Structural elucidation of mulberry leaf oligosaccharide and its selective promotion of gut microbiota to alleviate type 2 diabetes mellitus by Tenggen Hu, Yuanshan Yu, Jijun Wu, Yujuan Xu, Gengsheng Xiao, Kejing An, Erna Li, Sentai Liao, Yuxiao Zou

“…The results of simulated digestion showed that MLO 2-2 was a digestible oligosaccharide, which could be degraded by human digestive juice; while MLO 2-1 possessed the non-digestible property in the upper gastrointestinal tract and performed the function by regulating the gut microbiota. Hence, MLO 2-1 was selected for the further analysis. …”
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Sleep quality and the integrity of ascending reticular activating system – A multimodal MRI study by Viktória Kokošová, Lubomír Vojtíšek, Marek Baláž, Silvia Mangia, Shalom Michaeli, Pavel Filip

“…This study aimed at determining whether sleep quality and age, separately, affect brain integrity and subsequently, whether sleep significantly modulates the effect of age on brain structural and functional integrity. 113 healthy volunteers underwent a multi-modal MRI imaging to extract information about the microstructure and function of major nodes of the ascending reticular activating system. …”
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Tie2 activity in cancer associated myofibroblasts serves as novel target against reprogramming of cancer cells to embryonic-like cell state and associated poor prognosis in oral ca... by Paromita Mitra, Uday Saha, Kingsly Joshua Stephen, Priyanka Prasad, Subhashree Jena, Ankit Kumar Patel, Harshavardhan BV, Santosh Kumar Mondal, Sillarine Kurkalang, Sumitava Roy, Arnab Ghosh, Shantanu Saha Roy, Jayasri Das Sarma, Nidhan Kumar Biswas, Moulinath Acharya, Rajeev Sharan, Pattatheyil Arun, Mohit Kumar Jolly, Arindam Maitra, Sandeep Singh

“…Overall, our work has provided wider applicability of Tie2-specific functions in tumor biology, along with its known role in endothelial cell-specific function.…”
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User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: Multimethod Multiphase Study by Afra Selma Taygar, Sara Laureen Bartels, Rocío de la Vega, Ida Flink, Linnéa Engman, Suzanne Petersson, Sophie I Johnsson, Katja Boersma, Lance M McCracken, Rikard K Wicksell

“…The findings indicated that the intervention is promising while also providing relevant end-user suggestions (eg, video content, text-to-speech function, and add-on modules) to guide further improvements.…”
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The Effects of Different Probiotic Administration on Dexamethasone-Associated Metabolic Effects by Andreea Ioana Inceu, Maria Adriana Neag, Corina Ioana Bocsan, Anca Elena Craciun, Carmen Stanca Melincovici, Dana Maria Muntean, Florentina Claudia Militaru, Mădălin Mihai Onofrei, Raluca Maria Pop, Luciana-Mădălina Gherman, Marius Bichescu, Anca Dana Buzoianu

“…Probiotics have been shown to modulate basal metabolism, inflammation, and oxidative stress through the regulation of composition and function of the gut microbial environment. …”
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Node Classification Based on Kolmogorov-Arnold Networks by YUAN Lining, FENG Wengang, LIU Zhao

“…Most graph deep learning methods extract feature information from graph data by using learnable weights and specific activation functions. The selection of different activations has a significant impact on performance. …”
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Phospholipid conjugates: formation of the intramolecular π-cation complex by Valery P. Shendrikov, Erik F. Kot, Kirill I. Makrinsky, Abdulilah Ece, Ivan A. Boldyrev

“…The conjugation is needed to incorporate a functional group into the lipid bilayer of liposome or lipid nanoparticle and thus, either modulate the effect of the drug or bring a new function to the liposome. …”
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Protein phosphatase-1 regulates the binding of filamin C to FILIP1 in cultured skeletal muscle cells under mechanical stress by Thomas Kokot, Johannes P. Zimmermann, Anja N. Schwäble, Lena Reimann, Anna L. Herr, Nico Höfflin, Maja Köhn, Bettina Warscheid

“…Abstract The actin-binding protein filamin c (FLNc) is a key mediator in the response of skeletal muscle cells to mechanical stress. In addition to its function as a structural scaffold, FLNc acts as a signaling adaptor which is phosphorylated at S2234 in its mechanosensitive domain 20 (d20) through AKT. …”
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Interictal dysfunction of a brainstem descending modulatory center in migraine patients. by Eric A Moulton, Rami Burstein, Shannon Tully, Richard Hargreaves, Lino Becerra, David Borsook

“…In migraineurs, abnormal brainstem function during attacks suggest that dysfunction of descending modulation may facilitate migraine attacks, either by reducing descending inhibition or increasing facilitation. …”
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Key Considerations for Ovarian Preservation during Radiotherapy for Cervical Carcinoma by Xiaolong Cheng, Jiping Liu, Xiaojuan Lv, Long Sun

“…Safeguarding ovarian function during radiotherapy for cervical cancer has become a prominent focus of current clinical research. …”
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Intracellular spatial transcriptomic analysis toolkit (InSTAnT) by Anurendra Kumar, Alex W. Schrader, Bhavay Aggarwal, Ali Ebrahimpour Boroojeny, Marisa Asadian, JuYeon Lee, You Jin Song, Sihai Dave Zhao, Hee-Sun Han, Saurabh Sinha

“…Intra-cellular spatial patterns discovered by InSTAnT mirror diverse molecular relationships, including RNA interactions and shared sub-cellular localization or function, providing a rich compendium of testable hypotheses regarding molecular functions.…”
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Multi task detection method for operating status of belt conveyor based on DR-YOLOM by Yongan LI, Tengjie CHEN, Hongwei WANG, Zhihao ZHANG

“…Faster RCNN and Yolov8 were used to compare the performance of object detection, and the loss function and accuracy curve before and after model improvement were compared. …”
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Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain. by Sonja C Vernes, Peter L Oliver, Elizabeth Spiteri, Helen E Lockstone, Rathi Puliyadi, Jennifer M Taylor, Joses Ho, Cedric Mombereau, Ariel Brewer, Ernesto Lowy, Jérôme Nicod, Matthias Groszer, Dilair Baban, Natasha Sahgal, Jean-Baptiste Cazier, Jiannis Ragoussis, Kay E Davies, Daniel H Geschwind, Simon E Fisher

“…Forkhead-box protein P2 is a transcription factor that has been associated with intriguing aspects of cognitive function in humans, non-human mammals, and song-learning birds. …”
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The S-layer homology domain-containing protein SlhA from Paenibacillus alvei CCM 2051(T) is important for swarming and biofilm formation. by Bettina Janesch, Andrea Koerdt, Paul Messner, Christina Schäffer

“…To unravel a putative function of the SlhA protein, a knockout mutant was constructed. …”
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A Predictive Disease Risk Model for Ankylosing Spondylitis: Based on Integrated Bioinformatic Analysis and Identification of Potential Biomarkers Most Related to Immunity by Wenxin Gao, Ruirui Hou, Yungang Chen, Xiaoying Wang, Guoyan Liu, Wanli Hu, Kang Yao, Yanke Hao

“…Results. Biological function and immune score analyses identified central genes related to immunity, key immune cells, key related pathways, gene modules, and the coexpression network in AS. …”
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A quick response data collection and management system for digital twin production line based on cloud-fog-edge computing collaboration [version 1; peer review: 2 approved, 1 appro... by Xuesong Mei, Zhiyuan Li, Zheng Sun, Jun Xu, Dawei Zhang

“…Functional tests show that the system has the functions of data acquisition and transmission, device addition and viewing, device data querying and downloading, data and model visualization, and user rights setting. …”
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Identification of CCNB1 as a biomarker for cellular senescence in hepatocellular carcinoma: a bioinformatics and experimental validation study by Zhilan Zhang, Jie Zhou, Ruiru Huang, Xingxing Zhuang, Shoudong Ni

“…Correlation analysis, GO and KEGG functional enrichment analysis, and gene co-expression network analysis further elucidated the functions of AgHDEGs. …”
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modeling frame, flexible production system, search and selection algorithm, frame slot, graph diagram by J. F. Mamedov, K. S. Abdullaev, Z. M. Muradli, E. M. Hasanova, S. B. Alieva

“…To ensure the reliable functioning of the FMS automatic control system, an algorithm is proposed for searching sensors based on frame slots and achievable positioning errors of industrial robots and technological equipment. …”
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Brain dynamics alterations induced by partial sleep deprivation: An energy landscape study by Yutong Wu, Liming Fan, Wei Chen, Xing Su, Simeng An, Nan Yao, Qian Zhu, Zi-Gang Huang, Youjun Li

“…Additionally, the weaker functional segregation between two modules assigned by two complementary major states was found during PSD than FS in young group. …”
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Epigenome editing-mediated restoration of FBN1 expression by demethylation of CpG island shore in porcine fibroblasts by Rio Miyadai, Shiori Hinata, Yuya Amemiya, Satori Shigematsu, Kazuhiro Umeyama, Hiroshi Nagashima, Kenji Yamatoya, Jun Ohgane

“…Mutations in FBN1 result in haploinsufficiency, leading to Marfan syndrome, in which the expression of functional FBN1 is correlated with disease onset and severity. …”
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