Design and Research of a Parallel Cable-Driven Force Feedback Master Hand by Duanjiao Li, Wenxing Sun, Junwen Yao, Yilong Chen, Yuhui Chen, Jieren Zheng, Yupeng Zou

“…The system’s functional modules are designed based on the overall control scheme. …”
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TRIM29 alleviates intervertebral disc degeneration through the PI3K/AKT/mTOR pathway by Qinghua Yang, Junfei Feng, Hongyuan Xu, Tao Kang, Qingjun Wei, Hua Jiang

“…This study categorized nucleus pulposus cell (NPC) populations and identified co-expression gene modules linked to the adhesive NPCs (Adh-NPCs) subpopulation in IDD using hierarchical dynamic weighted gene co-expression network analysis (hdWGCNA). …”
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Associations between HLA-II variation and antibody specificity are predicted by antigen properties by Gabriel Innocenti, Sergio Andreu-Sánchez, Nicolai V. Hörstke, Hesham Elabd, Iros Barozzi, Andre Franke, Máté Manczinger, Thomas Vogl

“…Methods Here, we have leveraged paired data sets of SNP arrays and functional antibody epitope repertoires against 344,000 peptide antigens in 1940 individuals to mine for key determinants linking genetics and antibody specificity. …”
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Development of Experimental Setup to Investigate the Control System for Infusion Solutions Dosing Process by Fedir Matiko, Volodymyr Shaleva

“…The results of research confirmed that using CPU 1215C DC/DC/DC controller, it is possible to achieve the same speed and productivity of the dosing line as when using control systems based on single-chip processors, while significantly expanding the functional capabilities of the system. The algorithm for controlling the process of dosing the infusion solutions was also improved in order to adapt it to controlling the process of dosing the solutions of different viscosities into bottles of different capacities. …”
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Glypican-3 regulated epithelial mesenchymal transformation-related genes in osteosarcoma: based on comprehensive tumor microenvironment profiling by Jiaming Zhang, Wei Wang

“…Single-cell RNA-Seq (scRNA-Seq) analysis was conducted on OS samples to identify cell populations expressing model genes. Functional validation was performed using si-GPC3 in the MG-63 cell line.ResultsThe EMT-based prognostic model demonstrated strong predictive capacity across several validation cohorts. …”
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A novel extracellular metallopeptidase domain shared by animal host-associated mutualistic and pathogenic microbes. by Sirintra Nakjang, Didier A Ndeh, Anil Wipat, David N Bolam, Robert P Hirt

“…Moreover, 141 entries across various peptidase families described in the MEROPS database were also identified with carbohydrate-binding modules defining a new functional context for these glycan-binding domains and providing opportunities to engineer proteases targeting specific glycoproteins for both biomedical and industrial applications.…”
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Physiological Mechanisms and Core Genes in Response to Saline-Alkali Stress in Foxtail Millet (<i>Setaria italica</i> L.) by Huimin Wang, Yun Li, Yanan Yang, Yanrui Xu, Xiaoying Fan, Zhenqing Guo, Yucui Han, Xiaohu Lin

“…Further, WGCNA combining morphological and physiological indicators identified four key modules and five functional pathways (MAPK signaling, glycerolipid metabolism, phosphate and phosphonate metabolism, galactose metabolism, and endoplasmic reticulum protein processing) in response to saline-alkali stress, and identified a total of 24 core genes. …”
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Innovative Model of Socio-Professional Development of a Student’s Personality by E. F. Zeer, V. S. Tretyakova, M. V. Zinnatova

“…The content of each module is focused on the final result of educational activity: professional, diagnostic, competence, technological, functional. …”
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Orchard-Wide Visual Perception and Autonomous Operation of Fruit Picking Robots: A Review by CHEN Mingyou, LUO Lufeng, LIU Wei, WEI Huiling, WANG Jinhai, LU Qinghua, LUO Shaoming

“…[Conclusions and Prospects]The review underscores the critical importance of coordinating perception, movement, and picking modules to facilitate the transition from a basic functional prototype to a practical machine. …”
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Is There Room for SERMs or SARMs as Alternative Therapies for Adult Male Hypogonadism? by Vito A. Giagulli, Andrea Silvestrini, Carmine Bruno, Vincenzo Triggiani, Alvaro Mordente, Antonio Mancini

“…For such situation, according to results obtained in infertile women, the administration of selective estrogen receptor modulators (SERMs) has been proposed in males too, with positive results on both metabolic and sexual function. …”
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The evolutionary dynamics of plastic foraging and its ecological consequences: a resource-consumer model by Ledru, Léo, Garnier, Jimmy, Guillot, Océane, Faou, Erwan, Noûs, Camille, Ibanez, Sébastien

“…Consumers could either forage randomly, only as a function of resources abundance, or plastically, as a function of resource abundance, suitability and consumption by competitors. …”
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The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity by Tamara M Sirey, Kenny Roberts, Wilfried Haerty, Oscar Bedoya-Reina, Sebastian Rogatti-Granados, Jennifer Y Tan, Nick Li, Lisa C Heather, Roderick N Carter, Sarah Cooper, Andrew J Finch, Jimi Wills, Nicholas M Morton, Ana Claudia Marques, Chris P Ponting

“…Increased abundance of Cerox1 cooperatively elevates complex I subunit protein abundance and enzymatic activity, decreases reactive oxygen species production, and protects against the complex I inhibitor rotenone. Cerox1 function is conserved across placental mammals: human and mouse orthologues effectively modulate complex I enzymatic activity in mouse and human cells, respectively. …”
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Genome-wide, chromosome-naïve compartmentalization of major developmental networks tailored by modular placement of human embryo-regulatory Long Terminal Repeats by Gennadi V. Glinsky

“…Despite this physical segregation, eukaryotic genomes possess an intrinsic regulatory connectivity that facilitates remarkable chromosome-naive function-aligned integration and striking developmental precision in conveying genetic information from conception and embryogenesis to adulthood. …”
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Altered cytoskeleton dynamics in patient-derived iPSC-based model of PCDH19 clustering epilepsy by Rossella Borghi, Stefania Petrini, Valentina Apollonio, Marina Trivisano, Nicola Specchio, Sandra Moreno, Enrico Bertini, Marco Tartaglia, Claudia Compagnucci

“…The mechanism by which altered PCDH19 function drive pathogenesis is not yet fully understood. …”
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Higher‐order modular regulation of the human proteome by Georg Kustatscher, Martina Hödl, Edward Rullmann, Piotr Grabowski, Emmanuel Fiagbedzi, Anja Groth, Juri Rappsilber

“…Progulons consist of dozens to hundreds of proteins that together mediate core cellular functions. They are not restricted to physical interactions or co‐localisation. …”
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The Role of Transcranial Direct Current Stimulation in Chronic Shoulder Pain: A Scoping Review by Roberto Tedeschi, Federica Giorgi, Danilo Donati

“…Transcranial direct current stimulation (tDCS) has emerged as a non-invasive neuromodulatory intervention to modulate cortical excitability and potentially improve pain and functional outcomes. …”
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Mechanism of Transcranial Magnetic Stimulation in the Treatment of Neuropathic Pain by SUN Yu-jia, ZHANG Jun-feng, YAN Long, FAN Shi-yu, QIAN Yu-lin, CONG Shan, YU Tao

“…The mechanisms discussed include modulation of synaptic plasticity，functional reorganization of neural networks （inducing cortico-cortical functional connectivity and subcortical functional connectivity），adjustment of afferent nerve fiber sensitivity，alteration of neurotransmitter levels，and effects on neuroimmune interactions. …”
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Architecture of distributed geoinformation technology for snow cover monitoring in circumstances of limited telecommunications accessibility by Yu. V. Belysheva, D. D. Sutyagin, E. S. Zimina

“…The proposed architecture is capable of functioning in circumstances of limited telecommunication availability, while ensuring data integrity control and personalization of responsibility by introducing an electronic signature of each measurement session. …”
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Viral-mediated knockdown of Atxn2 attenuates TDP-43 pathology and muscle dysfunction in the PFN1C71G ALS mouse model by Zachary C. E. Hawley, Xueying Li, Dora Bodnar, Yuanzheng Gu, Yi Luo, Daniel Ferretti, Adam Sheehy, Rachelle Driscoll, Maria I. Zavodszky, Shaolong Cao, Isabel Isaza, Luke Jandreski, Yuqing Liu, Thomas Carlile, Shih-Ching Lo, Anna Grimard, Shawn Bourque, Aditya Utturkar, Samantha Desmarais, H. Moore Arnold, Dann Huh, Edward Guilmette, Deborah Y. Kwon

“…Lastly, we find significant gene co-expression network homology between PFN1C71G mice and human ALS, with shared dysregulation of modules related to neuroinflammation and neuronal function and uncover novel hub genes that provide biological insight into ALS and potential drug targets that can be further investigated in this mouse model.…”
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Contemporary treatment of right ventricular failure by Bibhuti B. Das, MD, Shashi Raj, MD, FAAP, FACC

“…Factors modulating RV function include afterload, preload, contractility, and interventricular dependency. …”
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