Development and Validation of a Brain Aging Biomarker in Middle-Aged and Older Adults: Deep Learning Approach by Zihan Li, Jun Li, Jiahui Li, Mengying Wang, Andi Xu, Yushu Huang, Qi Yu, Lingzhi Zhang, Yingjun Li, Zilin Li, Xifeng Wu, Jiajun Bu, Wenyuan Li

“…Brain age gap exhibited clinical feasibility combined with Functional Activities Questionnaire, with improved discriminative capacity in models achieving lower MAEs (AUC of 0.945 vs 0.923 and 0.911; AUC of 0.935 vs 0.900 and 0.881). …”
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RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation by Alejandro Rosell, Agata Adelajda Krygowska, Marta Alcón Pérez, Cristina Cuesta, Mathieu-Benoit Voisin, Juan de Paz, Héctor Sanz-Fraile, Vinothini Rajeeve, Ana Carreras-González, Alberto Berral-González, Ottilie Swinyard, Enrique Gabandé-Rodríguez, Julian Downward, Jordi Alcaraz, Juan Anguita, Carmen García-Macías, Javier De Las Rivas, Pedro R Cutillas, Esther Castellano Sanchez

“…This discovery uncovers a previously unknown role of the p110α isoform in immune regulation within macrophages, offering insight into the complex mechanisms governing their function during inflammation and opening new avenues for modulating inflammatory responses.…”
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Microparticles That Form Immune Complexes as Modulatory Structures in Autoimmune Responses by Catalina Burbano, Mauricio Rojas, Gloria Vásquez, Diana Castaño

“…Initially MPs were considered to be inert cellular products with no biological function. However, an extensive research and functional characterization have shown that the molecular composition and the effects of MPs depend upon the cellular background and the mechanism inducing them. …”
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Tuning the electronic states of Pd(II) defect-engineered metal-organic framework catalysts for efficient conversion of isocyanides by Shaoting Su, Yilei Cao, Yanwei Ren, Huanfeng Jiang, Wanqing Wu

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Subcellular localization and tissue expression pattern of SlMAPK7 gene in tomato by Guan Xiaoyan, Chen Lifei, He Yanjun, Wang Jie, Lu Gang

“…However, the most extensively studied MAPKs are MAPK3, MAPK4 and MAPK6 in Arabidopsis and rice. The function of other MAPK family members is not clear yet. …”
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Exome sequencing shows same pattern of clonal tumor mutational burden, intratumor heterogenicity and clonal neoantigen between autologous tumor and Vigil product by David Willoughby, Ernest Bognar, Laura Stanbery, Casey Nagel, Gladice Wallraven, Aman Pruthi, Nicholas Bild, Ericca Stamper, Donald Rao, Adam Walter, John Nemunaitis

“…In order to explore this relationship prospectively with Vigil, a triple function targeted immunotherapy involving ovarian cancer patients in long term follow up of the Phase 2b VITAL trial, we developed an exome sequencing procedure and associated bioinformatics pipeline to determine clonal signal patterns. …”
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International Natural Uranium Price Prediction Based on TF-CNN-BiLSTM Model by YANG Jingzhe, XUE Xiaogang

“…The study meticulously constructed and trained the TF-CNN-BiLSTM model using TensorFlow with the Adam optimizer and mean squared error loss function. The training process was optimized with learning rate reduction and early stopping callbacks to prevent overfitting. …”

TOPK promotes immune suppression in kidney renal clear cell carcinoma and emerges as a prognostic and therapeutic target by Zeyuan Zheng, Renhui Xiong, Xiuyuan Sui, Liyan Li, Huimin Sun, Chen Shao

“…In vivo experiments using TOPK-deficient tumor models in immunocompetent mice supported its role in modulating tumor-associated inflammation.While these experiments were based on a non-renal tumor model, the findings nonetheless provide meaningful insights into the immunoregulatory function of TOPK in vivo. …”
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Lipopolysaccharide affects metabolic processes and energy homeostasis in the corpus luteum by Karol Mierzejewski, Robert Stryiński, Iwona Bogacka, Monika Golubska, Mónica Carrera, Aleksandra Kurzynska

“…Moreover, we demonstrated that LPS decreases glucose levels and increases progesterone levels in the CL.ConclusionThese findings suggest that LPS modulates key metabolic pathways in the CL, potentially impacting its functional activity.…”
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Histological and Metabolic State of Dams Suckling Small Litter or MSG-Treated Pups by Claudia Regina Capriglioni Cancian, Nayara Carvalho Leite, Elisangela Gueiber Montes, Stefani Valeria Fisher, Leticia Waselcoski, Emily Caroline Lopes Stal, Renata Zanardini Christoforo, Sabrina Grassiolli

“…Lactation is an important function that is dependent on changes in the maternal homeostasis and sustained by histological maternal adjustments. …”
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Phase and Valence State Engineering of MOFs-Derived Iron Oxide@Carbon Polyhedrons for Advanced Microwave Absorption by Xiaojiao Yang, Shuai Han, Hongna Xing, Yi Dong, Xia Deng, Yan Zong, Juan Feng, Xiuhong Zhu, Xinghua Li, Xinliang Zheng

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Modular shape-changing tensegrity-blocks enable self-assembling robotic structures by Luyang Zhao, Yitao Jiang, Muhao Chen, Kostas Bekris, Devin Balkcom

“…Abstract Modular robots are currently designed to perform a variety of tasks, primarily focusing on locomotion or manipulation through the reconfiguration of rigid modules. However, the potential to integrate multiple functions, such as making each robot deployable and capable of building lattice structures for self-construction and infrastructure creation, remains largely unexplored. …”
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Dietary intervention with Polygonatum sibiricum polysaccharides mitigates cadmium liver toxicity: a gut-liver axis perspective by Qiannan Di, Huimin Zhou, Huifang Chen, Xiaowei Wang, Xiao Huang

“…PSP decreased Cd accumulation in both the liver and kidney, enhanced intestinal barrier function, promoted the growth of beneficial bacteria (Lactobacillus), and modulated the production of short-chain fatty acids (SCFAs). …”
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Effects of aerobic running vs. reading rest after fear extinction on recall: Decreased prefrontal cortex activity to distinguish threat and safety cues by Xiao Zhou, Juan Kou, E Mei, Yi Lei

“…These results suggest that aerobic running may facilitate fear extinction more effectively than reading rest by modulating dmPFC function. This study explores the neural mechanisms that underpin the effects of exercise on fear memory and proposes a potential method for enhancing exposure-based therapy, potentially through targeted physical activity interventions.…”
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Microarray Gene Expression Analysis of Murine Tumor Heterogeneity Defined by Dynamic Contrast-Enhanced MRI by Nick G. Costouros, Dominique Lorang, Yantian Zhang, Marshall S. Miller, Felix E. Diehn, Stephen M. Hewitt, Michael V. Knopp, King C. P. Li, Peter L. Choyke, H. Richard Alexander, Steven K. Libutti

“…Current methods of studying angiogenesis are limited in their ability to serially evaluate in vivo function throughout a target tissue. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and pharmacokinetic modeling provide a useful method for evaluating tissue vasculature based on contrast accumulation and washout. …”
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Parity influences postpartum adaptations in the maternal gut microbiota by Zharkyn Jarmukhanov, Elizaveta Vinogradova, Nurislam Mukhanbetzhanov, Samat Kozhakhmetov, Deniza Khassenbekova, Almagul Kushugulova

“…We identified parity-specific signatures, with first-time mothers showing enrichment in Dysosmobacter welbionis, Candidatus Saccharibacteria, and Anaerotruncus species. Functional analysis revealed distinct metabolic reprogramming patterns, including increased amino acid biosynthesis and modified fermentation pathways supporting postpartum recovery. …”
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SUMOylation is not a prerequisite for HSF1’s role in stress protection and transactivation by Miroslav Bardelcik, Oliver Simoncik, Kristina Bednarova, Ondrej Bonczek, Borivoj Vojtesek, Petr Muller

“…We generated HSF1 mutants with lysine-to-arginine substitutions at five SUMOylation sites and studied their function in H1299 lung carcinoma cells with HSF1/HSF2 knockout, which lack a functional HSR. …”
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The Effects of Tempol on Cyclophosphamide-Induced Oxidative Stress in Rat Micturition Reflexes by Eric J. Gonzalez, Abbey Peterson, Susan Malley, Mitchel Daniel, Daniel Lambert, Michael Kosofsky, Margaret A. Vizzard

“…We determined (1) the expression of oxidative stress markers 3-nitrotyrosine (3-NT), reactive oxygen species (ROS)/reactive nitrogen species (RNS), inflammatory modulators, neuropeptides calcitonin gene-related peptide (CGRP), substance P (Sub P), and adenosine triphosphate (ATP) that contribute to the inflammatory process in the urinary tract and (2) the functional role of oxidative stress in urinary bladder dysfunction with an antioxidant, Tempol, (1 mM in drinking water) combined with conscious cystometry. …”
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Three-Band Spectral Camera Structure Design Based on the Topology Optimization Method by Kai Hu, Yuzhu Wan, Jialong Guo, Chunbo Zou, Xiangtao Zheng

“…The analysis demonstrates that the optimized housing and bracket exhibit excellent dynamic and static performance, meeting all testing requirements, and, under gravitational conditions, the spot diagram and modulation transfer function effect are negligible. …”
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Biomarker_nlp: A Python Package for Mining Biomarker Information for Targeted Cancer Therapies by Junxia Lin, Yuezheng He, Subha Madhavan, Chul Kim, Simina M. Boca

“…Food and Drug Administration (FDA), as well as other biomedical free text. It contains modules and functions supporting the recognition and extraction of a variety of biomarkers, such as gene/protein, therapy, disease, and drug label. …”
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