Unraveling the molecular mechanisms of Fufangduzhong formula in alleviating high-fat diet-induced non-alcoholic fatty liver disease in mice by Yu Mou, Yu Mou, Yu Mou, Yao Tang, Yao Tang, Yao Tang, Xiuyan Zheng, Xiang Liu, Xiang Liu, Xiang Liu, Xuemei Wu, Xuemei Wu, Xuemei Wu, Hongji Wang, Hongji Wang, Hongji Wang, Jie Zeng, Jie Zeng, Jie Zeng, Qing Rao, Qing Rao, Qing Rao, Yaacov Ben-David, Yaacov Ben-David, Yaacov Ben-David, Yaacov Ben-David, Yanmei Li, Yanmei Li, Yanmei Li, Lei Huang, Lei Huang, Lei Huang

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SARS-CoV-2 Nsp14 binds Tollip and activates pro-inflammatory pathways while downregulating interferon-α and interferon-γ receptors by Naveen Thakur, Poushali Chakraborty, JoAnn M. Tufariello, Christopher F. Basler

“…Nsp14 also modulates host functions. This includes the activation of NF-κB and downregulation of interferon alpha/beta receptor 1 (IFNAR1). …”
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Recent Advances in Zinc Complexes for Stereoselective Ring-Opening Polymerization and Copolymerization by Xia Li, Yang Li, Gangqiang Zhang, Yat-Ming So, Yu Pan

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Platelets and diseases: signal transduction and advances in targeted therapy by Yuchen Tian, Yao Zong, Yidan Pang, Zhikai Zheng, Yiyang Ma, Changqing Zhang, Junjie Gao

“…Abstract Platelets are essential anucleate blood cells that play pivotal roles in hemostasis, tissue repair, and immune modulation. Originating from megakaryocytes in the bone marrow, platelets are small in size but possess a highly specialized structure that enables them to execute a wide range of physiological functions. …”
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NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27‐Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss by Bohao Li, Wuling Zhou, Yueming Yu, Boyu Chen, Zhicheng Lv, Jiarui Zhang, Tieqi Zhang, Shiwei Sun, Lei Zhou, Minghai Wang

“…ABSTRACT This study investigated how NPC1L1, a cholesterol transporter, regulates osteogenic differentiation through cholesterol metabolism independently of its transport function. We also explored the role of NPC1L1 in osteoporosis (OP), focusing on the downstream C/EBPα/Cyp27a1/27‐hydroxycholesterol (27‐OHC) axis. …”
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Comparative transcriptome profiling and co-expression network analysis reveals important genes regulating maize response to Southern corn rust by Jialong Liu, Kailai Wang, Nan Wang, Yuan Zhong, Xiuzhen Zhai, Yinsuo Jia, Zhiying Chu, Qing Miao, Hao Su, Mengyun Kou, Huijun Duan, Xiaocui Yan

“…This study used six maize inbred lines (DTMA-45, DTMA-50, R99, N110, P767 and 15B020F3) as materials to systematically explore the response mechanism of maize to southern corn rust through phenotype identification, transcriptome sequencing, functional enrichment analysis, gene co-expression network analysis, and quantitative RT-PCR experiments. …”
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Gut microbiota’s role in the enhancement of type 2 diabetes treatment by a traditional Chinese herbal formula compared to metformin by Chengdong Xia, Liya Yue, Yinyu Wang, Cuidan Li, Guannan Ma, Yingjiao Ju, Peihan Wang, Jie Wang, Xiaoyuan Jiang, Xiaotong Wang, Fei Chen

“…These unique pathways enriched by CCM may explain its superior therapeutic effects, indicating its distinct mechanisms in modulating gut microbiota.IMPORTANCEOur study demonstrates that CCM outperforms metformin in managing key clinical indicators in type 2 diabetes mellitus (T2DM) model mice and induces more significant alterations in gut microbiota composition and function. …”
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Integrated analysis of WGCNA and machine learning identified diagnostic biomarkers in trauma-induced coagulopathy by Qingsong Chen, Tao Li, Tao Zhang, Yue Zhou, Weifeng Huang, Hui Li, Li Shi, Jianxiao Li, Qi Zhang, Man Ma, Pan Wang, Hui Hu, Gongbin Wei, Jiangxia Xiang, Yuan Cheng, Jun Yang, Guangbin Huang, Yongming Li, Dingyuan Du

“…This approach included principal component analysis, differential gene expression analysis using DESeq2, Gene Set Enrichment Analysis (GSEA), weighted gene co-expression network analysis (WGCNA), and machine learning (ML) algorithms (support vector machine-recursive feature elimination, least absolute shrinkage and selection operator, and random forest) for feature gene identification. Functional analysis of genes and immunoinfiltration analysis were also conducted. …”
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Yoda1 Inhibits TGFβ-Induced Cardiac Fibroblast Activation via a BRD4-Dependent Pathway by Perwez Alam, Sara M. Stiens, Hunter J. Bowles, Hieu Bui, Douglas K. Bowles

“…Fibrosis represents a pivotal pathological process in numerous diseases, characterized by excessive deposition of extracellular matrix (ECM) that disrupts normal tissue architecture and function. In the heart, cardiac fibrosis significantly impairs both structural integrity and functional capacity, contributing to the progression of heart failure. …”
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Extracorporeal photopheresis as induction therapy in lung transplantation for cystic fibrosis: a pilot randomized trial by Ilaria Righi, Claudio Fenizia, Daria Trabattoni, Mario Nosotti, Mario Nosotti, Giacomo Grisorio, Claudia Vanetti, Claudia Vanetti, Sonia di Tella, Cristina Mocellin, Norma Fantini, Daniele Prati, Letizia Corinna Morlacchi, Valeria Rossetti, Francesco Blasi, Francesco Blasi, Mario Clerici, Mario Clerici, Lorenzo Paolo Rosso, Lorenzo Paolo Rosso

“…Interestingly, a correlation between immunological modulation induced by extracorporeal photopheresis and pulmonary function was observed.Clinical Trial Registrationhttps://clinicaltrials.gov/study/NCT03500575?…”
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Irisin attenuates cardiac injury and improves prognosis in rats with hemorrhagic shock by maintaining mitochondrial homeostasis via the AMPK/Drp1 pathway by Zheng Zhang, Zheng Zhang, Zheng Zhang, Yufang Zhang, Yufang Zhang, Xiaofang Zou, Jiake Li, Yunfei Chi, Hailiang Bai, Bin Wei, Huiting Yun, Huiting Yun, Quanxi Zhang, Quanxi Zhang, Weihua Cao, Haiyan Liu, Hongjie Duan

“…Irisin has been shown to improve mitochondrial function and protect against ischemia-reperfusion injury (IRI), but its specific effects on myocardial injury in HS are unknown. …”
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Census and Analysis of Higher-Order Interactions in Real-World Hypergraphs by Xihang Meng, Xuemeng Zhai, Gaolei Fei, Sheng Wen, Guangmin Hu

“…Our experimental results demonstrate that hypermotifs can serve as higher-order fingerprints of real-world hypergraphs, helping to identify hypergraph classes based on network functions. These motifs potentially represent preferential attachments and key modules in real-world hypergraphs, arising from specific mechanisms or constraints. …”
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Hollow-Type Integrated Assembly Design and Performance Validation of Conductive Slip Rings via Simulation-Driven Optimization by Zhiyuan Qian, Chao Han, Nianhuan Li, Gongqiang Tian, Junye Li, Haihong Wu

“…Conductive slip rings (CSRs) are precision components critical to industrial equipment, yet they face challenges such as unstable signal transmission, limited functionality, and difficulties in operational monitoring due to assembly-induced inaccuracies. …”
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Time-dependent phenotypical changes of microglia drive alterations in hippocampal synaptic transmission in acute slices by Laura Ferrucci, Bernadette Basilico, Bernadette Basilico, Ingrid Reverte, Ingrid Reverte, Francesca Pagani, Giorgia Scaringi, Giorgia Scaringi, Federica Cordella, Federica Cordella, Barbara Cortese, Gaia De Propris, Andrea Galeone, Letizia Mazzarella, Alessandro Mormino, Stefano Garofalo, Azka Khan, Valeria De Turris, Valentina Ferretti, Paola Bezzi, Paola Bezzi, Cornelius Gross, Daniele Caprioli, Daniele Caprioli, Cristina Limatola, Cristina Limatola, Silvia Di Angelantonio, Silvia Di Angelantonio, Davide Ragozzino, Davide Ragozzino

“…It is widely acknowledged that microglia actively regulate synaptic function in the brain. Remarkably, much of our understanding regarding the role of microglia in synaptic regulation is derived from studies in acute brain slices. …”
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Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons by Doris Krauter, Jussi Kupari, Dmitry Usoskin, Jie Su, Yizhou Hu, Ming-Dong Zhang, Patrik Ernfors

“…Cell type complexity is shown to be generated by layered co-regulated transcriptional modules representing shared functions across different scales of the neuronal type hierarchy with cell type specific contribution as the exception.…”
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A Typical Cross-Border Metaverse Model as a Counteraction to Its Fragmentation by Oleksii Kostenko, Dmytro Zhuravlov, Volodymir Nikitin, Volodymyr Manhora, Tamila Manhora, Ivan Gabani

“…This model is characterised by a specific structure composed of modules or ecosystems that functionally differ in purpose and structure and are not connected by similar features. …”
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High-performance reconfigurable encryption scheme for distributed storage by Zhihua FENG, Yuxuan ZHANG, Chong LUO, Jianing WANG

“…As the world embraces the digital economy and enters an information society, data has emerged as a critical production factor.The collection, processing, and storage of data have become increasingly prevalent.Distributed storage systems, known for their efficiency, are widely used in various data fields.However, as the scale of data storage continues to expand, distributed storage faces more significant security risks, such as information leakage and data destruction.These challenges drive the need for innovative advancements in big data distributed storage security technology and foster the integration of domestic cryptographic technology with computing storage technology.This work focused on addressing security issues, particularly information leakage, in distributed storage nodes.A dynamic and reconfigurable encryption storage solution was proposed, which considered the requirements for encryption performance and flexibility.A high-performance reconfigurable cryptographic module was designed based on the bio mapping framework.Based on this module, multiple storage pools equipped with different cryptographic algorithms were constructed to facilitate high-performance encryption and decryption operations on hard disk data.The scheme also enabled dynamic switching of cryptographic algorithms within the storage pools.A cryptographic protocol with remote online loading functions for cryptographic algorithms and keys was developed to meet the unified management and convenient security update requirements of reconfigurable cryptographic modules in various storage nodes.Furthermore, the scheme implemented fine-grained data encryption protection and logical security isolation functions based on cryptographic reconstruction technology.Experimental results demonstrate that the performance loss of this scheme for encryption protection and security isolation of stored data is approximately 10%.It provides a technical approach for distributed storage systems to meet the cryptographic application technology requirements outlined in GB/T 39786-2021 “Information Security Technology-Basic Requirements for Cryptography Applications” Level 3 and above in terms of device and computing security, application and data security.…”
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The Role of miRNA in Plant Adaptation to Abiotic Stress by Mohammad Hadi Taleb, Ahmad Arzani

“…These processes include leaf morphogenesis (the formation of leaves), vegetative phase change (the transition from vegetative growth to flowering), flowering time, and the ability to respond to environmental signals. miRNAs, recognized as one of the most crucial RNA molecules, play a pivotal role by modulating gene function through post-transcriptional and translational mechanisms. …”
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Evaluating the Synergy of Conflict Detection and Resolution Services for Constrained Urban Airspace by Calin Andrei Badea, Andrija Vidosavljevic, Joost Ellerbroek, Jacco Hoekstra

“…One important component of such a system is the conflict detection and resolution (CD&R), mainly composed of the strategic and tactical CD&R module. While many approaches towards these have been studied, insufficient analysis has been conducted on their compatibility when functioning within a unified, hybrid system. …”
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ecochange: An R‐package to derive ecosystem change indicators from freely available earth observation products by Wilson Lara, Maria C. Londoño, Ivan Gonzalez, Victor H. Gutierrez‐Velez

“…Its functionality is described with an example workflow to calculate ecosystem‐class areas and conditional entropy across an area of interest contained in the package documentation. …”
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