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5581
Green human resource management (GHRM) and sustainability: A mini review
Published 2025-03-01“…By reframing HR functions through a sustainability lens, GHRM facilitates a deeper organizational alignment with ecological objectives. …”
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5582
Lignans-rich extract of Schisandra chinensis prevent alcohol-associated liver disease by regulating the gut microbiota and tryptophan metabolism
Published 2025-01-01“…Schisandra chinensis, a functional edible berry, exhibits hepatoprotective properties. …”
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5583
Multi-omics analysis reveals the efficacy of two probiotic strains in managing feline chronic kidney disease through gut microbiome and host metabolome
Published 2025-06-01“…This study demonstrates an Lm-mediated interconnection between the modulation of microbial composition, metabolic functions, and systemic metabolite profiles. …”
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5584
Modular strategy with autologous bioreactor: a potential way for organ engineering
Published 2024-01-01“…In brief, different functional modules of natural organs are constructed in vitro , and autologous bioreactors in vivo are utilized to facilitate inter-module assembly to form a complete bioengineered organ capable of replacing natural organ functions. …”
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5585
Establishment of a glucocorticoid inducible system for regulating somatic embryogenesis in Liriodendron hybrids
Published 2024-01-01“…However, conventional overexpression approaches, commonly used for functional genetics, can lead to deleterious effects. …”
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5586
Comparative transcriptome analysis reveals a possible mechanism of starvation stress-induced fruit abscission in macadamia
Published 2025-06-01“…Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses revealed that the functions and pathways of these DEGs were related to hydrolases and transferases, carbohydrate metabolism, plant hormone synthesis, and signal transduction. …”
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5587
Canopy Chlorophyll Content Inversion of Mountainous Heterogeneous Grasslands Based on the Synergy of Ground Hyperspectral and Sentinel-2 Data: A New Vegetation Index Approach
Published 2025-06-01“…DRECAVI incorporates red-edge anti-saturation modules (bands B4 and B7) and aerosol correction modules (bands B1 and B8). …”
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5588
Expression Profiles of Housekeeping Genes and Tissue-Specific Genes in Different Tissues of Chinese Sturgeon (<i>Acipenser sinensis</i>)
Published 2024-11-01“…To comprehensively characterize the expression profiles of genes and their associated biological functions across different tissues, we performed a transcriptome-scale gene expression analysis, focusing on housekeeping genes (HKGs), tissue-specific genes (TSGs), and co-expressed gene modules in various tissues. …”
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5589
Ultrasound-activated bimetallic PtRu alloy nanozymes for synergistic sonodynamic and chemodynamic therapy of multidrug-resistant bacterial infection
Published 2025-10-01“…In this study, guided by density functional theory (DFT) predictions, we designed an ultrasound (US)-activated bimetallic PtxRuy alloy nanozyme (PR) that synergistically combines US-activated sonodynamic therapy (SDT) with chemodynamic therapy (CDT) for precise control of reactive oxygen species (ROS) generation. …”
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5590
High-intensity ethanol binge drinking accentuates bone damage in induced apical periodontitis in rats
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5591
Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise in mice
Published 2025-08-01“…Results: Resistance training increased the expression of a group of 11 miRNAs functionally divided into two clusters. Among them, miR-29a-3p emerges as a molecular mediator released in EVs by skeletal muscle, with a relevant role in adaptation to endurance training, by contributing to modulate the expression and secretion of other miRNAs associated with training and regulating processes related to substrate availability, transport, and metabolic use in skeletal muscle and liver. …”
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5592
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5593
Urban pulse: measuring pace of life through public camera-based cadence analysis
Published 2025-08-01“…Using K-Means clustering in pedestrian cadence cumulative distribution function (CDF) data from these regions, the study investigates the drivers behind these clusters. …”
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5594
Mesoderm-specific Stat3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes.
Published 2017-02-01“…While pathological coding-region mutations typically result in a non-functional SOX9 protein, little is known about what mechanism(s) controls normal SOX9 expression, and subsequently, which signaling pathways may be interrupted by alterations occurring around the SOX9 gene. …”
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5595
Ensemble-Based Binding Free Energy Profiling and Network Analysis of the KRAS Interactions with DARPin Proteins Targeting Distinct Binding Sites: Revealing Molecular Determinants a...
Published 2025-06-01“…In this study, we employ microsecond molecular dynamics simulations, mutational scanning, and binding free energy calculations together with dynamic network modeling to dissect how engineered DARPin proteins K27, K55, K13, and K19 engage KRAS through diverse molecular mechanisms ranging from effector mimicry to conformational restriction and allosteric modulation. Mutational scanning across all four DARPin systems identifies a core set of evolutionarily constrained residues that function as universal hotspots in KRAS recognition. …”
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5596
A multi-omics exploration of PPARG activation in colon cancer: kinases featuring a PPRE sequence within regulatory regions
Published 2025-06-01“…In individuals with CRC, the precise function of PPARG remains not entirely comprehended and elucidation of the PPARG transcriptional regulation in CRC seems promising. …”
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5597
Developing a novel aging assessment model to uncover heterogeneity in organ aging and screening of aging-related drugs
Published 2025-07-01“…Abstract Background The decline in organ function due to aging significantly impacts the health and quality of life of the elderly. …”
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5598
Time-dependent catalytic activity in aging condensates
Published 2025-07-01“…This aging process, characterized by protein aggregation and loss of selective barriers, impairs enzyme function both in vitro and living cells. We further demonstrate that small molecules which influence aging dynamics can modulate catalytic efficiency of condensates. …”
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5599
Unlocking ginsenosides’ therapeutic power with polymer-based delivery systems: current applications and future perspectives
Published 2025-07-01“…In this review, we delve into the mechanistic principles and synergistic interactions underlying each functional module within a cohesive, function-centred design roadmap. …”
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5600
Shaping the Future of Psychiatric Neurosurgery: From Connectomic Precision to Technological Integration
Published 2025-06-01“…Once controversial, surgical interventions are now guided by detailed functional brain mapping and precise neuromodulation techniques, such as deep brain stimulation (DBS), which offer therapeutic options for patients with severe, treatment-resistant psychiatric disorders. …”
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