Mitochondrial pyruvate carrier inhibits tumor growth by Bmi1 ubiquitination in renal cell carcinoma progression by Dan Jian, Nana Hu, Rong He, Le He, He Xiao, Xingqiao Peng, Yang Peng, Yuxin Yang, Xiaoyan Dai, Dong Wang, Yan Feng, Nan Dai, Qian Chen

“…These findings identify the MPC complex as a potential tumor suppressor and prognostic biomarker set in RCC, functioning in part through modulation of Bmi1 stability.…”
Get full text

Upstream open reading frames buffer translational variability during Drosophila evolution and development by Yuanqiang Sun, Yuange Duan, Peixiang Gao, Chenlu Liu, Kaichun Jin, Shengqian Dou, Wenxiong Tang, Hong Zhang, Jian Lu

Get full text

Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A Review by Tingting Zhang, Mingyue Li, Jingyang Lu, Jia Wang, Min Zhang, Pharkphoom Panichayupakaranant, Haixia Chen

“…Quinones can improve insulin resistance and regulate glucose homeostasis by modulating mitochondrial function, inflammation, lipid profile, gastrointestinal absorption, and by acting as insulin mimetics. …”
Get full text

Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model by Bolin Lin, Chi-Tang Ho, Yawen Wang, Jie Xiao, Muwen Lu

“…These results indicated that CAP could alleviate CD-induced hepatic clock gene disruption and gut microbiota dysbiosis in mice, providing theoretical basis for CAP to be used as a muti-functional ingredient with great health-promoting effects.…”
Get full text

Tumor suppressive activity of prolyl isomerase Pin1 in renal cell carcinoma by Brian L. Teng, Kathryn E. Hacker, Shufen Chen, Anthony R. Means, W. Kimryn Rathmell

“…Abstract Pin1 specifically recognizes and catalyzes the cis‐trans isomerization of phosphorylated‐Ser/Thr‐Pro bonds, which modulate the stability, localization, and function of numerous Pin1 targets involved in tumor progression. …”
Get full text

Expression quantitative trait loci associated with performance traits, blood biochemical parameters, and cytokine profile in pigs by Felipe André Oliveira Freitas, Felipe André Oliveira Freitas, Luiz F. Brito, Bárbara Silva-Vignato, Fernanda Nery Ciconello, Vivian Vezzoni de Almeida, Aline Silva Mello Cesar

“…In conclusion, the identification of three eQTL significantly associated with aspartate aminotransferase and cytokine levels in both serum and liver tissues suggests a potential role for these variants in modulating immune function and overall health in production pigs. …”
Get full text

Comprehensive analysis of the prognostic and immunological role of cavins in non-small cell lung cancer by Kelin Mou, Huan Wang, Siqi Zhu, Jing Luo, Jianmei Wang, Lin Peng, Yulin Lei, Yunke Zhang, Shike Huang, Huarong Zhao, Gang Li, Li Xiang, Yuhao Luo

“…Abstract Caveolae, specialized and dynamic subdomains of the plasma membrane, have a crucial role in diverse cellular functions encompassing endocytosis, signal transduction, mechanosensation, lipid storage, and metabolism. …”
Get full text

Giant energy storage density with ultrahigh efficiency in multilayer ceramic capacitors via interlaminar strain engineering by Ying Yang, Ke Xu, Bin Yang, Xu Hou, Zhanming Dou, Yuhong Li, Zihao Zheng, Gengguang Luo, Nengneng Luo, Guanglong Ge, Jiwei Zhai, Yuanyuan Fan, Jing Wang, Haoming Yang, Yao Zhang, Jing Wang, Changyuan Wang, Shenglin Jiang, Kanghua Li, Jinming Guo, Houbing Huang, Guangzu Zhang

Get full text

Acute Hypoxic Stress Affects Migration Machinery of Tissue O2-Adapted Adipose Stromal Cells by Olga O. Udartseva, Margarita V. Lobanova, Elena R. Andreeva, Sergey V. Buravkov, Irina V. Ogneva, Ludmila B. Buravkova

“…These results indicate that acute hypoxic stress can modulate MSC function in their native milieu, preventing their mobilisation from sites of injury.…”
Get full text

Spinal cord injury and electrical stimulation: analysis of neuroplasticity in a case report by Orcizo Francisco Silvestre, Julia Silva e Lima Schleder, Bruna Valentina Zuchatti, Cintia Kelly Bittar, Carla Alves Fakih, Marina Squarizi Simões Chagas, Vinicius Taboni Lisboa, Alberto Cliquet Junior

“…EMG assessment showed a bilateral increase of peak values as well as successful Quadriceps muscle contraction generating knee extension.ConclusionNeuromuscular electrical stimulation may be a promising strategy in the rehabilitation of spinal cord injuries, with the potential to aid in functional recovery and modulation of neuroplasticity. …”
Get full text

IDO1-mediated M2 macrophage polarization alleviates the progression of ankylosing spondylitis by Kangqi Ji, Lingfei Wang, Weijie Liu, Genfeng Li, Xiaoyu Lian, Jun Fan, Chen Song, Yanpeng Jian

“…However, its specific function in ankylosing spondylitis (AS) remain unclear. …”
Get full text

Pan-Genomic Insights into Rumen Microbiome-Mediated Short-Chain Fatty Acid Production and Regulation in Ruminants by Jingyi Shi, Hongren Su, Shichun He, Sifan Dai, Huaming Mao, Dongwang Wu

“…By integrating multi-omics datasets, pan-genomic approaches unveil unprecedented layers of microbial diversity, enabling precise identification of core functional genes and their dynamic contributions to carbohydrate degradation and SCFA biosynthesis. …”
Get full text

Point-Symmetric Extension-Based Interval Shannon-Cosine Spectral Method for Fractional PDEs by Ruyi Xing, Yanqiao Li, Qing Wang, Yangyang Wu, Shu-Li Mei

“…In the research, a power function of cosine function is introduced to modulate Shannon function, which takes full advantage of the waveform of the Shannon function to ensure that many excellent properties can be satisfied such as the partition of unity, smoothness, and compact support. …”
Get full text

Thalamocortical Connectivity and Microstructural Changes in Congenital and Late Blindness by N. H. Reislev, T. B. Dyrby, H. R. Siebner, H. Lundell, M. Ptito, R. Kupers

Get full text

Organization of regular passenger transportation taken into account of citizens’ appeals and dispatch control by L. S. Trofimova, D. V. Gavrilin, A. S. Kabzhamitova

“…The purpose of this study is to establish the relationship between the functioning of the Incident Management system and dispatch control of municipal passenger enterprises to fulfill the terms of the Contract when organizing regular passenger transportation on municipal routes.Materials and methods. …”
Get full text

Activation profile of the Atlantic salmon (Salmo salar) calcium-sensing receptor (Casr) by selected L-amino acids by Ana S. Gomes, Virginie Gélébart, Rute C. Félix, João C.R. Cardoso, Fabian Zimmermann, Floriana Lai, Deborah M. Power, Ivar Rønnestad

“…Abstract In mammals, the calcium-sensing receptor (CaSR) is involved in nutrient sensing and modulated by several amino acids. In teleosts, sequence homologues of the mammalian CaSR have been described but their function in sensing amino acids remains elusive, including in Atlantic salmon (Salmo salar), an important aquaculture species. …”
Get full text

Role of Meox1 in promoting lung tumor vascularization and impairing CD8+ T cell mediated immunity by Dacheng Yang, Dacheng Yang, Qian Li, Zisheng Chen, Wei Kevin Zhang, Wei Kevin Zhang

“…Meox1 has been implicated in promoting both tumor-promoting and immune-suppressing functions.MethodsIn this study, to systematically map TF dynamics across cancer and immune cells, we performed scRNA-seq on tumor tissues and used the SCENIC framework for regulon analysis, revealing cell-type-specific gene regulatory networks. …”
Get full text

Flexible modular dwelling for rural environments; specific case: Cebadas – Ecuador [version 2; peer review: 2 approved] by Karina Elizabeth Cajamarca Dacto, Maikol Josueé González Espinosa, Dany Marcelo Tasan Cruz, Erick Fabricio Nieto Páez, Jean Carlos Montero Riofrio

“…Results The spaces presented in the proposal respond to the spatial need for growth and expansion of the users of the sector, through 6 basic guidelines that this type of dwelling should have: Environment, Visual, Form, Function, Bioclimatic and Materials. Conclusions The flexible modular dwelling project for rural environments addresses complex housing needs, highlighting the flexibility and adaptability of an expandable module. …”
Get full text

Different Long-Term Nutritional Regimens of <i>Drosophila melanogaster</i> Shape Its Microbiota and Associated Metabolic Activity in a Sex-Specific Manner by Repac Jelena, Trajković Jelena, Rakić Marija, Lunić Tanja, Savić Tatjana, Božić Bojan, Božić Nedeljković Biljana, Sofija Pavković-Lučić

“…Bacterial families of lower abundance also emerged as differentially present among the studied fly groups. Additionally, functional prediction provided initial clues into how nutrient availability might modulate the metabolic traits of adult fly microbiota in a sex-specific manner to meet host metabolic needs. …”
Get full text

Bifunctional self‐segregated electrolyte realizing high‐performance zinc‐iodine batteries by Xueting Hu, Zequan Zhao, Yongqiang Yang, Hao Zhang, Guojun Lai, Bingan Lu, Peng Zhou, Lina Chen, Jiang Zhou

Get full text