CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation. by Vincent Vanoosthuyse, Pénélope Legros, Sjaak J A van der Sar, Gaël Yvert, Kenji Toda, Thierry Le Bihan, Yoshinori Watanabe, Kevin Hardwick, Pascal Bernard

“…We demonstrate that Swd2.2, Ppn1 and PP1Dis2 form an independent module within the CPF, which provides an essential function in the absence of the CPF-associated Ssu72 phosphatase. …”
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Auditory-Cortex Short-Term Plasticity Induced by Selective Attention by Iiro P. Jääskeläinen, Jyrki Ahveninen

“…More robust selective-attention short-term plasticity is manifested as modulation of responses peaking at ~100 ms from sound onset in functionally specialized nonprimary auditory-cortical areas by way of stimulus-specific reshaping of neuronal receptive fields that supports filtering of selectively attended sound features from task-irrelevant ones. …”
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Are probiotics useful in the treatment of chronic idiopathic constipation in adults? A review of existing systematic reviews, meta-analyses, and recommendations by Mikołaj Kamiński, Karolina Skonieczna-Żydecka, Igor Łoniewski, Anastasios Koulaouzidis, Wojciech Marlicz

“…The pathophysiology is complex and poorly understood, with evidence accumulating that gut microbiota can be implicated in the development and function of the enteric nervous system. Gut bacteria modulate gut barrier function, short chain fatty acid synthesis, and bile acid metabolism, factors which play roles in the gut peristalsis regulation. …”
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Downregulated PRNP Facilitates Cell Proliferation and Invasion and Has Effect on the Immune Regulation in Ovarian Cancer by Kuan Hu, Xiaofang Zhang, Lei Zhou, Juanni Li

“…Then, comprehensive evaluations concerning gene expression, clinical implication, in vitro validation of expression and functional experiments, prediction of downstream molecules and related signal pathways, and immune-modulating function were performed. …”
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The Δ40p53 isoform inhibits p53-dependent eRNA transcription and enables regulation by signal-specific transcription factors during p53 activation. by Cecilia B Levandowski, Taylor Jones, Margaret Gruca, Sivapriya Ramamoorthy, Robin D Dowell, Dylan J Taatjes

“…Such modulation of WTp53 activity may be an essential physiological function for Δ40p53. …”
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“In silico analysis of human TLR3 missense single nucleotide polymorphisms and their potential association with cancer” by Mohini Agarwal, Manish Kumar, Sarthak Dahiya, Anoop Kumar, Rupal Tripathi, Kumud Bala

“…The in silico analysis suggests that these genetic variations may contribute to the development and progression of cervical cancer by modulating TLR3 function. Further experimental studies are warranted to validate these findings and elucidate the underlying mechanisms, which may aid in developing novel therapeutic strategies for cervical cancer prevention and treatment.…”
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Transcriptome Analysis of Potato (<i>Solanum tuberosum</i> L.) Seedlings with Varying Resistance Levels Reveals Diverse Molecular Pathways in Early Blight Resistance by Jiangtao Li, Jie Li, Hongfei Shen, Rehemutula Gulimila, Yinghong Jiang, Hui Sun, Yan Wu, Binde Xing, Ruwei Yang, Yi Liu

“…These findings highlight critical molecular pathways and candidate genes involved in early blight resistance, providing a foundation for further functional studies and breeding strategies to enhance potato resilience.…”
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Identification of palmitoylated biomarkers in non-alcoholic fatty liver disease via integrated bioinformatics analysis and machine learning by Zheng Liu, Xiaohong Wang, Mingzhu Xiu, Rui Luo, Xiaomin Shi, Yizhou Wang, Yusong Ye, Ruiyu Wang, Sha Liu, Muhan Lv, Xiaowei Tang

“…The pivotal role of these genes in diagnosing NAFLD was confirmed using the validation dataset (AUC = 0.903). Functional enrichment linked these genes to TNF signaling, lipid metabolism, and immune pathways. …”
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Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors by Yan Zhang, Di Chen, Qiqi Lu, Yu Yao, Gaopeng Li, Chunxia Ji, Ying Qi, Chao Tang, Ji Xiong, Jian Hu, Fatma Betul Aksoy Yasar, Dave S B Hoon, Liangfu Zhou

“…The distinct B7-H4 pathways modulating T-cell function and immune evasion in glioma patients deserved to be further explored in the future during immunotherapy.…”
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Knowledge management: the tool of the conceptual map in the evaluation of a seminar on safety and security by Fernando Barcellos Razuck, FRANCISCO CESAR DA SILVA

“…Conceptual Maps are a tool that can gather knowledge of individuals and groups, facilitate the process of knowledge creation, function as a means of discussion and communication, and help in the distribution of knowledge and learning processes within an organization [4].   …”
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The Role of Lactobacillus reuteri DSM 17938 in Athletic Performance and Recovery by Julia Charkot, Wojciech Bieńkowski, Irmina Jaszczuk

“…Results: Evidence suggests that L. reuteri DSM 17938 contributes to gut barrier integrity, reduces exercise-related gastrointestinal discomfort, modulates inflammatory cytokines (e.g., IL-6, TNF-α), and supports immune function. …”
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Lactylation associated biomarkers and immune infiltration in aortic dissection by Jianfeng Ye, Yuntao Fu, Yuanjia Ke, Huanting Liu, Sini Fang, Yumeng Lei, Ying Mao, Liqiu Yan, Youcheng Wang

“…Transcriptomic data from public databases were analyzed to identify differentially expressed lactylation-related genes in AD. Functional enrichment analyses were performed, and Weighted Gene Co-expression Network Analysis (WGCNA) was utilized to identify gene modules associated with AD. …”
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Long-term results of medical treatment for lower extremity stress fractures by M. S. Ryazantsev, A. R. Zaripov, A. P. Afanasyev, M. N. Maysigov, N. E. Magnitskaya, D. O. Ilyin, A. N. Logvinov, A. V. Frolov, A. V. Korolev

“…The long-term results of treatment were assessed using the Foot and Ankle Ability Measure (FAAM) scale (ADL + sport modules) and the Lower Extremity Functional Scale (LEFS) scales.Results and discussion. …”
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Hybrid Optical Wireless Network for Future SAGO-Integrated Communication Based on FSO/VLC Heterogeneous Interconnection by Zhitong Huang, Zhenfang Wang, Minglei Huang, Wei Li, Tong Lin, Peixuan He, Yuefeng Ji

“…A hybrid optical wireless network based on FSO&#x002F;VLC heterogeneous interconnection is presented here for future space-air-ground-ocean-integrated communication architecture, especially in the radio-frequency-sensitive (RF) or security-required environments. The functional modules of the hybrid network coordinator are defined, along with the implementation and deployment details. …”
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Differential genetic interactions of yeast stress response MAPK pathways by Humberto Martin, Michael Shales, Pablo Fernandez‐Piñar, Ping Wei, Maria Molina, Dorothea Fiedler, Kevan M Shokat, Pedro Beltrao, Wendell Lim, Nevan J Krogan

“…We found an extensive number of conditional genetic interactions that recapitulate known stress‐specific functional associations. Furthermore, we have also uncovered previously unrecognized roles involving the phosphatase regulator Bud14, the histone methylation complex COMPASS and membrane trafficking complexes in modulating the cell wall integrity pathway. …”
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Model of e-learning with electronic educational resources of new generation by A. V. Loban, D. A. Lovtsov

“…Conclusion: The developed theoretical provisions and basis components for the model of variation e-learning with electronic educational resource of new generation allow the student to realize functional mastering of knowledge, abilities and skills of trainees on the base of variation approach, and also to choose a personal student-centered way of “finding concept (meaning)” of the given tasks in the process of motivated learning based on formalized information thesaurus-classifier of electronic educational resource.…”
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Improved image reconstruction from brain activity through automatic image captioning by Fatemeh Kalantari, Karim Faez, Hamidreza Amindavar, Soheila Nazari

“…Abstract Significant progress has been made in the field of image reconstruction using functional magnetic resonance imaging (fMRI). Certain investigations reconstructed images with visual information decoded from brain signals, yielding insufficient accuracy and quality. …”
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Artificial Intelligence Technology Based on Deep Learning in Building Construction Management System Modeling by Hongbo Wang, Yan Hu

“…Finally, the three functional modules of progress monitoring, progress reliability early warning, and progress prediction are realized by combining the S-curve comparison method, and the work of the system is described through case simulation. …”
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Open Education System in Management Training in the Digital Economy by L. P. Gancharik

“…It is presented that the necessary elements of a competitive digital transformation and an emerging information society are:A model of digital competence of managerial personnel, covering the considered roles with options related to different areas of activity.The digital environment of management personnel infrastructure and end-to-end digital technologies that support the strategies of the information society and the digital economy, ensuring the implementation of digital competencies.The system of certification of digital competencies, ensuring the competitiveness of the workforce and their controllability in the framework of the digital transformation.The competencies of management personnel in the digital economy with their grouping into functional blocks are considered.The analysis of the qualification levels of managerial competencies in the field of digital transformation, as well as the basic concepts that managerial personnel should have.The principles of the formation of educational modules in the system of open education on the formation of level models of managerial competencies of managerial personnel in the digital economy are proposed.Conclusion. …”
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Critical gene network and signaling pathway analysis of the extracellular signal-regulated kinase (ERK) pathway in ischemic stroke by Rui Mao, Lei Wang, Haitao Zhang, Jiaojiao Gong, Hua Liu

“…Differential expression analyses were performed using the limma package in R, followed by weighted gene co-expression network analysis (WGCNA) to identify ERK-associated gene modules. Gene Ontology (GO) enrichment and protein–protein interaction (PPI) network analyses further elucidated the functional and interaction landscapes of the key ERK pathway genes, collectively termed GSERK. …”
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