Evidence for a major role of antisense RNAs in cyanobacterial gene regulation by Jens Georg, Björn Voß, Ingeborg Scholz, Jan Mitschke, Annegret Wilde, Wolfgang R Hess

“…Transferring cultures to high light, carbon‐limited conditions or darkness influenced the expression levels of several asRNAs, suggesting their functional relevance. Examples include the asRNA to rpl1, which accumulates in a light‐dependent manner and may be required for processing the L11 r‐operon and the SyR7 noncoding RNA, which is antisense to the murF 5′ UTR, possibly modulating murein biosynthesis. …”
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Lawsonia intracellularis T3SS effector LI0758, an Rce1 ortholog, activates MAPK and NF-κB signaling in mammalian cells by Yuanxiu Zhong, Yiyun Duan, Fenju Lai, Jinhua Zhang, Yimin Dai

“…While displaying unique activity in the yeast a-factor reporter system, LI0758 restores Ras2 localization in Rce1Δ mutant strains, implying functional similarity. Our findings underscore LI0758’s pivotal role in activating MAPK pathways and suggest its potential to modulate the localization and function of host CAAX proteins. …”
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The impact of vascular endothelial growth factor on oral squamous cell carcinoma through dendritic cell induction and facilitation of tumor immune tolerance by Peng Zhang, Yue Xu, Bolei Cai, Jiaqiang Xu, Tao Wang, Hongyan Xu

“…Conclusion Our findings elucidate the crucial role of VEGF in OSCC progression by modulating DC function, offering new insights into potential immunotherapeutic strategies targeting VEGF-mediated pathways.…”
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Ocular-cerebral immune dialogue: a new perspective and therapeutic potential of regional lymphatic systems by Yiran Wang, Pei Guo, Weihong Li, Weihong Li, Tong Li

“…The Central Nervous System (CNS), due to its unique structure and function, possesses immune privilege, which is primarily maintained through mechanisms such as the blood-brain barrier, immune cell exclusion, and neuroglial cell regulation, effectively protecting the CNS from external insults. …”
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Trans-synaptic molecular context of NMDA receptor nanodomains by Michael C. Anderson, Poorna A. Dharmasri, Martina Damenti, Sarah R. Metzbower, Rozita Laghaei, Thomas A. Blanpied, Aaron D. Levy

“…Abstract Tight coordination of spatial relationships between protein complexes is required for cellular function. In neuronal synapses, proteins responsible for neurotransmission form subsynaptic nanoclusters whose trans-cellular alignment modulates synaptic signal propagation. …”
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Improvement and Neuroplasticity after Combined Rehabilitation to Forced Grasping by Michiko Arima, Atsuko Ogata, Kazumi Kawahira, Megumi Shimodozono

“…The results suggest that training under electrical stimulation after BTX-A treatment may modulate the activities of the ipsilesional SMC and MFC and lead to functional improvement of the affected upper limb with forced grasping.…”
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Mechanistic study on the nuclear modifier gene MSS1 mutation suppressing neomycin sensitivity of the mitochondrial 15S rRNA C1477G mutation in Saccharomyces cerevisiae. by Qiyin Zhou, Wei Wang, Xiangyu He, Xiaoyu Zhu, Yaoyao Shen, Zhe Yu, Xuexiang Wang, Xuchen Qi, Xuan Zhang, Mingjie Fan, Yu Dai, Shuxu Yang, Qingfeng Yan

“…Here we report that a nuclear modifier gene mss1 mutation suppresses the neomycin-sensitivity phenotype of a yeast C1477G mutant in fermentable YPD medium. Functional assays show that the mitochondrial function of the yeast C1477G mutant was impaired severely in YPD medium with neomycin. …”
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Mitochondria of transformed cell as a target of antitumor influence by E. M. Frantsiyants, I. V. Neskubina, E. A. Sheiko

“…The review examined and analyzed scientific publications on the role of mitochondria in the life support of transformed cells, the study of their functioning and structurally functional dysfunctions, as part of mitochondrial medicine. …”
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A generalized linear model for estimating spectrotemporal receptive fields from responses to natural sounds. by Ana Calabrese, Joseph W Schumacher, David M Schneider, Liam Paninski, Sarah M N Woolley

“…Several algorithms have been used to estimate STRFs from responses to natural stimuli; these algorithms differ in their functional models, cost functions, and regularization methods. …”
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An anticipatory mechanism enhances the cooperative behaviors of quorum sensing mutants in Pseudomonas aeruginosa. by Min Yuan, Huifang Qiu, Xiaoqing Zhou, Weijun Dai

“…In conclusion, our study reveals the functional plasticity of LasR variants, which can be modulated by secondary mutations, affecting cooperation and conflict within populations. …”
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Approximation by interpolation spectral subspaces of operators with discrete spectrum by M.I. Dmytryshyn

“…In this regard, the $E$-functional is used that plays a similar role as the module of smoothness in the function theory. …”
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Exploring the impact of telemedicine in chronic patients from diverse socioeconomic contexts: systematic review of qualitative studies by Yuzhe Li, Qifang Shi, Jing Yang, Li Ran

“…We should actively solve the problems and maximize the functions of telemedicine.ObjectiveTo explore the application and improvement of telemedicine in chronic disease self-management to provide important insights from functional module analysis for stakeholders, healthcare professionals, and policymakers to promote the development of telemedicine in chronic disease management.DesignWe conducted a systematic review and qualitative synthesis of five English databases including PubMed, Embase, Web of Science, Cochrane Database of Systematic Reviews, and Scopus, as well as three Chinese databases: China National Knowledge Infrastructure (CNKI), WanFang and VIP database. …”
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Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis. by Marcos V A S Navarro, Peter D Newell, Petya V Krasteva, Debashree Chatterjee, Dean R Madden, George A O'Toole, Holger Sondermann

“…Our structural and functional analyses identified a conserved system for the regulation of periplasmic proteases in a wide variety of bacteria, including many free-living and pathogenic species.…”
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Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity. by Derek A Costello, Marc Claret, Hind Al-Qassab, Florian Plattner, Elaine E Irvine, Agharul I Choudhury, K Peter Giese, Dominic J Withers, Paola Pedarzani

“…These deficits and the corresponding neurophysiological structural and functional alterations are linked to both metabolic and vascular changes, related to chronic hyperglycaemia, but probably also defects in insulin action in the brain. …”
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Macrophages: a double-edged sword in female reproduction and disorders by Mira Park, Yeon Sun Kim, Haengseok Song

“…Despite these advances, the functions of endometrial macrophages under physiological and pathophysiological conditions remain poorly understood, which complicates the development of targeted therapies. …”
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Potential effects of ursodeoxycholic acid on accelerating cutaneous wound healing. by Tarek El-Hamoly, Sahar S Abd El-Rahman, Megahed Al-Abyad

“…Among the initial responses to skin injury, triggering inflammatory mediators and modifying oxidative status provide the necessary temple for the subsequent output of a new functional barrier, fibroplasia and collagen deposition, modulated by NF-κB and TGF-β1 expressions. …”
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Stroke Rehabilitation Targeting the Cerebello-Cerebral Neural Circuit： Advances from Neuromodulation to Closed-Loop Brain-Computer Interface Technology by GUO Shuanghui, ZHANG Yumei

“…Stroke events profoundly impact this neural circuit, with the cerebellum serving as a key node and a promising target for post-stroke functional rehabilitation. This review aims to elucidate the effects of stroke on the cerebello-cerebral circuit, summarize recent advances in cerebellum-targeted neuromodulation techniques, and explore the potential of closed-loop brain-computer interface technology to modulate neural plasticity within this circuit to promote functional recovery in stroke patients.…”
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Integrated network pharmacology and in vivo experiments to reveal the anti-inflammatory mechanism of Qinghuo Rougan Formula in uveitis by Changying Jing, Changying Jing, Yaqi Sun, Yaqi Sun, Hongsheng Bi, Junguo Guo, Cong Ren, Jike Song, Beibei Wang, Qingmei Tian, Dadong Guo, Pengjuan He, Lijie Li, Xiaofeng Xie

“…The yellow module contained 120 genes had a strong correlation with uveitis using WGCNA. …”
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A transcriptomic survey of the impact of environmental stress on response to dengue virus in the mosquito, Aedes aegypti. by David S Kang, Martin S Barron, Diane D Lovin, Joanne M Cunningham, Matthew W Eng, Dave D Chadee, Jun Li, David W Severson

“…We further analyzed the top 30 hub or master regulatory genes in each of the modules, and validated our results via qRT-PCR. These hub genes reveal which functions are critical to the mechanisms that confer dengue virus refractoriness or susceptibility to stress conditioned A. aegypti, as well as the time points at which they are most important.…”
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Secretome Analysis of Human and Rat Pancreatic Islets Co-Cultured with Adipose-Derived Stromal Cells Reveals a Signature with Enhanced Regenerative Capacities by Erika Pinheiro-Machado, Bart J. de Haan, Marten A. Engelse, Alexandra M. Smink

“…Functional assays demonstrated that the co-culture secretome could enhance angiogenesis, collagen deposition, and immune modulation, depending on the stress conditions. …”
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