ILN-YOLOv8: A Lightweight Image Recognition Model for Crimped Wire Connectors by Xiaojian Zhou, Jicheng Kan, Nur Fatin Liyana Mohd Rosely, Xu Duan, Jiajing Cai, Zihan Zhou

“…Next, the improved Selective Boundary Aggregation(SBA) module replaces the Concat module in the Neck, enhancing the fusion of deep and shallow features. …”
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Intratentacular budding and zooid-dynamics in two coral genera by Matan Yuval, Amit Peleg, Elvan Ceyhan, Dan Tchernov, Yossi Loya, Avi Bar-Massada, Tali Treibitz

“…The patterns of addition of zooids (budding mechanics) determine much of the colony’s shape and function. Yet because zooids are small in size and large in numbers, ecological studies often focus on coral colonies as unitary organisms and little is known about how zooids vary within and between colonies and species. …”
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A Transformer-LSTM-SVR hybrid model for AI-driven emotional optimization in NEV embedded interior systems by Zongming Liu, Xuhui Chen, Xinan Liang, Zhicheng Sun, Fengqi Yang, Wenwen Ou, Linwei Li, Xiayan Qin

“…Abstract With the rapid expansion of the new energy vehicle (NEV) market, a shift from function-oriented toward emotion-oriented interior design has emerged as a key factor in enhancing user experience and brand differentiation. …”
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Coordinate regulation of G protein signaling via dynamic interactions of receptor and GAP. by Marc Turcotte, Wei Tang, Elliott M Ross

“…Signal output from receptor-G-protein-effector modules is a dynamic function of the nucleotide exchange activity of the receptor, the GTPase-accelerating activity of GTPase-activating proteins (GAPs), and their interactions. …”
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Digital gamification-based pursed lip breathing exercises driven by Behaviour Change Wheel in patients with COPD: a feasibility trial protocol using pre-post study design by Mark Hayter, Min Huang, Roger Watson, Houqiang Huang, Fake Liu, Mohannad Mohammad, Zihui Li

“…Additionally, several clinical outcomes in terms of the effects of the DT-PLB intervention on dyspnoea, exercise capability, quality of life, and pulmonary function index will be evaluated as secondary outcomes.Ethics and dissemination This study has received Manchester Metropolitan University ethical approval (REC reference 56631) and the Affiliated Hospital of Southwest Medical University ethical approval (REC reference KY2023105). …”
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Rapid diagnosis of rheumatoid arthritis and ankylosing spondylitis based on Fourier transform infrared spectroscopy and deep learning by Wei Shuai, Xue Wu, Chen Chen, Enguang Zuo, Xiaomei Chen, Zhengfang Li, Xiaoyi Lv, Lijun Wu, Cheng Chen

“…Objective: Rheumatoid arthritis and Ankylosing spondylitis are two common autoimmune inflammatory rheumatic diseases that negatively affect activities of daily living and can lead to structural and functional disability, reduced quality of life. Here, this study utilized Fourier transform infrared (FTIR) spectroscopy on dried serum samples and achieved early diagnosis of rheumatoid arthritis and ankylosing spondylitis based on deep learning models. …”
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Gut-Microbiome Signatures Predicting Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review by Ielmina Domilescu, Bogdan Miutescu, Florin George Horhat, Alina Popescu, Camelia Nica, Ana Maria Ghiuchici, Eyad Gadour, Ioan Sîrbu, Delia Hutanu

“…Conclusions: Despite heterogeneity, convergent functional and taxonomic signals underpin a microbiome-based radiosensitivity axis in LARC. …”
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Analysis of ferritinophagy-related genes associated with the prognosis and regulatory mechanisms in non-small cell lung cancer by Yuan Hao, Xin Wang, Zerong Ni, Yuhui Ma, Jing Wang, Wen Su

“…Further analyses focused on functional enrichment, drug sensitivity, and the immune microenvironment. …”
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In Silico Analysis of miRNA-mRNA Binding Sites in <i>Arabidopsis thaliana</i> as a Model for Drought-Tolerant Plants by Yryszhan Zhakypbek, Aizhan Rakhmetullina, Zhigerbek Kamarkhan, Serik Tursbekov, Qingdong Shi, Fei Xing, Anna Pyrkova, Anatoliy Ivashchenko, Bekzhan D. Kossalbayev, Ayaz M. Belkozhayev

“…These findings suggest the presence of conserved regulatory modules with potential roles in abiotic stress tolerance. …”
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Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COV... by Cai-xia Li, Jian Chen, Shu-kai Lv, Jin-hui Li, Lei-lei Li, Xiao Hu

“…We also established the protein-protein interaction (PPI) networks of up/downregulated DE mRNAs and identified 4 modules. Functional enrichment analyses indicated that these module targets were associated with positive regulation of cytokine production, cytokine-mediated signaling pathway, leukocyte differentiation, and migration. …”
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Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction by Jingjing Chen, Dan Zhang, Chengxiu Zhu, Lin Lin, Kejun Ye, Ying Hua, Mengjia Peng

“…Ribosome biogenesis, critical for cellular homeostasis, is hypothesized to drive placental dysfunction in PE, though its role remains underexplored.MethodsWe integrated placental transcriptomic data from two datasets (GSE75010, GSE10588) to systematically investigate ribosome biogenesis dysregulation in preeclampsia. Functional enrichment analyses delineated the dysregulation of pathways, while weighted gene co-expression network analysis identified hub genes within ribosome biogenesis-associated modules. …”
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Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids by Xiuling Cao, Xiang Wu, Lei Zhao, Ju Zheng, Xuejiao Jin, Xinxin Hao, Joris Winderickx, Shenkui Liu, Lihua Chen, Beidong Liu

“…We postulate that SY1 IB matures by association with the mitochondrion membrane, and that sphingolipids stimulate the maturation via their membrane-modulating function and thereby protecting cells from SY1 cytotoxicity. …”
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Logistics solutions and supply management in the company: the challenges of time by H.M.

“…The place of logistics strategy is determined between long-term decisions of the enterprise (enterprise mission, logistics mission, corporate strategy, production strategy, marketing strategy, logistics concept) and tactical and operational decisions (logistics technologies, systems, subsystems, modules, business processes, operations and functions, information support). …”
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Scalable synthesis of phosphorescent SiO2 nanospheres and their use for angle-dependent and thermoresponsive photonic gels with multimode luminescence by Changxing Wang, Yayun Ning, Yifan Yue, Guoli Du, Yuechi Xie, Jianing Li, Nazia Bibi, Xiaoxiang Wen, Jianing Li, Sen Yang, Xuegang Lu

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Microbial community succession during tobacco fermentation reveals a flavor-improving mechanism by Jingjing Zhu, Jingjing Zhu, Jitao Wang, Zichao An, Zichao An, Chen Shen, Hongxu Dong, Haojun Wang, Zhenxing Peng, Bo Yang, Juanjuan Liu, Juanjuan Liu, Xiaojie Wang, Xiaojie Wang, Zemin Fang, Zemin Fang

“…After 15 days of treatment with a combination of four Bacillus strains (Bacillus altitudinis YS193, Bacillus pumilus YH186, Bacillus tequilensis YS154, and Bacillus velezensis YS157), the sugar‒nicotine ratio of FCT was effectively optimized, the sensory flavor was enhanced, and the levels of volatile compounds associated with the aromatic amino acid metabolic pathway were significantly increased.DiscussionThis study reveals the critical role of microbial succession in FCT fermentation and demonstrates that targeted inoculation of functional Bacillus strains can significantly improve tobacco quality by modulating key metabolic pathways, providing a scientific basis for artificial microbial fermentation in tobacco processing.…”
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Therapeutic Potential of Rho Kinase Inhibitors in Corneal Disease: A Systematic Review of Preclinical and Clinical Studies by Laura Andreea Ghenciu, Diana Andrei, Claudia Borza, Roxana Iacob, Emil Robert Stoicescu, Sorin Lucian Bolintineanu, Daniela Iacob, Ovidiu Alin Haţegan

“…Inclusion criteria encompassed in vitro, ex vivo, in vivo, and clinical trials reporting functional outcomes (endothelial cell density, wound closure, visual acuity). …”
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Connecting dots of long COVID-19 pathogenesis: a vagus nerve- hypothalamic-pituitary- adrenal-mitochondrial axis dysfunction by Marta Camici, Giulia Del Duca, Anna Clelia Brita, Andrea Antinori

“…They achieve this by modulating the activity of innate and cell-mediated immunity, attenuating endothelial and platelet activation, and modulating mitochondrial function, which is crucial for cellular energy production and anti-inflammatory mechanisms. …”
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Hsa_circ_0007991 Promotes Immune Evasion in Hepatocellular Carcinoma via Regulation of the miR-505-3p/CANX Axis by Wang L, Liang L, Qian J, Yu C, Shi Y, Yan X, Chen X

“…The role of hsa_circ_0007991 as a ceRNA was further validated using dual-luciferase reporter assay, RNA immunoprecipitation, and nuclear-cytoplasmic fractionation.Results: A significant upregulation of hsa_circ_0007991 was observed in HCC tissues, with increased levels correlating with advanced TNM stages. hsa_circ_0007991 silencing significantly suppressed HCC cell proliferation and immune evasion, while promoting apoptosis, whereas hsa_circ_0007991 overexpression yielded the opposite effects. The function of hsa_circ_0007991 involves binding to miR-505-3p, which modulates the expression of calnexin (CANX), influencing the biological behaviors of HCC cells. …”
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Natural Killer Cells in Liver Disease and Hepatocellular Carcinoma and the NK Cell-Based Immunotherapy by Pingyi Liu, Lingling Chen, Haiyan Zhang

“…However, accumulating evidences were found that the NK cells were modulated by liver diseases and liver cancers including hepatocellular carcinoma (HCC) and showed impaired functions failing to activate the elimination of the viral-infected cells or tumor cells and were further involved in the pathogenesis of liver injury and inflammation. …”
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p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system. by Virginia Andreotti, Yari Ciribilli, Paola Monti, Alessandra Bisio, Mattia Lion, Jennifer Jordan, Gilberto Fronza, Paola Menichini, Michael A Resnick, Alberto Inga

“…<h4>Conclusions/significance</h4>We found that the small molecules Nutlin and RITA could both relieve the MDM2-dependent inhibition of WT p53 transactivation function, while only RITA could impact p53/53BP1 functional interactions. …”
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