DNA Damage-Induced Ferroptosis: A Boolean Model Regulating p53 and Non-Coding RNAs in Drug Resistance by Shantanu Gupta, Daner A. Silveira, José Carlos M. Mombach, Ronaldo F. Hashimoto

“…Post-translational modifications of p53 generate proteoforms that significantly enhance its functional diversity in regulating these mechanisms. …”
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Teriparatide mitigates oxidative stress following spinal cord injury and enhances neurological recovery via the Nrf2/HO-1 signaling pathway by Xiong Moliang, Ai Gangtong, Feng Yun, Luo Caiguang, Deng Liang, Guo Jia, Xiao Qiang

“…Teriparatide was administered to animals post-injury, and functional recovery was assessed using the open field test and Basso-Beattie-Bresnahan (BBB) locomotor rating scale. …”
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Multi-omics integrated analysis to generate transcriptome and protome profiles of resveratrol improving Paraquat-induced acute lung injury by Ziying Xu, Lijuan Huang, Zihui Yu, Yagang Gao, Ruikun Wang, Bing Du, Xiaohu Cui, Jing Yuan

“…Through transcriptomic and proteomic analysis, Resveratrol was found to upregulate genes and proteins associated with inflammation, cell death, and lipid peroxidation, while downregulating those related to lipid peroxidation and iron. Furthermore, cell functional analysis revealed that Resveratrol regulates mitochondrial function, the cell cycle, and inflammatory signaling pathways, improving the pathological state of both mice and A549 cells. …”
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Review on Multispectral Photoacoustic Imaging Using Stimulated Raman Scattering Light Sources by Yuon Song, Sang Min Park, Yongjae Jeong, Jeesu Kim, Hwidon Lee

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Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells by Stefanie Pfaender, Karl Föhr, Anne-Kathrin Lutz, Stefan Putz, Kevin Achberger, Leonhard Linta, Stefan Liebau, Tobias M. Boeckers, Andreas M. Grabrucker

“…We conclude that zinc deficiency in a critical time window during brain development might influence brain function by modulating neuronal differentiation.…”
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Forage Crop Research in the Modern Age by Qikun Liu, Gai Huang, Zhiqiang Zhang, Zhelong Lin, Xian Deng, Xueming Dong, Zhipeng Liu, Zan Wang, Yingjun Zhang, Hai‐chun Jing, Kang Chong, Xiaofeng Cao

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Elucidating the mechanism of triphenyl phosphate interference in bone metabolism via network toxicology and molecular docking methodologies by Min Xu, Yinxiang Wu, Jiaqi Meng, Mengchen Chen, Chen Ding

“…GO and KEGG analyses indicated that these targets predominantly function through the MAPK signaling pathway. Molecular docking results demonstrated strong binding affinities between TPhP and key targets, particularly BRAF and WNK4. …”
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The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway. by Jeffrey M Hollomon, Zhongle Liu, Scott F Rusin, Nicole P Jenkins, Allia K Smith, Katja Koeppen, Arminja N Kettenbach, Lawrence C Myers, Deborah A Hogan

“…Together, these data show that Ssn3 activity can modulate Flo8 and its direct and indirect interactions in different ways, and underscores the potential importance of considering Ssn3 function in the control of transcription factor activities.…”
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LST1 expression correlates with immune infiltration and predicts poor prognosis in acute myeloid leukemia by Haitao Xu, Dangui Chen, Jia Lu, Lihong Wang, Fei Chen, Long Zhong

“…While leukocyte-specific transcript 1 (LST1) is implicated in inflammation and immune regulation, its function in AML remains ambiguous. In this investigation, we conduct a comprehensive investigation into LST1 expression profiles, clinical implications, functional pathways, and immune interactions in AML, leveraging multi-omics data and experimental validations. …”
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Impact of virtual reality and mirror therapy on balance, muscle strength and quality of life in children with unilateral cerebral palsy: a double blinded randomized comparative stu... by Samar Salem Korney, Naglaa Ahmed Zaky, Walaa Abd-hakim Abd-El-Nabie

“…Their ages ranged between 6 to 10 years and their motor function ability fell between levels I and II on Growth Motor Functional Classification System (GMFCS). …”
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Construction and evaluation of a diagnostic model for Alzheimer’s disease based on mitophagy-related genes by Jiarui Liu, Mengyu Yan, Lihua Chen, Weihua Yu, Yang Lü

“…Mitophagy fulfills crucial functions in neurodegenerative disorders and neuronal survival but the relationship between mitophagy and AD is unclear. …”
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Mouse apolipoprotein B editing complex 3 (APOBEC3) is expressed in germ cells and interacts with dead-end (DND1). by Chitralekha Bhattacharya, Sita Aggarwal, Madhu Kumar, Amatul Ali, Angabin Matin

“…APOBEC3 is a multi-functional protein. It inhibits retroviral replication. …”
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Investigating the potential role of EIF2S2 in OSCC progression through comprehensive bioinformatics analysis and experimental validation by Zhiwen Shao, Tao Dong, Ke Yun, Zhaohui Wang, Yu Wen, Zongli Zhang, Tao Jia

“…There were notable differences in immune scoring, cell infiltration, and functional activity between high and low expression groups. …”
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Sex differences in expression of CGRP family of receptors and ligands in the rat trigeminal system by Aida Maddahi, Jacob C. A. Edvinsson, Lars Edvinsson

“…The co-localization of CLR and RAMP1 on Aδ-fibers with CASPR suggests a potential role for this receptor in modulating trigeminal nerve function and neuronal excitability, with implications for migraine pathophysiology. …”
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Effects of Osteocalcin on Synthesis of Testosterone and INSL3 during Adult Leydig Cell Differentiation by Gulfidan Coskun, Leman Sencar, Abdullah Tuli, Dilek Saker, Mustafa Muhlis Alparslan, Sait Polat

“…In addition, INSL3 produced by Leydig cells, such as testosterone, plays a critical role in bone metabolism and is known to reflect the development process and functional capacities of Leydig cells. This study is aimed at investigating OC-mediated testosterone regulation and INSL3 synthesis during differentiation of adult Leydig cells that are independent of LH. …”
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Catabolism Mechanism and Growth-Promoting Effect of Xylooligosaccharides in <i>Lactiplantibacillus plantarum</i> Strain B20 by Yini Shi, Huan Wang, Zhongke Sun, Zifu Ni, Chengwei Li

“…Enzymatic assays further demonstrated that RS06170 possesses β-xylosidase activity and can effectively degrade XOS. In addition, functional enrichment analysis suggested that the growth-promoting effect of XOS may be attributed to the upregulation of genes involved in cellular component biogenesis and cell division, potentially through modulation of ribosome function and carbohydrate metabolism in <i>Lb. plantarum</i> B20. …”
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Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury by Yuming Ding, Yuming Ding, Yuming Ding, Linmei Gao, Linmei Gao, Linmei Gao, Yi Chen, Yi Chen, Yi Chen, Yanheng Qiao, Yanheng Qiao, Bo Yang, Bo Yang

“…Current research efforts focus on therapeutic strategies aimed at modulating angiogenesis, such as exogenous VEGF administration, endothelial progenitor cell transplantation, and Notch signaling modulation, to promote functional vascular regeneration. …”
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Local Classification Guiding Attention for <italic>Malania Oleifera</italic> Recognition by Yongke Sun, Yong Cao, Weili Kou, Chunjiang Yu, Ning Lu, Yi Yang, Lei Liu, Juan Wang

“…By integrating the LCG module and the PIoU loss function, the average precision reached 0.979, average recall reached 0.836, and average F1-score reached 0.872. …”
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Nutrient Sensor mTOR and OGT: Orchestrators of Organelle Homeostasis in Pancreatic β-Cells by Nicholas Esch, Seokwon Jo, Mackenzie Moore, Emilyn U. Alejandro

“…Though acute stimulation of these sensors frequently improves β-cell function and promotes adaptation to cell stress, chronic and sustained activity disturbs organelle homeostasis. mTORC1 and OGT regulate organelle function by influencing the expression and activities of key proteins, enzymes, and transcription factors, as well as by modulating autophagy to influence clearance of defective organelles. …”
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Deepening the Modulatory Activity of Bioactive Compounds Against AFB1- and OTA-Induced Neuronal Toxicity Through a Proteomic Approach by Alessandra Cimbalo, Massimo Frangiamone, Lara Manyes

“…Gene ontology functional analysis revealed proteins primarily associated with nucleosome structure, such as the H3-H4 tetramer, H2A-H2B dimer, and HIRA, which were overexpressed in the presence of mycotoxins and, interestingly, downregulated with the addition of the functional ingredients. …”
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