Identification of biomarkers associated with proliferation and differentiation of mesenchymal stem cells in pulmonary adenocarcinoma and establishment of prognostic models by Xin-Xin Zeng, Ke-Xin Xian, Jie-Lun Wen, Qi-Zhe Wang, Xin-Yu Wang, Li-Yue Sun

“…A prognostic risk model was developed and validated, followed by functional, immune, and drug sensitivity analyses. Results Four biomarkers (MS4A2, IGSF10, NTRK3, MFAP3L) were identified from 1,061 DEGs1, 6,604 DEGs2, and 610 module genes. …”
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Fasting the mitochondria to prevent neurodegeneration: the role of ceramides by Luis Armando Valenzuela-Ahumada, Octavio Fabián Mercado-Gómez, Rubi Viveros-Contreras, Rosalinda Guevara-Guzmán, Alberto Camacho-Morales

“…IF is an eating protocol that involves alternating periods of fasting with periods of eating which modulate ceramide metabolism and mitochondria function in neurons. …”
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Epilepsy protein myoclonin1 interacts with inositol 1,4,5-trisphosphate receptor and reduces calcium ions stored in endoplasmic reticulum by Toshimitsu Suzuki, Kripamoy Aguan, Hideaki Mizuno, Ikuyo Inoue, Katsuhiko Mikoshiba, Atsushi Miyawaki, Kazuhiro Yamakawa

“…Because of the involvement of inositol 1,4,5-trisphosphate receptor type 1 (IP3R1) in epileptic phenotypes and the involvement of myoclonin1 in calcium ions (Ca2+) signaling, we investigated possible functional interplay between myoclonin1 and IP3R1. Methods: We performed immunohistochemical staining of brain tissues and co-immunoprecipitation assay of myoclonin1 and IP3R1, and Ca2+ imaging analyses using human HeLa.S3, mouse embryonic fibroblasts, or glial cells derived from Efhc1 homozygous knockout (Efhc1–/–) and wild-type (WT) littermates. …”
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Biochemistry and physiology of voltage-gated calcium channel trafficking: a target for gabapentinoid drugs by Annette C. Dolphin

“…Voltage-gated calcium channels are multi-pass transmembrane proteins that have key features that are essential for their correct function. For example, the concerted movement of the voltage sensor domains in response to depolarization is required to ensure the channels open over a particular range of voltages, essential for the physiological function of each of the 10 different mammalian calcium channels. …”
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Mitochondria and PGC-1α in Aging and Age-Associated Diseases by Tina Wenz

“…This paper discusses how mitochondrial function and PGC-1α are affected in age-associated diseases and how modulation of PGC-1α might offer a therapeutic potential for age-related pathology.…”
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Role and implications of the CXCL12/CXCR4/CXCR7 axis in atherosclerosis: still a debate by Hussam A. S. Murad, Misbahuddin M. Rafeeq, Thamer M. A. Alqurashi

“…Hence, a better understanding of this structural and functional heterogeneity and complex phenomenon involving CXCL12/CXCR4/ACKR3 axis in atherosclerosis would not only help in formulation of novel therapeutics, but also in elucidation of the CXCL12 ligand and its receptors, as possible diagnostic and prognostic biomarkers.Key messagesThe role of CXCL12 per se is proatherogenic in atherosclerosis development and progression.The CXCL12 receptors, CXCR4 and ACKR3 perform both proatherogenic and athero-protective functions in various cell typesDue to functional heterogeneity and cross talk of CXCR4 and ACKR3 at receptor level and downstream pathways, regional boosting with specific temporal and spatial modulators of CXCL12, CXCR4 and ACKR3 need to be explored.…”
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The default mode network and the working memory network are not anti-correlated during all phases of a working memory task. by Tommaso Piccoli, Giancarlo Valente, David E J Linden, Marta Re, Fabrizio Esposito, Alexander T Sack, Francesco Di Salle

“…We hypothesized that functional connectivity among nodes of the two networks could be dynamically modulated by task phases across time.…”
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Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells on Mouse Bone-Marrow-Derived Dendritic Cells by Minhwa Park, Yu-Hee Kim, Jung-Hwa Ryu, So-Youn Woo, Kyung-Ha Ryu

“…Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). …”
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A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity by Matias G. Perez, Victoria Gillan, William M. Anderson, François Gerbe, Fabien Herbert, Tom N. McNeilly, Rick M. Maizels, Philippe Jay, Eileen Devaney, Collette Britton

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Naturalight: A controlled illuminated environment to study light exposure impact on behavior and cognition in freely moving rats by Christophe Hecquet, Maylis Etcheberry, Nadine Ravel, Philippe Litaudon, Frédéric Pain

“…In humans, scientific studies have shown that the increased use of screens at night and prolonged exposure to artificial light, particularly blue light, can significantly disrupt the organization of sleep-wake cycles and the functions that depend on them like memory. In rodents, moderate and even weak exposures to light have been shown to have various and either detrimental or beneficial effects on circadian rhythms, behavior, cognition. …”
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Neutrophil Heterogeneity in Wound Healing by Filippo Renò, Corinna Anais Pagano, Monica Bignotto, Maurizio Sabbatini

“…Understanding the functional heterogeneity of neutrophils in wound healing can unveil potential pathological profiles and therapeutic targets. …”
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Hypoxia-induced metabolic reprogramming in mesenchymal stem cells: unlocking the regenerative potential of secreted factors by Wendy V. Jaraba-Álvarez, Ashanti C. Uscanga-Palomeque, Vanesa Sanchez-Giraldo, Claudia Madrid, Hector Ortega-Arellano, Karolynn Halpert, Karolynn Halpert, Carolina Quintero-Gil

“…We also discuss how these metabolic changes influence the composition and function of MSC-derived secreted factors, particularly exosomes and other extracellular vesicles, in modulating tissue repair. …”
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ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure by Xiuru Cui, Yawei Wang, Hanlin Lu, Lei Wang, Xianwei Xie, Shenghao Zhang, Pavel Kovarik, Shuijie Li, Shanshan Liu, Qunye Zhang, Jianmin Yang, Cheng Zhang, Jinwei Tian, Yan Liu, Wencheng Zhang

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Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy by Yingying Lv, Zongshang Li, Shutong Liu, Zhaokai Zhou, Jinling Song, Yuhao Ba, Siyuan Weng, Anning Zuo, Hui Xu, Peng Luo, Quan Cheng, Chuhan Zhang, Jingyuan Ning, Yukang Chen, Yuyuan Zhang, Zaoqu Liu, Xinwei Han

“…Abstract Immune cell metabolism plays a pivotal role in regulating cellular proliferation, differentiation, and functional responses, collectively shaping immune responses within the tumor microenvironment (TME). …”
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Effect of Taro Starch, Beet Juice, Probiotic, and/or Psicose on Gut Microbiota in a Type 2 Diabetic Rat Model: A Pilot Study by Ingrid S. Surono, Ata Aditya Wardana, Priyo Waspodo, Budi Saksono, Koen Venema

“…The aim of the present study was to test the effect of potential functional food ingredients, alone or in combination, on the gut microbiota composition in diabetic rats in a pilot study of 1 week of feeding. …”
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Mechanical and chemical element structures of sea urchin spines: specialization in ambulacral and interambulacral areas by Pathitta Suteecharuwat, Mayuka Arakawa, Yutaka Yoshida

“…These compositional and structural differences suggested that S. nudus modulates Mg concentration in calcite to achieve functional specialization of spines for locomotion and defense. …”
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Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo. by Upkar S Gill, Dimitra Peppa, Lorenzo Micco, Harsimran D Singh, Ivana Carey, Graham R Foster, Mala K Maini, Patrick T F Kennedy

“…The expansion in proliferating, functional NK cells was more pronounced following sequential NUCs than in comparison cohorts of patients treated with de novo NUCs or PegIFNα only. …”
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Capturing the emergent dynamical structure in biophysical neural models. by Borjan Milinkovic, Lionel Barnett, Olivia Carter, Anil K Seth, Thomas Andrillon

“…Using information theory, we apply Dynamical Independence (DI) to uncover the emergent dynamical structure in a minimal 5-node biophysical neural model, shaped by the interplay of two key aspects of brain organisation: integration and segregation. In our study, functional integration within the biophysical neural model is modulated by a global coupling parameter, while functional segregation is influenced by adding dynamical noise, which counteracts global coupling. …”
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Why It Is Necessary to Use the Entire Root rather than Partial Root When Doing Contralateral C7 Nerve Transfer: Cortical Plasticity Also Matters besides the Amount of Nerve Fibers by Jinding Guo, Xin Zhao, Jie Lao, Kaiming Gao

“…The aim of this study was to investigate the relationship between the division modes of the CC7 nerve and cortical functional reorganization of Sprague-Dawley rats. We hypothesized that different methods of CC7 nerve transection might induce differences in cortical functional reorganization, thus resulting in differences in surgery efficacy. …”
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Learning Materials as FAIR Digital Objects: A Shared Methodology for Training in H2IOSC by Giulia Pedonese, Francesca Fontini, Roberta Ottaviani, Federico Boschetti, Alessia Spadi, Lucia Francalanci, Alessia Scognamiglio, Pietro Restaneo, Antonina Chaban, Jana Striova, Laura Benassi

“…After describing the teaching strategy (Section 2) and the application of the Skills4EOSC FAIR-by-Design methodology to pre-existing learning materials (Section 3), the paper describes the process of designing two platforms with functionalities consistent with the requirements of learning objects, taking as an example the CLARIN course Introduction to Language Data: Standards and Repositories translated and adapted in H2IOSC (Section 4).…”
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