Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo. by Thomas M Wishart, Timothy M Rooney, Douglas J Lamont, Ann K Wright, A Jennifer Morton, Mandy Jackson, Marc R Freeman, Thomas H Gillingwater

“…We propose that the proteins and functional pathways identified in the current study represent attractive targets for developing therapeutics aimed at modulating synaptic and axonal stability and neurodegeneration in vivo.…”
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Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy by Amelia C. McCue, Stephen J. Demarest, Karen J. Froning, Michael J. Hickey, Stephen Antonysamy, Brian Kuhlman

“…The toxicity of TCEs may be ameliorated through the use of pro-drug forms of the TCE, which are not fully functional until recruited to the tumor microenvironment. …”
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Synergistic Antioxidant and Anti-Ferroptosis Therapy via BPNS-Encapsulated Thermoresponsive Chitosan Hydrogel for Spinal Cord Injury Regeneration by Yang Liu, Yingkai Wang, Xiangzi Wang, Wanchen Zeng, Zehong Zhang, Zhengmian Zhang, Zhongquan Qi

“…<b>Results</b>: The results demonstrate that this hydrogel effectively slows BPNS degradation, exhibits a high ROS scavenging capacity, reduces lipid peroxidation, and thereby inhibits ferroptosis and apoptosis, offering neuroprotective effects and promoting motor function recovery. <b>Conclusions</b>: Our findings establish the CS/β-GP/SA-BPNS hydrogel as a multifunctional therapeutic platform for SCI, synergizing sustained drug release with ROS–ferroptosis–apoptosis axis modulation to achieve neuroprotection and functional restoration. …”
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Systems biology approach delineates critical pathways associated with papillary thyroid cancer: a multi-omics data analysis by Febby Payva, Santhy K. S., Remya James, Amrisa Pavithra E, Venketesh Sivaramakrishnan

“…The effect of a nucleotide substitution on a protein's function was investigated. Additionally, significant transcription factors (TFs) and kinases were identified. …”
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SUMO conjugation susceptibility of Akt/protein kinase B affects the expression of the pluripotency transcription factor Nanog in embryonic stem cells. by Marcos Francia, Martin Stortz, Camila Vazquez Echegaray, Camila Oses, Paula Verneri, María Victoria Petrone, Ayelen Toro, Ariel Waisman, Santiago Miriuka, María Soledad Cosentino, Valeria Levi, Alejandra Guberman

“…Among other functions, Akt is known to promote the expression of Nanog, a central pluripotency transcription factor (TF). …”
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IDNet: A Diffusion Model-Enhanced Framework for Accurate Cranio-Maxillofacial Bone Defect Repair by Xueqin Ji, Wensheng Wang, Xiaobiao Zhang, Xinrong Chen

“…Cranio-maxillofacial bone defect repair poses significant challenges in oral and maxillofacial surgery due to the complex anatomy of the region and its substantial impact on patients’ physiological function, aesthetic appearance, and quality of life. …”
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Exploring Control Mechanism of Motoneuron Pools for the Forearm Antagonist Synergistic Muscles by Haoran Ren, Xinyu Jiang, Chenyun Dai

“…For enabling the prostheses to mimic the function of the human hand, it is essential to fully understand the principle of neuromuscular control of human hand. …”
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BFGF mitigates CTX-induced ovarian cytotoxicity via SERPINE1/HIF-1 and Nrf-2/HO-1 signaling pathways by Yao Li, Lin Zhang, Hongqing Lv, Chenxuan Mei, Min Hu

“…These findings demonstrate that BFGF protects ovarian cells from CTX-induced damage by modulating the Serpin Family E Member 1 (SERPINE1)/Hypoxia-inducible factor 1 (HIF-1) and Nuclear factor erythroid 2-related factor 2 (Nrf-2)/Heme Oxygenase 1 (HO-1) pathways, reducing apoptosis, and enhancing cell survival, providing a promising foundation for developing BFGF-based therapies to preserve ovarian function and fertility in female cancer patients undergoing chemotherapy.…”
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The Method of Miniaturization of a Microstrip Branch-Line Couplers by D. A. Letavin

“…They are also used as a functional  node fo r building power dividers, mixers, modulators, power  summators, and beamforming elements. …”
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Exploring transposons in macroalgae: LTR elements and neighboring genes in red seaweeds by Pilar Garcia-Jimenez, Rafael R. Robaina

“…TEs significantly influence gene expression through insertions that can disrupt gene function. Consequently, organisms have evolved mechanisms to regulate TE activity, particularly under stress conditions, where TE activation can lead to mutations. …”
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Age-Specific Physiological Adjustments of <i>Spirodela polyrhiza</i> to Sulfur Deficiency by Vesna Peršić, Anja Melnjak, Lucija Domjan, Günther Zellnig, Jasenka Antunović Dunić

“…For a comprehensive insight into electron transport efficiency and the redox states of the photosynthetic apparatus, rapid light curves, chlorophyll fluorescence (JIP test parameters), and modulated reflection at 820 nm were analyzed. Under S deficit, mother fronds relied on stored reserves to maintain functional PSII but accumulated reduced PQ pools, slowing electron flow beyond PSII. …”
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Identification of novel gut microbiota-related biomarkers in cerebral hemorrhagic stroke by Fengli Ye, Huili Li, Hongying Li, Xiue Mu

“…Gut microbiota-related genes (GMRGs) were obtained from GeneCards and literature, and overlapping genes were defined as gut microbiota-related DEGs (GMRDEGs). Functional enrichment, gene set enrichment analysis (GSEA), and protein–protein interaction (PPI) analyses were performed. …”
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Nb-FAR-1: A key developmental protein affects lipid droplet accumulation and cuticle formation in Nippostrongylus brasiliensis. by Wenmin Qi, Fei Shen, Chuyue Wang, Juan Wen, Xi Pan, Zhongying Zhao, Lihua Xiao, Yaoyu Feng, Dongjuan Yuan

“…Fatty acid and retinol binding proteins (FARs) are lipid-binding protein that may be associated with modulating nematode pathogenicity to their hosts. However, the functional mechanism of FARs remains elusive. …”
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Identification and validation of m6A RNA methylation and ferroptosis-related biomarkers in sepsis: transcriptome combined with single-cell RNA sequencing by Jinshuai Lu, Jianhao Wang, Kun Han, Yuxia Tao, Jiyi Dong, Xiaoyu Pan, Xiaolan Wen

“…Further in-depth analyses of the biomarkers were performed, including functional enrichment, immune infiltration, drug prediction, and molecular docking. …”
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Nitric Oxide restricts iron availability and induces quorum sensing in Streptococcus pyogenes by Ian E. McIntire, Venkatesan Kathiresan, Brian Hoffman, Jennifer Chang, Michael J. Federle, Douglas D. Thomas

“…Nitric oxide (NO) is a free radical signaling molecule with multiple biological functions. As part of the innate immune system, NO has antimicrobial properties playing an important role in host defense. …”
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Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein. by Daniel Sauter, Daniel Unterweger, Michael Vogl, Shariq M Usmani, Anke Heigele, Silvia F Kluge, Elisabeth Hermkes, Markus Moll, Edward Barker, Martine Peeters, Gerald H Learn, Frederic Bibollet-Ruche, Joëlle V Fritz, Oliver T Fackler, Beatrice H Hahn, Frank Kirchhoff

“…Here, we analyzed the function of Vpu proteins from seven group N strains from Cameroon, the place where this zoonosis originally emerged. …”
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Ipsilesional High Frequency Repetitive Transcranial Magnetic Stimulation Add-On Therapy Improved Diffusion Parameters of Stroke Patients with Motor Dysfunction: A Preliminary DTI S... by Zhiwei Guo, Yu Jin, Haitao Peng, Guoqiang Xing, Xiang Liao, Yunfeng Wang, Huaping Chen, Bin He, Morgan A. McClure, Qiwen Mu

“…Both groups significantly improved the neurological function after treatment. rTMS-treated patients showed better improvement in Fugl-Meyer Assessment (FMA) score and increased FA value in motor-related white matter and gray matter cortices compared with CT-treated patients and pretreatment status. …”
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Unravelling the gut-liver axis: The role of gut microbiota-mitochondria interactions in the pathogenesis and management of metabolic-associated fatty liver disease (MAFLD) by Binzhi Zhang, Xia Luo, Song Lei, Wenbo Gao, Zhipeng Chen, Qing Zhu, Lizheng Huang, Qinqiang Long

“…The therapeutic approach of modulating the gut microbiota to regulate mitochondrial function and restore liver health is promising. …”
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Impact of Autolysed Brewer’s Yeast and Soluble Dried Yeast Extract on Growth Performance and Mucosal Health of Atlantic Salmon (<i>Salmo salar</i>) Parr by Sheu G. Odu-Onikosi, Taofik A. Momoh, Sherilyn T. Abarra, Noah E. Wood, Folasade D. Amulejoye, Matthew Emery, Glenn M. Harper, Benjamin Eynon, Victor Kuri, Holger Kühlwein, Daniel L. Merrifield

“…Yeast-based feed additives have emerged as promising functional feed additives (FFAs) to promote sustainable aquaculture development through enhanced gut health and immune modulation in fish. …”
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Delocalized Ag−Ag dimer rattling mode contributes to reduced thermal conductivity and enhanced thermoelectric performance in AgAs2 by Jie Zhang, Minghao Zhan, Wending Wang, Xiaohong Xia, Yun Gao, Zhongbing Huang

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