Proper actin ring formation and septum constriction requires coordinated regulation of SIN and MOR pathways through the germinal centre kinase MST-1. by Yvonne Heilig, Anne Dettmann, Rosa R Mouriño-Pérez, Kerstin Schmitt, Oliver Valerius, Stephan Seiler

“…However, MST-1 also interacts with several components of the MOR network and modulates MOR activity at multiple levels. MST-1 functions as promiscuous enzyme and also activates the MOR effector kinase COT-1 through hydrophobic motif phosphorylation. …”
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Genetic implication of GABAB receptors in the etiology of neurological and psychiatric disorders by Martin Gassmann, Michal Stawarski, Stylianos E. Antonarakis, Stylianos E. Antonarakis, Bernhard Bettler

“…Advances in high-throughput genomic technologies, particularly whole-exome sequencing, have uncovered hundreds of variants in the genes encoding the GBR subunits, GABBR1 and GABBR2, many of which are linked to neurological and psychiatric disorders. Functional characterization of such variants in recombinant assay systems has revealed both gain-of-function (GOF) and loss-of-function (LOF) mutations, which can now be interpreted in the context of high-resolution structural models of GBR activation. …”
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IECAU-Net: A Wood Defects Image Segmentation Network Based on Improved Attention U-Net and Attention Mechanism by Yingda Dong, Chunguang He, Xiaoyang Xiang, Yuhan Cui, Yongkang Kang, Anning Ding, Huaqiong Duo, Ximing Wang

“…The improved Attention U-Net model encoding stage was introduced into CBAM, and AdamW optimization was used instead of SGD and Adam to achieve better crack semantic segmentation results. The ECA module was introduced in the skip connection part, and the weighted fusion multi loss function was used instead of the original cross entropy loss function. …”
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<i>Chimonanthus nitens</i> Oliv. Leaf Flavonoids Exert Anti-Inflammatory Effects Through TLR4 Receptor Affecting NF-κB/MAPK Signaling Pathway by Lirong Shen, Wenya Meng, Hui Chen, Lingli Chen, Suyun Lin, Kehui Ouyang, Wenjun Wang

“…Additionally, Western blotting analysis indicated that COLFs could influence the activity of the NF-κB/MAPK signaling pathway via the TLR4 receptor, thereby modulating its anti-inflammatory function. Overall, our results reveal a novel role for COLFs as natural inflammation regulators and provide a theoretical and molecular basis for their development and utilization.…”
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Lymphocyte Glucose and Glutamine Metabolism as Targets of the Anti-Inflammatory and Immunomodulatory Effects of Exercise by Frederick Wasinski, Marcos F. Gregnani, Fábio H. Ornellas, Aline V. N. Bacurau, Niels O. Câmara, Ronaldo C. Araujo, Reury F. Bacurau

“…Chronic exercise induces changes in lymphocyte functionality and substrate metabolism. In the present review, we discuss whether the beneficial effects of exercise on lymphocyte function in health and disease are associated with modulation of the glucose and glutamine metabolic pathways.…”
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Investigating the role of non-synonymous variant D67N of ADGRE2 in chronic myeloid leukemia by Ayesha Afzal, Harooma Jamshaid, Yasmin Badshah, Maria Shabbir, Janeen H. Trembley, Sameen Zafar, Ghulam Murtaza Kamal, Tayyaba Afsar, Fohad Mabood Husain, Suhail Razak

“…Results Various in silico analyses explored the impact of damaging SNP on the function, stability, and structure of EGF-like modules containing mucin-like hormone receptor-like2 (EMR2) protein encoded by the ADGRE2 gene. …”
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Structural mechanisms for centrosomal recruitment and organization of the microtubule nucleator γ-TuRC by Qi Gao, Florian W. Hofer, Sebastian Filbeck, Bram J. A. Vermeulen, Martin Würtz, Annett Neuner, Charlotte Kaplan, Maja Zezlina, Cornelia Sala, Hyesu Shin, Oliver J. Gruss, Elmar Schiebel, Stefan Pfeffer

“…In the pericentriolar material, the γ-TuRC is involved in microtubule organization, while the function of the centriole lumenal pool remains unclear. …”
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Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers by Jüri Reimand, Gary D Bader

“…Abstract Large‐scale cancer genome sequencing has uncovered thousands of gene mutations, but distinguishing tumor driver genes from functionally neutral passenger mutations is a major challenge. …”
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Microbes with higher metabolic independence are enriched in human gut microbiomes under stress by Iva Veseli, Yiqun T Chen, Matthew S Schechter, Chiara Vanni, Emily C Fogarty, Andrea R Watson, Bana Jabri, Ran Blekhman, Amy D Willis, Michael K Yu, Antonio Fernàndez-Guerra, Jessika Füssel, A Murat Eren

“…Here, we tested this hypothesis on a large scale, by developing a software framework to quantify the enrichment of microbial metabolisms in complex metagenomes as a function of microbial diversity. We applied this framework to over 400 gut metagenomes from individuals who are healthy or diagnosed with inflammatory bowel disease (IBD). …”
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Trojan-horse silk fibroin nanocarriers loaded with a re-call antigen to redirect immunity against cancer by Luca Mastracci, Patrizio Castagnola, Elia Bari, Francesca Ferrera, Tiziana Altosole, Sara Perteghella, Pierluigi Mauri, Rossana Rossi, Giulia Passignani, Martina Galati, Giuseppina Iliana Astone, Maddalena Mastrogiacomo, Daniela Fenoglio, Dario Di Silvestre, Maria Luisa Torre, Gilberto Filaci

“…Proteomics and systems biology showed that peritumoral treatment with either SFNs-OVA or SFNs-CpG dramatically modified tumor microenvironment with respect to the control (CTR), mainly involving functional modules and hubs related to angiogenesis, inflammatory mediators, immune function, T complex and serpins expression, redox homeostasis, and energetic metabolism. …”
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Exploring Genetic Factors Associated with <i>Moniezia</i> spp. Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach by Yunus Arzik, Mehmet Kizilaslan, Sedat Behrem, Lindsay M. W. Piel, Stephen N. White, Mehmet Ulaş Çınar

“…Its interaction with helminth-derived proteins modulates B-cell function, highlighting its potential as a therapeutic target. …”
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A generalizable approach for programming protease-responsive conformationally inhibited artificial transcriptional factors by Yinxia Liu, Lingyun Zhao, Jinshan Long, Zhenye Huang, Ying Long, Jianjun He, Jian-Hui Jiang

“…Fine-tuning the general structural functionality of ATFs is important for constructing orthogonal and composable transcriptional regulators. …”
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Strain-specific effects of Akkermansia muciniphila on the regulation of intestinal barrier by Yang Liu, Qing Liu, Chengcheng Zhang, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai

“…However, the strain-specific and underlying regulatory mechanisms of this species on gut barrier function were not well studied. Therefore, this study evaluated the protective effect of A. muciniphila strains on the intestinal barrier and investigated the mode of action and material basis of this modulatory effect. …”
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Antenna Model with Pattern Optimization Based on Genetic Algorithm for Satellite-Based SAR Mission by Saray Sánchez-Sevilleja, Marcos García-Rodríguez, José Luis Masa-Campos, Juan Manuel Cuerda-Muñoz

“…The antenna model incorporates a number of functions, which are divided into two primary modules: the first of these is the antenna pattern generation (APG) module, and the second is the antenna excitation generation (AEG) module. …”
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Cuproptosis-related genes associated with mitochondrial dysfunction in Parkinson's disease. by Tingting Liu, Jingwen Li, Junshi Zhang, Jianshe Wei

“…The findings revealed 6685 DEGs and 31 distinct modules, with gene functions predominantly enriched in immune-related pathways. …”
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Analysis of information flow security using software implementing business logic based on stored database program blocks by A. А. Timakov

“…This will enable the functions of controlling data integrity and confidentiality in software to be isolated into a separate task, which can be resolved by information security analysts.Methods. …”
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Movement Disorders and Neuromodulation by Edward A. Shipton

“…High-frequency DBS leads to a kind of functional deafferentation of the stimulated structure and to the modulation of cortical activity. …”
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Early cortical alterations and neuropsychological mechanisms in amyotrophic lateral sclerosis by Qianqian Zhang, Yu Ding, Yu Zhang, Qingyang Li, Shiyu Shi, Yaxi Liu, Sijie Chen, Qian Wu, Xiaoquan Xu, Feiyun Wu, Xi Cheng, Qi Niu

“…Objective: This study investigates the characteristics of cortical structural and functional alterations in amyotrophic lateral sclerosis (ALS) patients and their modulation of emotional and cognitive functions, as well as to discuss their diagnostic value in early-stage ALS. …”
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FSDN-DETR: Enhancing Fuzzy Systems Adapter with DeNoising Anchor Boxes for Transfer Learning in Small Object Detection by Zhijie Li, Jiahui Zhang, Yingjie Zhang, Dawei Yan, Xing Zhang, Marcin Woźniak, Wei Dong

“…The fuzzy Adapter Transformer Encoder utilizes adaptive fuzzy membership functions and rule-based smoothing to preserve critical details, such as edges and textures, while mitigating the loss of fine details in global feature processing. …”
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Data-Driven Mobility System for Vehicular Communication: A Step Towards Transport Resilience in Intelligent Transport Systems by Maryam Gillani, Hafiz Adnan Niaz, Beatriz Martinez-Pastor

“…The collected data optimizes ITS functional capacity and efficiency to build smart infrastructure or smart cities. …”
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