RNA-binding proteins as versatile metabolic regulators by Ellie Koletsou, Ina Huppertz

“…In particular, we emphasise the regulatory function of RNA-binding proteins (RBPs) in coordinating these metabolic shifts and examine how they modulate key pathways, such as glycolysis and oxidative phosphorylation, to meet the dynamic cellular energy demands. …”
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Biophysical and computational insights from modeling human cortical pyramidal neurons by Sapir Shapira, Ido Aizenbud, Daniela Yoeli, Yoni Leibner, Huibert D. Mansvelder, Christiaan P. J. de Kock, Michael London, Michael London, Idan Segev, Idan Segev

“…To integrate and interpret this diverse data, two complementary modeling approaches have emerged: detailed biophysical models, unraveling how morpho-electrical properties shape signal processing in human neurons, and machine learning models, which leverage the biophysical models to uncover hidden structure–function relationships. A major focus has been the disproportionately expanded layers 2/3 of the human cortex, where the large L2/3 pyramidal neurons (HL2/3 PNs) can track high-frequency input modulations, exhibit enhanced dendritic signaling, maintain numerous functional dendritic compartments, and display unique dendritic excitability. …”
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Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction by Yuanling Ye, Fan Shen, Maoli Yan, Conghui Zhan, Jiahua Lv, Mengqin Zou, Zhifeng Wang, Shaokai Ning, Yanfei Gao, Jingxian Wu, Wen Li

“…Intermediate filaments, which constitute a key element of the cytoskeleton, function not only as diagnostic markers but also play a role in malignant processes, including tumor proliferation, apoptosis, and migration. …”
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The eusocial non-code: Unveiling the impact of noncoding RNAs on Hymenoptera eusocial evolution by Egor Lebedev, Daniil Smutin, Pavel Timkin, Danil Kotelnikov, Amir Taldaev, Nick Panushev, Leonid Adonin

“…Understanding the ncRNA contributions offers not only a window into the molecular intricacies of Hymenoptera sociality but also extends our comprehension of how complex biological systems evolve and function.…”
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