Integrated Analyses Identify Immune-Related Signature Associated with Qingyihuaji Formula for Treatment of Pancreatic Ductal Adenocarcinoma Using Network Pharmacology and Weighted... by Xiang Qian, Zhuo Chen, Sha Sha Chen, Lu Ming Liu, Ai Qin Zhang

“…Functional enrichment analysis of putative targets and OGEs was conducted. …”
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Exploring potential key genes and disease mechanisms in early-onset genetic epilepsy via integrated bioinformatics analysis by Vasiliki Boulaki, Spiros Efthimiopoulos, Nicholas K. Moschonas, George Μ. Spyrou

“…Clustering analysis of the PPI network via MCODE showed significant functional modules, indicating also other pathways such as N-Glycan biosynthesis and protein N-linked glycosylation, retrograde endocannabinoid signaling, mTOR signaling and aminoacyl-tRNA biosynthesis. …”
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Optimization and benefit evaluation model of a cloud computing-based platform for power enterprises by Xueli Yin, Xuguang Zhang, Luyao Pei, Rong Hu, Kaihui Ye, Kangkang Cai

“…In contrast to existing studies that mainly address isolated functional modules such as equipment health monitoring or collaborative design, this research presents a novel paradigm characterized by architectural integration, methodological versatility, and industrial applicability. …”
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Selection and Application of the Data Transfer Operating Protocol Software Architecture for the Software-Defined Radio by Oleg V. Vorobyov, Alexey I. Rybakov

“…The study developed the structure and the functional description of the protocol used in the software for the simulation model of software-configurable radio channel. …”
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Degradation capability of Acinetobacter indicus LXX12 on tobacco straw and its whole genome analysis by Xiaoxiao Lu, Huang Ying, Jing Liu, Jianyu Gou, Zhengxiong Zhou, Shishuang Xie

“…Based on 16 S rDNA sequence alignment, the strain showed 99.78% similarity to Acinetobacter indicus CIP 110,367 strain A648, and was designated Acinetobacter indicus LXX12 despite notable phenotypic discrepancies. The isolation and functional characterization of this strain provide a novel microbial resource for lignocellulose bioconversion, combining high efficiency with environmental adaptability, and hold significant potential for agricultural waste valorization.…”
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Analyzing the mechanism of rhubarb in the treatment of cervical cancer based on network pharmacology and molecular docking technology by Yingying Xu, Jian Wang, Guodong Chen

“…The active ingredients of rhubarb were identified using TCMSP and HERB databases, and active ingredient target prediction was performed using SEA and Swiss TargetPrediction; cervical cancer-related targets were collected through four databases, namely, OMIM, GeneCards, CTD, and GDA; common targets of drugs and diseases were obtained through Draw Venn diagram; STRING online platform was applied to build protein-protein interaction networks (PPI) and core targets and most important modules were screened by cytoscape 3.10.3; use DAVID and REACTOM databases to perform GO functional enrichment analysis and KEGG pathway enrichment analysis, and visualize the results; Finally, molecular docking of key active ingredients and targets was performed by PubChem database and Auto Dock software, and the results were visualized by PyMOL. 23 active ingredients and 106 common targets were obtained after screening. …”
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Identification and validation of up-regulated TNFAIP6 in osteoarthritis with type 2 diabetes mellitus by Siyi Liu, Haitao Chen, Xu Yang, Yinxian Wen, Liaobin Chen

“…Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were performed to screen out hub genes between OA and T2DM, and functional enrichment was done. Single-cell sequencing analysis was further used to screen key genes on OA and T2DM datasets. …”
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Mechanistic role of the KRTAP5-AS1/miR-199b-5p/CYP19A1 axis in polycystic ovary syndrome pathogenesis by Ping Tao, Xiaohong Yan, Zhanxiang Wang

“…Abstract Background Polycystic ovary syndrome (PCOS) pathogenesis involves dysregulated granulosa cell function, but molecular mechanisms remain unclear. …”
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Architecture of the FindFISH Platform - A Service for Fishermen and More by Lidia Dzierzbicka-Glowacka, Michał Wójcik

“…The system has been realized in the form of several independently operable modules, each entrusted with distinct sets of requisite functionalities. …”
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Deep VMD-attention network for arrhythmia signal classification based on Hodgkin-Huxley model and multi-objective crayfish optimization algorithm. by Hang Zhao, Xiongfei Yin

“…The Pareto optimal front was generated using MOCOA with the indicators of spectral kurtosis and KL divergence, by which the optimal intrinsic mode functions were obtained. A deep VMD-attention network based on MOCOA was developed for ECG signal classification. …”
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Energetische upgrading van Nederlandse Wederopbouw flats by Frits Schultheiss

“…Eliminating structural and building physical defects of the existing stock (Flat 1.0) is an opportunity for functional upgrading in the field of accessibility and social safety. …”
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Network Meta-Analysis of Factors Influencing the Carbon Sink Capacity of Urban Park Green Spaces by Yutong JI, Tianyi LIN, Lian LIU, Xiong LI

“…In light of the increasingly prominent role of urban green spaces in mitigating climate change, the research also seeks to highlight strategies that balance ecological functions with urban recreational and aesthetic needs.MethodThis research employs the network Meta-analysis method to explore the critical factors influencing the carbon sequestration potential of urban park green spaces, and conduct a systematic quantitative assessment of their respective carbon sink capacity. …”
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Macrophage innate immune responses delineate between defective translocon assemblies produced by Yersinia pseudotuberculosis YopD mutants by Salah I. Farag, Monika K. Francis, Jyoti M. Gurung, Sun Nyunt Wai, Hans Stenlund, Matthew S. Francis, Aftab Nadeem

“…The activation and suppression of certain cytokines that function as central innate immune response modulators correlated well with the ability of mutant bacteria to alter anti-phagocytosis and programmed cell death pathways. …”
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Alternative splicing events driven by altered levels of GEMIN5 undergo translation by Rosario Francisco-Velilla, Salvador Abellan, Juan Antonio Garcia-Martin, Juan Carlos Oliveros, Encarnacion Martinez-Salas

“…Importantly, differential AS events in mRNAs engaged in polysomes, eventually rendering non-functional proteins, encode factors controlling cell growth. …”
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Near-term anti-CD25 monoclonal antibody administration protects murine liver from ischemia-reperfusion injury due to reduced numbers of CD4+ T cells. by Jinghui Yang, Xiaoyu Wang, Shaohua Song, Fang Liu, Zhiren Fu, Quanxing Wang

“…Liver function, histological damage, in vitro Proliferation, FACS, cytokine production, and immunofluorescence were assessed to evaluate the impact of antecedent near-term PC61 treatment on IR-induced liver injury.…”
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Primary Cilia, Hypoxia, and Liver Dysfunction: A New Perspective on Biliary Atresia by Patrícia Quelhas, Diogo Morgado, Jorge dos Santos

“…Interestingly, even isolated BA without extrahepatic anomalies presents morphological and functional ciliary abnormalities, suggesting that environmental triggers may disrupt the ciliary function. …”
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Amino Acid Regulation in Rice: Integrated Mechanisms and Agricultural Applications by Hangfei Luo, Bowen Wu, Bakht Amin, Jiaxu Li, Zhongbo Chen, Jian Shi, Weiting Huang, Zhongming Fang

“…Abstract This review synthesizes how amino acid (AA) metabolism regulates rice stress tolerance, growth and quality through stress protection and growth-modulating pathways, bridging mechanisms to field applications. …”
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Integrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression of athe... by Yifeng Zhang, Yifeng Zhang, Shuxian Lu, Shuxian Lu, Liang Qiu, Liang Qiu, Manman Qin, Manman Qin, Dan Shan, Lianhua Xie, Yao Yi, Yao Yi, Jun Yu

“…Moreover, we also found that the changes of the function and the number of Tregs could modulate endothelial cell and smooth muscle cell functions to counteract AS through ligand–receptor pairs such as the MIF signaling pathway. …”
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Equivalent Modeling of Disconnector Operation Based on Dynamic Arc Characteristics and VFTO Characteristic Analysis by Bin Liu, Yong Liu, Junjun Xiong, Xiaopin Deng, Zhenyu Guo, Xueyou Zhang, Bingyu Mei, Zhenhua Li

“…Furthermore, a comparative analysis of transient waveform characteristics from both experiment and simulation is conducted, with key parameters extracted and probability density functions constructed. The results demonstrate the high-precision fitting capability of the model and further reveal the statistical distribution patterns of very fast transient overvoltage single-pulse characteristics.…”
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High-Frequency Repetitive Transcranial Magnetic Stimulation Could Improve Impaired Working Memory Induced by Sleep Deprivation by Zhiwei Guo, Zhijun Jiang, Binghu Jiang, Morgan A. McClure, Qiwen Mu

“…Seventeen healthy adults received one session of 5.0 Hz rTMS over the left dorsolateral prefrontal cortex (DLPFC) following 24 hours of SD. Resting state functional magnetic resonance imaging (fMRI) and working memory test were performed during a rested waking period, after SD and rTMS. …”
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