P-modified biochar alters the microbial community in heavy metal-contaminated soils by regulating nutrient supply balance by Qiang Wang, Chenyang Xu, Kai Pan, Xiaogang Wu, Yanshuo Pan, Chengjiao Duan, Zengchao Geng

“…Modules 1 and 3 played important but opposite functions in the nitrogen and P cycle of the soil. …”
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Migrasomes: key players in immune regulation and promising medical applications by Shuping Li, Yanjie Zhou, Tingting Hu, Mei Li, Yao Luo, Jie Chen

“…Migrasomes are newly discovered extracellular organelles released by migrating cells, such as immune cells, tumor cells, and other special functional cells like podocytes and embryonic cells. …”
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Microglial dynamics and emerging therapeutic strategies in CNS homeostasis and pathology by Jie Cao, Jianqing Yuan, Nanhai Liu, Kai Huang, Mingwei Guo

“…Recently, pharmacological approaches targeting microglial depletion and repopulation have gained attention as a means to reset or modulate microglial function. Techniques such as CSF1R inhibition enable transient depletion of microglia, followed by rapid repopulation, potentially restoring homeostatic functions and mitigating chronic inflammation. …”
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Fibre Computer Enables More Accurate Recognition of Human Activity by Qianyi Cheng, Jianfeng Li, Qichong Zhang

“…Compared to single-fibre systems, multi-fibre computational architectures with coordinating modules exhibit higher reliability and more comprehensive functionalities.…”
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Modular Protective Materials Neutralizing Toxins (Organophosphorus Compounds and Mycotoxins) and Exhibiting Biocidity to Gram-positive and Gram-negative Bacterial Cells by V. V. Zavyalov, N. V. Zavyalova, V. I. Kholstov, V. A. Kovtun, V. K. Gorelenkov, G. A. Frolov, I. V. Lyagin, N. A. Stepanov, E. N. Efremenko

“…The experimental studies have demonstrated the possibility of combining modules containing metal carboxylates, metal nanoparticles, and enzyme nanocomplexes for multiple functionalization of the same fibrous material and/or fiber. …”
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Posttranslational modifications of YAP/TAZ: molecular mechanisms and therapeutic opportunities by Zhenxiong Zhang, Peiheng He, Li Yang, Jun Gong, Renyi Qin, Min Wang

“…Aberrant expression or activation of YAP/TAZ is implicated in the pathogenesis of many cancers and noncancerous diseases. Notably, their functional outputs demonstrate remarkable diversity, with context-dependent roles emerging across distinct disease models and tissue microenvironments. …”
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Secreted and transmembrane 1A is a novel co-stimulatory ligand. by Duncan Howie, Hugo Garcia Rueda, Marion H Brown, Herman Waldmann

“…Thus SECTM1A and SECTM1B represent novel reciprocal alternative ligands which may function to modulate the activation of effector and regulatory T cells. …”
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IL-27 Driven Upregulation of Surface HLA-E Expression on Monocytes Inhibits IFN-γ Release by Autologous NK Cells by Fabio Morandi, Irma Airoldi, Vito Pistoia

“…Their cell surface expression can be modulated by different cytokines. Since IL-27 and IL-30 may either stimulate or regulate immune responses, we have here tested whether these cytokines may modulate HLA-G and -E expression and function on human monocytes. …”
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Virus Isolation and Rice Protoplast Infection by Yu Huang, Zhirui Yang, Yi Li

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Thiol Redox Transitions in Cell Signaling: a Lesson from N-Acetylcysteine by Tiziana Parasassi, Roberto Brunelli, Graziella Costa, Marco De Spirito, Ewa Krasnowska, Thomas Lundeberg, Eugenia Pittaluga, Fulvio Ursini

“…Redox transitions occur in sensitive cysteine residues of regulatory proteins relevant to signaling, their evolution to metastable disulfides accounting for the functional redox switch. N-acetylcysteine (NAC) is a thiol-containing compound that is able to interfere with redox transitions of thiols and, thus, in principle, able to modulate redox signaling. …”
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BMRMI Reduces Depressive Rumination Possibly through Improving Abnormal FC of Dorsal ACC by Ming-Hao Yang, Zhi-Peng Guo, Xue-Yu Lv, Zhu-Qing Zhang, Wei-Dong Wang, Jian Wang, Lan Hong, Ying-Na Lin, Chun-Hong Liu

“…The above results indicate that BMRMI may regulate self-referential processing and cognitive function through modulating FC of the dACC in MDD with rumination.…”
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The landscape of renal protein S-acylation in mice with lipid-induced nephrotoxicity by Fangrui Xiu, Zhibo Gai, Peter Gehrig, Witold E. Wolski, Museer A. Lone, Michele Visentin

“…Because fatty acids can also be reversibly attached onto cysteine residues and modulate the function of several membrane-bound proteins, we studied the effect of high-fat diet (HFD) on the S-acylated proteome of mouse kidneys to uncover novel biochemical changes that might contribute to lipid-induced nephrotoxicity. …”
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Basketball team optimization algorithm (BTOA): a novel sport-inspired meta-heuristic optimizer for engineering applications by Yujie Chen, Guangyu Wang, Baichuan Yin, Chongyun Ma, Zhiqiao Wu, Ming Gao

“…Extensive experiments on the CEC2005 and CEC2017 benchmark suites with 30, 50 and 100 dimensions show that BTOA attains the lowest mean error on 82.61% of the CEC2005 functions and on 66.67%, 63.3% and 66.67% of the CEC2017 functions, respectively. …”
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Simulation and Validation of Dose Distribution in BNCT Treatment Planning System by LYU Tianqi, MENG Siqin, WANG Hongliang, HE Linfeng, RUAN Shihao, WANG Tianyun, WU Meimei, CHEN Jun, SHI Bin, GUAN Fengping, LI Yuqing, LI Tianfu, HAO Lijie, LIU Yuntao

“…Interpolation functions and adjustable voxel grids were used to establish a model for patients to meet the requirements of simulation. …”

GWAS and WGCNA analysis uncover candidate genes associated with drought in Brassica juncea L. by Yusong Zhang, Yusong Zhang, Xiaoyan Yuan, Xiaoyan Yuan, Yunyun Zhang, Yunyun Zhang, Yanqing Luo, Yanqing Luo, Kaiqin Zhao, Kaiqin Zhao, Feng Zu, Feng Zu, Zhengshu Tian, Zhengshu Tian, Jinfeng Li, Jinfeng Li, Lifan Zhang, Lifan Zhang, Xiaoying He, Xiaoying He, Jinxiang Gao, Jinxiang Gao, Minglian Fu, Minglian Fu, Genze Li, Genze Li, Feihu Liu

“…To screen drought-tolerant germplasm resources and key functional genes related to drought tolerance in Brassica juncea L.(193 accessions), three treatments were applied at the germination and seedling stages:control(CK), moderate drought stress (M), and severe drought stress (S). …”
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Nutraceutical Strategies for Targeting Mitochondrial Dysfunction in Neurodegenerative Diseases by Federica Davì, Antonella Iaconis, Marika Cordaro, Rosanna Di Paola, Roberta Fusco

“…It has been shown that these compounds represent safe and easily available sources for the development of innovative therapeutics, and by modulating mitochondrial function, nutraceuticals offer a promising approach to address neurodegenerative pathologies. …”
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NSUN5 promotes cholangiocarcinoma progression by enhancing GLS mRNA stabilization by Ming Shu, Kunpeng Guo, Yikai Huang, Weishan Wang

“…CCA cells exhibited resistance to cuproptosis by upregulating GLS expression. Functionally, NSUN5 was found to positively modulate GLS expression. …”
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Nanobodies targeting the tumor microenvironment and their formulation as nanomedicines by Liudmyla Maksymova, Yannick A. Pilger, Lutz Nuhn, Jo A. Van Ginderachter

“…Hence, effective therapeutic targeting of the tumor microenvironment requires modulation of immune cell function, overcoming resistance mechanisms associated with stromal components or the extracellular matrix, and/or direct elimination of cancer cells. …”
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Inflammatory profiling and immune cell infiltration in dysthyroid optic neuropathy: insights from bulk RNA sequencing by Qintao Ma, Yuanping Hai, Yongbo Duan, Genfeng Yu, Cheng Song, ShengAi Huang, Anqi Huang, Yan Zhu, Yongzhi Shen, Zimeng Huang, Xiao Wang, Lan Liu, Thomas Efferth, Huiyu Guo, Yi Wang, Yi Wang, Jie Shen

“…ROC analysis and single-gene GSEA were used to evaluate the diagnostic potential and functional relevance of core genes. Inflammatory-Related Differential Genes (IRDGS) were identified and preliminarily validated using Quantitative Real-Time PCR.ResultsDifferential gene expression analysis revealed 176 and 202 significantly upregulated genes in DON vs. non-DON and DON vs. …”
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Regulatory role of MicroRNA164 in heat and salinity stress responses via candidate target genes during seed germination in petunia by Tao Jiang, Keila Rodriguez, Sameena Ejaz Tanwir, Fangchen Liu, Fida Hussain, Jaideep Chandranshu Cherukula, Heqiang Huo

“…Taken together, our findings suggest that miR164 plays a crucial role in regulating NAC gene expression and stress responses in petunia, providing a foundation for further functional characterization of miR164-NAC regulatory modules in plant stress adaptation.…”
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