Longitudinal efficacy of risdiplam treatment in Chinese children with spinal muscular atrophy by Yue Yan, Danhui Zhu, Kai Ma, Xufeng Luo, Xiaoli Zhang, Xiaolong Deng, Mei Lu, Yang Li, Jianwei Li, Feng Gao, Shanshan Mao

“…Improvements in motor function were monthly quantified by generalized estimating equation analysis. …”
Get full text

Descriptive Comparative Transcriptomic Analysis of Genotype IV SHEV ORF3-Expressing HepG2 Cells by Hanwei Jiao, Chi Meng, Fengyuan Jiao, Gengxu Zhou, Lingjie Wang, Shengping Wu, Cailiang Fan, Jixiang Li, Liting Cao, Yu Zhao, Yichen Luo

“…However, its main function and pathogenic mechanism remain incompletely understood. …”
Get full text

Cellular hierarchy framework based on single-cell and bulk RNA sequencing reveals fatty acid metabolic biomarker MYDGF as a therapeutic target for ccRCC by Ning Wang, Ziyu Xu, Lina Zhang, Lina Zhang, Yanfang Lu, Yanfang Lu, Yanliang Wang, Yanliang Wang, Lei Yan, Lei Yan, Huixia Cao, Huixia Cao, Limeng Wang, Limeng Wang, Fengmin Shao, Fengmin Shao

“…Nevertheless, the effect of FAM reprogramming on the heterogeneity and prognosis of ccRCC individuals remains insufficiently understood.MethodsWe utilized single-cell sequencing and spatial transcriptomics to investigate the heterogeneity of FAM in ccRCC comprehensively. Functional enrichment algorithms, including AUCell, UCell, singscore, ssGSEA, and AddModuleScore, along with hdWGCNA analysis, were used to identify hub genes influencing high FAM of ccRCC. …”
Get full text

A combination of four Toxoplasma gondii nuclear-targeted effectors protects against interferon gamma-driven human host cell death by Brittany Henry, Aubrey J. Phillips, L. David Sibley, Alex Rosenberg

“…Recent genome-wide loss-of-function screens in IFNγ-primed primary human fibroblasts identified MYR translocon components as crucial for parasite resistance against IFNγ-driven vacuole clearance. …”
Get full text

CFTR ion transport deficiency primes the epithelium for partial epithelial-mesenchymal transition in cystic fibrosis by Cláudia S. Rodrigues, Matilde Canto, Raquel Torres, Violeta Railean, Sofia S. Ramalho, Carlos M. Farinha, Ines Pankonien, Margarida D. Amaral

“…MethodsHere, we investigated whether PM localisation of CFTR alone is sufficient to preserve epithelial integrity or if its ion transport function is also required using polarized CF bronchial epithelial (CFBE) cells expressing wt-, p.Phe508del-, or p.Gly551Asp-CFTR. …”
Get full text

UGT708S6 from Dendrobium catenatum, catalyzes the formation of flavonoid C-glycosides by Luyao Yu, Kun He, Yu Wu, Kai Hao, Yun Wang, Jinbo Yao, Yuxue Zhao, Qiaoxian Yu, Yanghui Shen, Mengxuan Chen, Ke Xu, Xinfeng Zhang, Lei Zhang

Get full text

Upregulation of ARHGAP18 by miR-613 Inhibits Cigarette Smoke Extract-Induced Apoptosis and Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells by Fu H, Liu K, Zheng Y, Zhao J, Xie T, Ding Y

“…Epithelial-mesenchymal transition (EMT)-associated proteins were determined by Western blotting. The function of miR-613 in COPD was further detected. Functional rescue experiments were performed to determine the mechanism of ARHGAP18 in COPD.Results: Our study identified ARHGAP18 as the key gene associated with epithelial dysfunction in COPD. …”
Get full text

FLZ attenuates Parkinson's disease pathological damage by increasing glycoursodeoxycholic acid production via down-regulating Clostridium innocuum by Meiyu Shang, Jingwen Ning, Caixia Zang, Jingwei Ma, Yang Yang, Yueqi Jiang, Qiuzhu Chen, Yirong Dong, Jinrong Wang, Fangfang Li, Xiuqi Bao, Dan Zhang

Get full text

Stress and Visceral Perception by Michel M Delvaux

“…Functional bowel disorders are characterized by the presence of a visceral hyperalgesia in most patients. …”
Get full text

Experimental Implementation of Automatic Control of Posture-Dependent Stimulation in an Implanted Standing Neuroprosthesis by Brooke M. Odle, Lisa M. Lombardo, Musa L. Audu, Ronald J. Triolo

“…To this end, a feedback controller, named the “Posture Follower Controller”, was developed to aid in task-dependent posture shifting by individuals with spinal cord injury standing with functional neuromuscular stimulation. In this experimental feasibility study, the controller modulated activation to the paralyzed lower extremity muscles as a function of the position of overall center of pressure (CoP), which was prescribed to move in a straight line in forward and diagonal directions. …”
Get full text

SPINK1 facilitates tumor progression via the EGFR/JAK/STAT3 axis in oral squamous cell carcinoma: insights from single-cell RNA sequencing by Mingyan Bao, Zhangui Tang

“…ObjectiveThis study aimed to elucidate the functional role and molecular mechanisms of Serine Peptidase Inhibitor Kazal Type 1 (SPINK1) in oral squamous cell carcinoma (OSCC) through integrative analysis of single-cell RNA sequencing (scRNA-seq) data.Materials and methodsCellular subpopulations within OSCC were stratified using transcriptomic datasets from the GEO database. …”
Get full text

Preliminary Evidence for Lensing-induced Alignments of High-redshift Galaxies in JWST-CEERS by Viraj Pandya, Abraham Loeb, Elizabeth J. McGrath, Guillermo Barro, Steven L. Finkelstein, Henry C. Ferguson, Norman A. Grogin, Jeyhan S. Kartaltepe, Anton M. Koekemoer, Casey Papovich, Nor Pirzkal, L. Y. Aaron Yung

“…On the chip scale, the average complex ellipticity 〈 e 〉 ∼ 10% is nonnegligible and beyond the level of our point-spread function (PSF) uncertainties. The shear variance $\langle {\overline{\gamma }}^{2}\rangle \sim 1{0}^{-3}$ is an order of magnitude above the conventional weak-lensing regime but is more sensitive to PSF systematics, intrinsic alignments, cosmic variance, and other biases. …”
Get full text

Self-splicing RNA circularization facilitated by intact group I and II introns by Yong Shen, Bohan Li, Lei Dong, Wei Tang, Jiwu Ren, Feng Chen, Wenjuan Zheng, Ying Yu, Lu Gao, Wensheng Wei

Get full text

Design and development of optimal route planning software for the inspection of earthquake monitoring stations by Weifeng Zhang, Jie Pan, Dong Fan, Liangliang Sun, Guibao Zhao, Jingsheng Li

“…The article expounds the design concept, main functions and technical implementation of the software, describes the design of key modules in detail, points out the issues that should be paid special attention to optimize the inspection route, and looks forward to the future application prospect of the software. …”
Get full text

Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing by Jingyuan Huo, Zhen Wang, Wenting Zhao, Miao Chen, Haoyang Li, Fengpu He, Xiao Tian, Yaqi Ma, Firyuza Husanova, Liang Ma, Yiming Ni, Hongda Ding, Weidong Li, Hongfei Xu

“…Furthermore, we observed suppressive macrophages (SPP1+ and OLR1+) and reduced mitochondrial gene MT‐RNR2 (MTRNR2L12) expression in TME‐infiltrating cells, indicating impaired mitochondrial function. Conclusion This study elucidates the complex cellular landscape and immune microenvironment of PCAS, highlighting potential molecular targets for the development of novel therapies. …”
Get full text

Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer by Pierre-Luc Mercier, Magdalena Bachvarova, Marie Plante, Jean Gregoire, Marie-Claude Renaud, Karim Ghani, Bernard Têtu, Isabelle Bairati, Dimcho Bachvarov

“…On the contrary, DOK1 was found to be strongly overexpressed in serous EOC tumors as compared to normal tissue and importantly, DOK1 overexpression significantly correlated with improved progression‐free survival (PFS) values of serous EOC patients. Ectopic modulation of DOK1 expression in EOC cells and consecutive functional analyses pointed toward association of DOK1 expression with increased EOC cell migration and proliferation, and better sensitivity to cisplatin treatment. …”
Get full text

Exploration of the clinical prognostic model of BRCA based on PCAT7 by Zhi Zhang, Chaocheng Xiang, Tong Chen, Aimin Ma, Xu Wang, Jiaying Li, Yixuan Chen, Yixuan Chen, Chengyu Huang, Chengyu Huang, Ting Li, Ting Li, Danmei Wu, Steven Mo, Dequan Li

“…Consequently, investigating the function and prognostic significance of PCAT7 in BRCA has become imperative.MethodsThis study used BRCA data from the Cancer Genome Atlas (TCGA) as a training cohort to evaluate the prognostic potential of PCAT7. …”
Get full text

Child Health, Agriculture and Integrated Nutrition (CHAIN): protocol for a randomised controlled trial of improved infant and young child feeding in rural Zimbabwe by Paul Kelly, Lisa Langhaug, Robert Ntozini, Kuda Mutasa, Bernard Chasekwa, Andrew Prendergast, Batsirai Mutasa, Naume V Tavengwa, Tim Brown, Laura E Smith, Dexter. T Chagwena, Claire Bourke, Ruairi Robertson, Shamiso Fernando, Jill Cairns, Thokozile Ndhlela, Exhibit Matumbu, Kavita Datta, Alice Tengende, Dzivaidzo Chidhanguro, Maggie Makanza, Jonathan Swann

“…Nested laboratory substudies will evaluate the gut microbiome, environmental enteric dysfunction, metabolic phenotypes and innate immune function. Qualitative substudies will explore the acceptability and feasibility of the IYCF-plus intervention among participants and community stakeholders, and the effects of migration on food production and consumption.Ethics and dissemination This trial is registered at ClinicalTrials.gov (NCT04874688) and was approved by the Medical Research Council of Zimbabwe (MRCZ/A/2679) with the final version 1.4 approved on 20 August 2021, following additional amendments. …”
Get full text

Protocol for capturing genome-wide chromatin interactions in Arabidopsis by Jiayue Shu, Suxin Xiao, Dingyue Wang, Minqi Yang, Yue Zhou

Get full text

Precise Regulations at the Subcellular Level through Intracellular Polymerization, Assembly, and Transformation by Le He, Fanying Meng, Ran Chen, Jinlong Qin, Min Sun, Zhen Fan, Jianzhong Du

Get full text