Amelioration of aging-induced muscular decline by black soybean (Rhynchosia nulubilis) and black rice (Oryza sativa L.) extracts by Hyejeong Park, Seungmin Yu, Wooki Kim

“…These findings suggest the potential of BBME as a functional food ingredient in alleviating aging-induced muscle loss by modulating mitochondrial activity and glucose metabolism.…”
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Utilizing small molecules to probe and harness the proteome by pooled protein tagging with ligandable domains by Katherine E. Larrimore, Yevgeniy V. Serebrenik

“…This review explores recent studies employing multifunctional domains at proteome scale, delving into how the associated chemical probes have been employed to enable insights into endogenous protein function, cellular processes, and disease mechanisms. …”
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SlSWEET10a negatively regulates sucrose transport in tomato fruit by Xinsheng Zhang, Jiaqi Sun, Xin Liu, Jing Jiang

“…Taken together, these results suggest that SlSWEET10a is essential for modulating tomato fruit sugar allocation and plant height development, which is of importance in enriching the cognition of SWEETs function in tomato.…”
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Seeking Optimal Region-Of-Interest (ROI) Single-Value Summary Measures for fMRI Studies in Imaging Genetics. by Yunxia Tong, Qiang Chen, Thomas E Nichols, Roberta Rasetti, Joseph H Callicott, Karen F Berman, Daniel R Weinberger, Venkata S Mattay

“…A data-driven hypothesis-free genome-wide association (GWA) approach in imaging genetics studies allows screening the entire genome to discover novel genes that modulate brain structure, chemistry, and function. …”
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Myostatin-driven muscle hypertrophy: a double-edged sword in muscle physiology by Ghisaram Dewasi, Parikshit Nagda, Gurusha Bahl, Vivek Jain, Sanjay Kumar Gupta

“…Abstract Myostatin (MSTN), a pivotal regulator of skeletal muscle homeostasis, belongs to the TGF-β family and functions as a potent inhibitor of muscle hypertrophy. …”
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Crystal structures of Cif from bacterial pathogens Photorhabdus luminescens and Burkholderia pseudomallei. by Allister Crow, Paul R Race, Grégory Jubelin, Carolina Varela Chavez, Jean-Michel Escoubas, Eric Oswald, Mark J Banfield

“…One mechanism used by a broad range of Gram negative bacterial pathogens is to deliver effector proteins directly into host cells through a dedicated type III secretion system where they modulate host cell function. The cycle inhibiting factor (Cif) family of effector proteins, identified in a growing number of pathogens that harbour functional type III secretion systems and have a wide host range, arrest the eukaryotic cell cycle. …”
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DISSECTION OF T CELL ACTIVATION PHASES FOR CHECK POINT BLOCKADE IMMUNOTHERAPY by Güneş Esendağlı

“…Here, we used a previously established ex-vivo model to display the decline in Th1 responses and to determine the state-of-function which may critically modulate the success of checkpoint blockade. …”
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Comprehensive Evaluation Method of Supply Chain Logistics System Quality Based on 3D Image Processing Technology by Dan Xu, Jiasheng Qi

“…This paper studies the supply chain logistics capability evaluation and optimization system from the aspects of system analysis, system function module design, and system architecture design and analyzes the overall goal, demand, feasibility, system business process, and data flow of the system construction. …”
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Emerging Epigenetic Therapies for the Treatment of Cardiac Fibrosis by Nerea Garitano, Laura Pilar Aguado-Alvaro, Beatriz Pelacho

“…Enzymes such as DNA methyltransferases (DNMTs), histone methyltransferases (HMTs), histone acetyltransferases (HATs), and histone deacetylases (HDACs) have emerged as potential therapeutic targets, and epigenetic inhibitors have shown promise in modulating these enzymes to attenuate fibrosis by controlling fibroblast function and ECM deposition. …”
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MC21 v.10 – coupled-radiation Monte Carlo transport solver with support for multiphysics simulations by Griesheimer David P., Gill Daniel F., Nease Brian R., Pavlou Andrew, Stedry Mark H., Thompson Jason T., Burke Paul E., Dobreff Peter S.

“…Over the past decade, the development of the MC21 Monte Carlo radiation transport solver has focused on extending the functionality of the code beyond static calculations of reactivity and reaction rate distributions, as well as improving accuracy, performance, and scalability. …”
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Neuroprotective effect of L-DOPA-induced interleukin-13 on striatonigral degeneration in cerebral ischemia by Eunhae Jeon, Myeong-Seong Seo, Enkhmaa Lkhagva-Yondon, Yu-Ree Lim, Seung-Woo Kim, Yu Jeong Kang, Jun Seok Lee, Byoung Dae Lee, Rayul Wi, So-Yoon Won, Young Cheul Chung, Eun S. Park, Eunhee Kim, Byung Kwan Jin, Myung-Shin Jeon

“…Abstract Levodopa (L-DOPA) treatment is a clinically effective strategy for improving motor function in patients with ischemic stroke. However, the mechanisms by which modulating the dopamine system relieves the pathology of the ischemic brain remain unclear. …”
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Targeting EGR1-ATF3 signaling mitigates paravertebral muscle degeneration by regulating cell death and inflammaging by Xuke Wang, Qingfeng Wang, Zhe Wang, Yingjie Zhou, Xiaobing Jiang, Yongjin Li

“…These genes are associated with cellular death, ECM metabolic dysregulation, and inflammaging. Functional experiments demonstrated that silencing ATF3 attenuated cellular death, reduced inflammatory signaling, and preserved ECM integrity by modulating downstream effectors including CDKN1A/p21, IL6, Gasdermin E (GSDME), and Glutathione Peroxidase 4 (GPX4). …”
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Lactylation-driven TNFR2 expression in regulatory T cells promotes the progression of malignant pleural effusion by Yao Liu, Qiong Zhou, Siyu Zhang, Wenbei Peng, Haolei Wang, Xuan Xiang, Linlin Ye, Xiaoshan Wei, Zihao Wang, Qianqian Xue

“…Moreover, we revealed that lactate upregulated TNFR2 expression on Treg cells, thereby enhancing their immunosuppressive function in MPE. Mechanistically, lactate modulated the gene transcription of transcription factor nuclear factor-κB p65 (NF-κB p65) through histone H3K18 lactylation (H3K18la), subsequently upregulating the gene expression of TNFR2 and expediting the progression of MPE. …”
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Separate brainstem circuits for fast steering and slow exploratory turns by Lulu Xu, Bing Zhu, Zhiqiang Zhu, Xingyu Tao, Tianrui Zhang, Abdeljabbar El Manira, Jianren Song

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Macrophage-derived SPP1 exacerbate myocardial injury by interacting with fibroblasts in viral myocarditis by Xiuyun Duan, Li Zhang, Keyu Liu, Kaiyin Guo, Yingnan You, Hailin Jia, Shan Zhou, Bo Han

“…After manually annotating cell types, functional analyses of macrophage were performed by cell ratio changes, customized gene set module scoring and CellPhoneDB. …”
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Directed evolution and modular integration of a high-affinity ICOS-L variant for potent T cell–mediated tumor elimination by Ji Yeon Ha, Tae Wook Song, Petrina Jebamani, Sun-Gu Lee, Sang Taek Jung

“…The Inducible T-cell Co-Stimulator (ICOS) is a clinically validated co-stimulatory receptor whose engagement enhances T-cell function. However, the development of ICOS-targeting biologics has been hindered by limited receptor affinity and format-dependent agonist activity. …”
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A comprehensive in silico and invitro analysis revealed the diagnostic, prognostic and therapeutic potential of GNAI family genes in colon adenocarcinoma (COAD) by Bei Wang, Fan Zhu, Yingying Chen

“…Restoration of GNAI function represents a promising avenue for diagnostic and therapeutic intervention in colorectal cancer. …”
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Development and evaluation of a non-invasive brain-spine interface using transcutaneous spinal cord stimulation by Carolyn Atkinson, Lorenzo Lombardi, Meredith Lang, Rodolfo Keesey, Rachel Hawthorn, Zachary Seitz, Eric C. Leuthardt, Peter Brunner, Ismael Seáñez

“…Abstract Motor rehabilitation is a therapeutic process to facilitate functional recovery in people with spinal cord injury (SCI). …”
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Intraoperative Brief Electrical Stimulation of the Spinal Accessory Nerve (BEST SPIN) for prevention of shoulder dysfunction after oncologic neck dissection: a double-blinded, rand... by Brittany Barber, Hadi Seikaly, K. Ming Chan, Rhys Beaudry, Shannon Rychlik, Jaret Olson, Matthew Curran, Peter Dziegielewski, Vincent Biron, Jeffrey Harris, Margaret McNeely, Daniel O’Connell

“…Conclusions Application of BES to the SAN may help reduce impaired shoulder function in patients undergoing oncologic neck dissection, and may be considered a viable adjunct to functional rehabilitation therapies. …”
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Dendritic cell-derived MYD88 potentiates as a biomarker for immune regulation in hepatocellular carcinoma and may predict a better immunological result by Zheming Liu, Zheming Liu, Hengbo Zhu, Fengxia Zhang, Wenting Huang, Shipeng Zhu, Songjiang He, Yi Yao, Qibin Song, Xue Zhang

“…Our in vitro experiments demonstrates that MyD88 modulates T cell function through DCs. In vivo, H22 tumor cells exhibited accelerated growth in MyD88 knockout mice and a reduced response to anti-PD-1 treatment, whereas wild-type mice showed the opposite trend.DiscussionThese findings underscore the critical role of MYD88 in DC function, suggesting its potential as a biomarker for immunoregulation in HCC. …”
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