The juxtamembrane domain of StkP is phosphorylated and influences cell division in Streptococcus pneumoniae by Mélisse Hamidi, Sathya Narayanan Nagarajan, Vaishnavi Ravikumar, Virginie Gueguen-Chaignon, Cédric Laguri, Céline Freton, Ivan Mijakovic, Jean-Pierre Simorre, Stéphanie Ravaud, Christophe Grangeasse

“…In conclusion, this study demonstrates that the function of the JMD of StkP is modulated by phosphorylation and is critical for the cell division of S. pneumoniae. …”
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Structure and oxygen saturation recovery of sparse photoacoustic microscopy images by deep learning by Shuyan Zhang, Jingtan Li, Lin Shen, Zhonghao Zhao, Minjun Lee, Kun Qian, Naidi Sun, Bin Hu

“…Additionally, we introduce an adaptive vascular attention mask module that focuses on vascular information recovery and design a vessel-specific loss function to enhance restoration accuracy. …”
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A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities by Franco J Vizeacoumar, Roland Arnold, Frederick S Vizeacoumar, Megha Chandrashekhar, Alla Buzina, Jordan T F Young, Julian H M Kwan, Azin Sayad, Patricia Mero, Steffen Lawo, Hiromasa Tanaka, Kevin R Brown, Anastasia Baryshnikova, Anthony B Mak, Yaroslav Fedyshyn, Yadong Wang, Glauber C Brito, Dahlia Kasimer, Taras Makhnevych, Troy Ketela, Alessandro Datti, Mohan Babu, Andrew Emili, Laurence Pelletier, Jeff Wrana, Zev Wainberg, Philip M Kim, Robert Rottapel, Catherine A O'Brien, Brenda Andrews, Charles Boone, Jason Moffat

“…The network uncovered examples of conserved genetic interactions, densely connected functional modules derived from comparative genomics with model systems data, functions for uncharacterized genes in the human genome and targetable vulnerabilities. …”
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Viroporins beyond pathogenesis: Ion channel properties as the key to unlocking a neglected antiviral target by Suya Peng, Yi Wang, Zhaobing Gao, Bingqing Xia

“…A class of proteins encoded by viral genomes, referred to as viroporins, is composed of small hydrophobic proteins that form pores or ion channels in host membranes. These proteins modulate the viral life cycle and pathogenicity. Despite their early discovery and functional significance, viroporins have long remained underexploited as antiviral drug targets—partly due to the emergence of alternative antiviral strategies, viral evolutionary complexity, and technical limitations in studying channel function. …”
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Immunometabolism in the Aging Heart by Kranti A. Mapuskar, Barry London, Zeb R. Zacharias, Jon C.D. Houtman, Bryan G. Allen

“…Interventions include modulating metabolic intermediates, improving mitochondrial function, and leveraging immune signaling pathways to restore cardiac health. …”
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Propofol Suppresses Microglia Inflammation by Targeting TGM2/NF-κB Signaling by Yuanyuan Hou, Xi Xiao, Wei Yu, Sihua Qi

“…BV2 cells and primary microglia were used for functional verification and mechanism studies. Results. …”
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Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer’s disease models by Saige K. Power, Sridevi Venkatesan, Sarah Qu, JoAnne McLaurin, Evelyn K. Lambe

“…Cholinergic pathways are vulnerable to neuropathology in AD and its preclinical models, and their modulation of deep layer prefrontal cortex is essential for attention and executive function. …”
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Global Grin2a loss causes divergent impairments to PV+ and SST+ interneurons and alters gamma oscillations in prefrontal cortex by Hassan Hosseini, Sky Evans-Martin, Kevin S. Jones

“…Background: Loss-of-function mutations in the Grin2a gene, encoding the GluN2A subunit of NMDA receptors, confer elevated schizophrenia (SCZ) risk. …”
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Calprotectin-mediated survival of Staphylococcus aureus in coculture with Pseudomonas aeruginosa occurs without nutrient metal sequestration by Wei H. Lee, Emily M. Zygiel, Celis H. Lee, Amanda G. Oglesby, Elizabeth M. Nolan

“…Treatment with CP site variants lacking functional transition-metal-binding sites and metalated CP also enhanced S. aureus survival in coculture with P. aeruginosa, revealing that this consequence of CP treatment is independent of its canonical metal-sequestering function. …”
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SCIENTIFIC AND METHODOLOGICAL SUPPORT FOR THE FORMATION OF STUDENTS' COMPETENCIES IN THE FIELD OF SOCIAL ENTREPRENEURSHIP by V. Shapovalov, I. Igropulo, M. Arutiunian, O. Minkina

“…The article is devoted to the analysis of the functions of universities in the development of social entrepreneurship in the regions in the context of the implementation of their «third mission». …”
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Integrated bioinformatics analysis identifies hub genes and immune regulatory networks in HIV infection by Xiaoxia Pang, Xiaoxia Pang, Xiaoxia Pang, Xinghong Chen, Yuxin Jing, Yuxin Jing, Yuxin Jing, Feng Shi, Feng Shi, Xiaoying Chen, Xiaoying Chen, Xiaoying Chen, Huatuo Huang, Huatuo Huang, Huatuo Huang, Chunhong Liu, Chunhong Liu, Chunhong Liu

“…Additionally, we analyzed immune cell infiltration and constructed drug-gene interaction, miRNA and transcription factor (TF) regulatory networks.Results101 intersection genes were identified by combining DEGs, Oxidative stress genes and module genes from WGCNA. Functional enrichment analysis highlighted key pathways, including oxidative stress response and apoptotic signaling. …”
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The Interplay between Estrogen and Fetal Adrenal Cortex by Jovana Kaludjerovic, Wendy E. Ward

“…Studies show that the fetal zone of the fetal adrenal cortex supplies 60% of DHEA for placental estrogen production, and that placental estrogen in turn modulates the morphological and functional development of the fetal adrenal cortex. …”
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Rough-and-Refine Model for Scene Graph Generation by Li Junliang, Lv Shirong, Li Wei

“…In ablation experiments, the results indicate that each module positively contributes to the prediction of scene graphs, with the removal of any single module leading to a decline in experimental results. …”
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Binding leverage as a molecular basis for allosteric regulation. by Simon Mitternacht, Igor N Berezovsky

“…Furthermore, our analysis of the catabolite activator protein, which is allosteric without conformational change, shows that its regulation involves other types of motion than those modulated at sites with high binding leverage. Our results point to the importance of incorporating dynamic information when predicting functional sites. …”
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Gastroparesis: Concepts, Controversies, and Challenges by Klaus Bielefeldt

“…While the definition of gastroparesis focuses on impaired gastric emptying, treatment options that affect gastric function are limited and often disappointing. The female predominance, the mostly idiopathic nature of the illness with a common history of abuse, and coexisting anxiety or depression show parallels with other functional disorders of the gastrointestinal tract. …”
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Expert Consensus on Formatted and Intelligent Documentation of Geriatric Rehabilitation Inpatient Medical Records by Geriatric Rehabilitation Committee of Chinese Rehabilitation Medical Association

“…This consensus emphasizes a function-oriented assessment framework and establishes a diagnostic classification system for the medical record homepage that aligns with current medical insurance payment standards. …”
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Three-stage sequential targeted nasal drops for correcting abnormal mitochondrial division in microglia by Miaomiao Fei, Qidong Liu, Hui Zhang, Yawei Du, Liang Chen, Juan Wang, Wenguo Cui, Cheng Li

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Sevoflurane exposure in early life: mitochondrial dysfunction and neurotoxicity in immature rat brains without long-term memory loss by Lin Qiu, Hongwei Li, Bingbing Li, Joakim Ek, Xiaoli Zhang, Yiwen Chen, Zehua Shao, Jie Zhang, Jiaqiang Zhang, Hongqi Lin, Changlian Zhu, Yiran Xu, Xiaoyang Wang

“…Transcriptomic analysis identified altered gene expression related to neurodevelopment and mitochondrial function. Various analyses emphasized upregulation in oxidative phosphorylation and DNA repair pathways. …”
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Performance comparison of microservices written using reactive and imperative approaches by Kacper Mochniej, Marcin Badurowicz

“…During the tests, functionalities related to operations of retrieving and inserting records into the database, data processing, and file transfer were invoked. …”
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Direct RNA sequencing reveals chicken post-transcriptional modifications in response to Campylobacter jejuni inoculation by Yanan Zhao, Yuanmei Wang, Yanru Ren, Long Liu, Tianyi Wang, Liying Liu, Xianyao Li

“…The transcripts containing m6A/m5C modifications displayed higher expression levels and shorter poly(A) tails than those without modifications. Functional analysis of these modules including differentially expressed transcripts (DETs), transcripts with differentially significant poly(A) tail length, m5C modified DETs, and m6A modified DETs showed that the negative regulation of interferon-beta production was enriched (P < 0.05). …”
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