The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy by Chen He, Chen He, Hui Shi, Zhijie Yu, Chunhan Ma, Zhiqiang Jiao, Jin Li, Fei Yang, Fei Yang

“…The microbiota-gut-brain axis, on the other hand, is a bidirectional communication network between the gut and the brain that modulates host behavior and cognitive function in many ways and is of central importance in the preservation of general health and homeostasis. …”
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Alkali‐Stable Metal–Organic Frameworks with Enhanced Electroconductivity for Black‐Brown Electrochromic Energy Storage Smart Window by Xinyi Wang, Zhiqiang Liu, Heqi Ma, Yiwen Liu, Qing Sui, Jifei Feng, Guofa Cai

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Activation of SIRT3 / PRDX5 signaling inhibits apoptosis after acute spinal cord injury in mice by Hui Ni, Weiping Sha, Tianli Xu, Qiancheng Zhu, Qun Huang, Jin Wang, Qi Gu, Yi Zhu, Liming Wang, Shoujin Tian, Rong Gao, Jianfei Ge, Xiaolong Lin

“…Genetic silencing of PRDX5 partially attenuated the protective effects of SIRT3 against neuronal apoptosis and the promotion of functional recovery. Overall, this study is the first to reveal the pivotal role of the SIRT3PRDX5 axis in modulating neuronal apoptosis after SCI, and thus offers a novel perspective on the restoration of function after SCI.…”
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Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents by Teng Teng, Fang Huang, Ming Xu, Xuemei Li, Lige Zhang, Bangmin Yin, Yuping Cai, Fei Chen, Luman Zhang, Jushuang Zhang, Aoyi Geng, Chengzhi Chen, Xiaofei Yu, Jing Sui, Zheng-Jiang Zhu, Kai Guo, Chenhong Zhang, Xinyu Zhou

“…Results We conducted a multi-omics study on 256 MDD patients and 307 healthy controls in children and adolescents, integrating plasma metabolomics, fecal metagenomics, and resting-state functional magnetic resonance imaging (rs-fMRI) of the brain. …”
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Microwave Photonic Links and Transversal Microwave Photonic Applications by Yunping Bai, Zhihui Liu, Mengmeng Duan, Jiaxue Feng, Xixi Xiong, Kelei Wei, Kainan Wu, Xiyao Jia, Ruilin Liao, Yuhang Song, Edwin Yue Bun Pun, Sha Zhu, Xingyuan Xu, Ning Hua Zhu, Kun Xu

“…Secondly, the architecture of MPLs used for different function modules of microwave photonic radar systems is reviewed, wherein the recent schemes based on MPLs are classified according to radar signal generation, radar signal processing, and radar signal transmission. …”
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Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids by Petra Geiser, Maria Letizia Di Martino, Ana C. C. Lopes, Alexandra Bergholtz, Magnus Sundbom, Martin Skogar, Wilhelm Graf, Kajsa Björner, Johan Vessby, Dominic-Luc Webb, Per M. Hellström, Jens Eriksson, Mikael E. Sellin

“…Taken together, the study reveals how a small set of virulence factors shapes divergent epithelial colonization strategies by related enterobacteria.IMPORTANCEPathogenic bacteria employ partially overlapping sets of virulence factor functions to colonize host epithelia but can differ markedly in their pathogenesis and disease kinetics. …”
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Exploration of M2 macrophage-related biomarkers and a candidate drug for glioblastoma using high-dimensional weighted gene co-expression network analysis by Suyin Feng, Suyin Feng, Suyin Feng, Long Zhu, Long Zhu, Long Zhu, Jinyuan Gu, Kun Kou, Yongtai Liu, Guangmin Zhang, Hua Lu, Honglai Zhang, Runfeng Sun, Runfeng Sun

“…Subsequently, the clusterProfiler package was employed to functionally annotate the genes specifically highly expressed in the cells. …”
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Irritable Bowel Syndrome: A Hallmark of Psychological Distress in Women? by Giuseppe Marano, Gianandrea Traversi, Roberto Pola, Antonio Gasbarrini, Eleonora Gaetani, Marianna Mazza

“…Women are disproportionately affected by IBS due to a complex interplay between genetic, environmental, and psychosocial factors, along with a crucial role of the gut–brain axis in modulating both bowel function and pain perception. …”
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The Alkaloid Gelsemine Reduces Aβ Peptide Toxicity by Targeting Transglutaminase Type 2 Enzyme by Jessica Panes-Fernández, Ana M. Marileo, Nicole Espinoza-Rubilar, Macarena E. Meza, Bernardita A. Salgado-Martínez, Krishna Gaete-Riquelme, Gustavo Moraga-Cid, Patricio A. Castro, Carlos F. Burgos, Jorge Fuentealba, Gonzalo E. Yévenes

“…Furthermore, gelsemine modulates the TG2-mediated Aβ aggregation process, thereby attenuating Aβ-induced neurotoxicity and preserving neuronal function. …”
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Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress by Lars Wilmes, Valentina Caputi, Thomaz F.S. Bastiaanssen, James M. Collins, Fiona Crispie, Paul D. Cotter, Timothy G. Dinan, John F. Cryan, Gerard Clarke, Siobhain M. O'Mahony

“…The early life gut microbiota of each of these clusters show distinct alterations in terms of diversity, genus level differential abundance, and functional modules. Multi-omic integrations points towards a role for different metabolic pathways underlying each cluster-specific phenotype. …”
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Sodium butyrate in Irritable Bowel Syndrome by Aleksandra Kołodziej, Wiktoria Zamirska, Nadia Hornig, Aleksandra Cieplak, Zuzanna Czyżewicz

“…Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by abdominal pain, bloating, and altered bowel habits. …”
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Toward generalizable prediction of antibody thermostability using machine learning on sequence and structure features by Ameya Harmalkar, Roshan Rao, Yuxuan Richard Xie, Jonas Honer, Wibke Deisting, Jonas Anlahr, Anja Hoenig, Julia Czwikla, Eva Sienz-Widmann, Doris Rau, Austin J. Rice, Timothy P. Riley, Danqing Li, Hannah B. Catterall, Christine E. Tinberg, Jeffrey J. Gray, Kathy Y. Wei

“…In this work, we show two machine learning approaches – one with pre-trained language models (PTLM) capturing functional effects of sequence variation, and second, a supervised convolutional neural network (CNN) trained with Rosetta energetic features – to better classify thermostable scFv variants from sequence. …”
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Microfluidics-Assisted Polymer Vesicle Budding in Emulsion Systems: A Promising Approach for the Preparation and Application of Polymer Vesicles by Donghua Dong, Jilai Zhan, Guoxing Liao, Tong Zhu, Qianqian Yu, Wei Zhang, Linge Wang

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A Bifunctional Fibrous Scaffold Implanted with Amorphous Co2P as both Cathodic and Anodic Stabilizer for High‐Performance Li─S Batteries by Gang Zhao, Tianran Yan, Lei Wang, Cheng Yuan, Tong Chen, Bin Wang, Chen Cheng, Pan Zeng, Yude Su, Liang Zhang

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Lactobacillus extracellular vesicle-driven oxygen-releasing photothermal hydrogel reprograms macrophages and promotes angiogenesis to accelerate diabetic wound healing by Pingyun Yuan, Meng Deng, Xueru Li, Xiaotong Lu, Hui Yang, Ronghua Jin, Lan Wang, Mi Chen, Tian Bai, Tao Liu, Wenhao Zhou, Xiangdong Wang

“…Mechanistic analysis indicated that the accelerated healing resulted from synergistic enhancement of Lac-EV-mediated inflammation modulation and functional angiogenesis via oxygen release and mild photothermal stimulation. …”
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Blue organic long-persistent luminescence via upconversion from charge-transfer to locally excited singlet state by Zesen Lin, Jinting Ye, Shin Shinohara, Yuya Tanaka, Rengo Yoshioka, Chin-Yiu Chan, Yi-Ting Lee, Xun Tang, Kirill Mitrofanov, Kai Wang, Hayato Ouchi, Liliia Moshniaha, Yemineni S. L. V. Narayana, Hisao Ishii, Xiao-Hong Zhang, Chihaya Adachi, Xian-Kai Chen, Ryota Kabe

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Impact of Legacy Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) on GABA Receptor-Mediated Currents in Neuron-Like Neuroblastoma Cells: Insights into Neurotoxic Mech... by Laura Lagostena, Davide Rotondo, Davide Gualandris, Antonio Calisi, Candida Lorusso, Valeria Magnelli, Francesco Dondero

“…These compounds are highly stable, allowing them to bioaccumulate in the environment and living organisms, potentially impacting critical physiological functions such as hormonal balance, immune response, and increasing cancer risk. …”
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Purification and identification of anti-inflammatory peptides from sturgeon (Acipenser schrenckii) cartilage by Li Yuan, Qian Chu, Bei Yang, Wei Zhang, Quancai Sun, Ruichang Gao

“…However, previous studies have proposed the possibility of producing peptides from cartilage with immune function modulation potential. The current study aimed to investigate the potential anti-inflammatory activity of peptides derived from sturgeon (Acipenser schrenckii) cartilage in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. …”
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Myocardial Proteome in Human Heart Failure With Preserved Ejection Fraction by Vivek P. Jani, Edwin J. Yoo, Aleksandra Binek, Alina Guo, Julie S. Kim, Jennifer Aguilan, Mohammad Keykhaei, Sydney R. Jenkin, Simone Sidoli, Kavita Sharma, Jennifer E Van Eyk, David A. Kass, Virginia S. Hahn

“…Ingenuity pathway analysis predicted downregulation of protein translation, mitochondrial function, and glucose and fat metabolism in HFpEF. …”
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Interaction Between Rumen Microbiota and Epithelial Mitochondrial Dynamics in Tibetan Sheep: Elucidating the Mechanism of Rumen Epithelial Energy Metabolism by Ying Xu, Yuzhu Sha, Xiaowei Chen, Qianling Chen, Xiu Liu, Yanyu He, Wei Huang, Yapeng He, Xu Gao

“…Investigating the functional interactions between rumen microbial fermentation and epithelial mitochondrial dynamics/energy metabolism in Tibetan sheep at different altitudes, this study examined ultrastructural changes in rumen epithelial tissues, expression levels of mitochondrial dynamics-related genes (fusion: <i>Mfn1</i>, <i>Mfn2</i>, <i>OPA1</i>, <i>Mic60</i>; fission: <i>Drp1</i>, <i>Fis1</i>, <i>MFF</i>), and ketogenesis pathway genes (<i>HMGS2</i>, <i>HMGCL</i>) in Tibetan sheep raised at three altitudes (TS 2500m, TS 3500m, TS 4500m). …”
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