Emerging interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors or degraders as therapeutic agents for autoimmune diseases and cancer by Yifan Feng, Chengjuan Chen, Anqi Shao, Lei Wu, Haiyu Hu, Tiantai Zhang

“…In this paper, we will provide a detailed description of the structure and function of IRAK4, the role of IRAK4 in related diseases, as well as the currently reported small molecule inhibitors and degraders of IRAK4. …”
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Valproic acid induces ferroptosis and suppresses the proliferation of MDA-MB-231 cells by targeting FDFT1 by Shuxian Zhang, Jiazhuo Liu, Yisong Yang, Ran Tao, Xin Ren, Xingzhi Zhou, Shuangping Liu

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Abnormal response to chronic social defeat stress and fear extinction in a mouse model of Lynx2-based cholinergic dysregulation by Kristin R. Anderson, Peter J. Rogu, Talulla B. Palumbo, Julie M. Miwa

“…Nicotinic receptor signaling is influential in modulating appropriate responses to salient stimuli within a complex environment. …”
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Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation. by Dominik Hotter, Teresa Krabbe, Elisabeth Reith, Ali Gawanbacht, Nadia Rahm, Ahidjo Ayouba, Benoît Van Driessche, Carine Van Lint, Martine Peeters, Frank Kirchhoff, Daniel Sauter

“…For example, HIV-2 and most simian immunodeficiency viruses (SIVs) use their accessory protein Nef to prevent T cell activation and antiviral gene expression by downmodulating the T cell receptor CD3. This Nef function was lost in HIV-1 and other vpu-encoding viruses suggesting that the acquisition of Vpu-mediated NF-κB inhibition reduced the selection pressure for inhibition of T cell activation by Nef. …”
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Development of JZ-8 Brake Control System for Locomotive by WANG Qiwei, XU Fenglei, LIU Ao, LI Li, WANG Lingjun

“…The important components of the brake control system were described in detail, such as the functions of the brake controller, the action of the brake screen, the modular features of the brake control cabinet, and the function principle, function and architecture of the BCU module of the core control unit. …”
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Ligand-tuning copper in coordination polymers for efficient electrochemical C–C coupling by Yu Yang, Cheng Zhang, Chengyi Zhang, Yaohui Shi, Jun Li, Bernt Johannessen, Yongxiang Liang, Shuzhen Zhang, Qiang Song, Haowei Zhang, Jialei Huang, Jingwen Ke, Lei Zhang, Qingqing Song, Jianrong Zeng, Ying Zhang, Zhigang Geng, Pu-Sheng Wang, Ziyun Wang, Jie Zeng, Fengwang Li

“…Abstract Cu catalyses electrochemical CO2 reduction to valuable multicarbon products but understanding the structure-function relationship has remained elusive due to the active Cu sites being heterogenized and under dynamic re-construction during electrolysis. …”
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Effects of vegetarian diet-associated nutrients on gut microbiota and intestinal physiology by Wei Xiao, Qingsong Zhang, Leilei Yu, Fengwei Tian, Wei Chen, Qixiao Zhai

“…People are increasingly aware of the role of vegetarian diets in modulating human gut microbial abundance and intestinal physiology. …”
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Ginsenoside Rg1 alleviates chronic testicular damage caused by cranial irradiation through the SCF/PI3K/Akt/mTOR pathway in mice by Qiuhua Zhou, Yiquan Ou, Xiangsheng Tian, Yujun Ning, Yuwei Mao, Weichao Zhao, Dingxin Long

“…Conclusions: Ginsenoside Rg1 potentially alleviate chronic testicular structural and functional damage by inhibiting germ cell apoptosis through the modulation of the HPG axis and the PI3K/Akt/mTOR pathway, suggesting that it is a potential therapeutic agent for reproductive disorders induced by cranial irradiation.…”
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Impact of Sleeve Gastrectomy on Body Weight and Food Intake Regulation in Diet-Induced Obese Mice by Sandra Lucinei Balbo, Gabriela Moreira Soares, Joseane Morari, Antonio Machado Felisberto, Jean Franciesco Vettorazzi, Gabriela Alves Bronczek, Maria Lúcia Bonfleur, Everardo Magalhães Carneiro, Antonio Carlos Boschero, Lício Augusto Velloso

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Calcium-dependent oligomerization of scavenger receptor CD163 facilitates the endocytosis of ligands by Hua Xu, Xiaohui Song, Xiao-dong Su

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Coexistence and interplay of pseudomagnetism and flexoelectricity in few-layer rippled graphene by Jinrong Xu, Zhenyu Zhang, Ping Cui

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A Chest Strap-Based System for Electrocardiogram Monitoring by Xiaoman Zhang, Yaoliang Zhan, Xue Wang, Jin Yang

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Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approach by Xiongfa Ji, Xin Qian, Guowen Luo, Wenjie Yang, Wenhan Huang, Zehua Lei, Jiaqi Zhou, Guoqing Zhong, Jielong Zhou, Nan Liu, Limin Ma, Mei Li, Xiangmei Liu, Shuilin Wu, Yu Zhang

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Elastic Fiber Programming for Simplified Pneumatic Control in Soft Robots by Xiaoli Yang, Tao Jin, Shiwei Tian, Jieyu Wang, Sicheng Yi, Yue Wang, Long Li, Yangqiao Lin

“…This fusion of material programming and mechanical intelligence simplifies control architectures while enhancing functionality, offering a scalable path toward deployable soft robotics.…”
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HA-CP-Net: A Cross-Domain Few-Shot SAR Oil Spill Detection Network Based on Hybrid Attention and Category Perception by Dongmei Song, Shuzhen Wang, Bin Wang, Weimin Chen, Lei Chen

“…By combining the category-perception loss function with the cross-entropy loss function, the network’s performance in discriminating between real and suspected oil films is thus maximized. …”
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Arsenic Primes Human Bone Marrow CD34+ Cells for Erythroid Differentiation by Yuanyuan Zhang, Shasha Wang, Chunyan Chen, Xiao Wu, Qunye Zhang, Fan Jiang

“…We discovered that arsenic trioxide enhanced the erythroid colony forming activity, which was accompanied by a decrease in the granulomonocytic differentiation function. Moreover, in erythroleukemic K562 cells, we showed that arsenic trioxide inhibited erythrocyte maturation, suggesting that arsenic might have biphasic effects on erythropoiesis. …”
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LncRNA mediated metabolic reprogramming: the chief culprits of solid tumor malignant progression: an update review by Kun Fang, Huizhe Xu, Shuai Yuan, Xiaoxi Li, Xiaoyu Chen, Xiushi Fan, Xiaoxin Gao, Lu Zhang, Shulan Sun, Xudong Zhu

“…Therefore, in this review, we mainly focus on summarizing the functional relevance and molecular mechanistic underpinnings of lncRNAs in modulating MR of solid tumors by targeting glucose metabolism, lipid metabolism, affecting mitochondrial function, and regulating interactions between tumor and non-tumor cells in tumor microenvironment. …”
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The solute carrier superfamily interactome by Fabian Frommelt, Rene Ladurner, Ulrich Goldmann, Gernot Wolf, Alvaro Ingles-Prieto, Eva Lineiro-Retes, Zuzana Gelová, Ann-Katrin Hopp, Eirini Christodoulaki, Shao Thing Teoh, Philipp Leippe, Brianda L Santini, Manuele Rebsamen, Sabrina Lindinger, Iciar Serrano, Svenja Onstein, Christoph Klimek, Barbara Barbosa, Anastasiia Pantielieieva, Vojtech Dvorak, Thomas J Hannich, Julian Schoenbett, Gilles Sansig, Tamara A M Mocking, Jasper F Ooms, Adriaan P IJzerman, Laura H Heitman, Peter Sykacek, Juergen Reinhardt, André C Müller, Tabea Wiedmer, Giulio Superti-Furga

“…Knowledge of their protein environment may elucidate the molecular basis for their functional integration with metabolic and cellular pathways and help conceive pharmacological interventions based on modulating proteostatic regulation. …”
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Non-canonical hemoglobin: An updated review on its ubiquitous expression by Emily C. Reed, Jacob D. Kim, Adam J. Case

“…Despite this variability, hemoglobin expression seems to broadly function as a redox modulator, whether it is involved in the hypoxic response, mitochondrial function, antioxidant balance or, like in erythrocytes, gas transport. …”
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Interfacial coupling effects in two-dimensional ordered arrays for microwave attenuation by Yijie Liu, Jintang Zhou, Chenchen Li, Henghui Zhang, Yucheng Wang, Yi Yan, Lvtong Duan, Zhenyu Cheng, Yao Ma, Zhengjun Yao

“…Abstract With the development of nanotechnology, nano-functional units of different dimensions, morphologies, and sizes exhibit the potential for efficient microwave absorption (MA) performance. …”
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