Prognostic analysis of bladder cancer with neddylation-related genes by Huang Xiaolong, Deng Min, Zhang Sizhou, Hu Daorong, Pan Juncheng, Wang Yanjian, Li Jie Gu Hong, Zheng Ji, Wu Qingjian

“…Additionally, a protein–protein interaction (PPI) network, gene set enrichment analysis (GSEA), and BLCA single-cell sequencing data were utilized to explore the functional roles of hub genes in BLCA and their impact on biological pathways. …”
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Identification and validation of hub genes associated with biotic and abiotic stresses by modular gene co-expression analysis in Oryza sativa L. by Izreen Izzati Razalli, Muhammad-Redha Abdullah-Zawawi, Rabiatul Adawiah Zainal Abidin, Sarahani Harun, Muhamad Hafiz Che Othman, Ismanizan Ismail, Zamri Zainal

“…Over-representation analysis was conducted to determine the functional association of each gene module with stress-related processes and pathways. …”
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clonevdjseq: A workflow and bioinformatics management system for sequencing, archiving, and analysis of VDJ sequences from clonal libraries by Keith Mitchell, Samuel Hunter, Lutz Froenicke, Karl Murray, Matthew Settles, James S. Trimmer

“…The results of this effort has yielded sequences used to develop functional recombinant monoclonal antibodies and single chain variable fragments as a part of the NeuroMabSeq initiative where thousands of hybridoma samples were processed (Mitchell et al. in Sci Rep 13(1):16200, 2023) as well as provide additional modeling and extensibility to other modalities. …”
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Exploration of drug repurposing for Mpox outbreaks targeting gene signatures and host-pathogen interactions by Saber Imani, Sargol Aminnezhad, Moslem Alikarami, Zahra Abedi, Iman Samei Mosleh, Mazaher Maghsoudloo, Zahra Taheri

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Quantifying treatment response to a macrophage-targeted therapy in combination with immune checkpoint inhibitors after exposure to conventional chemotherapy by Shelby N. Bess, Gaven K. Smart, Timothy J. Muldoon

“…In addition to using the spheroid model, conventional 2D co-culture monolayers were used to quantify ICD hallmarks and changes in macrophage functional behavior while correlating immune responses after exposure to the combinatory regimen of immune checkpoint inhibitors and an ICD inducer.ResultsResults indicate that the combination of two immune checkpoint inhibitors in addition to a chemotherapy agent reduced spheroid growth (~46%) and reduced M2 macrophage expression and cellular proliferation while modulating cellular metabolism, ICD hallmarks, and phagocytic function.ConclusionsOverall, this study not only quantified microregional metabolic and structural changes in a simulated spheroid model but also quantified changes in ICD hallmarks and macrophage functional behavior. …”
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Tree diversity’s impact on coarse woody debris biomass and spatial stability under different moisture stress levels in temperate forests, South Korea by Hae-In Lee, Young-Ju Lee, Chang-Bae Lee

“…High CMI conditions showed a positive association between SR and CWDB, while this relationship diminished under low CMI conditions, highlighting the modulating effect of climate moisture stress. Furthermore, we found that species and functional trait diversity play more crucial roles in maintaining spatial stability in CWD distribution at low CMI levels than at high CMI levels. …”
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Development of a Modular Design and Detachable Mechanism for Safety Support Products in Winter Ice Fishing by Cuiyu Li, Zhongjie Hao, Chen Su, Licen Bai

“…System clustering techniques were then applied to optimize the distribution of matrix values, allowing for the identification of functional module areas. Based on these results, a modular design scheme was proposed. …”
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EEGUnity: Open-Source Tool in Facilitating Unified EEG Datasets Toward Large-Scale EEG Model by Chengxuan Qin, Rui Yang, Wenlong You, Zhige Chen, Longsheng Zhu, Mengjie Huang, Zidong Wang

“…Leveraging the functionality of such modules, EEGUnity facilitates the efficient management of multiple EEG datasets, such as intelligent data structure inference, data cleaning, and data unification. …”
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Glial connexins in glaucoma by Qiuyi Song, Qiuyi Song, Xi Wu, Xi Wu, Jiawei Yang, Jiawei Yang, Jiawei Yang, Siqi Li, Junguo Duan, Junguo Duan, Junguo Duan, Junguo Duan

“…The regulation of neuroglia may serve as a safe and effective strategy for modulating neuroinflammatory responses and restoring glial homeostasis and defense functions. …”
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Characterization of the intestinal microorganism in patients with congenital intestinal atresia: the preliminary exploration for establishment and influence of initial intestinal f... by Yang Chen, Ling Zhou, Qianghui Liao, Dong Xiao, Ledao Zhu, Jinlong Yao, Jiashu Liu, Xu’ning Zhang, Xiaopeng Ma, Feng Ren, Zhiyong Wang

“…Conclusion The distinct microbial profiles observed among the three groups suggest that the establishment of neonatal intestinal flora may result from a combination of placental transmission and digestive tract colonization. Functional pathway analysis suggested these microbial metabolic differences may exert pleiotropic effects, demonstrating both protective roles in intestinal barrier function and potentially detrimental impacts on emotional modulation and glucose/lipid dysregulation.…”
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Forskolin treatment enhances muscle regeneration and shows therapeutic potential with limitations in Duchenne muscular dystrophy by Andreea Iuliana Cojocaru, Kaouthar Kefi, Jean-Daniel Masson, Laurent Tiret, Frederic Relaix, Valentina Taglietti

“…This study aimed to evaluate the effects of FSK on muscle repair, fibrosis, inflammation, and long-term muscle function in DMD using a preclinical rat model. Methods BaCl2-induced muscle injury was performed on 6-month-old DMD (R-DMDdel52) and wild-type (WT) rats. …”
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EnSLDe: an enhanced short-range and long-range dependent system for brain tumor classification by Wenna Chen, Junqiang Liu, Xinghua Tan, Jincan Zhang, Ganqin Du, Qizhi Fu, Hongwei Jiang

“…IntroductionBrain tumors pose significant harm to the functionality of the human nervous system. There are lots of models which can classify brain tumor type. …”
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Capivasertib enhances chimeric antigen receptor T cell activity in preclinical models of B cell lymphoma by Hui-Ju Hsieh, Ryan Urak, Mary C. Clark, Larry W. Kwak, Stephen J. Forman, Xiuli Wang

“…Capivasertib exerts a similar function to AKT Inhibitor VIII in modulating CAR T cells, and combining CAR T cell therapy with capivasertib both ex vivo and in vivo offers the potential to improve patient outcomes. …”
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Beyond physical exhaustion: Understanding overtraining syndrome through the lens of molecular mechanisms and clinical manifestation by Ondrej Fiala, Michaela Hanzlova, Lenka Borska, Zdenek Fiala, Drahomira Holmannova

“…While overreaching can be a temporary state, non-functional overreaching may progress to chronic OTS. …”
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Supplementation with the Postbiotic BPL1™-HT (Heat-Inactivated <i>Bifidobacterium animalis</i> subsp. Lactis) Attenuates the Cardiovascular Alterations Induced by Angiotensin II In... by Mario de la Fuente-Muñoz, Marta Román-Carmena, Sara Amor, Daniel González-Hedström, Verónica Martinez-Rios, Patricia Martorell, Antonio M. Inarejos-García, Reme García Bou, Sonia Guilera-Bermell, Ángel L. García-Villalón, Miriam Granado

“…However, there are no studies regarding the possible beneficial effects of postbiotics on cardiovascular function and particularly on hypertension-induced cardiovascular alterations. …”
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Deep attention model for arrhythmia signal classification based on multi-objective crayfish optimization algorithmic variational mode decomposition by Yihang Zhang, Hang Zhao

“…The Pareto optimal front was generated by MOCOA and the intrinsic mode functions of VMD with the best combination of K and $$\alpha$$ were obtained. …”
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Mesh Smoothing of 3D Prosthesis and Orthosis Models by A. R. Sufelfa, A. S. Voznesensky, D. I. Kaplun

“…Formation of a contact surface in prosthetics and orthotics is crucial for the restoration of human musculoskeletal functions. This paper considers specific features of methods currently used for denoising of a 3D model surface obtained by optical scanning. …”
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Identified VCAM1 as prognostic gene in gastric cancer by co-expression network analysis by Wenjuan Li, Hong Gao, Jianjun Liu

“…Data from RNA sequencing and clinical pathological details were acquired from The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus (GEO) dataset. Co‐expression gene modules were constructed via Weighted Gene Co‐Expression Network Analysis (WGCNA), followed by deciphering gene functions and protein–protein interaction networks within significantly associated modules. …”
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The role of senescence-related genes in major depressive disorder: insights from machine learning and single cell analysis by Kun Lian, Wei Yang, Jing Ye, Yilan Chen, Lei Zhang, Xiufeng Xu

“…Weighted Gene Co-expression Network Analysis (WGCNA) identified gene modules strongly linked to each cluster. Single-cell RNA sequencing was used to analyze MDD SRGs functions. …”
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Energetically self-sufficient robot group study kit by M. A. Rovbo, A. A. Malyshev

“…The hardware base has been validated by testing various energy modules and assembling robot using the modules of the proposed kit. …”
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