Postulated Role of Vasoactive Neuropeptide-Related Immunopathology of the Blood Brain Barrier and Virchow-Robin Spaces in the Aetiology of Neurological-Related Conditions by D. R. Staines, E. W. Brenu, S. Marshall-Gradisnik

“…Vasoactive neuropeptides (VNs) such as pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) have critical roles as neurotransmitters, vasodilators including perfusion and hypoxia regulators, as well as immune and nociception modulators. They have key roles in blood vessels in the central nervous system (CNS) including maintaining functional integrity of the blood brain barrier (BBB) and blood spinal barrier (BSB). …”
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Key Roles of Brown, Subcutaneous, and Visceral Adipose Tissues in Obesity and Insulin Resistance by Maria-Zinaida Dobre, Bogdana Virgolici, Olivia Timnea

“…Furthermore, we examine emerging therapeutic strategies aimed at modulating immune responses, enhancing mitochondrial function, and reprogramming adipose progenitor cells (APCs) to restore healthy tissue remodeling. …”
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Immunophenotyping of colon cancer for identification of potential antigens for colon cancer vaccines by Xuan Wang, Xuan Wang, Jingjiang Lai, Dawei Wang, Keyi Wei, Jing Yang

“…Drug sensitivity, immune cell infiltration, and gene set variation were analyzed using R packages such as “pRRophetic,” CIBERSORT, and GSVA. Functional enrichment analysis was performed with GO, KEGG, and GSEA. …”
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Integrated transcriptomic and metabolomic analyses reveal tissue-specific accumulation and expression patterns of monoterpene glycosides, gallaglycosides, and flavonoids in Paeonia... by Pan Xu, Jinghui Li, Cuiting Chen, Jing Chen, Meiping Yang, Huimin Deng, Xuechun Jiang, Kelang Lou, Xiaojun Wu, Rubing Chen, Yijuan Hu, Weiqing Liang, Jinbao Pu

“…Protein structure prediction and similarity analysis further supported their functional conservation with known terpenoid-modifying enzymes and flavonoid-specific glycosyltransferases, respectively. …”
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Comprehensive analysis of lactylation-related gene and immune microenvironment in atrial fibrillation by Yazhe Ma, Youcheng Wang, Yuanjia Ke, Yuanjia Ke, Yuanjia Ke, Qingyan Zhao, Qingyan Zhao, Qingyan Zhao, Jie Fan, Yang Chen

“…Co-expression and WGCNA analyses identified lactylation- and immune-associated gene modules in AF. Functional enrichment analysis highlighted immune-related pathways such as T cell activation and neutrophil degranulation. …”
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Bioinformatics identification and validation of pyroptosis-related gene for ischemic stroke by Xinying Shang, Rui Wei, Di Yang, Bawei Yu, Wei Zhang

“…We screened for LASSO regression to construct a prognostic model of GSE131193 and PRGs and examined by GSE137482. The functional enrichment analysis of Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA) were performed on pyroptosis-related differentially expressed genes (PRDEGs) of GSE202659.The key modules for CIRI and pyroptosis were identified by Weight Gene Co-expression Network Analysis (WGCNA). …”
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Fall risk perception toolkit based on “digital human” for community-dwelling older patients with stroke: development and validation by Jiang Nan, Yi Hou, Manyao Sun, Xueying Huang, Jing Gao, Xueqiong Zou, Zhongyi Chen, Yuyu Jiang

“…The corresponding measurement tools were calculation of RP and RA, Fall Risk Perception Scale for community-dwelling older adults (FRPS), Timed Up and Go test (TUG), and the Short Version of the Stroke Specific Quality of Life scale (SV-SS-QoL). Results Four functional modules of FRP-digital human were determined. 20 participants completed the usability test. …”
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Identification and Validation of Ferritinophagy-Related Biomarkers in Periodontitis by Yi-Ming Li, Chen‑Xi Li, Reyila Jureti, Gulinuer Awuti

“…In addition, biomarker-associated immune cells and functional pathways were analysed to predict the upstream regulatory molecules. …”
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Research of Neutron-thermal Hydraulic Coupling Calculation Method in Fast Reactor Code System MOSASAUR by ZHANG Bin, WANG Lianjie, LOU Lei, ZHAO Chen

“…There are four main functional modules in the previous version: cross-sections generation module, flux spectrum correction module, core simulation module and sensitivity and uncertainty analysis module. …”
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Expression of metabolic genes in NK cells is associated with clinical outcomes in patients with severe COVID-19: a brief report by Kenia Y. Osuna-Espinoza, Manuel G. Mejia-Torres, Adrian Camacho-Ortiz, Eduardo Perez-Alba, Azalia M. Martinez-Castilla, Mario C. Salinas-Carmona, Adrian G. Rosas-Taraco

“…The pandemic of the coronavirus disease 2019 (COVID-19) has increased the investigation of their role in disease severity. However, their functional status and modulators remain controversial. …”
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MELGYM: A dynamic control interface for MELCOR simulations by Antonio Manjavacas, Juan Gómez-Romero, Damien Ernst, Manuel A. Vázquez-Barroso, Francisco Martín-Fuertes

“…MELGYM enables the training of reinforcement learning agents on MELCOR simulations, introducing real-time interaction and enabling the definition of reward functions based on simulation outcomes.…”
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Reward signalling in brainstem nuclei under fluctuating blood glucose. by Tobias Morville, Kristoffer H Madsen, Hartwig R Siebner, Oliver J Hulme

“…To test this hypothesis, we collected a large volume of functional MRI data from five human volunteers on four separate days. …”
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Application of lossless signal transmission technology in piano timbre recognition by Li Lin

“…Furthermore, utilizing envelope function based electronic synthesis technology, an analog signal processing module has been developed to optimize the quality of audio signals. …”
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Effect of individual variations in genes related to dopamine brain transmission on performance with and without rewards during motor sequence and probabilistic learning tasks in ch... by Barrett Dryden, Jesse Matsubara, Eric Wassermann, Hans Forssberg, Diane L Damiano

“…Children with cerebral palsy (CP) often participate in training to improve mobility, hand function and other motor abilities. However, responses to these interventions vary considerably across individuals even those with similar brain injuries, ages and functional levels. …”
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Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day. by Lukasz P Slomnicki, George Wei, Darlene A Burke, Emily R Hodges, Scott A Myers, Christine D Yarberry, Johnny R Morehouse, Scott R Whittemore, Sujata Saraswat Ohri, Michal Hetman

“…Consistent with those minor effects on functional recovery, terminal histological analysis revealed no significant differences in white matter sparing at the injury epicenter. …”
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Towards Extracellular Vesicles in the Treatment of Epidermolysis Bullosa by Aaron Gabriel W. Sandoval, Evangelos V. Badiavas

“…However, emerging research highlights the potential of extracellular vesicles (EVs) derived from mesenchymal stem cells as a promising approach to address both the symptoms and underlying pathology of EB. EVs function as carriers of bioactive molecules, modulating inflammation, promoting tissue regeneration, and even delivering functional type VII collagen to RDEB patient cells. …”
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Microfluidic 3D printing hydrogels based on fish liver decellularized extracellular matrix for liver regeneration by Haozhen Ren, Danqing Huang, Mengdi Qiu, Lingling Xue, Shaoshi Zhu, Jingjing Gan, Cheng Chen, Dayu Chen, Jinglin Wang

“…Abstract Liver tissue engineering offers potential in liver transplantation, while the development of hydrogels for scalable scaffolds incorporating natural components and effective functionalities is ongoing. Here, we propose a novel microfluidic 3D printing hydrogel derived from decellularized fish liver extracellular matrix for liver regeneration. …”
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Alpha EEG Spectral Characteristics in the Parieto-Occipital lobe of Elderly Patients with Chronic Insomnia and Mild Cognitive Impairment by GUO Zhenxing, BAI Linxin, ZHANG Lin, GAO Jiahui, RAO Ting, LIU Zhizhen

“…Moreover, Parieto-Occipital lobe alpha spectral power can modulate cognitive function in this population.…”
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Mathematical models of structural and parametric synthesis of load trolley metalware of bridge cranes on basis of multipurpose layout drawing by Goncharov K.A., Denisov I.A.

“…The general structure of the developed mathematical models is shown, and the description of the functionality of the separate matrix groups of the different calculation modules is given.…”
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Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle by Kai Wang, Mailin Gan, Yuhang Lei, Tianci Liao, Jiaxin Li, Lili Niu, Ye Zhao, Lei Chen, Yan Wang, Li Zhu, Linyuan Shen

“…A critical contributing factor is the loss of mitochondrial metabolism and function in MuSCs within skeletal muscle. The mitochondrial quality control system plays a pivotal role as a modulator, counteracting aging-associated abnormalities in energy metabolism and redox imbalance. …”
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